JP7316666B2 - Cleansing composition and method for producing same - Google Patents

Description

TECHNICAL FIELD The present invention relates to a cleansing composition (cleansing composition/cleansing agent/external agent) and a method for producing the same, and in particular to a cleansing composition for removing stains or cleaning the outer surface of the body such as skin, body hair, and head hair. and a method for producing the same.

Conventionally, a wide variety of such cleansing compositions have been considered, including cleansing alcohols, topical alcohols, soaps, shampoos, and disinfecting alcohols. Accordingly, various production methods have been considered.

JP 2003-155225 A JP-A-57-75937 JP 2016-88910 A JP-A-63-199795 Japanese Patent Publication No. 10-513189 JP 2016-041660 A Japanese Patent Publication No. 09-511244 JP 2004-026657 A JP 2007-056009 A Japanese Patent No. 6651104 Chinese Patent Application Publication No. 103705391

The present invention was made to solve the above-mentioned problems, and an object of the present invention is to clean, wipe, wash, disinfect, etc. the outer surface of the body, etc., compared to conventional cleansing compositions. To provide a cleansing composition and a method for producing the same, which can realize an optimal state in

Thus, the cleansing composition of the present invention comprises 25% to 95% by weight of water, 0.001% to 50% by weight of glyceryl laurate, 0.001% to 30% by weight of an anti-itch ingredient, 0.001% to 30% by weight of the deodorizing component and 0.001% to 30% by weight of the moisturizing component were mixed substantially uniformly within a range not exceeding 100% by weight in total.

In addition, the cleaning composition contains 0.001% to 30% by weight of components extracted from bamboo grass, large bamboo grass, Chishima bamboo grass, suzutake mushroom, kumazasa, chimakisasa, miyakosasa, Chinese grass grass, bamboo grass or bamboo, 100% in total. They were mixed substantially uniformly within the range not exceeding the weight percent.

This allows the exterior surface of the body to be cleaned, deodorized, cleaned or disinfected by simply wiping with the cleansing composition without cleaning. Of course, they may be wiped with the cleaning composition after washing. In addition, even when this cleansing composition is applied to the skin, etc., the skin is neither too humid nor too dry, nor too much or too little oil, and just the right amount of moisture and oil is achieved. can.

Fig. 10 shows the state of reduction of nitric oxide NO in mouse monocytic leukemia RAW264.7 cells by the Kumasasa leaf extract alone with increasing amount of Kumasasa leaf extract added. Fig. 2 shows the reduction of nitric oxide NO in mouse monocytic leukemia RAW264.7 cells by glyceryl laurate/monolaurin alone with increasing amounts of glyceryl laurate/monolaurin. Fig. 3 shows the reduction of nitric oxide NO in mouse monocytic leukemia RAW264.7 cells by a mixture of glyceryl laurate/monolaurin and Kumasasa leaf extract with increasing amounts of glyceryl laurate/monolaurin and Kumasasa leaf extract added.

(1) Cleansing composition such as wipes Attach the cleansing composition to wipes such as tissue paper, towels, handkerchiefs, cloths, masks, gloves, protective clothing, and protective caps, and clothing. It is a material that can clean the dirty hands, feet, face, arms, legs, torso, neck, head, armpits, genitals, buttocks, local areas, etc. of a person requiring care simply by wiping.

The water, which may be soft, hard, tap, or distilled water, 25% to 95% by weight, is substantially uniformly mixed, optionally emulsified, in the cleansing composition, such as a skin cleanser. The cleaning composition includes 0.001% to 50% by weight of the glyceryl laurate wipe, and the total amount of the cleaning composition does not exceed 100% by weight. It mixes almost uniformly with the substance and is emulsified in some cases.

This glyceryl laurate has a chemical formula of C15H30O4 and has a structure represented by "Chemical 1", "Chemical 2" . . . monoglyceryl laurate, polyglyceryl laurate, polyglyceryl-2 laurate, monoglyceryl-10 laurate, polyglyceryl-10 laurate, monoglyceryl-20 laurate, polyglyceryl-20 laurate, . A plurality is mixed and optionally emulsified. Some of the above-mentioned glyceryl laurate have the following chemical structures.

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

The numbers in the above and following chemical formulas are originally displayed in small sizes at the bottom right of the respective chemical symbols, but in the present application, they are displayed in large normal size for the sake of convenience to make them easier to read.

Glyceryl laurate/monolaurin is found in breast milk and the like, and can be extracted from human or animal breast milk. Glyceryl laurate/monolaurin can also be formed from the monoglyceride glycerin or glycerin and lauric acid, which is a monoester, but can be a polyester, either monolauric or polylauric.

Lauric acid is obtained by esterifying a mixed fatty acid of coconut oil, fractionating it under reduced pressure, and then saponifying it. It is also contained in various vegetable oils such as coconut oil and bay oil as glycerides. Monoglyceride glycerin is obtained by decomposing various fats into fatty acids and monoglyceride glycerin with lipase or the like.

Glycerin forms an ester bond with a fatty acid and is present in many animals and plants in the form of oils, fats, and the like. Starting from propylene, it is synthesized via allyl chloride and allyl alcohol, and it is also produced by decomposition of fats and oils, by-products of soap production, alcohol, etc. by fermentation. Glyceryl laurate/monolaurin is usually monomeric, but may optionally be dimer, trimer or polymer.

Glyceryl laurate/monolaurin is used in cosmetics such as deodorants and as a food additive such as surfactants and emulsifiers. In the body, lauric acid is converted into monolaurate/glyceryl laurate. This monolaurin/glyceryl laurate is present in coconut oil, human or animal milk and the like. Monolaurin/glyceryl laurate has anti-inflammatory and antibacterial viral effects and is thought to be useful in the prevention and treatment of infections.

The cleansing composition containing glyceryl laurate is impregnated into tissues, handkerchiefs, towels, pulp, paper, cloth, etc., and used to clean the dirty hands of persons requiring nursing care, the elderly, the handicapped, infants, toddlers, infants, and the like. , feet, face, arms, legs, torso, neck, head, belly, chest, back, armpits, genitals, buttocks, local areas, etc., sebum stains, excrement, vomit, unnecessary stains on the skin , Other dirt can be easily removed, it is excellent in cleaning, can be cleaned, disinfected, moisturized, and protects the skin.

In addition, various bacteria such as Staphylococcus aureus, Bacillus subtilis, Clostridium perfringens, Escherichia coli, various viruses such as coronavirus, influenza virus, norovirus, novel coronavirus, and other bacteria can be sterilized or removed. However, it does not remove the amino acids, oil, and water that are necessary for the skin, and is excellent in moisturizing, water retention, oil retention, and oil retention.

Therefore, the moist feeling, elasticity, moist feeling and smooth feeling of the skin are maintained, the skin is not damaged, the skin is hypoallergenic, the dry skin is prevented in winter, etc., and the skin is protected in this way. This is different from rubbing alcohol, bleach, and the like. In addition to the skin, it may be used on mucous membranes, nails, hair, body hair, mouth, etc., may be used on animals other than humans, may be used externally, and may be used internally. .

Such glyceryl laurate/monolaurin synergistically exerts an anti-inflammatory effect when mixed with the Kumasasa leaf extract described later. FIG. 1 shows a state in which the amount of nitric oxide NO produced in mouse monocytic leukemia RAW264.7 cells decreases as the amount of the Kumusa leaf extract alone added is gradually increased. FIG. 2 shows a state in which the amount of nitric oxide NO produced in mouse monocytic leukemia RAW264.7 cells decreases as the amount of glyceryl laurate/monolaurin alone added is gradually increased.

On the other hand, the “right end” of FIG. 3 shows the state in which nitric oxide NO decreased in mouse monocytic leukemia RAW264.7 cells when a mixture of glyceryl laurate/monolaurin and Kumasasa leaf extract was added. Nitric oxide NO is a substance that induces inflammation.

Compared to FIGS. 1 and 2, the decrease in nitric oxide NO in FIG. In FIG. 3, compared to the kumasasa leaf extract alone (-++) and the glyceryl laurate/monolaurin alone (+-+), the "rightmost" mixture of glyceryl laurate/monolaurin and kumasasa leaf extract (+++) The amount of nitric oxide NO generated is remarkably reduced.

Here, it should be noted that the left ends of FIGS. 1, 2, and 3 show that no LPS inflammatory substance that induces inflammation was added, and therefore almost no nitric oxide NO was generated. there is Also, the scale of the vertical axis in each figure is different, and the nitric oxide NO generation amount in FIG. 3 is the smallest.

In FIG. 3, the added amount of glyceryl laurate/monolaurin is 30 μg/ml, and the condition is the same as the amount of nitric oxide NO generated in the second from the right, not the rightmost in FIG. 3 should be contrasted with the second from the right in FIG. In this experiment, the amount of nitric oxide NO generated was measured using living cells.

The cleaning composition contains 0.1% to 50% by weight of alcohol, and the total amount of the cleaning composition such as wipes does not exceed 100% by weight. It mixes almost uniformly with the substance and is emulsified in some cases.

The alcohol is, for example, one or Multiple. A butylene-based alcohol is, for example, 1,3-butylene glycol, and a propylene-based alcohol is, for example, dipropylene glycol.

This 1,3-butylene glycol has a chemical formula of C4H10O2, has a structure represented by "Chemical Formula 3", is a dihydric alcohol, is easily soluble in water and ethanol, is also soluble in acetone and ether, and is Insoluble in aromatic hydrocarbons. This 1,3-butylene glycol is obtained by catalytic reduction of butynediol obtained by Reppe reaction from acetylene and formaldehyde.

1,3-butylene glycol is 1,3-butanediol, butane-1,3-diol, 1,3-dihydroxy Also called butane (1,3-dihydroxybutane), each one of the four isomers of butanediol, all of which are included in this application.

It is used as a solvent for food flavors and as a comonomer for polyurethane and polyester resins. It acts as a hypoglycemic agent for organisms. 1,3-Butanediol converts to β-hydroxybutyrate, which is believed to serve as a substrate for brain metabolism.

The dipropylene glycol is also called propylene glycol and propane-1,2-diol, has a chemical formula of C3H8O2, has a structure represented by "Chemical Formula 4", is a dihydric alcohol, and is colorless, tasteless, and odorless at room temperature. It is a hygroscopic oily liquid, soluble in water, acetone and chloroform. Produced by hydrolysis of propylene oxide.

The above dipropylene glycol is an organic compound classified as a glycol, serves as a solvent, and has a pair of enantiomers because the central carbon is a chiral center. It has low toxicity to organisms, is tasteless and odorless, and can be used as moisturizing agents, lubricants, emulsifiers, antifreeze liquids, intermediate raw materials for plastics, solvents, etc. Furthermore, it can be used as moisturizing agents, antifungal agents, pharmaceuticals, and cosmetics. , the possibility of use as a food quality improving agent, etc. is being investigated.

Glycerin is a trihydric alcohol with a molecular formula of CH2(OH)CH(OH)CH2OH, and is a sweet, viscous, colorless liquid. It is obtained as a by-product of manufacturing and is industrially synthesized from propylene. It is highly soluble in water and has potential applications in the manufacture of nitroglycerin (a raw material for explosives) and alkyd resins, as well as in pharmaceuticals and cosmetics. Also known as glycerol and lysrin. Antiseptic action and moisturizing action were observed.

The above-mentioned ethyl alcohol is one of alcohols, has a molecular formula of C2H5OH, is a colorless and transparent liquid with a unique smell and taste, and is easily volatile and combustible. It is produced by the alcoholic fermentation of sugars. In addition to being a component of alcoholic beverages, it is also used as a synthetic raw material for solvents, fuels, and various chemicals, and is simply called alcohol. Also known as alcohol and ethanol. Antiseptic action and moisturizing action were observed.

Such alcohols are mixed in the cleansing composition in an amount about the same as or less than the water. As a result, among the above or below glyceryl laurate/monolaurin, anti-rash ingredients, anti-itch ingredients, deodorizing ingredients, moisturizing ingredients, and components extracted from Kumasasa, the components that are difficult to dissolve or extract with water are dissolved in alcohol. Alternatively, it can be extracted with alcohol and finally made into an aqueous solution, and the effect of the component that is difficult to dissolve in water or difficult to extract with water can be exhibited even in the aqueous solution, and the cleaning ability of the cleaning composition can be fully exhibited.

In addition, the above alcohol has moisturizing properties. As a result, even when dirt is removed, washed, cleansed or sterilized, moisturization can be performed, and even when dirt is wiped off, excess moisture and/or oil is not removed or dried, and the skin is moisturized. Moisture feeling, elasticity, moistness and smoothness are maintained, it does not damage the skin, is hypoallergenic, moisturizes, prevents dry skin, and protects the skin.

The cleansing composition contains 0.001% to 30% by weight of the anti-rash component, and the total amount of the cleansing composition such as wipes does not exceed 100% by weight. It is generally uniformly mixed and optionally emulsified in the cleansing composition. An anti-rash ingredient is an ingredient that prevents rashes and inflammations on the skin caused by irritations such as dirt, filth, and other substances.

This anti-rash component is, for example, evening primrose, yellow primrose, phellodendron bark, loquat, sage, hydroxypropyl chitosan, extracts/ingredients extracted from evening primrose leaves, seeds, stems or bark, yellowfin primrose leaves, seeds, stems or bark. Extracts/ingredients, extracts/ingredients extracted from Phellodendron bark leaves, seeds, stems or bark, extracts/ingredients extracted from loquat leaves, seeds, stems or bark, extracts/ingredients extracted from sage leaves, seeds, stems or bark one or more of the following ingredients: tricapryl glycerol/tricapryl glycerol, sorbitan monooleate/sorbitan oleate, cyclomethicone, hydroxypropyl chitosan, and the like.

Such anti-rash ingredients are extracted and purified by decocting the leaves, seeds, stems or bark of evening primrose, yellow primrose, phellodendron bark, loquat, sage, chitosan, evening primrose, seeds, stems or bark, which are crushed or shredded, or By immersing in a solvent such as water, oil, alcohol, ether, carbon tetrachloride, etc., the above components/extracts are melted, taken out and extracted.

The tricaprylglyceride/tricaprylglyceride is made from one or from medium chain triglycerides, such as Neobee® 1053 made by Stepan. Said sorbitan monooleate/sorbitan oleate is for example selected from the group consisting of monoesters, diesters, triesters of sorbitol and fatty acids, for example Span 80V Pharma manufactured by Uniqema. The above cyclomethicone is, for example, ST-cyclomethicone 5-NF manufactured by Dow Corning as a raw material. Cyclomethicone and hydroxypropyl chitosan are known.

Such a rash-preventing component prevents rashes, but the rash-preventing component may be omitted and replaced with the above-mentioned Kumasasa leaf extract or the like. This is because Kumasasa leaf extract and the like exhibit an anti-inflammatory effect as described above. Of course, in addition to the bamboo grass, the same effect is exhibited with large bamboo grass, Chishima bamboo grass, suzutake, bamboo grass, chimakisasa, miyakosasa, Chinese grass, bamboo grass, bamboo, rush, reed, iris, and jojoba bamboo grass.

The cleansing composition contains 0.001% to 30% by weight of the anti-itch component, and the total amount of the cleansing composition such as wipes does not exceed 100% by weight. It is generally uniformly mixed and optionally emulsified in the cleansing composition. The above-mentioned anti-itch component is a component that prevents an itchy feeling caused by weak stimulation of painful points on the skin and mucous membranes due to stimulation by dirt, filth, other substances, and the like.

The anti-itch component is, for example, one or more of extracts/ingredients extracted from the leaves, seeds, stems or bark of cherry trees such as Somei Yoshino, antihistamines, adrenal corticosteroids, isomerized linoleic acid, hydrocortisone, methdilazine, trimebrazine, etc. Multiple.

Such anti-itch ingredients are extracted and refined by crushing or shredding the leaves, seeds, stems or bark of cherry trees such as Somei Yoshino, or extracting and refining them by decoction. By soaking in a solvent such as carbon chloride, the above components/extracts are melted, removed and extracted.

The above-mentioned antihistamines are obtained, for example, by drying plant tissue of stevia, finely pulverizing it, fermenting it as it is or by extracting an extract, and further extracting and concentrating it. Adrenal cortical hormones are produced, for example, from cholesterol in the adrenal cortex of animals, and are also synthesized artificially.

The above isomerized linoleic acid, for example, commercially available products contain normal linoleic acid and neighboring fatty acids as impurities in addition to 9,11-octadecadienoic acid and 10,12-octadecadienoic acid. is common. The hydrocortisone, the methdilazine, the trimebradine are known.

The cleaning composition contains 0.001% to 30% by weight of the deodorant component, and the total amount of the cleaning composition such as cleaning items does not exceed 100% by weight. substantially uniformly mixed and optionally emulsified in the composition. This deodorizing component is a component that eliminates, removes, or prevents unpleasant odors given to humans by dirt, filth, other substances, and the like.

This deodorant component is, for example, one or more of persimmon tannin, activated carbon, Bacillus natto, microorganisms, bacteria that decompose bad odors such as bacteria, photocatalyst substances, fragrances, etc. It may be one or more of physical deodorant, biological deodorant, and sensory deodorant. Persimmon tannin is a liquid collected/extracted from persimmon tannin. Persimmon tannin was found to have deodorant, waterproof, and antiseptic effects.

Chemical deodorization is a method of chemically reacting with odor-causing ingredients to make them odorless. Physical deodorization is a method of using a substance that suppresses or envelops the components that cause bad odors. Biological deodorization is a method of decomposing odor-causing components or decomposing malodorous fungi, microorganisms, and bacteria through propagation of various germs, microorganisms, and bacteria. Sensory deodorization is a method of enveloping malodorous components with aromatic components.

Persimmon tannin is contained in the liquid collected from the astringent persimmon fruit, dissolved in water, and extracted from the aqueous solution of persimmon tannin. In particular, it is excellent in deodorizing nonenal, which is a foul-smelling component. Depending on the situation, it is conceivable that it may be applied to cloth, wood, linen, paper, etc. for deodorization, waterproofing, and antiseptic purposes.

The cleaning composition contains 0.001% to 30% by weight of Kumasasa leaf extract, and the total amount of the cleaning composition such as cleaning items does not exceed 100% by weight. substantially uniformly mixed and optionally emulsified in the composition. This Kumasasa leaf extract is obtained by, for example, crushing or cutting the leaves of Kumasasa and extracting and refining them by decoction, or immersing them in a solvent such as water, oil, alcohol, ether, carbon tetrachloride, etc. Ingredients/extracts are melted, removed and extracted.

This Kumasasa leaf extract can be extracted not only from leaves but also from seeds, stems or bark of Kumasasa. In addition to this bamboo grass, the same effect is exhibited with large bamboo grass, Chishima bamboo grass, suzutake, bamboo grass, chimakisasa, miyakosasa, Chinese grass, bamboo grass, bamboo, rush, reed, iris, jojoba, and the like.

Coumaric acid, ferulic acid, and caffeic acid (caffeic acid), which will be described later, are obtained by crushing or shredding the leaves, seeds, stems, and bark of Kuma sasa, extracting and purifying them by boiling them, or by adding water, By soaking in a solvent such as oil, alcohol, ether, carbon tetrachloride, etc., the above components/extracts are melted, taken out and extracted.

The cleansing composition contains 0.001% to 30% by weight of a moisturizing ingredient such as one or more of sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, sodium lysine dilauroyl glutamate, and pellicea. , wipes, etc., in a total amount not exceeding 100% by weight of the cleaning composition, generally uniformly mixed and optionally emulsified. The moisturizing ingredient keeps the humidity within a certain range so that the object to which the cleansing composition is applied does not become too dry.

The sodium lactate is a sodium lactate, a compound represented by the chemical formula C3H5NaO3, and is obtained by neutralizing lactic acid produced by fermentation of sugar. It is liquid in nature, but powder formulations are also commercially available. It has antibacterial and moisturizing effects, and is thought to have the potential to improve the shelf life and flavor of many foods, including meat, and to prevent water separation. Although "milk" is attached, it is not an allergen for milk allergy. Considered to have moisturizing potential.

The above sodium lactate is obtained by reacting the above lactic acid with a sodium hydroxide solution or other sodium solution, and is well soluble in water, ethanol and glycerin, but insoluble in ether, chloroform and oils and fats. A 50 to 60% aqueous solution is considered to have a wide range of applications, and is considered to be excellent in moisturizing properties and emulsion stability.

The above-mentioned potassium lactate is obtained by reacting the above-mentioned lactic acid with a potassium hydroxide solution or other potassium solution, and is well soluble in water, ethanol and glycerin, but insoluble in ether, chloroform and oils and fats. A 50 to 60% aqueous solution is considered to have a wide range of applications, and is considered to be excellent in moisturizing properties and emulsion stability.

The potassium lactate is commercially available, for example, as PURASAL HiPure™ P by Purac Biochem BV, The Netherlands, as a 60% solution. When converting lactic acid to potassium lactate, concentrations higher than 60% are theoretically obtained.

Lactic acid is one of the organic acids, and is produced by decomposing sugar in anoxic conditions, such as lactic acid fermentation or vigorous muscle exercise. It is usually produced by fermenting glucose with lactic acid bacteria. It is a colorless, syrup-like substance with a sour taste and no odor.

Hyaluronic acid is a type of linear glycosaminoglycan (mucopolysaccharide), and is academically called hyaluronan. It is highly water-retentive and has viscosity due to water retention. The molecular weight of hyaluronic acid can reach as high as 2,000,000, but the lowest is 411.

Injection for osteoarthritis and beauty care for adults has medical approval by the FDA, and it is possible that it may be added to cosmetics as a moisturizing ingredient, and it is possible to treat discomfort in the knees and dry skin. In industrial production, hyaluronic acid is mainly isolated from chicken combs, and there is also hyaluronic acid produced by lactic acid bacteria. In medical applications, non-animal collagen is used, such as the brand Restylane.

Hyaluronic acid has a moisturizing effect on the skin surface. Due to its extremely high molecular weight of 800,000 to 1,200,000, it was thought that it would be difficult to absorb by application. Volume and elasticity are improved over placebo. When the water retention capacity of the epidermis decreases, fine wrinkles commonly called "crepe wrinkles" occur, and moisturizing may prevent such fine wrinkles due to dryness.

Since hyaluronic acid retains moisture and is hydrophilic, it is possible to process it so that it is less likely to be repelled by sebum, and in a blind test, applying it to half of the face improved the moisture content and texture compared to the unpainted surface. . A soap bubble liquid that uses a lotion containing hyaluronic acid is also considered, focusing on the water retention capacity and viscosity of hyaluronic acid, making it difficult to break. You can also use woolen gloves and work gloves to make it bounce.

It uses microneedle technology to increase skin penetration. It is possible to administer hyaluronic acid to the skin through painful injections, and it is thought that by processing hyaluronic acid into the shape of fine needles, it can be absorbed through the skin without feeling pain. It can also be used for medical patch-type vaccines for the purpose of absorbing medicinal ingredients.

The above polyquaternium is also called polyquaternium-51, one of the lipidures, a water-soluble polymer that is close to the components of human cell membranes, has twice the moisturizing power of hyaluronic acid, and retains moisture even when wet with sweat or water. It is considered to have a higher function than hyaluronic acid in that it does not lower the Furthermore, it is thought to support the barrier function of the skin, prevent rough skin, and keep the skin in a beautiful state.

The lipidure is a water-soluble polymer and refers to a homopolymer of 2-methacryloyloxyethylphosphorylcholine or a copolymer containing 2-methacryloyloxyethylphosphorylcholine with a structure similar to that of phospholipids.

The common name of the homopolymer (Lipidure HM) is poly(2-methacryloyloxyethylphosphorylcholine), CAS registry number [67881-99-6]. The CAS registration number of copolymer with n-butyl methacrylate (Lipidure PMB) is [125275-25-4]. The ingredients are indicated as "MPC", "lipidure", or the like.

This lipidure has a moisturizing property and maintains a high moisturizing power even when dried after one hour of washing with water, and its moisturizing power is about twice that of hyaluronic acid. Since it retains its high moisturizing power even after washing with water after application, it is thought that this Lipidure is suitable for hand creams, contact lens preservation solutions, shampoos and conditioners, etc.

The sodium lysine dilauroyl glutamate mentioned above is a moisturizing agent made from vegetable fatty acids and amino acids (glutamic acid and lysine). , is thought to increase water retention. In addition, it is a condensate in which two sodium lauroyl glutamates, which are chemically anionic surfactants, are linked with lysine, which is a kind of basic amino acid, and is an anionic gemini surfactant with two chains and three hydrophilic groups. But also.

Pellicer is a highly biodegradable, high-performance cosmetic raw material made from natural fatty acids, glutamic acid, which is a type of amino acid, and lysine, and is a cosmetic raw material developed by Asahi Kasei Chemicals Corporation. Sodium lysine dilauroyl glutamate), and conventional PPT, are considered to have quicker penetration and higher persistence. It is thought that there is an improvement effect also about hair.

Pellicer is also a highly biodegradable and highly functional cosmetic raw material made from natural fatty acids, glutamic acid, which is a type of amino acid, and lysine. Penetrates into the keratin of the human body, works in the same way as ceramide, improves the barrier function of the skin, and promotes the recovery of skin elasticity and texture. It is considered that excellent feeling of use such as moisturizing feeling and permeation feeling can be achieved.

The cleaning compositions optionally contain one or more of additives or fragrances such as citric acid, sodium citrate, potassium citrate, etc., from 0.001% to 30% by weight of wipes and the like. Generally uniformly mixed and optionally emulsified, not exceeding 100% by weight of the total cleansing composition. This additive is in addition to the cleansing composition. Flavors are substances added to foods, cosmetics, etc. to give them fragrance.

Citric acid is an organic compound contained in citrus fruits and the like, and is one of hydroxy acids. Due to its refreshing acidity, it is often used as a food additive.枸櫞 is the Chinese name for marbushkan (citron). It is abundantly released in lemons and other citrus fruits, and is extracted from these citrus fruits, pickled plums, etc., or manufactured by fermenting sugar with microorganisms. It is also a food additive and is added to various processed foods including soft drinks.

The sodium citrate is obtained by reacting the citric acid with a sodium hydroxide solution or other sodium solution, and the potassium citrate is obtained by reacting the citric acid with a potassium hydroxide solution or another potassium solution. It is a food additive and is added to various processed foods including soft drinks.

In addition, it alkalizes the urine and promotes the excretion of uric acid, and is thought to be a therapeutic drug for hyperuricemia represented by gout, and is also suitable for the treatment of urinary calculi and metabolic acidosis. Similar to ornithine, it is also effective in reducing fatigue odor caused by decreased liver function.

The cleansing composition optionally contains from 0.001% to 30% by weight of one or more surfactants such as cocamidopropyl betaine, 2K glycyrrhizinate, sodium lysine dilauroyl glutamate, and the like. The total amount of the cleansing composition, such as a product, does not exceed 100% by weight, and is generally uniformly mixed and optionally emulsified.

Cocamidopropyl betaine is a double-sided active agent made from coconut oil. It is a kind of amino acid contained in radish.

An amphoteric surfactant is a surfactant whose hydrophilic group portion is positively or negatively charged depending on the pH. Cleaners and disinfectants using alkyldiaminoethylglycine hydrochloride are used in medical and nursing care settings. Coconut oil fatty acid (mainly lauric acid) and dimethylaminopropylamine are heated and condensed, the product is reacted with sodium chloroacetate, and tertiary alkylamine and sodium chloroacetate are reacted.

Glycyrrhizic acid 2K, that is, dipotassium glycyrrhizate, is a salt of glycyrrhizic acid and potassium, and is also called dipotassium glycyrrhizinate, glycyrrhizic acid 2K, glycyrrhizic acid K2, or glytinone K2, any of which may be used. CAS is 68797-35-3.

Its chemical formula is C42H60K2O16 and its molecular weight is 899.1128. Glycyrrhizic acid 2K has anti-inflammatory and anti-allergic effects in glycyrrhizin, which is the main active ingredient, and is suitable for skin pharmaceuticals, hair growth agents, etc. Dipotassium glycyrrhizinate derived from glycyrrhizin also has similar effects. It is a condensate in which two sodium lauroyl glutamates, which are chemically structurally anionic surfactants, are linked with lysine, which is a kind of basic amino acid, and is an anionic gemini type surfactant with two chains and three hydrophilic groups.

The above sodium lysine dilauroyl glutamate is chemically a condensate in which two sodium lauroyl glutamates, which are anionic surfactants, are linked with lysine, which is a kind of basic amino acid. It is a sexual gemini type surfactant. It is also a moisturizing and moisturizing agent made from vegetable fatty acids and amino acids (glutamic acid, lysine). .

The cleaning composition optionally contains 0.001% to 10% by weight of phenoxyethanol or the like, and the total amount of the cleaning composition such as wipes does not exceed 100% by weight. Mix and optionally emulsify.

This phenoxyethanol is an organic compound having a structure in which one hydroxyl group of ethylene glycol and a hydroxyl group of phenol are ether-bonded, and is classified into glycol ethers, phenol ethers, and aromatic alcohols according to its structure. Phenoxyethanol can be used as a formaldehyde-releasing preservative for medicines such as vaccines, cosmetics, dyes, inks, resins, and lubricants.

This phenoxyethanol is used as an antifungal agent for paints, a retention agent for fragrances, an insect repellent, a printing aid for textiles, an additive for photographic film, a disinfectant, a solvent for acetylcellulose, an anesthetic for aquaculture, and an organic synthetic chemistry. considered available. In addition, like the quaternary ammonium compound, it can be used as a disinfectant for agricultural chemicals and a gelation stabilizer.

The phenoxyethanol is produced by hydroxyethylation of phenol (Williamson Synthesis) in the presence of an alkali metal hydroxide or alkali metal borohydride. Phenoxyethanol is believed to be effective against Gram-negative and Gram-positive bacteria, as well as the yeast form Candida albicans.

Each of the above-described components of such a cleaning composition may be added all at once, or added sequentially, and mixed sufficiently to substantially uniformity, such as with a stirrer. In this case, the above water or alcohol serves as a solvent for each component. Here, water and water-soluble components may be mixed, alcohol and alcohol-soluble components may be mixed, and then both may be mixed. This is how the present cleaning compositions, such as the present wipes, are produced.

Coumaric acid, ferulic acid, and caffeic acid (caffeic acid) are extracted from the above-mentioned bamboo grass, large bamboo grass, Chishima bamboo grass, suzutake mushroom, kumazasa, chimakisasa, miyakosasa, Chinese grass, bamboo grass, bamboo, rush, reed, iris, and jojoba.

The above-mentioned coumaric acid is an organic compound having the chemical formula C9H8O3 and a structure represented by "Chemical 5", and having a structure in which a hydroxyl group is attached to cinnamic acid. There are three isomers of -coumaric acid, m-coumaric acid and p-coumaric acid. Of these, p-coumaric acid is the most abundant in nature. Although o-coumaric acid is also called coumaric acid, it is different from the English name coumaric acid. Any of o-coumaric acid, m-coumaric acid and p-coumaric acid may be used as coumaric acid.

p-Coumaric acid is crystalline and hard, and is slightly soluble in water, but well soluble in ethanol and diethyl ether. Due to its antioxidant effect, p-coumaric acid is thought to reduce the risk of stomach cancer by inhibiting the formation of carcinogenic nitrosamines.

The coumaric acid includes o-coumaric acid, m-coumaric acid, and p-coumaric acid. not exceeding 100% by weight, it is substantially uniformly mixed and optionally emulsified in the cleaning composition such as the wipe.

Ferulic acid has a chemical formula of C10H10O4, has a structure represented by Chemical Formula 6, and is an organic compound present as a phytochemical in the cell walls of plants. A derivative of cinnamic acid, it constitutes lignin and is a precursor for the synthesis of other aromatic compounds.

Ferulic acid and dihydroferulic acid play a role in connecting lignin and polysaccharides in the lignocellulose of the cell wall. It is also found in the seeds of rice, wheat, rye, barley, coffee, apples, artichokes, peanuts, oranges, and pineapples. It is extracted from wheat or soybean bran using concentrated alkali. It is biosynthesized by the action of O-methyltransferase (COMT, EC 2.1.1.68, reaction) on caffeic acid.

Ferulic acid, like other phenols, has an antioxidant effect and reacts with radicals such as reactive oxygen species. Reactive oxygen species and radicals cause DNA damage and cancer, and accelerate cell aging. Animal experiments and in vitro experiments show that ferulic acid has antitumor activity against breast cancer and liver cancer. It also has the function of causing apoptosis in cancer cells.

It also has the effect of preventing carcinogenesis caused by benzopyrene and the like. However, these are not based on randomized controlled trials in humans, and these results may not necessarily apply directly to humans. When coexisting with ascorbic acid and vitamin E, it reduces oxidative stress and forms thiamine dimer to protect the skin. Ferulic acid is generally uniformly distributed in the cleaning composition, such as a wipe, in the range of 0.001% to 30% by weight, and not exceeding 100% by weight in total of the cleaning composition, such as a wipe. Mix and optionally emulsify.

The caffeic acid has a chemical formula of C9H8O4 and has a structure represented by "Chemical Formula 7", and is an aromatic carboxylic acid having a structure in which the para- and meta-positions of cinnamic acid are hydroxylated. It is an acid and a phenylpropanoid. The molecular weight is 180.16. The IUPAC name is 3,4-dihydroxycinnamic acid. Also known as caffeic acid or caffeic acid. Caffeic acid is an important intermediate in lignin biosynthesis.

The ester with quinic acid is chlorogenic acid, and the hydroxy group at the meta position is known as ferulic acid. Others are widely distributed in the plant kingdom as esters, some of which are known as tannins. Biosynthesis is based on tyrosine or phenylalanine, and oxidation of cinnamic acid.

Chlorogenic acid is a compound having a structure in which the carboxyl group of caffeic acid is dehydrated and condensed with the hydroxy group at the 5-position of quinic acid. Caffeic acid is generally uniformly distributed in the cleaning composition, such as a wipe, in the range of 0.001% to 30% by weight, and not exceeding 100% by weight in total of the cleaning composition, such as a wipe. Mix and optionally emulsify.

The coumaric acid, ferulic acid, and caffeic acid (caffeic acid) can be obtained, for example, by brewing Kumasasa and extracting and purifying these components, as described above. In addition to bamboo grass, large bamboo grass, Chishima bamboo grass, suzutake, bamboo grass, chimakisasa, miyakosasa, Chinese grass, bamboo grass, bamboo, rush, reed, iris, jojoba, and the like may be used.

(2) Other Embodiments/Examples The present invention is not limited to the above-described examples, and some steps can be omitted without departing from the gist of the present invention. For example, the alcohol may be monohydric alcohol, dihydric alcohol, trihydric alcohol, tetrahydric alcohol, pentahydric alcohol, hexahydric alcohol, ..., primary alcohol, secondary alcohol, tertiary alcohol , quaternary alcohols, . Any hydroxy compound in which a hydrogen atom of a chain or ring-type hydrocarbon is substituted with a hydroxyl group OH may be used. The alcohol desirably has moisturizing properties, but may not have moisturizing properties depending on the case. The alcohol was the same amount or less than the water, but more is possible.

All or part of the above water is the above alcohol or oil (olive oil, jojoba oil, coconut oil, jojoba oil, coconut oil, palm oil, castor oil, peppermint oil, almond oil, soybean oil, camellia oil, sesame oil, safflower oil) , coconut oil, sunflower oil, corn oil, rapeseed oil, rice oil, peanut oil, cottonseed oil), the water may be mixed with the alcohol or the oil, or the water may be omitted. good. The oil may be of vegetable origin, but may also include animal oils.

Olive oil, jojoba oil, coconut oil, palm oil, coumaric acid, ferulic acid, caffeic acid extracted olive, jojoba, palm, palm, kumasasa may be filtered from water and discarded, or water or alcohol may be left in The above olive oil and olive oil-derived compounds and compositions include jojoba oil, coconut oil, palm oil, castor oil, peppermint oil, almond oil, soybean oil, camellia oil, sesame oil, safflower oil, coconut oil, sunflower oil, corn oil, Liquid or solid oils such as rapeseed oil, rice oil, peanut oil and cottonseed oil may be used.

In this case, 0.001 to 30% by weight, preferably 0.1 to 10% by weight of surfactant may be mixed. As a result, the composition for external use or the aqueous solution becomes an emulsion or microemulsion.

The above-mentioned anti-itch ingredients may be those other than ingredients extracted from cherry leaves, seeds, stems or bark, or ingredients extracted from Yoshino cherry leaves, seeds, stems or bark, antihistamines, adrenal corticosteroids, and isomerized linoleic acid. . The above-mentioned deodorant component may be anything other than persimmon tannin extracted from persimmons, activated carbon, Bacillus natto, microbes, bacteria that decompose bad odors, photocatalyst substances, and aromatics.

The moisturizing ingredients may be other than sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, sodium lysine dilauroyl glutamate, and pellicea. The above rash-preventing ingredients are other than evening primrose, yellowfin tuna, phellodendron bark, loquat, sage, chitosan, ingredients extracted from evening primrose leaves, seeds, stems or bark, tricapryl glycerol/tricaprin glycerol, sorbitan monooleate/sorbitan oleate. may be of

Extracted from the water of the cleansing composition, glyceryl laurate, anti-rash ingredient, anti-itch ingredient, deodorant ingredient, moisturizing ingredient, bamboo grass, large bamboo grass, Chishima bamboo grass, suzutake mushroom, kumasazasa, chimakisasa, miyakosasa, Chinese sasa, bamboo or bamboo alcohol, 1,3-butylene glycol, dipropylene glycol, glycerin, ethyl alcohol, evening primrose, yellowfin tuna, bark, loquat, sage, chitosan, evening primrose leaves, seeds, stems or bark, tricapryl glycerol / tricaprine glycerin, sorbitan monooleate / sorbitan oleate, ingredients extracted from cherry leaves, seeds, stems or bark, or ingredients extracted from Yoshino cherry leaves, seeds, stems or bark, antihistamines, adrenal cortical hormones, isomers Hydrogenated linoleic acid, persimmon tannin, activated carbon, Bacillus natto, microorganisms, bacteria that decompose bad odors such as bacteria, photocatalytic substances, air fresheners, sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, sodium lysine dilauroyl glutamate , Pellicer, and some or all of the cleansing composition may be omitted, and each may be liquid, solid, gas, sol, or gel.

(3) Effects of other inventions [1] 25% to 95% by weight of water, 0.001% to 50% by weight of glyceryl laurate, 0.001% to 30% by weight of an anti-itch component, 0.001% to 30% by weight of a deodorant component and 0.001% to 30% by weight of a moisturizing component are mixed substantially uniformly within a range not exceeding 100% by weight in total. Cleansing composition.

[2] The cleansing composition contains 0.001% to 30% by weight, in total, of components extracted from bamboo grass, large bamboo grass, Chishima bamboo grass, suzutake mushroom, kumazasa, chimakisasa, miyakosasa, Chinese grass grass, bamboo grass, or bamboo. 2. The cleansing composition of claim 1, wherein the composition does not exceed 100% by weight and is substantially homogeneously mixed.

As a result, along with glyceryl laurate/monolaurin, the production of nitric oxide NO, which is an inflammatory substance, can be inhibited, and inflammation can be suppressed "synergistically". Kuma sasa leaf extract alone (Fig. 1), or glyceryl laurate/monolaurin alone (Fig. 2) exerts a stronger inhibitory effect on nitric oxide NO production and synergistically exerts a stronger anti-inflammatory effect (Fig. 3). .

[3] The cleansing composition further contains 0.1% to 50% by weight of alcohol, which is approximately the same amount as or less than the water, and the total amount exceeds 100% by weight. 3. The cleansing composition according to claim 2, wherein the alcohol is mixed substantially uniformly within a range of no more than 100%, and the alcohol has moisturizing properties.

As a result, among the above-mentioned glyceryl laurate/monolaurin, anti-rash, anti-itch, deodorant, moisturizing, and components extracted from Kumasasa, the components that are difficult to dissolve or extract with water are dissolved in alcohol or dissolved in alcohol. It can be extracted with and finally made into an aqueous solution, and the effects of ingredients that are difficult to dissolve in water or difficult to extract with water can be exhibited even in the aqueous solution, and the cleaning ability of the cleaning composition can be fully exhibited and moisturizing. It retains its properties, and can be used to remove stains, wash, cleanse, or disinfect, and still retain moisture and protect the skin.

[4] A claim characterized in that the above cleansing composition is further substantially uniformly mixed with an anti-rash component in a range of 0.001% to 30% by weight and not exceeding 100% by weight in total. Item 4. The cleansing composition according to item 3. As a result, rashes can be prevented simply by wiping. Of course, it may be washed with running or/and pooled hot water and/or a surfactant.

[5] The above-mentioned anti-itch ingredient is an ingredient extracted from cherry blossom leaves, seeds, stems or bark, or an ingredient extracted from Yoshino cherry tree leaves, seeds, stems or bark, antihistamines, adrenal corticosteroids, isomerized linoleic acid. 5. The cleansing composition of claim 4, wherein the composition is one or more of . As a result, itching can be prevented simply by wiping. Of course, it may be washed with running or/and pooled hot water and/or a surfactant.

[6] The deodorant component is one or more of persimmon tannin extracted from persimmons, activated carbon, natto bacteria, microorganisms, bacteria that decompose bad odors, photocatalytic substances, and aromatics. 6. The cleansing composition of claim 5. As a result, rashes can be prevented simply by wiping. Of course, it may be washed with running or/and pooled hot water and/or a surfactant. This makes it possible to eliminate odors simply by wiping. Of course, it may be washed with running or/and pooled hot water and/or a surfactant.

[7] The cleanser according to claim 6, wherein the moisturizing ingredient is one or more of sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, sodium lysine dilauroyl glutamate, and pericea. composition. As a result, even if dirt or the like is wiped off, excess moisture and/or oil is not removed or dried, and the skin's moisture, elasticity, moistness, and smoothness are maintained, and the skin is not damaged. It is non-irritating, hypoallergenic, prevents dry skin and protects the skin.

[8] The rash-preventing ingredients are those extracted from evening primrose, yellowfin tuna, phellodendron bark, loquat, sage, chitosan, evening primrose leaves, seeds, stems or bark, tricapryl glycerol/tricaprin glycerol, sorbitan monooleate/sorbitan. 8. A cleansing composition according to claim 7, characterized in that it is one or more of oleate. As a result, rashes can be prevented simply by wiping. Of course, it may be washed with running or/and pooled hot water and/or a surfactant.

[9] The cleaning composition of Claim 8, wherein the alcohol is one or more of 1,3-butylene glycol, dipropylene glycol, glycerin, and ethyl alcohol. As a result, ingredients that are difficult to dissolve or extract with water can be dissolved in alcohol or extracted with alcohol, and finally made into an aqueous solution. The cleansing composition can exert its cleansing ability sufficiently, and furthermore, retains moisturizing properties, and can retain moisture and protect the skin even when dirt is removed, washed, cleansed or sterilized.

[10] A method for producing a cleansing composition, characterized by producing the cleansing composition according to any one of claims 1 to 9 above.

Even after cleansing, the moisture, elasticity, moistness, and smoothness of the skin are maintained. The cleansing composition contains 25% to 95% water, 0.001% to 50% glyceryl laurate, 0.001% to 30% anti-rash ingredient, and 0.001% to 30% anti-itch ingredient. 001% to 30% by weight, 0.001% to 30% by weight of the deodorant component, and 0.001% to 30% by weight of the moisturizing component, in a range not exceeding 100% by weight in total, almost Mix evenly.

In addition, components extracted from kumasasa or the like were mixed substantially homogeneously within the range of 0.001% to 30% by weight and not exceeding 100% by weight in total. Further, 0.1% to 50% by weight of alcohol, which is approximately the same amount as the water or less than the water, is mixed almost uniformly in a range not exceeding 100% by weight in total, and the Alcohol was assumed to have moisturizing properties.

Claims (5)

25% to 95% by weight of water, 0.001% to 30% by weight of bamboo or a component extracted from bamboo, 0.001% to 50% by weight of glyceryl laurate, persimmon tannin , activated carbon, microorganisms, 0.001% to 30% by weight of a photocatalytic substance or fragrance , sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, sodium lysine dilauroylglutamate or poly(2-methacryloyloxy) 0.001% by weight to 30% by weight of ethyl phosphoryl choline) , in a range not exceeding 100% by weight in total, substantially uniformly mixed. 25% to 95% by weight of water, 0.001% to 30% by weight of a component extracted from Kumasasa, Osasa, Chishimasasa, Suzutake, Kumosa, Chimakisasa, Miyakosasa or Chugokusasa, 0.001% by weight of glyceryl laurate 0.001% to 30% by weight of persimmon tannin, activated carbon, microorganisms, photocatalytic substances or fragrances, sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, sodium lysine dilauroyl glutamate or poly (2-methacryloyloxyethylphosphorylcholine) in an amount of 0.001% to 30% by weight, in a range not exceeding 100% by weight in total, substantially uniformly A cleansing composition characterized in that it is mixed with The cleansing composition further contains one or more of components extracted from cherry leaves, seeds, stems or bark, antihistamines, adrenal corticosteroids, and isomerized linoleic acid. Item 3. The cleansing composition according to Item 1 or 2 . The cleansing composition is further mixed with one or more of components extracted from evening primrose, yellowfin tuna, phellodendron bark, loquat, sage, chitosan, evening primrose leaves, seeds, stems or bark. A cleansing composition according to claim 3 . A method of producing a cleaning composition, comprising producing the cleaning composition of any one of claims 1 to 4 .

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