JP7306452B2 - フラボノイド配糖体の分解方法、及び、フラボノイドの製造方法 - Google Patents
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Description
本実施形態に係るフラボノイド配糖体の分解方法は、フラボノイド配糖体を含む原料液をオートクレーブ内で水熱処理することで、上記フラボノイド配糖体をフラボノイドに分解する水熱処理工程と、上記原料液が水熱処理されて得られた溶液を冷却する冷却工程と、を有し、上記冷却工程において、圧縮気体を上記オートクレーブ内に導入することで、上記オートクレーブ内の圧力を上記溶液の飽和蒸気圧以上に維持しながら、上記溶液を冷却する方法である。
本実施形態に係るフラボノイドの製造方法は、フラボノイド配糖体を分解する分解工程と、分解工程で得られた分解生成物からフラボノイドを抽出する抽出工程と、を含む。分解工程は、上述した本実施形態に係るフラボノイド配糖体の分解方法によりフラボノイド配糖体を分解する工程である。
スダチチン含有量1000質量ppm、配糖体由来スダチチン含有量9000質量ppmであるスダチ果皮エキス粉(池田薬草株式会社製)を超純水に5質量%となるように溶解/分散させ、スダチ果皮エキス水分散液を作製した。この水分散液を15Lステンレスタンク(日東金属工業株式会社製、容器深さ:27cm)及び1Lポリテトラフルオロエチレン(PTFE)ボトル(アズワン株式会社製、商品名:ビッグボーイ広口1000ml、容器深さ20cm)に表1に示す所定量投入した。
分解処理後、自然冷却等を行うことなく、直ちに圧力弁を全開にして減圧を行ったこと以外は実施例1と同様にして配糖体分解物及びスダチチン濃縮粉末を得た。減圧速度は180kPa/分であった。
(スダチチン濃縮粉末のスダチチン濃度測定)
各実施例及び比較例で得られたスダチチン濃縮粉末のスダチチン濃度は、以下の方法で測定した。まず、スダチチン濃縮粉末0.1gを希釈倍率500となるようにエタノールに溶解/分散させ、孔径0.1μmのPTFEフィルターでろ過して、エタノール溶液を得た。このエタノール溶液について、高速液体クロマトグラフィー(HPLC)により成分分析を行った。標準物質に市販のスダチチン標準精製試料を用いて検量線を作成し、それを用いてスダチチン濃縮粉末のスダチチン濃度を概算した。HPLC装置には、日立ハイテク製「クロムマスター」を用いた。結果を表2に示す。
スダチチン濃縮粉末の質量及びスダチチン濃度から、スダチチンの収率を求めた。収率は、分解処理前のサンプル中のスダチチン及び配糖体由来スダチチンの質量の合計に対する、得られたスダチチン濃縮粉末に含まれるスダチチンの質量の割合を示す。結果を表2に示す。
Claims (10)
- フラボノイド配糖体を含む原料液をオートクレーブ内で水熱処理することで、前記フラボノイド配糖体をフラボノイドに分解する水熱処理工程と、
前記原料液が水熱処理されて得られた溶液を冷却する冷却工程と、を有し、
前記冷却工程において、圧縮気体を前記オートクレーブ内に導入することで、前記オートクレーブ内の圧力を前記溶液の飽和蒸気圧以上に維持しながら、前記溶液を冷却する、フラボノイド配糖体の分解方法。 - 前記冷却工程において、前記オートクレーブ内の圧力を、前記溶液の飽和蒸気圧の100.5%以上300%以下の範囲内に維持する、請求項1に記載の分解方法。
- 前記冷却工程において、前記圧縮気体を、前記オートクレーブの槽容積の5%/分以上200%/分以下の速度で連続的に又は断続的に前記オートクレーブ内に導入する、請求項1又は2に記載の分解方法。
- 前記圧縮気体が、空気、窒素、酸素及び二酸化炭素からなる群より選択される少なくとも1種の気体からなる、請求項1~3のいずれか一項に記載の分解方法。
- 導入する前記圧縮気体の圧力を、当該圧縮気体を導入する時点での前記溶液の飽和蒸気圧の100.5%以上300%以下の範囲内とする、請求項1~4のいずれか一項に記載の分解方法。
- 前記冷却工程により、前記オートクレーブ内における前記溶液を、当該溶液の常圧下での沸点以下まで冷却する、請求項1~5のいずれか一項に記載の分解方法。
- 前記水熱処理は、前記オートクレーブ内に外部から水蒸気を供給することで行われる、請求項1~6のいずれか一項に記載の分解方法。
- 前記水熱処理工程において、前記オートクレーブ内の圧力が0.2~1.6MPaであり、温度が120~200℃である、請求項1~7のいずれか一項に記載の分解方法。
- 前記フラボノイド配糖体がスダチチン配糖体及び/又はデメトキシスダチチン配糖体を含む、請求項1~8のいずれか一項に記載の分解方法。
- 請求項1~9のいずれか一項に記載の分解方法によりフラボノイド配糖体を分解する分解工程と、
前記分解工程で得られた分解生成物からフラボノイドを抽出する抽出工程と、
を含む、フラボノイドの製造方法。
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WO2008155890A1 (ja) | 2007-06-21 | 2008-12-24 | J-Oil Mills, Inc. | 配糖体アグリコンの製造方法 |
JP2014073455A (ja) | 2012-10-04 | 2014-04-24 | Kimura Chem Plants Co Ltd | 圧力調整機構およびそれを備えた高圧処理装置 |
WO2014141465A1 (ja) | 2013-03-15 | 2014-09-18 | テルモ株式会社 | 医療器具の滅菌方法及び滅菌制御装置 |
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WO2008155890A1 (ja) | 2007-06-21 | 2008-12-24 | J-Oil Mills, Inc. | 配糖体アグリコンの製造方法 |
JP2014073455A (ja) | 2012-10-04 | 2014-04-24 | Kimura Chem Plants Co Ltd | 圧力調整機構およびそれを備えた高圧処理装置 |
WO2014141465A1 (ja) | 2013-03-15 | 2014-09-18 | テルモ株式会社 | 医療器具の滅菌方法及び滅菌制御装置 |
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Journal of Agricultural and Food Chemistry,2013年,Vol.61, No.48,pp.11840-11847 |
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