JP7352542B2 - 運動失調を処置するためのリルゾールプロドラッグの使用 - Google Patents

運動失調を処置するためのリルゾールプロドラッグの使用 Download PDF

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Publication number
JP7352542B2
JP7352542B2 JP2020526149A JP2020526149A JP7352542B2 JP 7352542 B2 JP7352542 B2 JP 7352542B2 JP 2020526149 A JP2020526149 A JP 2020526149A JP 2020526149 A JP2020526149 A JP 2020526149A JP 7352542 B2 JP7352542 B2 JP 7352542B2
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Prior art keywords
ataxia
patient
administered
riluzole
medicament according
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JP2020526149A
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Japanese (ja)
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JP2021502392A5 (enExample
JP2021502392A (ja
Inventor
ブラディミア・コリック
ロバート・バーマン
メリッサ・バイナー
ギルバート・リタリエン
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Biohaven Therapeutics Ltd
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Biohaven Therapeutics Ltd
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Priority to JP2023149803A priority Critical patent/JP2023175823A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020526149A 2017-11-12 2018-11-11 運動失調を処置するためのリルゾールプロドラッグの使用 Active JP7352542B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023149803A JP2023175823A (ja) 2017-11-12 2023-09-15 運動失調を処置するためのリルゾールプロドラッグの使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762584856P 2017-11-12 2017-11-12
US62/584,856 2017-11-12
US201862717948P 2018-08-13 2018-08-13
US62/717,948 2018-08-13
PCT/US2018/060232 WO2019094851A1 (en) 2017-11-12 2018-11-11 Use of riluzole prodrugs to treat ataxias

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023149803A Division JP2023175823A (ja) 2017-11-12 2023-09-15 運動失調を処置するためのリルゾールプロドラッグの使用

Publications (3)

Publication Number Publication Date
JP2021502392A JP2021502392A (ja) 2021-01-28
JP2021502392A5 JP2021502392A5 (enExample) 2021-10-21
JP7352542B2 true JP7352542B2 (ja) 2023-09-28

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JP2020526149A Active JP7352542B2 (ja) 2017-11-12 2018-11-11 運動失調を処置するためのリルゾールプロドラッグの使用
JP2023149803A Pending JP2023175823A (ja) 2017-11-12 2023-09-15 運動失調を処置するためのリルゾールプロドラッグの使用

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JP2023149803A Pending JP2023175823A (ja) 2017-11-12 2023-09-15 運動失調を処置するためのリルゾールプロドラッグの使用

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US (3) US20210023061A1 (enExample)
EP (2) EP4483956B1 (enExample)
JP (2) JP7352542B2 (enExample)
KR (2) KR20250034521A (enExample)
CN (1) CN112292127A (enExample)
AU (1) AU2018364749C1 (enExample)
BR (1) BR112020009173A2 (enExample)
CA (1) CA3082096A1 (enExample)
DK (1) DK3706739T3 (enExample)
ES (1) ES2996892T3 (enExample)
FI (1) FI3706739T3 (enExample)
HR (1) HRP20241675T1 (enExample)
HU (1) HUE070302T2 (enExample)
IL (1) IL274532B2 (enExample)
LT (1) LT3706739T (enExample)
MD (1) MD3706739T2 (enExample)
MX (2) MX2020004678A (enExample)
PH (1) PH12020550583A1 (enExample)
PL (1) PL3706739T3 (enExample)
PT (1) PT3706739T (enExample)
RS (1) RS66277B1 (enExample)
SG (1) SG11202004332XA (enExample)
SI (1) SI3706739T1 (enExample)
SM (1) SMT202500022T1 (enExample)
WO (1) WO2019094851A1 (enExample)
ZA (1) ZA202002626B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2978158C (en) 2015-03-03 2022-04-12 Biohaven Pharmaceutical Holding Company Ltd. Riluzole prodrugs and their use
US12295942B2 (en) 2015-03-03 2025-05-13 Biohaven Therapeutics Ltd. Riluzole prodrugs and their use
US12029731B2 (en) 2016-08-10 2024-07-09 Biohaven Therapeutics Ltd. Acyl benzo[d]thiazol-2-amine and their methods of use
EP4277624A4 (en) * 2021-01-18 2024-11-20 Biohaven Therapeutics Ltd. USE OF RILUZOLE PRODRUGS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
US20250101034A1 (en) * 2021-11-04 2025-03-27 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
CN120018855A (zh) * 2022-05-23 2025-05-16 拜奥海芬治疗学有限公司 治疗脊髓小脑性共济失调的方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2016140879A1 (en) 2015-03-03 2016-09-09 Biohaven Pharmaceutical Holding Company Ltd. Riluzole prodrugs and their use

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GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
WO1995001782A2 (en) 1993-07-09 1995-01-19 R.P. Scherer Corporation Method for making freeze dried drug dosage forms
US5457895A (en) 1993-10-01 1995-10-17 R. P. Scherer Corporation Method of identifying freeze-dried dosage forms
US5837287A (en) 1994-10-28 1998-11-17 R P Scherer Corporation Process for preparing solid pharmaceutical dosage forms
WO1998036738A1 (en) 1997-02-20 1998-08-27 Therics, Inc. Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
EP1001748B1 (en) 1997-07-25 2006-04-19 Alpex Pharma S.A. A process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets
FR2774592B1 (fr) * 1998-02-06 2000-03-17 Rhone Poulenc Rorer Sa Application du 2-amino-6-trifluoromethoxybenzothiazole pour la prevention ou le traitement des dysfonctionnements du cervelet
RU2233654C2 (ru) 1998-11-20 2004-08-10 Ртп Фарма Инк. Диспергируемые стабилизированные фосфолипидом микрочастицы
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BIOHAVEN COMPLETES ENROLLMENT IN SPINOCEREBELLAR ATAXIA CLINICAL TRIAL WITH TRIGRILUZOLE，Biohaven Pharmaceuticals [online]，2017年05月30日，[令和4年7月19日検索]，インターネット＜URL：https://www.biohavenpharma.com/investors/news-events/press-releases/05-30-2017＞
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Also Published As

Publication number Publication date
ZA202002626B (en) 2025-02-26
MD3706739T2 (ro) 2025-02-28
KR20200103658A (ko) 2020-09-02
SG11202004332XA (en) 2020-06-29
CA3082096A1 (en) 2019-05-16
PH12020550583A1 (en) 2021-05-31
WO2019094851A1 (en) 2019-05-16
EP3706739A4 (en) 2021-08-04
SI3706739T1 (sl) 2025-03-31
US20230355592A1 (en) 2023-11-09
ES2996892T3 (en) 2025-02-13
KR20250034521A (ko) 2025-03-11
PL3706739T3 (pl) 2025-03-10
FI3706739T3 (fi) 2024-12-27
HRP20241675T1 (hr) 2025-02-14
HUE070302T2 (hu) 2025-05-28
US20210023061A1 (en) 2021-01-28
EP4483956B1 (en) 2025-12-31
AU2018364749C1 (en) 2024-02-15
IL274532B1 (en) 2024-01-01
AU2018364749A1 (en) 2020-07-02
LT3706739T (lt) 2024-12-27
CN112292127A (zh) 2021-01-29
JP2023175823A (ja) 2023-12-12
PT3706739T (pt) 2024-12-04
JP2021502392A (ja) 2021-01-28
AU2018364749B2 (en) 2023-11-09
EP4483956A2 (en) 2025-01-01
RS66277B1 (sr) 2025-01-31
US12102618B2 (en) 2024-10-01
EP4483956A3 (en) 2025-03-19
IL274532B2 (en) 2024-05-01
EP3706739B1 (en) 2024-10-16
NZ765220A (en) 2023-11-24
IL274532A (en) 2020-06-30
EP3706739A1 (en) 2020-09-16
MX2023012640A (es) 2023-11-08
US20230390252A1 (en) 2023-12-07
SMT202500022T1 (it) 2025-03-12
MX2020004678A (es) 2020-08-13
BR112020009173A2 (pt) 2020-11-03
DK3706739T3 (da) 2024-12-02

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