JP2021008306A - Lid material for PTP packaging - Google Patents

Abstract

To provide a lid material for a PTP packaging capable of reliably fluorescing with even a small amount of taggant pigment to discriminate authenticity.SOLUTION: A lid material 1 for a PTP packaging includes a light emitting layer 3 containing a taggant pigment 4 that fluoresces at a wavelength different from a wavelength of irradiated light, on one side or both sides of an aluminum foil layer 2, in which a thickness of the light emitting layer 3 is smaller than an average particle size (d50) of the taggant pigment 4. The light emitting layer 3 of the lid material 1 for the PTP packaging is irradiated with light of a specific wavelength, light fluorescently emitted from the taggant pigment 4 is visually detected and is detected by a detection device, and the authenticity can be determined by collating it with genuine data.SELECTED DRAWING: Figure 1

Description

The present invention relates to a lid material for a PTP package suitable for packaging pharmaceutical products such as tablets and capsules.

Counterfeit medicines are on the rise worldwide, threatening patient safety. Taking counterfeit medicines not only has no therapeutic effect, but side effects can cause disability and, in the worst case, death. In recent years, with the spread of the Internet, it has become possible for individuals to import and obtain medicines, and the risk of taking counterfeit medicines is increasing.

Therefore, packaging of pharmaceutical products has been developed that can easily determine the authenticity.
For example, in Patent Document 1 below, the ratio of wire lines (parallel straight lines) of line portions and non-line portions formed by fine embossing on a lid material made of aluminum foil is 1: 1. It is characterized by forming a perpendicular pattern in which perpendicular lines are arranged in parallel, and having a latent image permanent pattern formed by shifting the phase of the antenna by half a pitch with respect to the pattern in the domain. A PTP packaging material with a latent image pattern is disclosed. This PTP packaging material can facilitate the determination of authenticity by confirming the latent image.

Further, in Patent Document 2 below, a polymer layer containing a luminescent component, the luminescent component exhibits luminescence when ultraviolet rays in the range of 200 nm to 300 nm are applied, and the polymer layer is in the range of 200 nm to 300 nm. A film containing a polymer layer having a transmittance of about 10% or more with respect to ultraviolet rays is disclosed. By applying this film to anti-counterfeit blister packaging and irradiating it with specific ultraviolet rays, it is possible to determine authenticity based on the presence or absence of luminescence.

The following Patent Document 3 describes a PTP package including a bottom material made of a plastic sheet and a lid material made of aluminum foil bonded to the bottom material, and has a plurality of convex lenses on the outer surface of the bottom material. A convex lens assembly part is provided, and the lid material is provided with a pattern part in which a plurality of patterns are arranged on the bottom material side, and this pattern part is colored with at least one color of ink and has a resolution of 3200 dpi or more. Discloses a PTP package that can be directly printed on an aluminum foil and can be viewed in three dimensions through a convex lens assembly. In this package, it is possible to easily determine the authenticity by checking the pattern of the pattern portion.

JP-A-2007-145428 Special Table 2008-506565 Japanese Patent No. 6446219

In this way, anti-counterfeiting measures have been provided in pharmaceutical packaging such as PTP packaging to enable the determination of authenticity, but recently anti-counterfeiting measures have also been imitated, making it difficult to determine authenticity. ing.
Incorporating a component (also referred to as a taggant pigment) that fluoresces when irradiated with light of a specific wavelength as shown in Patent Document 2 in the polymer layer is a taggant that absorbs light of any wavelength. Since the manufacturer and seller can decide whether to use a pigment or what kind of fluorescently emitting taggant pigment is used, it is effective in preventing counterfeiting.

In order for the taggant pigment in the polymer layer to fluoresce, the taggant pigment must be present near the surface of the polymer layer. However, even if a small amount of taggant pigment is contained in the polymer layer, it may be buried and do not emit fluorescence. Therefore, a large amount of taggant pigment is included, which may increase the cost. In addition, if the polymer contains a large amount of taggant pigment, the conventional manufacturing apparatus may not operate.

Therefore, an object of the present invention is to provide a lid material for a PTP package that can emit fluorescent light even with a small amount of taggant pigment and can discriminate authenticity.

The lid material for a PTP package of one embodiment of the present invention is a PTP package having a light emitting layer containing a tagant pigment that fluoresces at a wavelength different from the wavelength of the incident light on one side or both sides of the aluminum foil layer. It is a lid material, and is characterized in that the thickness of the light emitting layer is made smaller than the average particle size (d50) of the tagant pigment.

In this way, by making the thickness of the light emitting layer provided on one side or both sides of the aluminum foil layer smaller than the average particle size of the tagant pigment, there is a tagant pigment that does not fit in the light emitting layer and protrudes to the outside. Therefore, when the light emitting layer is irradiated with light having a specific wavelength, fluorescence can be reliably emitted.

In the above-mentioned one form of the lid material for a PTP package, it is preferable that the taggant pigment is contained in the light emitting layer in the range of 5 ppm to 100 ppm and in the range of 10 ppm to 50 ppm. Since there is a taggant pigment that protrudes to the outside even in such a small amount, the light emitting layer can be made to emit fluorescent light.

In the above-mentioned lid material for a PTP package, the ratio of the average particle size (d50) of the taggant pigment to the thickness of the light emitting layer is preferably in the range of 1.1 to 2.5. More specifically, it is preferable that the thickness of the light emitting layer is in the range of 1 μm to 5 μm, and the average particle size (d50) of the taggant pigment is in the range of 3 μm to 10 μm, particularly in the range of 3 μm to 5 μm. If the average particle size (d50) of the taggant pigment is smaller than this, all of the taggant pigment may be buried in the light emitting layer, and if it is larger than this, it may fall off from the light emitting layer.

In the above-mentioned one form of the lid material for a PTP package, it is preferable that the main agent of the light emitting layer is an epoxy resin, a nitrocellulose resin, or an acrylic resin. Since these resins are transparent, they do not interfere with the fluorescence emission of the taggant pigment. Further, it has been conventionally used as an OP (overprint) agent for a lid material for a PTP package, and there is no problem in its use.
In the above-mentioned lid material for a PTP package, it is preferable to provide a light emitting layer on the outermost surface, and since there is no layer that hinders fluorescence emission, it becomes easy to determine the authenticity.

In the above-mentioned one form of the lid material for a PTP package, a coating agent containing a tagant pigment that fluoresces at a wavelength different from the wavelength of the irradiated light is applied to at least one surface side of the aluminum foil to form a light emitting layer. Can be produced by forming the thickness of the taganto pigment smaller than the average particle size (d50) of the tagant pigment.

Using the above-mentioned one form of lid material for PTP packaging, the light emitting layer is irradiated with light of a specific wavelength, the light emitted from the tagant pigment is visually recognized to determine the authenticity, and the fluorescently emitted light is detected. It can be detected by and collated with the genuine product data to determine the authenticity.
In this way, not only can the fluorescence emission be visually confirmed, but also the authenticity can be determined by detecting the fluorescence emission with the detection device and collating the emission characteristics and the like with the data of the genuine product.
In the present invention, the average particle size (d50) of the taggant pigment can be determined by a laser diffraction / scattering type particle size distribution measurement method.

It is a schematic cross-sectional view which showed the lid material for a PTP package of one Embodiment of this invention.

Hereinafter, a lid material for a PTP package according to an embodiment of the present invention will be described. However, the present invention is not limited to this embodiment.

As shown in FIG. 1, the lid material 1 for a PTP package according to an embodiment of the present invention includes an aluminum foil layer 2 and a light emitting layer 3 containing a taggant pigment 4.

As the aluminum foil layer 2, for example, a conventional hard or soft aluminum foil can be used. Specifically, JIS standard 1000 series, 8000 series and other aluminum foils can be used.
One side is glossy (mirror surface), the other side is matte (matte), both sides are glossy (mirror), and both sides are matte (matte). Any type of aluminum foil may be used.

The thickness of the aluminum foil layer 2 is not particularly limited, but is preferably in the range of 12 μm to 45 μm, particularly preferably in the range of 17 μm to 25 μm.

The light emitting layer 3 is provided on one side or both sides of the aluminum foil layer 2. When it is provided on one side, it may be positioned so as to be on the inner surface side (heat seal side) when it is made into a PTP package, but it is preferably positioned so as to be on the outer surface side.
The light emitting layer 3 contains, in addition to the tagant pigment 4, a transparent resin such as an epoxy resin, a nitrocellulose resin, or an acrylic resin. It is preferable that the transparent resin is contained in the light emitting layer 3 in an amount of 50% by mass or more, preferably 60% by mass or more, and particularly preferably 70% by mass or more after drying.

The tagant pigment 4 is a pigment that fluoresces at a wavelength different from that by irradiating light of a specific wavelength. For example, a so-called down-conversion type phosphor that fluoresces as visible light by irradiating ultraviolet rays, or near It contains a so-called up-conversion type phosphor that fluoresces as visible light by irradiating infrared rays. Further, it may be irradiated with red visible light to emit fluorescence as blue visible light, or may be irradiated with purple visible light to emit fluorescence as yellow visible light.
Specifically, the down-conversion type phosphor is a pigment that fluoresces light having a wavelength of 550 nm to 600 nm by irradiating ultraviolet light having a wavelength of 360 nm to 390 nm, and irradiating blue light having a wavelength of 430 nm to 480 nm to emit light having a wavelength of 550 nm to 600 nm. It is preferable to use a pigment that fluoresces light, a pigment that fluoresces light having a wavelength of 680 nm to 730 nm by irradiating green light having a wavelength of 500 nm to 550 nm, and the like.

As the tagant pigment 4, a conventionally known composition can be used, for example, Ca ₂ B ₅ O ₉ Cl: Eu ²⁺ , CaWO ₄ , ZnO: Zn, Zn ₂ SiO ₄ : Mn, Y ₂ O ₂ S :. _{Eu, ZnS: Ag, YVO 4} : Eu, Zn 2 GeO 4: Mn, Y (P, V) O 4: Eu, 0.5MgF 2 · 3.5MgO · GeO 2: Mn, ZnS: Cu, ZnS: Mn And so on.
The fluorescence characteristics can be adjusted by appropriately selecting the material, composition ratio, and the like.

The taggant pigment 4 is not particularly limited, but the average particle size (d50) is preferably in the range of 3 μm to 10 μm, particularly preferably in the range of 3 μm to 5 μm. The average particle size (d50) of the taggant pigment 4 can be determined by a laser diffraction / scattering type particle size distribution measurement method.

The taggant pigment 4 is preferably contained in the light emitting layer 3 in the range of 5 ppm to 100 ppm, particularly in the range of 10 ppm to 50 ppm.

The thickness of the light emitting layer 3 is set to be smaller than the average particle size (d50) of the tagant pigment 4, for example, the ratio of the average particle size (d50) of the tagant pigment 4 to the thickness of the light emitting layer 3 is 1.1 to 2. It is preferably within the range of .5, especially within the range of 1.4 to 2.0. Specifically, it is preferable that the thickness of the light emitting layer 3 is in the range of 5 μm to 30 μm, particularly in the range of 10 μm to 20 μm. By doing so, as shown in FIG. 1, since the taggant pigment 4 that does not fit in the light emitting layer 3 and protrudes is present, it is possible to reliably exhibit fluorescence emission by irradiating with light.
The thickness of the light emitting layer 3 is a measurement of the portion of the light emitting layer 3 excluding the taggant pigment 4.

The lid material 1 can be manufactured, for example, as follows.
The taggant pigment 4 is added to the coating agent containing the transparent resin, solvent and the like, and mixed. At this time, it is preferable to use the taggant pigment 4 having an average particle size (d50) in the range of 3 μm to 10 μm, particularly in the range of 3 μm to 5 μm, and the compounding ratio of the taggant pigment 4 is 5 ppm to 100 ppm after drying. It is preferably within the range of 10 ppm to 50 ppm.

The coating agent can be applied to one side or both sides of the aluminum foil layer 2 and dried to form the light emitting layer 3. At this time, the coating amount is adjusted so that the thickness of the light emitting layer 3 after drying is smaller than the average particle size (d50) of the blended taggant pigment 4. This coating is not particularly limited, but can be performed by gravure printing or the like.

The fluorescent layer 3 may be directly laminated on the aluminum foil layer 2, but another layer may be provided between them and the fluorescent layer 3 may be laminated on the other layer. For example, an anchor coat layer, a colored layer, a heat seal layer, and the like may be laminated. The colored layer is, for example, a white layer containing titanium oxide as a white pigment.
Further, the fluorescent layer 3 is preferably located on the outermost surface when it is made into a PTP package, and is preferably laminated as an overprint (OP) layer, but another layer is laminated on the fluorescent layer 3. Alternatively, for example, a printing layer formed of an ink containing carbon black may be laminated.

The total thickness of the lid material 1 is not particularly limited, but is preferably in the range of 17 μm to 45 μm, particularly preferably in the range of 20.3 μm to 32 μm.

A PTP package can be produced by adhering the lid material 1 to the bottom material by heat sealing or the like.

Using the lid material 1, for example, the authenticity can be determined as follows.
The light emitting layer 3 of the lid material 1 is irradiated with light having a specific wavelength, for example, visible light (blue) having a wavelength of 430 nm to 480 nm. The taggant pigment 4 absorbs this light and emits fluorescence. For example, if it is set to emit visible light (yellow) having a wavelength of 550 nm to 600 nm, the authenticity can be determined by visually recognizing the light. By disclosing how many colors the lid material 1 emits light only to the manufacturer or the distributor, it is possible to easily determine the authenticity.

Further, it is preferable that the light emitted by the taggant pigment 4 fluorescently emitted by the detection device is detected by a detection device so that the authenticity can be determined by collating with the data of the genuine product.
As a detection device, more specifically, for a down-conversion type phosphor, a dedicated detector having an excitation light source and a fluorescence spectrum (peak wavelength, CIE color system coordinates, half-value full width) measurement function can be mentioned. it can. As for the up-conversion type, a dedicated detector having a function of measuring excited electron attenuation characteristics (attenuation characteristic curves of the three primary colors) can be mentioned.
By disclosing the data on the fluorescence spectrum of the genuine product only to the manufacturer or the distributor, it is possible to accurately determine the authenticity.

It is recommended that a birefringence deflection filter be attached to the receiving portion of the detection device in order to eliminate light reflection by the aluminum foil layer 2 when irradiating a specific wavelength and receiving the light fluorescently emitted by the tagant pigment 4. preferable.

As described above, even if the amount of the taggant pigment 4 in the light emitting layer 3 is small, the lid material 1 can not only visually determine the authenticity by irradiating light of a specific wavelength to emit fluorescent light, but also using a detection device. Is also effective in preventing counterfeiting because it can determine the authenticity.

Hereinafter, the lid material for the PTP package according to the embodiment of the present invention will be described. However, the present invention is not limited to this embodiment.

(Example 1)
The lid material for the PTP package of Example 1 was prepared as follows.

As the aluminum foil layer, an 8079 hard material (JIS) aluminum foil having a thickness of 20 μm was used.

The light emitting layer was prepared as follows.
A taggant pigment (manufactured by LWB, Germany) having an average particle size (d50) of 4 μm is mixed with a coating agent containing an epoxy resin, and this coating agent is applied on an aluminum foil layer by gravure printing, dried, and a light emitting layer. Was formed. The light emitting layer after drying contains 70% by mass of epoxy resin and 30 ppm of taggant pigment. The thickness of the light emitting layer after drying was 2 μm.
This taggant pigment is adjusted so that when it is irradiated with light having a wavelength of 430 nm to 480 nm, light (yellow) having a wavelength of 550 nm to 600 nm is emitted by fluorescence.

(Reference example 1)
The lid material for the PTP package of Reference Example 1 was prepared as follows.

It was produced in the same manner as in Example 1 except that the light emitting layer after drying contained 200 ppm of a taggant pigment.

(Fluorescence emission test)
Using the lid materials for PTP packages of Example 1 and Reference Example 1, each of them was irradiated with light having a wavelength of 430 nm to 480 nm, and it was visually confirmed whether or not the fluorescent light was emitted.
It was confirmed that the lid material of Example 1 emitted yellow light. It was also confirmed that the lid material of Reference Example 1 also emitted yellow light.

Next, the lid materials for the PTP packaging body of Example 1 and Reference Example 1 were irradiated with light having a wavelength of 430 nm to 480 nm, and the fluorescent light was measured by a dedicated detection device. This measurement was performed 5 times.
The lid material of Example 1 was able to detect fluorescence emission five times, measure the fluorescence spectrum, collate it with the characteristic data of the genuine product, and determine the authenticity. The lid material of Reference Example 1 also detected fluorescence emission five times, measured the fluorescence spectrum and collated it with the characteristic data of the genuine product, and was able to determine the authenticity.

(result)
Since the thickness of the light emitting layer of the lid material of Example 1 is smaller than the average particle size (d50) of the taggant pigment, the authenticity can be reliably determined even if a large amount of the taggant pigment is not contained as in Reference Example 1. I was able to.

1 ... Lid material for PTP packaging 2 ... Aluminum foil layer 3 ... Fluorescent layer 4 ... Taggant pigment

Claims (11)

A lid material for a PTP package having a light emitting layer containing a tagant pigment that fluoresces at a wavelength different from the wavelength of the irradiated light on one side or both sides of the aluminum foil layer.
A lid material for a PTP package in which the thickness of the light emitting layer is smaller than the average particle size (d50) of the taggant pigment. The lid material for a PTP package according to claim 1, wherein the taggant pigment is contained in the light emitting layer in the range of 5 ppm to 100 ppm. The lid material for a PTP package according to claim 1, wherein the taggant pigment is contained in the light emitting layer in the range of 10 ppm to 50 ppm. The lid material for a PTP package according to any one of claims 1 to 3, wherein the ratio of the average particle size (d50) of the tagant pigment to the thickness of the light emitting layer is in the range of 1.1 to 2.5. The lid material for a PTP package according to any one of claims 1 to 4, wherein the thickness of the light emitting layer is in the range of 1 μm to 5 μm. The lid material for a PTP package according to any one of claims 1 to 5, wherein the average particle size (d50) of the taggant pigment is in the range of 3 μm to 10 μm. The lid material for a PTP package according to any one of claims 1 to 5, wherein the average particle size (d50) of the taggant pigment is in the range of 3 μm to 5 μm. The lid material for a PTP package according to any one of claims 1 to 7, wherein the main agent of the light emitting layer is any of epoxy resin, nitrocellulose resin, and acrylic resin. The lid material for a PTP package according to any one of claims 1 to 8, wherein the light emitting layer is provided on the outermost surface. A method for producing a lid material for a PTP package, which forms a light emitting layer by applying a coating agent containing a tagant pigment that fluoresces at a wavelength different from the wavelength of the irradiated light on at least one surface side of an aluminum foil.
A method for producing a lid material for a PTP package in which the thickness of the light emitting layer is made smaller than the average particle size (d50) of the taggant pigment. The method for determining the authenticity of a lid material for a PTP package according to any one of claims 1 to 9.
The light emitting layer is irradiated with light of a specific wavelength, the light emitted from the tagant pigment is visually recognized to determine the authenticity, and the fluorescently emitted light is detected by a detection device and collated with genuine data. How to judge the authenticity.

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