JP7323165B2 - Lid material for PTP package - Google Patents

Description

TECHNICAL FIELD The present invention relates to a lid material for a PTP package suitable for packaging pharmaceuticals such as tablets and capsules.

Counterfeit medicines are on the rise worldwide, threatening patient safety. Counterfeit medicines not only have no therapeutic effect, but can also lead to disability and even death due to side effects. In recent years, the spread of the Internet has made it possible for individuals to import and obtain medicines, increasing the risk of taking counterfeit medicines.

Therefore, pharmaceutical packages have been developed that can facilitate authenticity determination.
For example, in Patent Document 1 below, a line portion and a non-line portion formed by fine embossing on a cover material made of aluminum foil have a line (parallel straight line) ratio of 1:1. A parallel line pattern in which parallel lines are arranged is formed, and a latent image parallel line pattern is formed in the parallel line pattern area by shifting the parallel line phase by half a pitch with respect to the parallel line pattern. A PTP packaging material with a latent image pattern is disclosed. This PTP packaging material can facilitate the judgment of authenticity by confirming the latent image.

Further, Patent Document 2 below discloses a polymer layer containing a light-emitting component, the light-emitting component exhibits luminescence upon application of ultraviolet rays in the range of 200 nm to 300 nm, and the polymer layer has a wavelength in the range of 200 nm to 300 nm. A film is disclosed that includes a polymer layer that has a transmittance of about 10% or greater to ultraviolet radiation of about 10%. This film is applied to anti-counterfeiting blister packaging, and by irradiating it with specific ultraviolet rays, it is possible to judge authenticity by the presence or absence of luminescence.

Patent Document 3 below discloses a PTP package including a bottom material made of a plastic sheet and a lid material made of aluminum foil attached to the bottom material, wherein the bottom material has a plurality of convex lens shapes on the outer surface. The cover material is provided with a patterned part in which a plurality of patterns are arranged on the bottom material side, the patterned part is colored with at least one color of ink, and the resolution is 3200 dpi or more. is directly printed on the aluminum foil, and the pattern of the pattern portion can be stereoscopically viewed through the convex lens collective portion. This package can be easily authenticated by confirming the pattern of the pattern portion.

Japanese Patent Application Laid-Open No. 2007-145428 Japanese Patent Publication No. 2008-506565 Japanese Patent No. 6446219

In this way, anti-counterfeit means are provided in pharmaceutical packages such as PTP packages to enable authentication. ing.
As shown in Patent Document 2, it is possible to include a component that emits fluorescent light (also referred to as a taggant pigment) when irradiated with light of a specific wavelength in the polymer layer. It is effective in preventing counterfeiting because the manufacturer and seller can decide whether to use a pigment or what kind of fluorescent taggant pigment to use.

In order for the taggant pigment in the polymer layer to fluoresce, the taggant pigment must be present near the surface of the polymer layer. However, even if a small amount of taggant pigment was included in the polymer layer, it was sometimes buried and did not exhibit fluorescence emission. Therefore, a large amount of taggant pigment is included, and there is a possibility that the cost increases. In addition, when a large amount of taggant pigment is contained in the polymer, there is a possibility that conventional production equipment may not work.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a cover material for a PTP package that can emit fluorescent light even with a small amount of taggant pigment and can be authenticated.

A lid material for a PTP package according to one embodiment of the present invention has an average particle diameter (d50) of 3 μm to 10 μm, which emits fluorescence at a wavelength different from the wavelength of light irradiated on one side or both sides of an aluminum foil layer. A lid material for a PTP package comprising a light emitting layer containing a taggant pigment within the range and a transparent resin , wherein the light emitting layer contains the taggant pigment within a range of 5 ppm to 100 ppm, and the thickness of the light emitting layer is It is characterized by being smaller than the average particle size (d50) of the taggant pigment.

By making the thickness of the light-emitting layer provided on one side or both sides of the aluminum foil layer smaller than the average particle size of the taggant pigment, the existence of the taggant pigment that does not fit in the light-emitting layer and protrudes outside is prevented. Therefore, when the light-emitting layer is irradiated with light of a specific wavelength, fluorescence can be reliably emitted.

In the lid material for a PTP package of the one form described above, it is preferable that the taggant pigment is contained in the light-emitting layer within the range of 5 ppm to 100 ppm, and within the range of 10 ppm to 50 ppm. Since even such a small amount of the taggant pigment protrudes outward, the light-emitting layer can emit fluorescent light.

In the lid material for a PTP package of the one form described above, it is preferable that the ratio of the average particle size (d50) of the taggant pigment to the thickness of the luminescent layer is within the range of 1.1 to 2.5. More specifically, the thickness of the light-emitting layer is preferably in the range of 1 μm to 5 μm, and the average particle diameter (d50) of the taggant pigment is preferably in the range of 3 μm to 10 μm, particularly in the range of 3 μm to 5 μm. If the average particle size (d50) of the taggant pigment is smaller than this, all of the taggant pigment may be buried in the light-emitting layer, and if it is larger than this, it may drop out of the light-emitting layer.

In the lid material for a PTP package according to the above aspect, it is preferable that the base material of the light-emitting layer is any one of epoxy resin, nitrocellulose resin, and acrylic resin. Since these resins are transparent, they do not interfere with the fluorescent emission of the taggant pigment. In addition, since it has been conventionally used as an OP (overprint) agent for lid materials for PTP packages, there is no problem in using it.
In the lid material for a PTP package of the one form described above, it is preferable to provide a light-emitting layer on the outermost surface, and since there is no layer that interferes with fluorescence emission, it is easy to determine authenticity.

The lid material for a PTP package of the above embodiment is formed by applying a coating agent containing a taggant pigment that emits fluorescence at a wavelength different from the wavelength of the irradiated light to at least one side of an aluminum foil to form a light emitting layer. can be produced by forming the thickness of the taggant pigment to be smaller than the average particle size (d50) of the taggant pigment.

A device for determining authenticity by irradiating light of a specific wavelength to the light-emitting layer using the lid material for a PTP package of one form above, recognizing light emitted by fluorescence from the taggant pigment, and detecting light emitted by fluorescence can be detected and compared with genuine product data to determine authenticity.
In this way, it is possible not only to visually confirm fluorescence emission, but also to determine authenticity by detecting fluorescence emission with a detection device and collating the emission characteristics and the like with the data of the genuine product.
In the present invention, the average particle size (d50) of the taggant pigment can be determined by a laser diffraction scattering particle size distribution measuring method.

1 is a schematic cross-sectional view showing a lid material for a PTP package according to one embodiment of the present invention; FIG.

A lid material for a PTP package according to one embodiment of the present invention will be described below. However, the present invention is not limited to this embodiment.

A lid material 1 for a PTP package according to one embodiment of the present invention includes an aluminum foil layer 2 and a luminescent layer 3 containing a taggant pigment 4, as shown in FIG.

For the aluminum foil layer 2, for example, a conventional hard or soft aluminum foil can be used. Specifically, JIS standard 1000 series, 8000 series, etc. aluminum foil can be used.
One side is glossy (mirror) and the other is matte (matte), both sides are glossy (mirror), both sides are matte Any type of aluminum foil may be used.

Although the thickness of the aluminum foil layer 2 is not particularly limited, it is preferably within the range of 12 μm to 45 μm, particularly within the range of 17 μm to 25 μm.

The light emitting layer 3 is provided on one side or both sides of the aluminum foil layer 2 . When provided on one side, it may be positioned on the inner surface side (heat-sealed side) of the PTP package, but is preferably positioned on the outer surface side.
The light-emitting layer 3 contains, in addition to the taggant pigment 4, a transparent resin such as epoxy resin, nitrocellulose resin, or acrylic resin. This transparent resin is contained in the light-emitting layer 3 in an amount of 50% by mass or more, preferably 60% by mass or more, and particularly preferably 70% by mass or more after drying.

The taggant pigment 4 is a pigment that emits fluorescence at a different wavelength when irradiated with light of a specific wavelength. It contains a so-called up-conversion phosphor that emits fluorescent light as visible light when irradiated with infrared rays. Further, it may be irradiated with red visible light to emit fluorescent light as blue visible light, or may be irradiated with purple visible light to emit fluorescent light as yellow visible light.
Specifically, for down-conversion phosphors, pigments that fluoresce light with a wavelength of 550 nm to 600 nm when irradiated with ultraviolet light with a wavelength of 360 nm to 390 nm, and blue light with a wavelength of 430 nm to 480 nm with a wavelength of 550 nm to 600 nm. It is preferable to use a pigment that emits fluorescent light, or a pigment that emits fluorescent light with a wavelength of 680 nm to 730 nm when irradiated with green light having a wavelength of 500 nm to 550 nm.

_{A conventionally} known composition can be used for the taggant pigment 4. For example, _Ca2B5O9Cl :Eu2 ⁺ , _CaWO4 , ZnO: _Zn , _Zn2SiO4 : _Mn , _Y2O2S : Eu, ZnS _: Ag, _YVO4 :Eu, _Zn2GeO4 : _Mn , Y(P,V) _O4 :Eu, _{0.5MgF2.3.5MgO.GeO2} :Mn, ZnS:Cu, ZnS:Mn etc. can be mentioned.
Fluorescence properties can be adjusted by appropriately selecting materials, composition ratios, and the like.

The taggant pigment 4 is not particularly limited, but preferably has an average particle size (d50) within the range of 3 μm to 10 μm, particularly within the range of 3 μm to 5 μm. The average particle size (d50) of the taggant pigment 4 can be determined by a laser diffraction scattering particle size distribution measurement method.

The taggant pigment 4 is preferably contained in the light emitting layer 3 within the range of 5 ppm to 100 ppm, particularly within the range of 10 ppm to 50 ppm.

The thickness of the light-emitting layer 3 is made smaller than the average particle size (d50) of the taggant pigment 4. For example, the ratio of the average particle size (d50) of the taggant pigment 4 to the thickness of the light-emitting layer 3 is 1.1-2. 0.5, preferably 1.4 to 2.0. Specifically, the thickness of the light-emitting layer 3 is preferably in the range of 5 μm to 30 μm, particularly in the range of 10 μm to 20 μm. By doing so, as shown in FIG. 1, there is the taggant pigment 4 which does not fit in the light-emitting layer 3 and protrudes.
The thickness of the light-emitting layer 3 is obtained by measuring the portion of the light-emitting layer 3 excluding the taggant pigment 4 .

The lid member 1 can be manufactured, for example, as follows.
The taggant pigment 4 is added to the coating agent containing the transparent resin, solvent, etc. and mixed. In this case, the average particle size (d50) of the taggant pigment 4 is preferably in the range of 3 μm to 10 μm, particularly in the range of 3 μm to 5 μm. is preferably within the range of 10 ppm to 50 ppm.

The light-emitting layer 3 can be formed by applying a coating agent to one side or both sides of the aluminum foil layer 2 and drying it. At this time, the coating amount is adjusted so that the thickness of the luminescent layer 3 after drying is smaller than the average particle size (d50) of the blended taggant pigment 4 . Although this coating is not particularly limited, it can be performed by gravure printing or the like.

The fluorescent layer 3 may be laminated directly on the aluminum foil layer 2, or another layer may be provided between them and the fluorescent layer 3 may be laminated thereon. For example, an anchor coat layer, a colored layer, a heat seal layer, and the like may be laminated. The colored layer is, for example, a white layer containing titanium oxide as a white pigment.
In addition, the fluorescent layer 3 is preferably positioned on the outermost surface of the PTP package, and is preferably laminated as an overprint (OP) layer. Alternatively, for example, a printed layer formed with an ink containing carbon black may be laminated.

Although the overall thickness of the lid member 1 is not particularly limited, it is preferably within the range of 17 μm to 45 μm, particularly within the range of 20.3 μm to 32 μm.

A PTP package can be produced by adhering the lid material 1 to the bottom material by heat sealing or the like.

Using the cover member 1, for example, authenticity can be determined as follows.
Light having a specific wavelength, for example, visible light (blue) having a wavelength of 430 nm to 480 nm is irradiated to the light emitting layer 3 of the lid member 1 . The taggant pigment 4 absorbs this light and emits fluorescence. For example, if it is set to emit visible light (yellow) with a wavelength of 550 nm to 600 nm, it is possible to determine authenticity by visually recognizing the light. By disclosing to the manufacturer or distributor only what color the lid member 1 emits, it is possible to easily determine authenticity.

Furthermore, it is preferable that the fluorescent light emitted by the taggant pigment 4 is detected by a detection device, and the authenticity can be determined by collating it with the data of the genuine article.
As a detection device, more specifically, for a down-conversion phosphor, a dedicated detector having an excitation light source and fluorescence spectrum (peak wavelength, CIE color system coordinates, full width at half maximum) measurement function can be mentioned. can. Further, for the up-conversion type, a dedicated detector having a function of measuring excitation electron attenuation characteristics (attenuation characteristic curves of three primary colors) can be mentioned.
Accurate authenticity determination is possible by disclosing data on the fluorescence spectrum of genuine products only to manufacturers or distributors.

In order to eliminate light reflection by the aluminum foil layer 2 when receiving light emitted by the taggant pigment 4 by irradiating with a specific wavelength, it is preferable to attach a birefringence polarizing filter to the receiving portion of the detection device. preferable.

In this way, even if the amount of the taggant pigment 4 in the light-emitting layer 3 is small, the cover material 1 can be visually authenticated by irradiating it with light of a specific wavelength to emit fluorescent light. It is also possible to discriminate the authenticity, and it is effective in preventing forgery.

Hereinafter, lid materials for PTP packages according to examples of the present invention will be described. However, the present invention is not limited to this example.

(Example 1)
A lid material for a PTP package of Example 1 was produced as follows.

As the aluminum foil layer, an aluminum foil of 8079 hard material (JIS) having a thickness of 20 μm was used.

The light-emitting layer was produced as follows.
A coating agent containing an epoxy resin is mixed with a taggant pigment (manufactured by LWB of Germany) having an average particle size (d50) of 4 μm, and this coating agent is applied onto an aluminum foil layer by gravure printing and dried to form a light-emitting layer. formed. The light-emitting layer after drying contains 70% by mass of the epoxy resin and 30 ppm of the taggant pigment. Moreover, the thickness of the light-emitting layer after drying was 2 μm.
This taggant pigment is adjusted to fluoresce light (yellow) with a wavelength of 550 nm to 600 nm when irradiated with light of a wavelength of 430 nm to 480 nm.

(Reference example 1)
A lid material for a PTP package of Reference Example 1 was produced as follows.

It was produced in the same manner as in Example 1, except that the luminescent layer after drying contained 200 ppm of a taggant pigment.

(Fluorescence emission test)
Using the PTP package lid materials of Example 1 and Reference Example 1, each was irradiated with light having a wavelength of 430 nm to 480 nm, and it was visually confirmed whether or not fluorescence was emitted.
It was confirmed that the lid material of Example 1 emitted yellow light. It was also confirmed that the cover material of Reference Example 1 emitted yellow light.

Next, the PTP package lid materials of Example 1 and Reference Example 1 were irradiated with light having a wavelength of 430 nm to 480 nm, and fluorescence spectra of the emitted light were measured using a dedicated detection device. This measurement was performed 5 times.
For the lid material of Example 1, fluorescence emission was detected five times, the fluorescence spectrum was measured, and compared with the characteristic data of the genuine product, the authenticity could be determined. For the cover material of Reference Example 1, fluorescence emission was detected five times, and the fluorescence spectrum was measured and compared with the characteristic data of the genuine product, so that authenticity could be determined.

(result)
In the lid material of Example 1, the thickness of the light-emitting layer was made smaller than the average particle diameter (d50) of the taggant pigment, so that authenticity determination could be reliably performed without containing a large amount of the taggant pigment as in Reference Example 1. I was able to

DESCRIPTION OF SYMBOLS 1... Lid material for PTP packages 2... Aluminum foil layer 3... Fluorescent layer 4... Taggant pigment

Claims (9)

Light emission containing a taggant pigment having an average particle size (d50) in the range of 3 μm to 10 μm, which emits fluorescence at a wavelength different from the wavelength of the irradiated light , and a transparent resin, on one or both sides of the aluminum foil layer. A cover material for a PTP package comprising a layer,
A cover material for a PTP package , wherein the taggant pigment is contained in the light emitting layer within the range of 5 ppm to 100 ppm, and the thickness of the light emitting layer is smaller than the average particle diameter (d50) of the taggant pigment. 2. The lid material for a PTP package according to claim 1, wherein the taggant pigment is contained in the luminescent layer within a range of 10 ppm to 50 ppm. 3. The lid material for a PTP package according to claim 1 , wherein the ratio of the average particle size (d50) of the taggant pigment to the thickness of the luminescent layer is set within the range of 1.1 to 2.5. The cover material for a PTP package according to any one of claims 1 to 3, wherein the thickness of said light emitting layer is in the range of 1 µm to 5 µm. The cover material for a PTP package according to any one of claims 1 to 3, wherein the taggant pigment has an average particle size (d50) within the range of 3 µm to 5 µm. The cover material for a PTP package according to any one of claims 1 to 5 , wherein the transparent resin of the light emitting layer is one of epoxy resin, nitrocellulose resin and acrylic resin. The lid material for a PTP package according to any one of claims 1 to 6 , wherein the light-emitting layer is provided on the outermost surface. A coating agent containing a taggant pigment having an average particle diameter (d50) in the range of 3 μm to 10 μm, which emits fluorescence at a wavelength different from the wavelength of the irradiated light , and a transparent resin is applied to at least one side of the aluminum foil. A method for manufacturing a lid material for a PTP package in which a light-emitting layer is formed by
A method for producing a lid material for a PTP package , wherein the luminescent layer contains the taggant pigment within a range of 5 ppm to 100 ppm, and the thickness of the luminescent layer is formed to be smaller than the average particle size (d50) of the taggant pigment. A method for determining authenticity of a lid material for a PTP package according to any one of claims 1 to 7 ,
The luminescent layer is irradiated with light of a specific wavelength, the fluorescent light emitted from the taggant pigment is visually recognized to determine authenticity, and the fluorescent light is detected by a detection device and compared with the data of the authentic product. method to determine authenticity.

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