JP7326568B1 - sampling system - Google Patents

Abstract

A sampling system capable of suppressing the contamination of bacteria from the outside and sampling a liquid product while maintaining a sterilized state is provided. A first supply unit (14) is operated in a state in which a communicating channel (12) is doubly blocked by a first valve plug portion and a second valve plug portion that constitute a double valve plug portion (16), thereby sampling a sampling channel (11). is sterilized, and in a state in which the liquid product is circulated in the circulation part L, the first valve plug part and the second valve plug part are operated to open the communication channel 12, and from the circulation part L to the sampling channel 11 After the liquid product is allowed to flow in and the communication channel 12 is blocked by operating the first valve plug part and the second valve plug part while the liquid product is circulating in the circulation part L, the liquid in the sampling channel 11 is The products are supplied to the collection section 18 . [Selection drawing] Fig. 2

Description

The present invention relates to a sampling system for collecting sterilized liquid products in plants that manufacture liquid products.

Conventionally, some plants that manufacture liquid products such as pharmaceuticals are equipped with a sampling system for collecting sterilized liquid products and the like. For example, as a culturing device for culturing biological cells that produce substances that are the main raw materials of pharmaceuticals, etc., there is a device that is equipped with a sampling device that collects the culture solution from the culture tank in order to analyze the culture solution with an analyzer. (See Patent Document 1).

The sampling device described in Patent Document 1 aims to suppress the contamination of various bacteria in the culture tank, and is connected to a culture solution extraction pipe connected to the culture tank via a valve and a sampling pipe via a valve. and a culture solution outlet pipe, and by appropriately controlling the opening and closing of each valve (single seat valve), the culture solution is collected from the culture tank through the culture solution withdrawal pipe and the culture solution outlet pipe. do.

JP 2009-180594 A

Even with the configuration described in Patent Document 1, although it is possible to suppress contamination of various bacteria from the outside in the sampling work, the sanitary property of the sampling system (sampling device) is not necessarily sufficient, and further improvement is desired. It is rare.

Such a problem exists not only in the sampling system provided in the culture apparatus, but also in the sampling system provided in the liquid processing system that constitutes the plant for manufacturing liquid products.

Liquid handling systems include, for example, a sterilization device that sterilizes a liquid product and a filling device that fills containers with the liquid product, and the filling device fills the containers with the liquid product sterilized by the sterilization device. . In such a liquid processing system, when the liquid product sterilized by the sterilizer is sampled by the sampling system, the above problems may occur.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a sampling system capable of suppressing the contamination of bacteria from the outside and sampling a liquid product while maintaining a sterilized state. do.

A first aspect of the present invention for solving the above problems is a sampling system for collecting a liquid product from a distribution section through which the sterilized liquid product is distributed, wherein the sampling system is connected to a collection section for collecting the liquid product. a channel, a communication channel communicating between the sampling channel and the circulation portion, a pair of intermediate channels connected to the communication channel between the circulation portion and the sampling channel, and the sampling a first supply unit connected to the opposite side of the channel to the collecting part to supply sterilizing fluid to the sampling channel; and a first supply unit connected to the intermediate channel to supply sterilizing gas to the intermediate channel. a second supply unit, a double valve plug portion disposed in the communication channel to open and close the communication channel, and controlling the operations of the first supply unit, the second supply unit, and the double valve plug portion. and a control unit including sampling means for performing a sampling operation of the liquid product, wherein the double valve plug portion is a first valve seat formed closer to the flow portion than the intermediate flow passage of the communication flow passage. and a second valve seat portion which is driven independently of the first valve plug portion and which is formed closer to the sampling channel than the intermediate channel of the communication channel. and a second valve plug portion that can be brought into close contact with the first supply valve plug portion, wherein the sampling means is provided with the first supply valve plug portion and the second valve plug portion doubly blocking the communication channel. The unit is operated to sterilize the sampling channel, and in a state in which the liquid product is being circulated in the circulation part, the first valve plug part and the second valve plug part are operated to close the communication channel. The liquid product is allowed to flow into the sampling channel from the circulation portion by opening, and the first valve plug portion and the second valve plug portion are operated while the liquid product is flowing through the circulation portion. A sampling system, characterized in that the liquid product in the sampling channel is supplied to the collecting part after closing the communication channel.

A second aspect of the present invention is the sampling system of the first aspect, wherein the sampling means operates the first valve plug portion and the second valve plug portion to open the communication flow path. 1. The sampling system is characterized in that the first supply unit is operated to supply sterilized air to the sampling flow path to keep the inside of the sampling flow path at a positive pressure.

A third aspect of the present invention is the sampling system of the second aspect, wherein the sampling flow path discharges the sterilizing fluid supplied from the first supply unit to the outside together with the recovery section. and the sampling means supplies the sterilizing liquid as the sterilizing fluid to the sampling channel and the collecting part by the first supply unit, and then supplies the sterilizing liquid to the sampling channel and the discharging part. The sampling system is characterized in that the sampling channel is sterilized by circulating a sterilizing gas as a sterilizing fluid.

A fourth aspect of the present invention is the sampling system according to the third aspect, wherein the sampling means supplies sterilized air to the intermediate flow path by the second supply unit when sterilizing the sampling flow path. is supplied, and the inside of the intermediate flow path is maintained at a positive pressure.

A fifth aspect of the present invention is the sampling system of the first aspect, wherein the sampling means operates the first valve plug portion and the second valve plug portion to open the communication flow path. and a sampling system characterized in that the second supply unit supplies a sterilizing gas to the intermediate flow path to keep the inside of the intermediate flow path at a positive pressure.

According to the sampling system of the present invention, it is possible to suppress the contamination of various bacteria from the outside, and to sample the liquid product while maintaining the sterilized state. In particular, it is possible to suppress the contamination of various germs in the circulation section.

1 is a diagram showing a schematic configuration of a liquid processing system including a sampling system according to one embodiment of the present invention; FIG. It is a figure showing a schematic structure of a sampling system concerning one embodiment of the present invention. FIG. 2 is a cross-sectional view showing a schematic configuration of a double valve plug portion that constitutes the sampling system according to one embodiment of the present invention; FIG. 2 is a cross-sectional view showing a schematic configuration of a double valve plug portion that constitutes the sampling system according to one embodiment of the present invention; It is a figure explaining operation|movement of the sampling system which concerns on one Embodiment of this invention. It is a figure explaining operation|movement of the sampling system which concerns on one Embodiment of this invention. It is a figure explaining operation|movement of the sampling system which concerns on one Embodiment of this invention. It is a figure explaining operation|movement of the sampling system which concerns on one Embodiment of this invention. It is a figure explaining operation|movement of the sampling system which concerns on one Embodiment of this invention.

An embodiment of the present invention will be described in detail below with reference to the drawings.

FIG. 1 is a diagram showing a schematic configuration of a liquid processing system including a sampling system according to one embodiment of the present invention.

First, the overall configuration of the liquid treatment system I according to this embodiment will be described. The liquid processing system I is a part of a plant that manufactures liquid pharmaceuticals (hereinafter referred to as “medicine”) as an example of liquid products, and includes a filling device 1 . Specifically, the liquid processing system I comprises a preparation tank 2, a sterilizer (sterilizer) 3, a filling device 1 including a storage tank 4, a filter device 5 and a filling unit (filler) 6, and these devices. and a production line L consisting of piping connecting the same.

The preparation tank 2 is a tank for obtaining a chemical solution by adjusting raw materials of the chemical solution and a solvent such as water. The sterilizer 3 is a device for sterilizing the chemical solution by heat treatment, filtration treatment with a filter, or the like.

The filling device 1 is, for example, a device for filling a container such as a vial with a chemical liquid, and in this embodiment, it is configured with a storage tank 4 , a filter device 5 and a filling unit 6 .

The storage tank 4 stores the chemical solution prepared in the preparation tank 2 and sterilized by the sterilizer 3 . The capacity of the storage tank 4 is not particularly limited, but a relatively large capacity is used.

The filter device 5 is a device for further filtering the chemical solution supplied from the storage tank 4 , and is arranged near the filling unit 6 .

The filling unit 6 fills the container with the chemical solution supplied from the storage tank 4 through the filter device 5, and includes a plurality of filling needles for filling the container with the chemical solution. The configuration of the filling unit 6 is not particularly limited, and an existing one may be adopted, so a detailed description of the filling unit 6 is omitted.

The production line L is a pipe through which chemical solutions and cleaning fluids flow, and connects the preparation tank 2, the sterilizer 3, the storage tank 4 of the filling device 1, the filter device 5, and the filling unit 6 in sequence. . That is, the chemical solution in the preparation tank 2 is distributed to the filling unit 6 via the production line L, the sterilizer 3, the storage tank 4 and the filter device 5.

The liquid processing system I includes a sampling system 10 that is connected to a production line L, which is a distribution section, on the downstream side of the sterilizer 3 and that collects a chemical solution, which is a liquid product, from the production line L. That is, the liquid processing system I includes a sampling system 10 that collects the chemical liquid sterilized by the sterilizer 3 . The sampling system 10 may be located at any position downstream of the sterilizer 3 as long as it is within a range where the device can be sterilized. It is connected to the manufacturing line L in between.

Next, a schematic configuration of this sampling system 10 will be described. The sampling system 10, as shown in FIG. A unit 16 and a control unit 17 for controlling the operations of these devices.

One end of the sampling channel 11 is connected to a production line (pipe) L, which is a flow part, via a double valve plug part 16 and a communication channel 12, and the other end is a recovery part 18 for recovering the chemical solution. connected to In this embodiment, the side of the sampling channel 11 opposite to the communication channel 12 is bifurcated and connected to the first branch channel 19 and the second branch channel 20. The first branch channel 19 is It is connected to the collection part 18 . The first branch channel 19 is connected to the sampling channel 11 via a first open/close valve 21 .

The second branch flow path 20 is a flow path to which sterilization gas is supplied as described later, and a temperature sensor 22 and a throttle valve (needle valve) 23 are provided in the second branch flow path 20. there is One end of the second branch flow path 20 is connected to the sampling flow path 11 via a second open/close valve 24, and the other end is connected to a discharge portion 48 through which sterilization gas is discharged.

The communication channel 12 is a channel that communicates the production line L and the sampling channel 11, and the communication channel 12 opens and closes the communication channel 12, that is, communicates or communicates the production line L and the sampling channel 11. A double valve plug portion (double valve plug device) 16 is arranged for blocking. A connection channel 25 connected to the first supply unit 14 is connected to the communication channel 12 via a third opening/closing valve 26 . The connection channel 25 communicates with the sampling channel 11 via the communication channel 12 even when the communication channel 12 is closed by the double valve plug portion 16 .

A pair of intermediate flow paths 13 (13A, 13B) are connected to the communication flow path 12 between the production line L and the sampling flow path 11, respectively. These intermediate flow paths 13A and 13B communicate with each other via the communication flow path 12 even when the communication flow path 12 is closed by the double valve plug portion 16 . 13 A of intermediate|middle flow paths are flow paths connected with the 2nd supply unit 15, and are connected to the communication flow path 12 via the 4th opening-and-closing valve 27. As shown in FIG. On the other hand, the intermediate flow path 13B is a flow path that communicates with the outside (atmosphere) and is connected to the communication flow path 12 via the fifth opening/closing valve 28 . A temperature sensor 29 and a throttle valve 30 are provided in the intermediate flow path 13B.

The first opening/closing valve 21, the second opening/closing valve 24, the third opening/closing valve 26, the fourth opening/closing valve 27, and the fifth opening/closing valve 28 are for opening and closing the respective flow paths. consists of

The first supply unit 14 is a device for supplying a fluid for sterilization or the like in order to perform cleaning-in-place (CIP), sterilization-in-place (SIP), etc. for the flow path including the sampling flow path 11 . Although not shown, the first supply unit 14 includes a supply source of sterilizing liquid (eg, cleaning liquid) used for cleaning in place, a supply source of sterilizing gas (eg, saturated steam) used for sterilizing in place, and a sterilization unit for these. It is equipped with a device (pump or a device for pressure-feeding by gas) for pressure-feeding liquids and sterilization gas, etc., and is also equipped with a supply source of sterilized air (sterilized air).

The second supply unit 15 is a device for supplying a sterilization gas or the like in order to perform sterilization in place (SIP) or the like of the intermediate flow path 13. A device for pumping gas or the like is provided, and, like the first supply unit 14, a supply source of sterilized air is also provided.

The sterilizing liquid (washing liquid) used for cleaning in place (CIP) may be water with an alkaline agent such as caustic soda added, water with an acidic agent added, water containing a surfactant, or any of these. For example, water that does not contain chemicals. Of course, these may be used together. Sterilization gas used for sterilization in place (SIP) is, for example, saturated steam (pure steam) using purified water as raw water.

Next, a schematic configuration of the double valve plug portion (double valve plug device) 16 arranged in the communication flow path 12 will be described with reference to FIGS. 3 and 4 are cross-sectional views showing a schematic configuration of the double valve plug portion, FIG. 3 is a diagram showing a state in which the communication channel is closed by the double valve plug portion, and FIG. FIG. 4 is a diagram showing a state in which a communication channel is opened by a double valve plug;

As shown in FIGS. 3 and 4, the double valve plug portion 16 includes a first valve plug portion 31 and a second valve plug portion 32 that can be driven independently. The first valve plug portion 31 includes a first valve shaft portion 33 extending in the axial direction (the X-axis direction in the drawing) of the communication passage 12 and a first valve shaft portion 33 provided at the end portion of the first valve shaft portion 33 on the production line L side. 1 valve body 34; The second valve plug portion 32 is provided on the production line L side of the second valve shaft portion 35 extending in the axial direction of the communication passage 12 and the second valve shaft portion 35, and is arranged in the direction orthogonal to the X direction. and a second valve body 36 having a diameter larger than that of the first valve body 34 . The first valve shaft portion 33 of the first valve plug portion 31 is inserted into the second valve shaft portion 35 so as to be slidable in the axial direction.

The first valve plug portion 31 and the second valve plug portion 32 are connected to drive means such as an actuator (not shown), and are configured to be linearly movable in the X direction by the drive means.

The second valve shaft portion 35 of the second valve plug portion 32 is held in a holding hole 38 formed in the device main body portion 37 via a back plate 39 . A diaphragm 40 is provided between the second valve plug portion 32 and the apparatus main body portion 37 to separate the inside of the communication channel 12 from the second valve plug portion 32 . The diaphragm 40 is supported in a non-fixed state by the back plate 39 on the side opposite to the communicating channel 12 and is fixed to the device main body 37 . Further, an integrally formed synthetic resin film 41 is provided continuously from the diaphragm 40 on the outer surface portions of the first valve body 34 and the second valve body 36 .

On the other hand, in the communicating passage 12 where the double valve plug portion 16 is arranged, there are a first valve seat portion 42 with which the first valve body 34 can come into close contact, and a second valve seat portion with which the second valve body 36 can come into close contact. 43 and are provided. More specifically, as shown in FIG. 4, the communication channel 12 includes a first hole portion 44, a second hole portion 45, and a third hole portion 46 having different inner diameters. , the second hole portion 45 and the third hole portion 46 form the first valve seat portion 42 and the second valve seat portion 43 .

In the direction perpendicular to the X direction, the first hole portion 44 is formed with an inner diameter smaller than the diameter of the first valve body 34, and the second hole portion 45 is formed with an inner diameter larger than the diameter of the first valve body 34. And it is formed with a diameter smaller than the diameter of the second valve body 36 . Also, the third hole portion 46 is formed to have a diameter larger than that of the second valve body 36 .

As a result, the step surface at the boundary between the first hole portion 44 and the second hole portion 45 functions as the first valve seat portion 42, and the step surface at the boundary portion between the second hole portion 45 and the third hole portion 46 functions as the first valve seat portion 42. functions as the second valve seat portion 43 .

Since the first valve body 34 is in close contact with the first valve seat portion 42 and the second valve body 36 is in close contact with the second valve seat portion 43, the communication flow path 12 is closed. That is, the production line L and the sampling flow path 11 are cut off (see FIG. 3).

Here, the pair of intermediate flow paths 13A and 13B communicate with the second hole portions 45 forming the communication flow path 12, respectively. In other words, the first valve body 34 is in close contact with the first valve seat portion 42 provided closer to the production line L than the intermediate flow path 13 of the communication flow path 12 , and the second valve body 36 is in close contact with the communication flow path 12 . It is in close contact with the second valve seat portion 43 provided on the sampling channel 11 side rather than the intermediate channel 13 .

Therefore, in the intermediate flow path 13 (13A, 13B), the first valve body 34 is in close contact with the first valve seat portion 42, and the second valve body 36 is in close contact with the second valve seat portion 43, so that the communication flow path 12 is closed. are closed, they communicate with each other through the communication channel 12 (the second hole portion 45).

In addition, from the state in which the communication passage 12 is closed in this way, the first valve plug portion 31 and the second valve plug portion 32 are slightly moved in the -X direction, which is the device main body portion 37 side, by a driving means (not shown). As a result, the first valve body 34 is separated from the first valve seat portion 42 and the second valve body 36 is separated from the second valve seat portion 43 . That is, the production line L and the sampling channel 11 are in communication with each other through the communication channel 12 (see FIG. 4).

The control unit 17 comprehensively controls the sampling system 10 as described above, and includes a sampling means 47 that performs a liquid medicine collection operation (sampling operation). The sampling means 47 controls the operation of the double valve plug portion 16, and also controls the operations of the first supply unit 14, the second supply unit 15, each open/close valve, etc., to sample the chemical solution. Next, an example of the liquid medicine sampling operation by the sampling means 47 will be described with reference to FIGS. 5 to 9. FIG. The penetrating arrows in FIGS. 5-9 indicate the flow of sterilizing liquid, sterilizing gas or liquid product.

First, the first valve body 34 of the double valve plug portion 16 is brought into close contact with the first valve seat portion 42 and the second valve body 36 is brought into close contact with the second valve seat portion 43 to doubly close the communication passage 12. In this state, the first supply unit 14 is operated to sterilize the sampling channel 11 .

Specifically, as shown in FIG. 5, with the first opening/closing valve 21 and the third opening/closing valve 26 opened and the second opening/closing valve 24 closed, the first supply unit 14 is operated to 25. Sterilization liquid (washing liquid) as a sterilization fluid is circulated in the sampling channel 11 and the first branch channel 19, and the sterilization liquid is discharged to the recovery unit 18, thereby performing stationary cleaning of these channels. (CIP).

At this time, the fourth opening/closing valve 27 and the fifth opening/closing valve 28 were opened to operate the second supply unit 15, thereby supplying saturated steam (pure steam) as the sterilization gas to the intermediate flow paths 13A and 13B. state. That is, a pure steam barrier is formed between the production line L and the sampling flow path 11 . The temperature of the saturated steam flowing through the intermediate flow paths 13A and 13B is controlled based on the detection result of the temperature sensor 29. FIG. Also, the flow rate of the saturated steam flowing through the intermediate passages 13A and 13B is adjusted by a throttle valve 30. As shown in FIG.

When the cleaning-in-place (CIP) of the sampling channel 11 and the like is finished, next, as shown in FIG. Sterilization-in-place (SIP) of these flow paths is performed by circulating saturated steam (pure steam) as a sterilizing gas through the second branch flow path 20 and discharging the saturated steam through the discharge section 48 . The temperature of the saturated steam supplied to the sampling channel 11 and the like is controlled based on the detection result of the temperature sensor 22 , and the flow rate of the saturated steam is adjusted by the throttle valve 23 . Also at this time, the intermediate flow paths 13A and 13B are in a state of being supplied with saturated steam, which is a gas for sterilization.

After the sterilization-in-place (SIP) of the sampling channel 11 is completed, the inside of the sampling channel 11 is then kept at a positive pressure as shown in FIG. Specifically, with the first opening/closing valve 21 and the second opening/closing valve 24 closed and the third opening/closing valve 26 opened, the sterilization is carried out from the first supply unit 14 to the sampling channel 11 via the connecting channel 25. Air is supplied to keep the inside of the sampling channel 11 at a positive pressure.

Next, the first valve plug portion 31 and the second valve plug portion 32 of the double valve plug portion 16 are is operated to open the communication channel 12, and as shown in FIG. As a result, the chemical solution can be appropriately filled into the sampling channel 11 from the manufacturing line L through the communication channel 12 . That is, it is possible to fill the sampling channel 11 with the chemical solution while suppressing the contamination of bacteria from the outside. When the double valve plug portion 16 is operated to open the communication channel 12 , the third opening/closing valve 26 is closed to stop the supply of sterile air from the first supply unit 14 into the sampling channel 11 .

Then, when the sampling flow path 11 is filled with the chemical solution, the first valve plug portion 31 and the second valve plug portion 32 of the double valve plug portion 16 are operated while the chemical solution is circulating in the production line L. It closes the communication channel 12 . After that, by opening the first opening/closing valve 21, the chemical liquid filled in the sampling channel 11 is supplied to the recovery unit 18 via the first branch channel 19 as shown in FIG. Collect the chemical solution in a container at . This completes a series of collection operations (sampling operations).

As described above, in the sampling system 10 according to the present embodiment, the production line L and the sampling flow path 11 are opened and closed by the double valve plug portion 16, which improves sanitation. Therefore, it is possible to suppress the contamination of various germs from the outside, to collect the chemical solution while maintaining the sterilized state, and to suppress the contamination of the production line L, which is the distribution section, with the various germs.

Furthermore, it is possible to suppress wasteful disposal of liquid chemicals, which are liquid products. For example, when mixing two types of aseptic raw material liquids in a container, conventionally, quality inspections were conducted after filling the container. All the raw material liquid had to be discarded, resulting in a large amount of waste. On the other hand, in the sampling system 10 according to the present embodiment, each sterilized raw material liquid can be sampled and inspected before filling the container, so if one raw material liquid does not meet the quality standard, , only one of the raw material liquids needs to be discarded, and wasteful disposal of the raw material liquid (chemical liquid) can be suppressed.

When mixing a plurality of types (for example, two types) of raw material liquids in this way, the liquid processing system I is provided with a plurality of production lines (distribution units) through which the respective raw material liquids circulate. It comprises a plurality of sampling systems 10 each connected to a line. That is, the liquid processing system I mixes a plurality of sterilized raw material liquids to produce a liquid product, and provides a sampling system in each distribution section (manufacturing line) through which the sterilized raw material liquids are distributed. good too.

Although one embodiment of the present invention has been described above, the present invention is, of course, not limited to the above-described embodiments. and other modifications are possible.

For example, when filling the sampling channel 11 from the production line L with a chemical solution, which is a liquid product, until the communication channel 12 is opened by operating the double valve plug part 16, the flow from the second supply unit 15 to the intermediate channel 13 You may make it supply sterile air.

In addition, in the above-described embodiment, the sampling system 10 is connected to the production line L, which is the distribution section, but may be connected to the storage tank 4, for example. In other words, the circulation section includes not only the manufacturing line L but also the storage tank 4 in which the chemical liquid is stored.

Also, for example, in the above-described embodiments, a medicine has been described as an example of a liquid product, but the present invention is not limited to this. The sampling system of the present invention can be applied not only to pharmaceuticals but also to beverages and foods in general.

I... Liquid handling system L... Production line 1... Filling device 2... Preparation tank 3... Sterilizer 4... Storage tank 5... Filter device 6... Filling unit 10... Sampling system 11... Sampling stream 12... Communication channel 13... Intermediate channel 14... First supply unit 15... Second supply unit 16... Double valve plug part 17... Control part 18... Recovery part 19... First branch Flow path 20 Second branch flow path 21 First opening/closing valve 22 Temperature sensor 23 Throttle valve 24 Second opening/closing valve 25 Connection flow path 26 Third opening/closing valve 27 Fourth on-off valve 28 Fifth on-off valve 29 Temperature sensor 30 Throttle valve 31 First valve plug 32 Second valve plug 33 First valve stem 34 First Valve body 35 Second valve stem 36 Second valve body 37 Apparatus body 38 Holding hole 39 Back plate 40 Diaphragm 41 Synthetic resin membrane 42 First valve seat Part, 43... Second valve seat part, 44... First hole part, 45... Second hole part, 46... Third hole part, 47... Sampling means, 48... Discharge part

Claims (5)

A sampling system for collecting a liquid product from a distribution section through which the sterilized liquid product is distributed,
a sampling channel connected to a recovery unit that recovers the liquid product;
a communication channel that communicates the sampling channel and the circulation part;
a pair of intermediate channels connected to the communication channel between the circulation part and the sampling channel;
a first supply unit connected to the opposite side of the sampling channel from the collecting part and supplying a sterilizing fluid to the sampling channel;
a second supply unit connected to the intermediate flow path and supplying sterilization gas to the intermediate flow path;
a double valve plug portion disposed in the communication channel to open and close the communication channel;
a control unit including sampling means for controlling operations of the first supply unit, the second supply unit, and the double valve plug unit to perform a sampling operation of the liquid product;
The double valve plug part
a first valve plug portion that can come into close contact with a first valve seat portion that is formed closer to the flow portion than the intermediate flow path of the communication flow path;
a second valve plug portion that is driven independently of the first valve plug portion and can come into close contact with a second valve seat portion that is formed closer to the sampling channel than the intermediate channel of the communication channel; prepared,
The sampling means are
activating the first supply unit to sterilize the sampling channel in a state in which the communication channel is doubly blocked by the first valve plug portion and the second valve plug portion;
While the liquid product is being circulated in the circulation portion, the first valve plug portion and the second valve plug portion are operated to open the communication channel, and the liquid is transferred from the circulation portion to the sampling channel. let the product flow,
After closing the communication channel by operating the first valve plug part and the second valve plug part in a state in which the liquid product is circulating in the circulation part, the liquid product in the sampling channel is removed. A sampling system, characterized in that it supplies to the collection unit. The sampling system of claim 1, comprising:
The sampling means are
When opening the communication channel by operating the first valve plug portion and the second valve plug portion,
A sampling system according to claim 1, wherein the first supply unit is actuated to supply sterile air to the sampling channel, thereby maintaining the inside of the sampling channel at a positive pressure. 3. The sampling system of claim 2, wherein
The sampling channel is connected together with the recovery section to a discharge section for discharging the sterilization fluid supplied from the first supply unit to the outside,
The sampling means distributes the sterilizing liquid as the sterilizing fluid to the sampling flow path and the recovery section by the first supply unit, and then distributes the sterilizing liquid as the sterilizing fluid to the sampling flow path and the discharge section. A sampling system, wherein the sampling flow path is sterilized by circulating a sterilizing gas. A sampling system according to claim 3, wherein
The sampling means are
When sterilizing the sampling channel,
A sampling system according to claim 1, characterized in that the second supply unit supplies sterilized air to the intermediate flow path to keep the inside of the intermediate flow path at a positive pressure. The sampling system of claim 1, comprising:
The sampling means are
When opening the communication channel by operating the first valve plug portion and the second valve plug portion,
A sampling system according to claim 1, wherein the second supply unit supplies a sterilizing gas to the intermediate flow path to keep the inside of the intermediate flow path at a positive pressure.

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