JP7306614B2 - トラジピタントを用いた胃腸疾患の治療方法 - Google Patents

トラジピタントを用いた胃腸疾患の治療方法 Download PDF

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Publication number
JP7306614B2
JP7306614B2 JP2020527780A JP2020527780A JP7306614B2 JP 7306614 B2 JP7306614 B2 JP 7306614B2 JP 2020527780 A JP2020527780 A JP 2020527780A JP 2020527780 A JP2020527780 A JP 2020527780A JP 7306614 B2 JP7306614 B2 JP 7306614B2
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tradipitant
day
amount
pharmaceutical composition
nausea
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Japanese (ja)
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JP2021503480A5 (https=
JP2021503480A (ja
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ポリメロポウロス、ミハエル、エイチ．
バージニックス、ガンザー
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Vanda Pharmaceuticals Inc
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Vanda Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020527780A 2017-11-17 2018-11-16 トラジピタントを用いた胃腸疾患の治療方法 Active JP7306614B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762587681P 2017-11-17 2017-11-17
US62/587,681 2017-11-17
PCT/US2018/061593 WO2019099883A1 (en) 2017-11-17 2018-11-16 Method of treatment of gastrointestinal diseases with tradipitant

Publications (3)

Publication Number Publication Date
JP2021503480A JP2021503480A (ja) 2021-02-12
JP2021503480A5 JP2021503480A5 (https=) 2021-12-23
JP7306614B2 true JP7306614B2 (ja) 2023-07-11

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ID=64734107

Family Applications (1)

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JP2020527780A Active JP7306614B2 (ja) 2017-11-17 2018-11-16 トラジピタントを用いた胃腸疾患の治療方法

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US (4) US20200030307A1 (https=)
EP (1) EP3710000B1 (https=)
JP (1) JP7306614B2 (https=)
KR (2) KR20250140655A (https=)
CN (2) CN111343981A (https=)
AU (1) AU2018367623B2 (https=)
BR (1) BR112020009520A2 (https=)
CA (1) CA3081582A1 (https=)
CL (1) CL2020001290A1 (https=)
DK (1) DK3710000T3 (https=)
ES (1) ES3032138T3 (https=)
FI (1) FI3710000T3 (https=)
HR (1) HRP20250615T1 (https=)
HU (1) HUE071527T2 (https=)
IL (1) IL274541B2 (https=)
MX (1) MX2020005167A (https=)
PT (1) PT3710000T (https=)
SI (1) SI3710000T1 (https=)
WO (1) WO2019099883A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2978736C (en) * 2015-03-04 2023-11-07 Vanda Pharmaceuticals Inc. Dosing regimen of tradipitant
CN112218636B (zh) * 2018-06-08 2025-05-06 万达制药公司 使用川地匹坦进行治疗的方法
US10821099B2 (en) 2018-09-28 2020-11-03 Vanda Pharmaceuticals Inc. Use of tradipitant in motion sickness
KR102863233B1 (ko) * 2018-09-28 2025-09-22 반다 파마슈티칼즈, 인코퍼레이티드. 멀미에서의 트라디피탄트의 용도
WO2020117811A1 (en) 2018-12-03 2020-06-11 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
WO2021195205A1 (en) 2020-03-26 2021-09-30 Vanda Pharmaceuticals Inc. Treatment of lower respiratory tract infection with tradipitant
WO2023019084A1 (en) 2021-08-12 2023-02-16 Vanda Pharmaceuticals Inc. Treatment of gastric accommodation with tradipitant
US20240350469A1 (en) 2021-08-31 2024-10-24 Vanda Pharmaceuticals Inc. Treatment of lower respiratory tract infection with tradipitant
CN120641099A (zh) 2022-12-21 2025-09-12 万达制药公司 使用曲地匹坦的治疗方法
EP4599831A1 (en) 2024-02-09 2025-08-13 Vanda Pharmaceuticals Inc. Treatment of gastroparesis with tradipitant

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536458A (ja) 2002-04-26 2005-12-02 イーライ・リリー・アンド・カンパニー タキキニン受容体アンタゴニストとしてのトリアゾール誘導体
JP2007509143A (ja) 2003-10-24 2007-04-12 イーライ リリー アンド カンパニー ｛２−［１−（３，５−ビストリフルオロメチルベンジル）−５−ピリジン−４−イル−１ｈ−［１，２，３］トリアゾル−４−イル］−ピリジン−３−イル｝−（２−クロロフェニル）−メタノンの新規の結晶形態
WO2016141341A1 (en) 2015-03-04 2016-09-09 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
WO2017112792A1 (en) 2015-12-22 2017-06-29 Takeda Pharmaceutical Company Limited Tripartite modulators of endosomal g protein-coupled receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101568523A (zh) 2006-12-20 2009-10-28 伊莱利利公司 用于制备{2-[1-(3,5-二-三氟甲基-苄基)-5-吡啶-4-基-1h-[1,2,3]三唑-4-基]－吡啶－3－基｝·(2－氯苯基)甲酮的新中间体和方法
PT2722045T (pt) * 2009-11-18 2016-10-18 Helsinn Healthcare Sa Composições para o tratamento de náuseas e vómitos mediadas centralmente

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536458A (ja) 2002-04-26 2005-12-02 イーライ・リリー・アンド・カンパニー タキキニン受容体アンタゴニストとしてのトリアゾール誘導体
JP2007509143A (ja) 2003-10-24 2007-04-12 イーライ リリー アンド カンパニー ｛２−［１−（３，５−ビストリフルオロメチルベンジル）−５−ピリジン−４−イル−１ｈ−［１，２，３］トリアゾル−４−イル］−ピリジン−３−イル｝−（２−クロロフェニル）−メタノンの新規の結晶形態
WO2016141341A1 (en) 2015-03-04 2016-09-09 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
WO2017112792A1 (en) 2015-12-22 2017-06-29 Takeda Pharmaceutical Company Limited Tripartite modulators of endosomal g protein-coupled receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Kirsten Tillisch et al.，T1261 The Effect of Chronic Neurokinin-1 Receptor Antagonism On Sympathetic Nervous System Activity in Irritable Bowel Syndrome (IBS)，Gastroenterology，2009年05月，Vol.136, No.5, Supplement 1，A-534, T1261
Science，2008年，Vol.319，p.1536-1539

Also Published As

Publication number Publication date
SI3710000T1 (sl) 2025-07-31
CN111343981A (zh) 2020-06-26
CL2020001290A1 (es) 2020-11-13
KR20200088346A (ko) 2020-07-22
IL274541A (en) 2020-06-30
IL274541B1 (en) 2024-06-01
WO2019099883A1 (en) 2019-05-23
NZ764107A (en) 2024-07-05
AU2018367623A1 (en) 2020-05-21
MX2020005167A (es) 2020-08-20
KR20250140655A (ko) 2025-09-25
EP3710000A1 (en) 2020-09-23
IL274541B2 (en) 2024-10-01
ES3032138T3 (en) 2025-07-15
JP2021503480A (ja) 2021-02-12
PT3710000T (pt) 2025-05-29
KR102864285B1 (ko) 2025-09-24
CA3081582A1 (en) 2019-05-23
US20230390269A1 (en) 2023-12-07
US20210093621A1 (en) 2021-04-01
US20210330656A1 (en) 2021-10-28
DK3710000T3 (da) 2025-06-16
EP3710000B1 (en) 2025-04-23
BR112020009520A2 (pt) 2020-11-03
CN119074729A (zh) 2024-12-06
FI3710000T3 (fi) 2025-07-03
HRP20250615T1 (hr) 2025-07-18
HUE071527T2 (hu) 2025-09-28
AU2018367623B2 (en) 2024-03-28
RU2020119259A (ru) 2021-12-17
US20200030307A1 (en) 2020-01-30

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