JP7342428B2 - Biological tissue attachment film and transfer sheet - Google Patents

Description

The present invention relates to a film for applying biological tissue and a transfer sheet.

2. Description of the Related Art Bandages and dressings are known as members that are attached to the skin for purposes such as treating wounds and fixing joints. Various properties are desired for these members for application to the skin depending on their use. For example, as described in Patent Document 1, the skin patch member used for taping joints has elasticity that allows it to follow the movement of the joint, low modulus that prevents the skin from being restrained due to stretching, and elasticity that allows the taping to loosen. Kickback properties that can be suppressed are required. Patent Document 1 proposes a skin patch member having a laminated structure of a stretchable knitted fabric, a polyurethane film, and an adhesive layer as a skin patch member that satisfactorily obtains each of the above characteristics. .

Patent No. 4102129 specification

By the way, when a semi-solid agent such as an ointment or cream is applied to the skin, the applied area becomes sticky. As a result, problems arise in which the user feels uncomfortable and the semi-solid agent adheres to clothing or the like that has touched the application area. These problems can be solved by covering the application area with a skin patch member, but if the skin texture, that is, the ability of the skin patch member to follow minute irregularities on the skin is poor, the application area of the skin patch member may be damaged. The user may feel an uncomfortable sensation of tightness on the skin, the applied part may have an appearance that is different from the skin and stand out, and the skin application member may peel off easily. As described in Patent Document 1, a highly flexible skin patch member has been proposed, but its flexibility is only at a level that allows it to follow the bending of a joint, and it does not conform to the unevenness of the surface of living tissue such as the skin. Not enough to follow.

An object of the present invention is to provide a biological tissue sticking film and a transfer sheet that can suppress stickiness caused by a semi-solid agent and improve conformability to the surface shape of an adherend.

A biological tissue attachment film that solves the above problems comprises a polymer film having an average mass of 0.1 g/m ² or more and 3.0 g/m ² or less, and a polymer film located on one of two surfaces of the polymer film. , a semi-solid agent layer composed of at least one of an ointment and a cream.

According to the above configuration, when the biological tissue application film is attached to an adherend so that the semisolid agent layer is in contact with the adherend, the semisolid agent layer has a high temperature that can suppress oozing of the semisolid agent. Covered with molecular film. Therefore, the appearance of stickiness caused by the semi-solid agent on the adherend can be suppressed. On the other hand, since the polymer film is an extremely thin film, the film for applying biological tissue can highly follow the surface shape of the adherend.

In the above configuration, the polymer film may include a hydrophobic polymer, and the semisolid agent layer may include a hydrophilic base.
In the above configuration, the polymer film may include a hydrophilic polymer, and the semisolid agent layer may include a hydrophobic base.

According to each of the above configurations, the semi-solid agent constituting the semi-solid agent layer is prevented from permeating into the polymer film. As a result, the oozing of the semi-solid agent onto the surface of the film for applying to living tissue is suitably suppressed, and therefore the stickiness caused by the semi-solid agent is suppressed more suitably.

In the above configuration, the semi-solid agent layer may be located on the one surface of the polymer film in an area other than an annular area along the outer edge of the polymer film.
According to the above configuration, since the polymer film and the adherend come into direct contact near the outer edge where the film for applying biological tissue tends to peel off, the adhesion between the film for applying biological tissue and the adherend is enhanced. . Therefore, the biological tissue sticking film becomes difficult to peel off from the adherend. In addition, when the film for applying biological tissue is applied to an adherend, it is possible to prevent the semi-solid agent from being pushed out from the side of the film for applying biological tissue and to prevent the active ingredients in the semi-solid agent layer from evaporating. .

A transfer sheet that solves the above problem includes the above-mentioned film for attaching living tissue and a support base material that supports the film for attaching living tissue.
According to the above configuration, since the living tissue sticking film is supported by the support base material, deformation of the living tissue sticking film is suppressed, and the living tissue sticking film becomes easier to handle.

A method of using a polymer film to solve the above problem is a method of using a polymer film to protect an area where a semi-solid agent is applied, the polymer film having a weight of 0.1 g/m 2 or more and 3.0 g/m ² or more. /m ² or less, the semi-solid agent is at least one of an ointment and a cream, and the method includes attaching the polymer film to the application area located on the surface of living tissue.

According to the above method, the application area of the semi-solid agent is covered with a polymer film that can suppress oozing of the semi-solid agent, so that stickiness due to the semi-solid agent does not become apparent on the adherend, which is biological tissue. It can be suppressed. On the other hand, since the polymer film is an extremely thin film, it can highly follow the surface shape of the adherend.

According to the present invention, in a film for pasting biological tissue, it is possible to suppress stickiness due to the semi-solid agent and to improve conformability to the surface shape of an adherend.

The figure which shows the cross-sectional structure of the film for biological tissue sticking about one embodiment of the film for biological tissue sticking. FIG. 1 is a diagram showing a planar structure of a biological tissue sticking film of one embodiment. FIG. 1 is a diagram showing a cross-sectional structure of a transfer sheet according to an embodiment. FIG. 3 is a diagram showing a method of transferring a biological tissue sticking film using a transfer sheet of one embodiment, and shows a state in which the transfer sheet is placed on an adherend. FIG. 3 is a diagram showing a method of transferring a biological tissue sticking film using a transfer sheet of one embodiment, and is a diagram showing a step of peeling off a supporting base material.

With reference to the drawings, an embodiment of a method of using a biological tissue sticking film, a transfer sheet, and a polymer film will be described. The adherend to which the biological tissue pasting film of this embodiment is pasted is a living tissue, for example, skin.

[Configuration of film for attaching biological tissue]
As shown in FIG. 1, the biological tissue sticking film 10 has a first surface 10F and a second surface 10R, which is a surface opposite to the first surface 10F. The first surface 10F is a surface to be attached to an adherend. The second surface 10R is a surface that is exposed to the outside air when the biological tissue application film 10 is applied to an adherend.

The biological tissue sticking film 10 includes a polymer film 11 and a semi-solid agent layer 12. The semi-solid agent layer 12 is laminated on one of the two surfaces of the polymer film 11. The first surface 10F is a surface of the semi-solid agent layer 12, and the second surface 10R is a surface of the polymer film 11. That is, when the biological tissue application film 10 is applied to an adherend, the semi-solid agent layer 12 comes into contact with the adherend.

The polymer film 11 is thin enough to exhibit adhesiveness to an adherend by itself. For example, the thickness of the polymer film 11 is 10 nm or more and 5000 nm or less. If the thickness of the polymer film 11 is within the above range, the ability of the polymer film 11 to follow the surface shape of the adherend can be obtained satisfactorily, and the ability of the film 10 for applying biological tissue to follow the surface shape can be improved. can be obtained in good condition. From the viewpoint of further improving the ability to follow irregularities on the surface of the skin, the thickness of the polymer film 11 is preferably 1000 nm or less. Furthermore, the thickness of the polymer film 11 is preferably 100 nm or more, since the strength of the polymer film 11 can be obtained well and the oozing of the semi-solid agent can be suppressed well. The polymer film 11 may be composed of a single thin film, or may be a laminate of a plurality of thin films. In addition, the said thickness is an average thickness, Comprising: It is the average value of the film thickness of the polymer film 11 measured at 5 or more measurement points.

If the mass of the polymer film 11 is expressed in place of the thickness to indicate that it is thin enough to exhibit adhesiveness to the adherend, for example, if the density of the polymer film 11 is 1 g/cm ³ or more and 3 g/cm ^{3 or} less, then In some cases, the average mass per unit area of the polymer film 11 is 0.1 g/m ² or more and 3.0 g/m ² or less. The above average mass is the mass of the polymer film 11 calculated per portion having an area of 1 m ² in plan view. If the average mass of the polymer film 11 is 3.0 g/m ² or less, the polymer film 11 can satisfactorily follow the surface shape of the adherend, and as a result, it can be used for attaching living tissue to the surface shape. Good followability of the film 10 is obtained. When the average mass of the polymer film 11 is 0.1 g/m ² or more, oozing of the semi-solid agent can be suppressed well.

The polymer film 11 contains a biocompatible polymer as a main component. The polymer may be hydrophobic or hydrophilic. The weight average molecular weight of the main component polymer is selected, for example, from the range of 10,000 to 1,000,000. Note that the main component of the polymer film 11 is a substance that has the highest content (% by mass) among the substances that constitute the polymer film 11.

Moreover, the polymer film 11 may contain various additives. Examples of additives include various fillers, pigments, proteins, enzymes, drugs, and cosmetic ingredients. The polymer film 11 may be colored, for example, in skin color.

The semi-solid agent layer 12 is a layer made of a semi-solid agent which is an ointment or cream. The semisolid agent constituting the semisolid agent layer 12 includes a base and an active ingredient. The base material may be a hydrophobic base material or a hydrophilic base material. Further, the semi-solid agent may not contain water or may contain oil and water and be emulsified. For example, semi-solid preparations include ointments made by kneading fat, fatty oil, wax, vaseline, glycerin, resin, etc. with a compound that functions as an active ingredient, or emulsifying the active ingredient by mixing oil, fat, wax, glycerin, etc. with an emulsifier. It is a cream containing a compound that functions as Further, the semi-solid agent layer 12 may include a portion made of ointment and a portion made of cream.

The active ingredient contained in the semi-solid agent may be any ingredient that exhibits a predetermined function in medical or cosmetic applications, such as an ingredient that has a wound or inflammation healing function, an ingredient that has an antibacterial effect or an analgesic effect, Examples include antibiotics, enzymes, beauty ingredients with moisturizing functions, etc. Note that if the base itself has a desired function such as a moisturizing function, the semisolid agent may not contain any active ingredients other than the base.

The thickness of the semi-solid agent layer 12 is not particularly limited, and it is sufficient that the semi-solid agent layer 12 is composed of the amount of semi-solid agent required to obtain the desired effect on the adherend. For example, the thickness of the semi-solid agent layer 12 is greater than the thickness of the polymer film 11, and is 500 nm or more and 50 μm or less. In addition, the said thickness is an average thickness, Comprising: It is the average value of the film thickness of the semi-solid agent layer 12 measured at 5 or more measurement points. Further, for example, the average mass per unit area of the semi-solid agent layer 12 is 1 g/m ² or more and 50 g/m ² or less.

In order to prevent the semi-solid agent constituting the semi-solid agent layer 12 from penetrating the polymer film 11 and exuding to the second surface 10R, when the main component of the polymer film 11 is hydrophobic, The base of the semi-solid agent layer 12 is preferably hydrophilic, and when the main component of the polymer film 11 is hydrophilic, the base of the semi-solid agent layer 12 is preferably hydrophobic.

Examples of the hydrophobic polymer constituting the polymer film 11 include polylactic acid, polyglycolic acid, oxidized cellulose, polycaprolactone, polydioxanone, polyhydroxyalkanoate, polyamide, polyether, and copolymers of these compounds. can be used. Examples of the hydrophilic polymer constituting the polymer film 11 include polyethylene glycol, polyvinyl acetate, gelatin, polyglucuronic acid, hyaluronic acid, carboxymethyl cellulose, cellulose ether, chitosan, mixtures thereof, and polyvinylpyrrolidone. Water-soluble resins can be used.

Examples of the hydrophilic base constituting the semi-solid agent layer 12 include polyethylene glycol, polysorbates, sodium carboxymethyl cellulose, methyl cellulose, guar gum, sodium alginate, carrageenan, glycerin, 1,3-butylene glycol, propylene glycol, and the like. Can be used. As the hydrophobic base constituting the semi-solid agent layer 12, petrolatum, silicone elastomer, Japanese wax, carnauba wax, beeswax, gay wax, candelilla wax, liquid paraffin, squalane, fatty acid ester of glycerin, fatty acid ester of higher alcohol, etc. Can be used. For example, oily ointments are produced on the basis of which these bases are prepared into a paste. A mixture of two or more types of materials may be used as the base material.

Further, if the polymer film 11 contains a component that makes it difficult for the semi-solid agent constituting the semi-solid agent layer 12 to pass through the polymer film 11 as an additive, the second surface 10R of the semi-solid agent leakage can be more effectively suppressed. For example, when the semi-solid agent is an oil-based ointment, if the polymer film 11 contains a filler that adsorbs oil, the semi-solid agent will not penetrate from the semi-solid agent layer 12 into the polymer film 11. Even if this occurs, the semi-solid agent is adsorbed by the filler inside the polymer film 11, thereby suppressing the semi-solid agent from seeping out onto the second surface 10R.

The semi-solid agent layer 12 may be located on at least a portion of one surface of the polymer film 11. In other words, the semi-solid agent layer 12 may cover the entire one surface of the polymer film 11, or may cover only a portion thereof.

FIG. 2 is a view of the biological tissue sticking film 10 viewed from a position facing the first surface 10F, and shows an example of a form in which the semi-solid agent layer 12 is located in a part of the polymer film 11. In FIG. 2, the semi-solid agent layer 12 is located in a region including the center of the polymer film 11 when viewed from a position facing the first surface 10F, and the semi-solid agent layer 12 is located in an annular region extending along the outer edge of the polymer film 11. The semi-solid agent layer 12 is not located in the area. That is, the annular region along the outer edge of the biological tissue sticking film 10 is composed only of the polymer film 11.

In this form, the polymer film 11 and the adherend are in direct contact near the outer edge of the biological tissue sticking film 10, so that the polymer film 11 contacts the adherend along the surface shape of the adherend. In close contact. As a result, the adhesion between the living tissue sticking film 10 and the adherend is enhanced near the outer edge where the living tissue sticking film 10 tends to peel off, so the living tissue sticking film 10 is less likely to peel off from the adherend. Become. Furthermore, when the film 10 for applying biological tissue is applied to an adherend, the semi-solid agent layer 12 may be crushed and the semi-solid agent may be pushed out from the side of the film 10 for applying biological tissue, or the semi-solid agent may be extruded from the side of the film 10 for applying biological tissue. It is also possible to suppress evaporation of the active ingredients in the agent layer 12.

[Composition of transfer sheet]
As shown in FIG. 3, the transfer sheet 20 includes a biological tissue sticking film 10 and a support base material 21.

The support base material 21 is in contact with the second surface 10R of the film 10 for attaching living tissue and supports the film 10 for attaching living tissue. That is, the support base material 21 is in contact with the polymer film 11.

The support base material 21 is used to support the living tissue sticking film 10 when storing the living tissue sticking film 10 or when moving the living tissue sticking film 10 onto an adherend when using the living tissue sticking film 10. It has the function of suppressing deformation. By being supported by the support base material 21, the biological tissue sticking film 10 becomes easier to handle.

It is preferable that the support base material 21 is a porous base material. A porous base material is a base material that has a large number of minute gaps inside, and allows liquid to penetrate or permeate therethrough. Porous base materials that can be used as the support base material 21 include, for example, sheets made of fibrous materials such as nonwoven fabrics, paper, knitted fabrics, and woven fabrics, and resin sheets having a mesh-like structure including gaps. Among these base materials, nonwoven fabrics are preferably used. The fibers constituting the nonwoven fabric include, for example, natural fibers such as cotton, hemp, wool, and pulp, semi-synthetic fibers such as rayon, and synthetic fibers such as polyvinyl alcohol and polyacrylic acid. Among the above-mentioned fibers, natural fibers, especially pulp, are preferably used. The nonwoven fabric may be composed of one type of fiber, or may be composed of two or more types of fiber.

Note that the support base material 21 is not limited to a porous base material, and may be a base material such as a resin sheet or metal foil that does not have any gaps inside. Moreover, as the supporting base material 21, a base material having mold releasability, such as a resin sheet having a surface made of silicone or fluororesin, may be used.

The transfer sheet 20 may include a protective layer that covers the first surface 10F of the biological tissue sticking film 10. The protective layer protects the semi-solid agent layer 12. Covering the semi-solid agent layer 12 with the protective layer prevents the semi-solid agent constituting the semi-solid agent layer 12 from adhering to external articles. The transfer sheet 20 can be stored in a roll, or the transfer sheet 20 can be rolled up and stored.

The protective layer is preferably made of a material that can be easily peeled off from the semisolid agent layer 12 and that prevents the semisolid agent constituting the semisolid agent layer 12 from adhering to the protective layer when peeled off. For example, a resin sheet having a surface made of silicone or fluororesin can be used as the protective layer.

[Method for manufacturing biological tissue attachment film and transfer sheet]
An example of a method for manufacturing the biological tissue sticking film 10 and the transfer sheet 20 will be described.
Note that a manufacturing method different from that described below may be used as long as it is possible to manufacture the biological tissue sticking film 10 and transfer sheet 20 described above.

First, a polymer film 11 is formed on the surface of a film-forming base material. The film-forming base material may be any base material that has releasability, and for example, a polyethylene terephthalate film or an olefin film having a surface made of silicone or fluororesin is suitably used.

Specifically, the material of the polymer film 11 is dissolved in a solvent suitable for the material, and this coating liquid is applied to the surface of the film-forming base material. The polymer film 11 is then formed by drying and solidifying the coating film.

Various coating methods are used to apply the coating liquid, including direct gravure, reverse gravure, small diameter reverse gravure, Meyer coating, die, curtain, spray, spin coating, screen printing, comma, knife, gravure offset, and roll coating. It is possible. The thickness and average mass of the polymer film 11 can be controlled by the solid content ratio in the coating liquid and the coating method.

Subsequently, the supporting base material 21 is brought into contact with the surface of the polymer film 11 on the film-forming base material, and the polymer film 11 is transferred from the film-forming base material to the supporting base material 21. As the transfer method, any known transfer method may be used, such as a method using peeling by suction or a method using a sacrificial film.

Furthermore, a semi-solid agent layer 12 is formed by applying a semi-solid agent to the surface of the polymer film 11 on the supporting base material 21 . Thereby, the biological tissue sticking film 10 and the transfer sheet 20 are formed. There are various coating methods for applying semi-solid agents, such as direct gravure, reverse gravure, small diameter reverse gravure, Meyer coating, die, curtain, spray, spin coating, screen printing, comma, knife, gravure offset, and roll coating. Available for use. If the semi-solid agent has a high viscosity and is difficult to apply, the viscosity may be adjusted by diluting with a solvent or heating before application. When forming a patterned semi-solid agent layer 12, such as when forming a semi-solid agent layer 12 on a part of the polymer film 11, each coating method is direct gravure, spray, screen printing, and gravure offset. It is suitable to use the method.

Note that the film-forming base material may be used as the support base material 21. In this case, the biological tissue sticking film 10 and the transfer sheet 20 can be formed by coating and forming the semi-solid agent layer 12 on the surface of the polymer film 11 on the film-forming base material.
When forming the transfer sheet 20 provided with a protective layer, the protective layer is laminated on the surface of the semi-solid agent layer 12 after the formation of the semi-solid agent layer 12.

[Method for attaching biological tissue attaching film]
A method for attaching the biological tissue attaching film 10, that is, a method for transferring the biological tissue attaching film 10 using the transfer sheet 20 will be described.

First, as shown in FIG. 4, the transfer sheet 20 is placed on an adherend so that the first surface 10F of the biological tissue sticking film 10 is in contact with the surface of the adherend, which is, for example, skin Sk.
Subsequently, as shown in FIG. 5, the support base material 21 is peeled off from the polymer film 11. Thereby, the biological tissue sticking film 10 is transferred to the skin. Since the semi-solid agent layer 12 has adhesive properties to the adherend due to its stickiness, the support base material 21 can be peeled off while leaving the biological tissue sticking film 10 on the adherend. If the supporting base material 21 has a releasable structure, it becomes easier to peel the supporting base material 21 from the biological tissue sticking film 10.

By using the biological tissue sticking film 10 of this embodiment, the semi-solid agent layer 12 on the adherend is covered with the polymer film 11 that can suppress the exudation of the semi-solid agent. The appearance of stickiness caused by the solid agent is suppressed. Therefore, the user is prevented from feeling uncomfortable and the semi-solid agent is prevented from adhering to clothes or the like. On the other hand, since the polymer film 11 is an extremely thin film, the biological tissue sticking film 10 can highly follow the surface shape of the adherend. Therefore, the user may feel an uncomfortable feeling as if the applied part of the biological tissue applying film 10 is tight, the applied part may have a different appearance from the surrounding area and stand out, or the biological tissue applying film 10 may be attached to the adherend. This prevents the film from peeling off easily.

Furthermore, since the semi-solid agent layer 12 is covered with the polymer film 11 on the adherend, the semi-solid agent layer 12 is protected by the polymer film 11, and the semi-solid agent is prevented from falling off the adherend. . Therefore, when the adherend is the skin, clothing such as stockings that tightly adhere to the skin may be worn over the biological tissue application film 10, or cosmetics such as foundation may be applied on the biological tissue application film 10. It is also possible to apply it.

Furthermore, since the biological tissue sticking film 10 of the present embodiment includes a predetermined amount of semi-solid agent as the semi-solid agent layer 12, the user can apply any amount of semi-solid agent to the adherend. Compared to the case where the semi-solid agent is applied to the adherend, it is possible to supply the semi-solid agent quantitatively to the adherend. That is, it is possible to prevent over-applying the semi-solid agent or under-applying the semi-solid agent.

Note that the polymer film 11 may be used to protect the area on the adherend where the semi-solid agent is applied. That is, after applying the semi-solid agent to the surface of the adherend, the polymer film 11 is attached to the application area of the semi-solid agent, thereby covering the application area with the polymer film 11. This results in a state in which the layer made of the semi-solid agent and the polymer film 11 are laminated on the adherend, similar to the form shown in FIG. Even in this method of using the polymer film 11, stickiness caused by the semi-solid agent on the adherend can be suppressed, and the polymer film 11 By following the surface shape of the adherend, it is possible to suppress the user's discomfort and the conspicuousness of the part to which the polymer film 11 is attached.

[Example]
The above-mentioned biological tissue sticking film and transfer sheet will be explained using specific examples and comparative examples.

(Example 1)
A coating solution in which poly DL lactic acid (manufactured by BMG) is dissolved in methyl ethyl ketone is applied onto a polyethylene terephthalate film (manufactured by Toyobo Co., Ltd.) with mold releasability using a gravure coating method, and the polymer film is made by drying. Formed. The polyethylene terephthalate film functions as a film-forming base material and a supporting base material. The polymer film was formed so that the average mass after drying was 1.5 g/m ² .

A semi-solid agent layer was formed by applying glycerin to the surface of the polymer film on the supporting base material, which was the polyethylene terephthalate film. Glycerin was applied so that the average mass of the semi-solid agent layer was 40.0 g/m ² . Thereafter, the laminate of the supporting base material, the polymer film, and the semi-solid agent layer was cut into a square shape with one side of 50 mm in plan view to form the biological tissue sticking film and transfer sheet of Example 1. did.

The transfer sheet of Example 1 was placed on the skin of the left arm, which was the adherend, so that the first surface, which was the surface of the semisolid agent layer, was in contact with the skin of the left arm. Then, the sample of Example 1 was prepared by peeling the supporting base material from the polymer film.

(Example 2)
A coating liquid in which polyvinyl acetate was dissolved in isopropanol was applied by gravure coating onto a polyethylene terephthalate film (manufactured by Toyobo Co., Ltd.) having mold release properties, and dried to form a polymer film. The polyethylene terephthalate film functions as a film-forming base material and a supporting base material. The polymer film was formed so that the average mass after drying was 1.5 g/m ² .

A semi-solid agent layer was formed by applying vaseline to the surface of the polymer film on the supporting base material, which was the polyethylene terephthalate film. Vaseline was applied so that the average mass of the semi-solid agent layer was 40.0 g/m ² . Thereafter, the laminate of the supporting base material, the polymer film, and the semisolid agent layer was cut into a square shape with one side of 50 mm in plan view to form the biological tissue sticking film and transfer sheet of Example 2. did.

The transfer sheet of Example 2 was placed on the skin of the left arm, which was the adherend, so that the first surface, which was the surface of the semisolid agent layer, was in contact with the skin of the left arm. Then, a sample of Example 2 was prepared by peeling the supporting base material from the polymer film.

(Example 3)
The biological tissue sticking film and transfer sheet of Example 3 were prepared using the same materials and steps as in Example ² , except that the polymer film was formed to have an average mass after drying of 0.1 g/m2. was formed to prepare the sample of Example 3.

(Example 4)
The biological tissue sticking film and transfer sheet of Example 4 were prepared using the same materials and steps as in Example 2, except that the polymer film was formed to have an average mass of 3.0 g/m ² after drying. was formed to prepare the sample of Example 4.

(Comparative example 1)
A sample of Comparative Example 1 was prepared by applying 0.1 g of petrolatum to a square area of 50 mm on each side on the skin of the left arm.

(Comparative example 2)
A coating solution in which poly DL lactic acid (manufactured by BMG) is dissolved in methyl ethyl ketone is applied onto a polyethylene terephthalate film (manufactured by Toyobo Co., Ltd.) with mold releasability using a gravure coating method, and the polymer film is made by drying. Formed. The polyethylene terephthalate film functions as a film-forming base material and a supporting base material. The polymer film was formed so that the average mass after drying was 3.5 g/m ² .

A semi-solid agent layer was formed by applying glycerin to the surface of the polymer film on the supporting base material, which was the polyethylene terephthalate film. Glycerin was applied so that the average mass of the semi-solid agent layer was 40.0 g/m ² . Thereafter, the laminate of the supporting base material, the polymer film, and the semisolid agent layer was cut into a square shape with one side of 50 mm in plan view to form the biological tissue sticking film and transfer sheet of Comparative Example 2. did.

The transfer sheet of Comparative Example 2 was placed on the skin of the left arm, which was the adherend, so that the first surface, which was the surface of the semisolid agent layer, was in contact with the skin of the left arm. Then, a sample of Comparative Example 2 was prepared by peeling the supporting base material from the polymer film.

(Comparative example 3)
The biological tissue sticking film and transfer sheet of Comparative Example 3 were prepared using the same materials and steps as Comparative Example ² , except that the polymer film was formed to have an average mass after drying of 0.05 g/m2. A sample of Comparative Example 3 was prepared.

(Evaluation method)
<Suppression of stickiness>
After preparing the samples of each Example and each Comparative Example, the samples were allowed to stand for 30 minutes, and then the second surface of the film for attaching biological tissue was touched with a finger to evaluate the stickiness on a three-grade scale. Regarding the sample of Comparative Example 1, the sticky state was evaluated by touching the surface of the Vaseline application area with a finger. ``〇'' indicates that no stickiness is felt; ``△'' indicates that there is a slight sticky sensation, but no semi-solid agent is observed adhering to the fingers; stickiness is felt, and adhesion of the semi-solid agent to the fingers is observed. Cases in which this is the case are marked as “×”.

<Skin adhesion>
As an evaluation of the followability of the film for applying biological tissue to the surface shape of the skin, the adhesion of the film for applying biological tissue to the skin was evaluated in three stages. Specifically, after preparing the samples of each Example and Comparative Examples 2 and 3, after leaving the samples for 30 minutes, the area where the biological tissue adhesive film was applied was different from the area where the biological tissue adhesive film was not applied. It was observed whether there were any differences in appearance and whether peeling occurred at the edges of the film for applying biological tissue. ``〇'' indicates that there is no difference in appearance and peeling of the edges, ``△'' indicates that a small amount of at least one of the differences in appearance and peeling of the edges is observed, and ``△'' indicates that there is no difference in appearance and peeling of the edges. Cases where it was clearly observed were marked as "×".

(Evaluation results)
Table 1 shows the evaluation results of stickiness suppression and skin adhesion in each Example and each Comparative Example.

As shown in Table 1, in Comparative Example 1 in which the area where the semi-solid agent was applied was not covered with a polymer film, stickiness was noticeable. In addition, in Comparative Example 3 in which the average mass of the polymer film was less than 0.1 g/m ² , the semi-solid agent constituting the semi-solid agent layer permeated the polymer film to the second surface of the film for applying biological tissue. It oozes into the skin, and the control of stickiness is insufficient.

On the other hand, in Examples 1 to 4 in which the average mass of the polymer film was 0.1 g/m2 or ^more , stickiness was suitably suppressed by suppressing oozing of the semi-solid agent to the second surface. There is.

On the other hand, in Comparative Example 2 in which the average mass of the polymer film exceeds 3.0 g/m ² , the adhesion to the skin is insufficient. On the other hand, in Examples 1 to 4 in which the average mass of the polymer film was 3.0 g/m ² or less, good adhesion to the skin was obtained.

Based on the above results, if the film for biological tissue application is a laminate of a polymer film having an average mass of 0.1 g/m ² or more and 3.0 g/m ² or less and a semi-solid agent layer, the semi-solid agent It was confirmed that it is possible to suppress stickiness and improve adhesion to the skin, that is, ability to follow the surface shape of the adherend.

As described above in the embodiments and examples, the biological tissue sticking film and transfer sheet can provide the effects listed below.
(1) The biological tissue sticking film 10 is a semi-solid agent layer composed of a polymer film 11 having an average mass of 0.1 g/m ² or more and 3.0 g/m ² or less, and at least one of an ointment and a cream. 12. According to the above configuration, it is possible to suppress stickiness caused by the semi-solid agent and to improve conformability to the surface shape of the adherend.

(2) The polymer constituting the polymer film 11 is hydrophobic and the base of the semi-solid agent layer 12 is hydrophilic, or the polymer constituting the polymer film 11 is hydrophilic; If the base of the semi-solid agent layer 12 is hydrophobic, the semi-solid agent constituting the semi-solid agent layer 12 is prevented from permeating into the polymer film 11. As a result, the exudation of the semi-solid agent to the second surface 10R of the biological tissue sticking film 10 is suitably suppressed, and therefore the stickiness caused by the semi-solid agent is suppressed more suitably.

(3) If the semi-solid agent layer 12 is located in an area other than the annular area along the outer edge of the polymer film 11 on one surface of the polymer film 11, the film 10 for attaching biological tissue By directly contacting the polymer film 11 and the adherend in the vicinity of the outer edge where peeling is likely to occur, the adhesion between the biological tissue sticking film 10 and the adherend is enhanced. Therefore, the biological tissue sticking film 10 becomes difficult to peel off from the adherend. Furthermore, when the biological tissue application film 10 is applied to an adherend, the semi-solid agent is prevented from being extruded from the side surface of the biological tissue application film 10 and the active ingredient of the semi-solid agent layer 12 is prevented from evaporating. You can also do that.

(4) In the transfer sheet 20, the living tissue sticking film 10 is supported by the support base material 21, so that deformation of the living tissue sticking film 10 is suppressed and the living tissue sticking film 10 becomes easier to handle. .

DESCRIPTION OF SYMBOLS 10... Film for biological tissue attachment, 10F... First surface, 10R... Second surface, 11... Polymer film, 12... Semi-solid agent layer, 20... Transfer sheet, 21... Support base material.

Claims (5)

A polymer film having an average mass of 0.1 g/m ² or more and 3.0 g/m ² or less and a density of 1 g/cm ³ or more and 3 g/cm ³ or less , and one of the two surfaces of the polymer film. a semi-solid agent layer comprising at least one of an ointment and a cream ;
a support base material that supports the biological tissue sticking film on the opposite side of the semi-solid agent layer with respect to the polymer film;
a protective layer covering the semi-solid agent layer on a side opposite to the polymer film with respect to the semi-solid agent layer,
The polymer film includes a hydrophilic polymer,
The semi-solid agent layer includes a hydrophobic base.
Transfer sheet . A polymer film having an average mass of 0.1 g/m ² or more and 3.0 g/m ² or less and a density of 1 g/cm ³ or more and 3 g/cm ³ or less , and one of the two surfaces of the polymer film. a semi-solid agent layer comprising at least one of an ointment and a cream ;
a support base material that supports the biological tissue sticking film on the opposite side of the semi-solid agent layer with respect to the polymer film;
a protective layer covering the semi-solid agent layer on a side opposite to the polymer film with respect to the semi-solid agent layer,
The polymer film includes a hydrophobic polymer,
The semi-solid agent layer includes a hydrophilic base.
Transfer sheet . A polymer film having an average mass of 0.1 g/m ² or more and 3.0 g/m ² or less , and a density of 1 g/cm ³ or more and 3 g/cm ³ or less ,
a semi-solid agent layer located on one of the two surfaces of the polymer film and composed of at least one of an ointment and a cream;
The polymer film includes a hydrophilic polymer and a filler that adsorbs oil,
The semi-solid agent layer includes a hydrophobic base.
Film for pasting biological tissue. The film for applying biological tissue according to claim 3 , wherein the semi-solid agent layer is located on the one surface of the polymer film in an area excluding an annular area along the outer edge of the polymer film. The biological tissue sticking film according to claim 3 or 4 ,
a support base material that supports the biological tissue sticking film;
A transfer sheet comprising:

Images