JP6873469B2 - Pest control aerosol - Google Patents
Pest control aerosol Download PDFInfo
- Publication number
- JP6873469B2 JP6873469B2 JP2017073852A JP2017073852A JP6873469B2 JP 6873469 B2 JP6873469 B2 JP 6873469B2 JP 2017073852 A JP2017073852 A JP 2017073852A JP 2017073852 A JP2017073852 A JP 2017073852A JP 6873469 B2 JP6873469 B2 JP 6873469B2
- Authority
- JP
- Japan
- Prior art keywords
- pest control
- solvent
- insecticidal
- drug substance
- propellant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000443 aerosol Substances 0.000 title claims description 34
- 241000607479 Yersinia pestis Species 0.000 title claims description 30
- 239000002904 solvent Substances 0.000 claims description 69
- 230000000749 insecticidal effect Effects 0.000 claims description 51
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 32
- 229940088679 drug related substance Drugs 0.000 claims description 32
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 30
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 239000003380 propellant Substances 0.000 claims description 19
- 239000003350 kerosene Substances 0.000 claims description 16
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 12
- 239000011550 stock solution Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 6
- 239000003915 liquefied petroleum gas Substances 0.000 claims description 5
- VPRAQYXPZIFIOH-UHFFFAOYSA-N imiprothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCN1C(=O)N(CC#C)CC1=O VPRAQYXPZIFIOH-UHFFFAOYSA-N 0.000 claims description 4
- 229960005199 tetramethrin Drugs 0.000 claims description 4
- CXBMCYHAMVGWJQ-UHFFFAOYSA-N tetramethrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCN1C(=O)C(CCCC2)=C2C1=O CXBMCYHAMVGWJQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000006184 cosolvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 description 12
- 241000238631 Hexapoda Species 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- -1 fatty acid ester Chemical class 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 230000001747 exhibiting effect Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000002917 insecticide Substances 0.000 description 3
- 239000002728 pyrethroid Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000013011 aqueous formulation Substances 0.000 description 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- HNAGHMKIPMKKBB-UHFFFAOYSA-N 1-benzylpyrrolidine-3-carboxamide Chemical compound C1C(C(=O)N)CCN1CC1=CC=CC=C1 HNAGHMKIPMKKBB-UHFFFAOYSA-N 0.000 description 1
- HCGFUIQPSOCUHI-UHFFFAOYSA-N 2-propan-2-yloxyethanol Chemical compound CC(C)OCCO HCGFUIQPSOCUHI-UHFFFAOYSA-N 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000257159 Musca domestica Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000008107 benzenesulfonic acids Chemical class 0.000 description 1
- 239000013590 bulk material Substances 0.000 description 1
- OBNCKNCVKJNDBV-UHFFFAOYSA-N butanoic acid ethyl ester Natural products CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940116333 ethyl lactate Drugs 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
本発明は、害虫駆除用エアゾール剤に関し、特に、主溶剤に難溶解性の殺虫原体を溶解させるための補助溶剤を含有する技術分野に属する。 The present invention relates to an aerosol agent for pest control, and particularly belongs to a technical field containing an auxiliary solvent for dissolving a poorly soluble insecticide in a main solvent.
従来より、石油系溶剤に難溶解性のピレスロイド系殺虫原体を含有するエアゾール剤が知られている（たとえば特許文献１参照）。この特許文献１では、ピレスロイド系殺虫原体のエステル系溶剤溶液及び石油系溶剤をエアゾール缶内で混合した後、ジメチルエーテルをエアゾール缶に充填する方法が開示されている。エステル系溶剤としては、高級脂肪酸エステルが用いられている。 Conventionally, an aerosol agent containing a pyrethroid-based insecticide that is sparingly soluble in a petroleum-based solvent has been known (see, for example, Patent Document 1). Patent Document 1 discloses a method in which an ester solvent solution of a pyrethroid insecticidal substance and a petroleum solvent are mixed in an aerosol can, and then dimethyl ether is filled in the aerosol can. A higher fatty acid ester is used as the ester solvent.
また、特許文献２には、ピレスロイド系殺虫原体を含有する水性製剤が開示されている。この水性製剤には、アルキル化ベンゼンスルホン酸や親水性溶剤等が含有されている。 Further, Patent Document 2 discloses an aqueous preparation containing a pyrethroid insecticidal drug substance. This aqueous preparation contains an alkylated benzenesulfonic acid, a hydrophilic solvent and the like.
殺虫エアゾール剤においては、害虫に対する効力向上を目的として、虫体表面との親和性が高い油性溶剤を特に選定する場合がある。一方で、害虫駆除剤の効力は殺虫原体に大きく依存するため、駆除対象の虫に応じて殺虫原体を選定する必要があり、たとえば特許文献１に開示されているように、主溶剤に溶解し難い難溶解性を示す殺虫原体を使用したい場合がある。この場合、殺虫原体が主溶剤に対して難溶解性であることから、製造上の問題が発生するとともに、沈殿等が生じ易いという問題も発生する。しかしながら、溶剤も殺虫原体も理由があって選定されたものであるから、別のものに変更することは容易ではない。 For insecticidal aerosols, an oily solvent having a high affinity with the surface of the insect body may be particularly selected for the purpose of improving the efficacy against pests. On the other hand, since the efficacy of the pest control agent largely depends on the insecticidal substance, it is necessary to select the insecticidal substance according to the insect to be exterminated. For example, as disclosed in Patent Document 1, the main solvent is used. You may want to use an insecticidal substance that is difficult to dissolve and exhibits poor solubility. In this case, since the insecticidal drug substance is poorly soluble in the main solvent, there is a problem in manufacturing and a problem that precipitation or the like is likely to occur. However, since both the solvent and the insecticidal drug substance were selected for some reason, it is not easy to change to another one.
そこで、主溶剤とは別に補助溶剤を含有させることによって難溶解性の殺虫原体を溶解させることが考えられるが、上記のように、溶剤も殺虫原体の効力を高める作用を発揮している場合があるので、補助溶剤の添加によって主溶剤の相対量が減少して効力の低下を招くことも考えられるし、補助溶剤の存在自体が効力に悪影響を及ぼす可能性もある。従って、単純に補助溶剤を選定することはできない。また、エアゾール組成物とする場合には噴射剤との相性もあり、このことも補助溶剤の選定を困難なものにしている。 Therefore, it is conceivable to dissolve the poorly soluble insecticidal substance by containing an auxiliary solvent in addition to the main solvent, but as described above, the solvent also exerts an effect of enhancing the efficacy of the insecticidal substance. In some cases, the addition of the auxiliary solvent may reduce the relative amount of the main solvent, resulting in a decrease in efficacy, and the presence of the auxiliary solvent itself may adversely affect the efficacy. Therefore, it is not possible to simply select the auxiliary solvent. Further, when the aerosol composition is used, it is compatible with the propellant, which also makes it difficult to select the auxiliary solvent.
本発明は、かかる点に鑑みてなされたものであり、その目的とするところは、効力の低下を招くことなく、かつ、噴射剤との混合による沈殿等を生じさせることなく、難溶解性の殺虫原体を溶解させることができるようにすることにある。 The present invention has been made in view of the above points, and an object of the present invention is that it is poorly soluble without causing a decrease in efficacy and without causing precipitation or the like due to mixing with a propellant. The purpose is to be able to dissolve the insecticidal drug substance.
上記目的を達成するために、本発明では、ケロシンを主溶剤とした油性製剤を前提とし、補助溶剤としてイソブタノールを含有させるようにした。 In order to achieve the above object, in the present invention, an oil-based preparation containing kerosene as a main solvent is premised, and isobutanol is contained as an auxiliary solvent.
第１の発明は、エアゾール容器に収容される害虫駆除用エアゾール剤において、主溶剤と、上記主溶剤に難溶解性を示す殺虫原体と、上記殺虫原体を溶解させる補助溶剤としてのイソブタノールと、上記主溶剤、上記殺虫原体及び上記補助溶剤を噴射させる噴射剤とを含有し、油性製剤であり、上記噴射剤は、液化石油ガス及びジメチルエーテルのうち、一方、または両方を混合したものであることを特徴とする。 According to the first invention, in an aerosol agent for exterminating pests contained in an aerosol container, a main solvent, an insecticidal substance exhibiting poor solubility in the main solvent, and isobutanol as an auxiliary solvent for dissolving the insecticidal substance. If, the main solvent, and containing a propellant for ejecting the insecticidal drug substance and the auxiliary solvent, the oily formulation der is, the propellant of the liquefied petroleum gas and dimethyl ether, on the other hand, or a mixture of both and wherein the Monodea Rukoto.
この構成によれば、難溶解性の殺虫原体をイソブタノールで溶解させることができ、殺虫原体を主溶剤に存在させることが可能になる。この状態で、噴射剤が混合されても殺虫原体が沈殿することはない。さらに、害虫の体表への親和性の高い油性製剤としたので、主溶剤に存在している殺虫原体による効力が十分に得られる。 According to this configuration, the poorly soluble insecticidal drug substance can be dissolved in isobutanol, and the insecticidal drug substance can be present in the main solvent. In this state, the insecticide drug substance does not precipitate even if the propellant is mixed. Furthermore, since it is an oil-based preparation having a high affinity for the body surface of pests, the effect of the insecticidal drug substance present in the main solvent can be sufficiently obtained.
第２の発明は、第１の発明において、上記殺虫原体は、ｄ−Ｔ９８フタルスリン、イミプロトリン及びモンフルオロトリンのうちの１つであることを特徴とする。 The second invention is characterized in that, in the first invention, the insecticidal drug substance is one of d-T98 phthalthrin, imiprothrin and monfluorothrin.
この構成によれば、主溶剤に難溶解性のｄ−Ｔ９８フタルスリン、イミプロトリン及びモンフルオロトリンをイソブタノールによって溶解させることが可能になる。 According to this configuration, poorly soluble d-T98 phthalthrin, imiprothrin and monfluorothrin can be dissolved in the main solvent by isobutanol.
第３の発明は、第１または２の発明において、上記主溶剤は、ケロシンであることを特徴とする。 The third invention is characterized in that, in the first or second invention, the main solvent is kerosene.
この構成によれば、害虫の体表への親和性の高いケロシンを主溶剤とすることで、殺虫原体による効力が十分に得られる。 According to this configuration, the effect of the insecticidal drug substance can be sufficiently obtained by using kerosene, which has a high affinity for the body surface of the pest, as the main solvent.
本発明によれば、効力の低下を招くことなく、かつ、噴射剤との混合による沈殿等を生じさせることなく、難溶解性の殺虫原体を溶解させて害虫の駆除効果を高めることができる。 According to the present invention, it is possible to dissolve a poorly soluble insecticidal drug substance and enhance the pest control effect without causing a decrease in efficacy and without causing precipitation or the like due to mixing with a propellant. ..
以下、本発明の実施形態を詳細に説明する。尚、以下の好ましい実施形態の説明は、本質的に例示に過ぎず、本発明、その適用物或いはその用途を制限することを意図するものではない。 Hereinafter, embodiments of the present invention will be described in detail. It should be noted that the following description of the preferred embodiment is essentially merely an example and is not intended to limit the present invention, its application or its use.
本発明の実施形態に係る害虫駆除用エアゾール剤は、エアゾール容器に収容される油性製剤であり、主溶剤と、該主溶剤に難溶解性を示す殺虫原体と、該殺虫原体を溶解させる補助溶剤としてのイソブタノールと、噴射剤とを含有している。害虫駆除用エアゾール剤のうち、噴射剤を除いた部分が原液である。すなわち、原液は、主溶剤と、殺虫原体と、補助溶剤とを含んでいる。 The pest control aerosol agent according to the embodiment of the present invention is an oil-based preparation contained in an aerosol container, and dissolves the main solvent, the insecticidal substance exhibiting poor solubility in the main solvent, and the insecticidal substance. It contains isobutanol as an auxiliary solvent and a propellant. Of the pest control aerosols, the portion excluding the propellant is the undiluted solution. That is, the stock solution contains a main solvent, an insecticidal drug substance, and an auxiliary solvent.
エアゾール容器は、図示しないが、従来から周知のものであり、エアゾール缶等からなる本体部と、本体部の上部に設けられた押動操作可能なステムを備えた弁機構と、ステムを押動操作するボタンを備えたキャップとで構成されている。 Although not shown, the aerosol container has been well known in the past, and has a main body made of an aerosol can or the like, a valve mechanism provided on the upper part of the main body and provided with a push-operable stem, and a push-pushing stem. It consists of a cap with buttons to operate.
主溶剤は、害虫の体表への親和性の高い溶剤であり、たとえばケロシンを挙げることができる。殺虫原体は、ケロシンに難溶解性を示す殺虫原体である。ケロシンへの難溶解性を示す殺虫原体とは、たとえば２５℃のケロシンに殺虫原体を投入して攪拌した際に、溶解度が１％以下である殺虫原体である。このような殺虫原体としては、たとえばｄ−Ｔ９８フタルスリン、イミプロトリン及びモンフルオロトリンを挙げることができ、これらのうちの１種または任意の複数種を混合して用いることができる。また、これらに加えて、ケロシンに溶け易い殺虫原体を更に含んでいても良い。 The main solvent is a solvent having a high affinity for the body surface of pests, and examples thereof include kerosene. The insecticidal drug substance is an insecticidal drug substance that is poorly soluble in kerosene. The insecticidal drug substance exhibiting poor solubility in kerosene is, for example, an insecticidal drug substance having a solubility of 1% or less when the insecticidal drug substance is put into kerosene at 25 ° C. and stirred. Examples of such an insecticidal drug substance include d-T98 phthalthrin, imiprothrin and monfluorothrin, and one of these or any plurality of them can be mixed and used. In addition to these, an insecticidal drug substance that is easily dissolved in kerosene may be further contained.
補助溶剤の原液中の含有量は、主溶剤の原液中の含有量よりも少なく設定されている。補助溶剤は、イソブタノールである。イソブタノールは、ケロシンに難溶解性を示す殺虫原体を溶解させることができるとともに、溶解した殺虫原体を主溶剤に存在させておくことができる。また、イソブタノールは主溶剤との相性がよく、噴射剤をエアゾール容器に充填しても沈殿等を生じることはない。 The content of the auxiliary solvent in the stock solution is set to be lower than the content of the main solvent in the stock solution. The auxiliary solvent is isobutanol. Isobutanol can dissolve a poorly soluble insecticidal drug substance in kerosene, and the dissolved insecticidal drug substance can be present in the main solvent. In addition, isobutanol has good compatibility with the main solvent, and even if the propellant is filled in the aerosol container, precipitation or the like does not occur.
ここで、たとえば、補助溶剤として、脂肪酸エステルを用いた場合について検討した結果を説明すると、比較的低級の脂肪酸エステル（乳酸エチル、酢酸ブチル、酪酸エチル等）では、ケロシンに難溶解性を示す殺虫原体を溶かすことはできなかった。一方、高級脂肪酸エステルは常温で固体のものが多く、溶剤としては使い難いという問題がある。また高級脂肪酸エステルは揮発性も低いため、これを配合した場合は殺虫原体が蒸散しにくくなる結果、殺虫効果の即効性の低下が懸念される。 Here, for example, the result of examining the case where a fatty acid ester is used as an auxiliary solvent will be described. Insects showing poor solubility in kerosene with relatively low-grade fatty acid esters (ethyl lactate, butyl acetate, ethyl butyrate, etc.) The original body could not be melted. On the other hand, many higher fatty acid esters are solid at room temperature, and have a problem that they are difficult to use as a solvent. In addition, since the higher fatty acid ester has low volatility, when it is added, the insecticidal bulk material is less likely to evaporate, and as a result, there is a concern that the immediate effect of the insecticidal effect may be reduced.
また、補助溶剤として、エーテル系の溶剤、たとえばエチレングリコールモノイソプロピルエーテル等を用いた場合について検討した結果を説明すると、ケロシンに難溶解性を示す殺虫原体を溶かすことはできたが、噴射剤との相性が悪く、噴射剤をエアゾール容器に充填すると沈殿が生じてしまった。 In addition, explaining the results of examining the case where an ether solvent such as ethylene glycol monoisopropyl ether was used as the auxiliary solvent, it was possible to dissolve the insecticidal substance showing poor solubility in kerosene, but the propellant The compatibility with the above was poor, and when the propellant was filled in the aerosol container, precipitation occurred.
従って、補助溶剤をイソブタノールとすることで、ケロシンに難溶解性を示す殺虫原体を溶かすことできるとともに、エアゾール製剤としてエアゾール容器に収容した状態で安定状態を維持することができる。 Therefore, by using isobutanol as the auxiliary solvent, the insecticidal drug substance exhibiting poor solubility in kerosene can be dissolved, and the stable state can be maintained in the state of being contained in the aerosol container as an aerosol preparation.
噴射剤は、液化石油ガス（ＬＰＧ）及びジメチルエーテル（ＤＭＥ）のうち、１種またはこれらを混合して使用することができる。また、液化石油ガス及びジメチルエーテル以外の噴射剤を使用することもできる。 The propellant may be one of liquefied petroleum gas (LPG) and dimethyl ether (DME), or a mixture thereof. In addition, propellants other than liquefied petroleum gas and dimethyl ether can also be used.
原液と噴射剤との比率は、原液：噴射剤が体積比で１０：９０〜３０：７０の範囲で設定することができる。 The ratio of the undiluted solution to the propellant can be set in the range of 10:90 to 30:70 in terms of the volume ratio of the undiluted solution: propellant.
原液中における主溶剤と補助溶剤の含有割合は、殺虫効力と、殺虫原体の溶解性と、のバランスを考慮して決定する。即ち、殺虫効力を増大させる観点からは、主溶剤が多いほど害虫の体表面への親和性が向上するので好ましく、殺虫原体の溶解性を向上させる観点からは、補助溶剤が多いほど好ましい。従って一般論としては、必要量の殺虫原体を溶解させることができる範囲内で、補助溶剤の割合をできるだけ少なく（主溶剤の割合をできるだけ多く）するのが殺虫効力の観点から好ましい。 The content ratio of the main solvent and the auxiliary solvent in the stock solution is determined in consideration of the balance between the insecticidal efficacy and the solubility of the insecticidal drug substance. That is, from the viewpoint of increasing the insecticidal efficacy, it is preferable that the amount of the main solvent is large, because the affinity of the pest on the body surface is improved, and from the viewpoint of improving the solubility of the insecticidal drug substance, the larger the amount of the auxiliary solvent is, the more preferable. Therefore, as a general theory, it is preferable to reduce the proportion of the auxiliary solvent as much as possible (the proportion of the main solvent as much as possible) within the range in which the required amount of the insecticidal drug substance can be dissolved, from the viewpoint of insecticidal efficacy.
ちなみに害虫の体表面の組成は害虫の種類によって異なるので、主溶剤の割合が少なくても殺虫効力はあまり低下しない害虫がありうる。このような場合などは、必要に応じて補助溶剤（イソブタノール）の配合割合をより多くすることも可能である。なお、ケロシンとイソブタノールは任意の割合で相溶するので、原理的には任意の配合割合とすることができる。この点でも、ケロシンとイソブタノールの組み合わせは優れている。 By the way, since the composition of the body surface of the pest differs depending on the type of pest, there may be some pests whose insecticidal efficacy does not decrease so much even if the ratio of the main solvent is small. In such a case, it is possible to increase the blending ratio of the auxiliary solvent (isobutanol) as needed. Since kerosene and isobutanol are compatible with each other at an arbitrary ratio, in principle, an arbitrary blending ratio can be used. In this respect as well, the combination of kerosene and isobutanol is excellent.
主溶剤と補助溶剤の具体的な含有量は、対象害虫の種類、および殺虫原体の種類と必要量によって異なるが、例えば一般的な飛翔害虫であるハエやハチ等を対象とする場合、補助溶剤の原液中の濃度を５ｗ／ｖ％以上１０ｗ／ｖ％以下とするのが好ましい。補助溶剤の濃度が高ければ高いほど殺虫原体を溶かし易くなるが、その分主溶剤（ケロシン）の濃度が下がって効力が低下してしまうので、上記した範囲内で設定するのが好ましい。なお、補助溶剤（イソブタノール）の原液中の濃度が１０ｗ／ｖ％以下であれば、殺虫効力の低下はほとんど見られない。より好ましいのは、補助溶剤の原液中の濃度を７ｗ／ｖ％以上９ｗ／ｖ％以下の範囲で設定することである。 The specific contents of the main solvent and auxiliary solvent differ depending on the type of target pest, the type of insecticidal substance, and the required amount, but for example, when targeting general flying pests such as flies and bees, auxiliary The concentration of the solvent in the stock solution is preferably 5 w / v% or more and 10 w / v% or less. The higher the concentration of the auxiliary solvent, the easier it is to dissolve the insecticidal drug substance, but the concentration of the main solvent (kerosene) decreases by that amount and the efficacy decreases, so it is preferable to set it within the above range. If the concentration of the auxiliary solvent (isobutanol) in the stock solution is 10 w / v% or less, the insecticidal efficacy is hardly reduced. More preferably, the concentration of the auxiliary solvent in the stock solution is set in the range of 7 w / v% or more and 9 w / v% or less.
次に、本発明の実施例及び比較例に係る各製剤について説明する。 Next, each pharmaceutical product according to an example and a comparative example of the present invention will be described.
表１は本発明の実施例に係る製剤例を示しており、表２は比較例に係る製剤例を示している。実施例では主溶剤としてネオチオゾールＦを使用しており、油性製剤となっている。一方、比較例では、ネオチオゾールＦの代わりにイオン交換水を使用しており、水性製剤となっている。殺虫原体の含有量及びイソブタノールの含有量は、実施例と比較例とで同じにしている。 Table 1 shows a formulation example according to an example of the present invention, and Table 2 shows a formulation example according to a comparative example. In the examples, neothiosol F is used as the main solvent, and it is an oil-based preparation. On the other hand, in the comparative example, ion-exchanged water is used instead of neothiol F, which is an aqueous preparation. The content of the insecticidal drug substance and the content of isobutanol are the same in the examples and the comparative examples.
次に、実施例及び比較例の各製剤の試験結果について説明する。試験方法は次の通りである。まず、用意した供試虫を直径が９ｃｍのガラスリングの中に入れた後、該ガラスリングの開口部をナイロン製のメッシュで覆って蓋をする。供試虫はイエバエのメスである。そのガラスリングをエアゾール噴射装置のガラスシリンダー内に設置した。供試虫とエアゾール噴射装置の噴霧口との距離は１５０ｃｍとし、供試剤の噴射時間は０．２秒間とした。供試剤の噴射を開始してから、供試虫がノックダウン（ＫＴ）するまでの時間（ノックダウン時間）を計測し、３回反復試験した後の平均値を算出した。尚、ノックダウンとは、供試虫の正常な動きが停止した状態を言い、具体的には、飛翔や歩行に異常をきたした供試虫が仰天した（ひっくり返った）状態になることを指す。 Next, the test results of the respective formulations of Examples and Comparative Examples will be described. The test method is as follows. First, the prepared test insects are placed in a glass ring having a diameter of 9 cm, and then the opening of the glass ring is covered with a nylon mesh to cover the glass ring. The test insect is a female housefly. The glass ring was installed in the glass cylinder of the aerosol injection device. The distance between the test insect and the spray port of the aerosol injection device was 150 cm, and the injection time of the test agent was 0.2 seconds. The time (knockdown time) from the start of injection of the test agent to the knockdown (KT) of the test insect was measured, and the average value after three repeated tests was calculated. Knockdown refers to a state in which the normal movement of the test insect has stopped. Specifically, the test insect that has abnormal flight or walking becomes astonished (turned over). Point to.
供試剤が表１に示す実施例（油性処方）の場合には、ＫＴ５０が４０．８１秒、ＫＴ９０が８３．１０秒であったのに対し、表２に示す比較例（水性処方）の場合には、ＫＴ５０が９９．７３秒、ＫＴ９０が２０６．１８秒であった。従って、本発明に係る害虫駆除用エアゾール剤は水性処方のエアゾール剤に比べて高い効力が得られ、具体的には、ノックダウン時間を１／２以下にすることができる。 When the test agent was the example (oil-based formulation) shown in Table 1, the KT50 was 40.81 seconds and the KT90 was 83.10 seconds, whereas the comparative example (aqueous formulation) shown in Table 2 was used. In this case, the KT50 was 99.73 seconds and the KT90 was 206.18 seconds. Therefore, the pest control aerosol agent according to the present invention can obtain higher efficacy than the aqueous formulation aerosol agent, and specifically, the knockdown time can be reduced to 1/2 or less.
上述の実施形態はあらゆる点で単なる例示に過ぎず、限定的に解釈してはならない。さらに、特許請求の範囲の均等範囲に属する変形や変更は、全て本発明の範囲内のものである。 The above embodiments are merely exemplary in all respects and should not be construed in a limited way. Furthermore, all modifications and modifications that fall within the equivalent scope of the claims are within the scope of the present invention.
以上説明したように、本発明に係る害虫駆除用エアゾール剤は、各種害虫を駆除する場合に使用することができる。 As described above, the pest control aerosol agent according to the present invention can be used for exterminating various pests.
Claims (5)
主溶剤と、
上記主溶剤に難溶解性を示す殺虫原体と、
上記殺虫原体を溶解させる補助溶剤としてのイソブタノールと、
上記主溶剤、上記殺虫原体及び上記補助溶剤を噴射させる噴射剤とを含有し、油性製剤であり、
上記噴射剤は、液化石油ガス及びジメチルエーテルのうち、一方、または両方を混合したものであることを特徴とする害虫駆除用エアゾール剤。 In the pest control aerosol agent contained in the aerosol container,
With the main solvent
An insecticidal drug substance that is sparingly soluble in the above main solvent,
Isobutanol as an auxiliary solvent that dissolves the above insecticidal drug substance,
The main solvent, and containing a propellant for ejecting the insecticidal drug substance and the cosolvent, Ri oily formulation der,
The propellant of a liquefied petroleum gas and dimethyl ether, on the other hand, or pest control aerosol, characterized in der Rukoto that both were mixed.
上記殺虫原体は、ｄ−Ｔ９８フタルスリン、イミプロトリン及びモンフルオロトリンのうちの１つであることを特徴とする害虫駆除用エアゾール剤。 In the pest control aerosol agent according to claim 1,
The pest control aerosol agent, wherein the insecticidal drug substance is one of d-T98 phthalthrin, imiprothrin and monfluorothrin.
上記主溶剤は、ケロシンであることを特徴とする害虫駆除用エアゾール剤。 In the pest control aerosol agent according to claim 1 or 2.
The main solvent is an aerosol agent for pest control, which is characterized by being kerosene.
上記害虫駆除用エアゾール剤のうち、上記噴射剤を除いた部分を原液としたとき、上記補助溶剤の上記原液中の濃度は、１０ｗ／ｖ％以下であることを特徴とする害虫駆除用エアゾール剤。 The pest control aerosol agent according to any one of claims 1 to 3.
When the portion of the pest control aerosol agent excluding the propellant is used as the stock solution, the concentration of the auxiliary solvent in the stock solution is 10 w / v% or less. ..
上記害虫駆除用エアゾール剤のうち、上記噴射剤を除いた部分を原液としたとき、上記補助溶剤の上記原液中の濃度は、５ｗ／ｖ％以上であることを特徴とする害虫駆除用エアゾール剤。 The pest control aerosol agent according to any one of claims 1 to 4.
When the portion of the pest control aerosol agent excluding the propellant is used as the stock solution, the concentration of the auxiliary solvent in the stock solution is 5 w / v% or more. ..
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017073852A JP6873469B2 (en) | 2017-04-03 | 2017-04-03 | Pest control aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017073852A JP6873469B2 (en) | 2017-04-03 | 2017-04-03 | Pest control aerosol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018177641A JP2018177641A (en) | 2018-11-15 |
| JP6873469B2 true JP6873469B2 (en) | 2021-05-19 |
Family
ID=64281125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073852A Active JP6873469B2 (en) | 2017-04-03 | 2017-04-03 | Pest control aerosol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6873469B2 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6270784B1 (en) * | 1995-08-16 | 2001-08-07 | Bayer Aktiengesellschaft | Active substance combinations comprising pyrethroids and insect development inhibitors |
| JP4277402B2 (en) * | 1999-02-19 | 2009-06-10 | 住友化学株式会社 | Aerosol for dwarf pest control |
| JP6370022B2 (en) * | 2012-08-03 | 2018-08-08 | フマキラー株式会社 | Insecticidal aerosol composition |
| ZA201306508B (en) * | 2012-09-13 | 2016-08-31 | Sumitomo Chemical Co | Composition for aerosol for controlling flying-insect pest |
| JP6754197B2 (en) * | 2015-12-28 | 2020-09-09 | 大日本除蟲菊株式会社 | Pest control aerosol |
-
2017
- 2017-04-03 JP JP2017073852A patent/JP6873469B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018177641A (en) | 2018-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5352531B2 (en) | Pest control method | |
| JP6490847B2 (en) | Pest control aerosol and pest control method using the same | |
| JP6034658B2 (en) | Clothing pest control method | |
| JP2014019674A (en) | Flying insect pest control method | |
| JP6420621B2 (en) | Bee control aerosol and bee control method | |
| JP5754925B2 (en) | Aerosol products for controlling fly flies | |
| JP2020186271A (en) | Pest control aerosol agent | |
| JP6873469B2 (en) | Pest control aerosol | |
| JP5934583B2 (en) | Composition for killing pests | |
| JP2014005271A (en) | Microemulsion composition and product using thereof for insect pest control | |
| JP6718875B2 (en) | Aerosol composition for controlling pests, aerosol product for controlling pests, and method for enhancing the efficacy of insecticidal components | |
| JP6086757B2 (en) | Aerosol insecticide | |
| JP2018115113A (en) | Insecticidal aerosol product | |
| JP4578835B2 (en) | Stabilized microemulsion aerosol | |
| JP6155220B2 (en) | Aerosol insecticide | |
| JP6738259B2 (en) | Pesticide extermination agent | |
| JP6539407B2 (en) | Injection products and methods | |
| JP7333115B2 (en) | Potency enhancement method | |
| JP7133838B2 (en) | Pest control compositions, aerosol agents and aerosol products | |
| TWI812850B (en) | One-component water-based spray composition | |
| JP7368817B2 (en) | Slug repellent | |
| JP2018115112A (en) | Insecticidal aerosol product | |
| JP2011144141A (en) | Insecticide and spray insecticidal device | |
| JP2016164187A (en) | Composition for killing insect pest | |
| JP2006056810A (en) | Harmful insect-controlling composition and harmful insect-controlling method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200205 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201030 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201201 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210127 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210406 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210414 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6873469 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |