JP7333115B2 - Potency enhancement method - Google Patents

Description

The present invention relates to a method of enhancing efficacy for controlling insect pests.

Conventionally, as an aerosol product used for controlling pests, for example, as disclosed in Patent Document 1, it contains a pyrethroid insecticidal active ingredient and a solvent, and these are filled in an aerosol can together with a propellant such as dimethyl ether. what has been done is known. Specifically, in Patent Document 1, an ester solvent solution of a pyrethroid insecticidal active ingredient and a petroleum solvent are mixed, and the weight ratio of the pyrethroid insecticidal active ingredient and the ester solvent is 1: 1 to 1. : 100. Also, sparingly soluble imiprothrin having a solubility of 1% or less in nC ₁₂ H ₂₆ at 25° C. is used as a pyrethroid insecticidal active ingredient.

JP 2003-160418 A

By the way, as disclosed in Patent Document 1, pyrethroid insecticidal active ingredients include sparingly soluble pyrethroid insecticidal active ingredients. In order to dissolve this, in Patent Document 1, an ester solvent is used, and the weight ratio of the pyrethroid insecticidal active ingredient and the ester solvent is between 1:1 and 1:100. This is said to dissolve the sparingly soluble pyrethroid insecticidal active ingredient.

In an aerosol product for pest control, not only the pyrethroid insecticidal active ingredient is dissolved, but also further improvement of efficacy against pests is required. In other words, there is a demand not only to be able to sufficiently draw out the efficacy of the pyrethroid insecticidal active ingredient by dissolving the pyrethroid insecticidal active ingredient, but also to obtain an effect greater than that of the pyrethroid insecticidal active ingredient alone. .

The present invention has been made in view of the above points, and its object is to dissolve a pyrethroid insecticidal active ingredient so that the effect of the pyrethroid insecticidal active ingredient can be fully drawn out, and to dissolve the pyrethroid insecticidal active ingredient. To obtain efficacy higher than that of an insecticidal active ingredient alone.

In order to achieve the above object, the present invention contains a pyrethroid insecticidal active ingredient and an amide solvent.

A first invention is characterized by containing a pyrethroid-based insecticidal active ingredient, an efficacy enhancer comprising an amide-based solvent, and kerosene. The efficacy enhancer is 3-butoxy-N,N-dimethylpropanamide, and the pyrethroid insecticidal active ingredient is at least one of d-T80-phthalthrin and d-T80-resmethrin.

According to this configuration, the pyrethroid insecticidal active ingredient dissolved in kerosene can be maintained for a long period of time. As a result, the efficacy of the pyrethroid-based insecticidal active ingredient can be sufficiently brought out. Furthermore, the potency enhancer comprising the amide solvent improves the potency of the pyrethroid insecticidal active ingredient against pests.

In addition, the potency enhancement effect becomes remarkable without inhibiting the solubility of the pyrethroid insecticidal active ingredient.

In addition, sufficient efficacy can be obtained while d-T80-phthalthrin and d-T80-resmethrin are dissolved by the efficacy enhancer.

A second invention is characterized in that the content of the efficacy enhancer is set to 2 w/v % or more.

According to this configuration, the efficacy enhancement effect of the efficacy enhancer becomes remarkable.

A third invention is characterized in that the content of the efficacy enhancer is set to 10 w/v % or less.

That is, when the content of the efficacy enhancer exceeds 10 w/v%, the efficacy enhancement effect may hardly change, or may be lower than when the content is 10 w/v% or less, but the content of the efficacy enhancer may be By setting the concentration to 10 w/v% or less, the efficacy enhancement effect of the efficacy enhancer can be obtained.

Also, the content of the efficacy enhancer may be set to 6 w/v% or less. This further enhances the efficacy enhancing effect of the efficacy enhancer.

A fourth aspect of the invention is an aerosol agent containing the pest control composition and a propellant for injecting the pest control composition.

A fifth invention is an aerosol product, characterized in that the aerosol agent is filled in an aerosol can.

According to the present invention, since an efficacy enhancer comprising an amide solvent is contained, the efficacy of the pyrethroid insecticidal active ingredient can be sufficiently brought out without inhibiting the solubility of the pyrethroid insecticidal active ingredient. At the same time, it is possible to obtain efficacy higher than that of the pyrethroid insecticidal active ingredient alone.

1 is a side view of an aerosol product according to an embodiment of the invention; FIG. Fig. 3 is a graph showing the relationship between the concentration of potency enhancer (0 w/v% to 25 w/v%) and the knockdown effect. 1 is a graph showing the relationship between the concentration of potency enhancers (0 w/v % to 10 w/v %) and the knockdown effect. It is a graph which shows the efficacy ratio when it does not contain an efficacy enhancer, and when it contains an efficacy enhancer.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described in detail based on the drawings. It should be noted that the following description of preferred embodiments is essentially merely illustrative, and is not intended to limit the invention, its applications, or its uses.

FIG. 1 is a side view of an aerosol product 1 according to an embodiment of the invention. The aerosol product 1 is for pest control, and includes an aerosol can (aerosol container) 10 made of a sealed pressure-resistant can and a head cap 20 . The aerosol can 10 may be made of steel, for example, but may be constructed of other materials. A valve (not shown) is provided on the top of the aerosol can 10 . The valve has a conventionally well-known structure, and has a stem and a spring that biases the stem upward. When the stem is pushed down against the pressure, the discharge port is opened.

The inside of the aerosol can is filled with an aerosol agent. Aerosol formulations contain a pest control composition for controlling pests and a propellant. The propellant is, for example, a mixture of one or both of dimethyl ether (DME) and liquefied petroleum gas (LPG), but propellants other than these can also be used.

The pest control composition contains at least a pyrethroid insecticidal active ingredient, an efficacy enhancer consisting of an amide solvent, and kerosene. Pyrethroid insecticidal active ingredients include, for example, d-T80-phthalthrin (neopinamin forte) and d-T80-resmethrin (crislon forte), but are not limited to these. Any soluble pyrethroid insecticidal active ingredient may be used. The pyrethroid insecticidal active ingredient may be either d-T80-phthalthrin or d-T80-resmethrin, or a combination thereof. d-T80-phthalthrin is called a so-called knock-down agent that frightens pests or stops the movement of pests. d-T80-resmethrin is called a lethal agent for killing pests. A pyrethroid insecticidal active ingredient can also be called an insecticidal protozoan, or simply a protozoan.

The potency enhancer may be an amide solvent capable of dissolving the pyrethroid insecticidal active ingredient, and examples thereof include 3-butoxy-N,N-dimethylpropanamide. The content of the potency enhancer is set lower than that of kerosene. Specifically, the content (concentration) of the efficacy enhancer is set to 2 w/v % or more. The upper limit of the content of the efficacy enhancer can be set to 10 w/v% or less. The upper limit of the content of the efficacy enhancer is preferably 6 w/v% or less, more preferably 5 w/v% or less.

Kerosene is one of fractionated components of petroleum, and any one conventionally used in aerosol formulations may be used. For example, Neothiosol F etc. can be mentioned. The concentration of kerosene can be set to, for example, 60 w/v% or more and 80 w/v% or less.

A pest control composition can be obtained by mixing a pyrethroid insecticidal active ingredient, an efficacy enhancer and kerosene. In the pest control composition thus obtained, even if the propellant is mixed inside the aerosol can 10, each component does not separate, and the pyrethroid insecticidal active ingredient is uniformly dissolved in the entirety for a long time. It can be maintained over a period of time.

Target pests of the pest control composition, aerosol agent, and aerosol product 1 of the present embodiment are, for example, cockroaches such as the German cockroach, the black cockroach, the American cockroach, the brown cockroach, and the Asian cockroach, spiders, centipedes, ants, and stink bugs. It is kind. Target pests also include flies such as the house fly, the common fly, the peregrine flea, the blackfly, the fruit fly, the fruit fly, the fruit fly, the mosquitoes such as the Culex pipiens and the Aedes albopictus, and the flying insects such as the bee.

(Efficacy Confirmation Test)
Next, a confirmation test of the efficacy of the pest control composition against pests will be described. A knockdown effect confirmation test and a lethal effect confirmation test were performed.

(Knockdown effect confirmation test)
The test insect is a female (adult) German cockroach. The test method is a knockdown confirmation method by topical application (microdrop method). First, the test insects are put to sleep by carbon dioxide (gas), the wings are grasped with clips and left until awake. After that, when the test insect wakes up, a fixed amount of the test solution is applied to the base of the wing of the test insect, and the clip is immediately removed. Then, the movement of the test insect is observed, and the time required from application of the test solution to knockdown is measured. A knockdown is, for example, a startled or immobile state. Test liquids are as shown in Tables 1 and 2.

Table 1 shows the amount of each component in grams per 100 ml of the test solution. "Effect enhancer concentration (w/v%)" is "0" is a comparative example, "efficacy enhancer concentration (w/v%)" is "1", "2", "3", " 4", "5", "7.5", "10", and "15" are each examples of the present invention.

Table 2 shows the compounding amount of each component in grams per 100 grams of the test liquid. As in Table 1, "efficacy enhancer concentration (w / v%)" is "1", "2", "3", "4", "5", "7.5", "10", Each "15" is an embodiment of the present invention.

The "neopinamine forte ratio" in Table 2 means content of efficacy enhancer/content of neopinamine forte. The "Cryslon forte ratio" in Table 2 means the content of the efficacy enhancer/the content of Cryslon forte.

As shown in FIGS. 2 and 3, when the potency enhancer was 0 w/v%, the knockdown time was about 51 seconds, whereas the potency enhancer was 1 w/v%, 2 w/v%, In the case of 3 w/v %, 4 w/v %, 5 w/v %, 7.5 w/v %, 10 w/v % and 15 w/v %, the knockdown time is significantly below 50 seconds. In other words, the addition of the potency enhancer significantly shortens the knockdown time as compared to the case of not blending. In particular, by setting the compounding concentration of the efficacy enhancer to 2 w/v% or more, the knockdown time is shortened to about 40 seconds, and the effect of blending the efficacy enhancer becomes remarkable.

Further, by setting the blending concentration of the efficacy enhancer to 10 w/v% or less, the knockdown time can be shortened compared to the case of blending more than 10 w/v %. In particular, by setting the blending concentration of the efficacy enhancer to 6 w/v% or less, the knockdown time is shortened to about 40 seconds, and the effect of blending the efficacy enhancer becomes remarkable. Furthermore, by setting the compounding concentration of the efficacy enhancer to 5 w/v%, the knockdown time becomes shorter than 40 seconds, and the effect of compounding the efficacy enhancer becomes even more remarkable. A preferred concentration range of the efficacy enhancer is 2 w/v% or more and 6 w/v% or less, and particularly preferably 2 w/v% or more and 5 w/v% or less.

Although not shown, the knockdown time may not be shortened even if the concentration of the efficacy enhancer exceeds 10 w/v%, so 10 w/v% is preferable as the upper limit.

(Lethal effect confirmation test)
The test insect is a female (adult) German cockroach. The test method is a method of calculating LD50 by a very small drop method. LD50 is an abbreviation for Lethal Dose, 50%, and means the amount of the test liquid at which half of the test insects to which the test liquid is administered die. First, as shown in Tables 3 and 4, test solutions were prepared with five different concentrations of the protozoan insecticide, and the test solution at each concentration was quantified and measured against the test insect. Apply to the place and obtain the mortality rate of the test insects after a certain period of time (after 72 hours in this test). It is calculated by probit statistical processing from the obtained "dose-lethal rate".

To explain the test procedure, first, a test insect is placed in a plastic cup and anesthetized using carbon dioxide (gas). A certain amount of the test solution is applied to the base of the wings of the anesthetized test insect. Place the test insects coated with the test liquid in a plastic cup that can eat sugar water. After 72 hours from application, the number of fatalities was counted, and LD50 was calculated.

Table 5 and FIG. 4 show the results of the lethal effect confirmation test.

As shown in these figures, by blending the efficacy enhancer, an efficacy ratio of 1.5 was obtained compared to the case where the efficacy enhancer was not blended, and the lethal effect was greatly enhanced. Incidentally, the "efficacy ratio" is the one when the comparative example is set to 1.

(Action and effect of the embodiment)
As described above, according to this embodiment, since an efficacy enhancer comprising an amide solvent is contained, the efficacy of the pyrethroid insecticidal active ingredient can be improved without inhibiting the solubility of the pyrethroid insecticidal active ingredient. can be sufficiently drawn out, and an effect greater than that of the pyrethroid insecticidal active ingredient alone can be obtained.

The above-described embodiments are merely examples in all respects and should not be construed in a restrictive manner. Furthermore, all modifications and changes within the equivalent scope of claims are within the scope of the present invention.

An amide solvent, particularly 3-butoxy-N,N-dimethylpropanamide, can dissolve a sparingly soluble pyrethroid insecticidal active ingredient. Poorly soluble can be defined as having a solubility of 1% or less in nC ₁₂ H ₂₆ at 25° C., but may be defined by other definitions. Poorly soluble pyrethroid insecticidal active ingredients include, for example, monfluorothrin, cyfluthrin, imiprothrin, tralomethrin, and the like. For example, about 0.3 g of monfluorothrin dissolves in 100 g of kerosene, but 65 g or more dissolves in 100 g of amide solvent. Less than 1 g of cyfluthrin dissolves in 100 g of kerosene, but 60 g or more dissolves in 100 g of amide solvent. The pyrethroid insecticidal active ingredient of the present invention may be used as a sparingly soluble pyrethroid insecticidal active ingredient. A sparingly soluble pyrethroid insecticidal active ingredient and a readily soluble pyrethroid insecticidal active ingredient can also be mixed and used.

As described above, the pest control composition, aerosol agent and aerosol product according to the present invention can be used, for example, for controlling pests such as cockroaches.

1 aerosol product 10 aerosol can 20 head cap

Claims (2)

A method for enhancing efficacy, which comprises adding 3-butoxy-N,N-dimethylpropanamide to a pyrethroid insecticidal active ingredient as a knockdown agent to enhance the knockdown effect of the pyrethroid insecticidal ingredient. A method for enhancing efficacy, which comprises adding 3-butoxy-N,N-dimethylpropanamide to a pyrethroid insecticidal active ingredient as a lethal agent to enhance the lethal effect of the pyrethroid insecticidal ingredient.

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