JP7297685B2 - 唾液中でメラトニンを可溶性にする酸性化剤を有する経口溶解メラトニン製剤 - Google Patents
唾液中でメラトニンを可溶性にする酸性化剤を有する経口溶解メラトニン製剤 Download PDFInfo
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- JP7297685B2 JP7297685B2 JP2019570491A JP2019570491A JP7297685B2 JP 7297685 B2 JP7297685 B2 JP 7297685B2 JP 2019570491 A JP2019570491 A JP 2019570491A JP 2019570491 A JP2019570491 A JP 2019570491A JP 7297685 B2 JP7297685 B2 JP 7297685B2
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US62/522,473 | 2017-06-20 | ||
| PCT/US2018/037698 WO2018236678A1 (en) | 2017-06-20 | 2018-06-15 | Orally dissolving melatonin formulation with acidifying agent that renders melatonin soluble in saliva |
Publications (4)
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| JP2020524162A JP2020524162A (ja) | 2020-08-13 |
| JPWO2018236678A5 JPWO2018236678A5 (https=) | 2022-08-03 |
| JP2020524162A5 JP2020524162A5 (https=) | 2022-08-03 |
| JP7297685B2 true JP7297685B2 (ja) | 2023-06-26 |
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| SG11201912172YA (en) | 2017-06-20 | 2020-01-30 | Physicians Seal Llc | Orally dissolving melatonin formulation with acidifying agent that renders melatonin soluble in saliva |
| US10828254B2 (en) | 2018-09-28 | 2020-11-10 | Intelgenx Corp. | Oral film formulation for modulating absorption profile |
| CN112426408B (zh) * | 2020-12-08 | 2023-12-19 | 广州帝奇医药技术有限公司 | 一种褪黑素组合物及其制备工艺 |
| WO2022170442A1 (en) * | 2021-02-12 | 2022-08-18 | Intelgenx Corp. | Novel tryptamine oral film formulation |
| CA3221463A1 (en) * | 2021-06-09 | 2022-12-15 | Agb-Pharma Ab | Melatonin formulation in solid dosage form |
| US12440472B2 (en) | 2021-06-16 | 2025-10-14 | Intelgenx Corp. | Stable tryptamine oral films |
Citations (5)
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| US20120195968A1 (en) | 2011-01-28 | 2012-08-02 | Shah Syed M | Controlled-release melatonin compositions and related methods |
| US20130052234A1 (en) | 2011-08-25 | 2013-02-28 | Purebrands LLC | Edible strips |
| US20140303227A1 (en) | 2013-03-14 | 2014-10-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| JP2014237700A (ja) | 2007-04-11 | 2014-12-18 | ファーマシューティカル プロダクションズ， インコーポレイテッド | メラトニンタブレットならびに調剤及び使用方法 |
| WO2016141069A1 (en) | 2015-03-02 | 2016-09-09 | Medlab Clinical U.S., Inc. | Transmucosal and transdermal delivery systems |
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| US20030091629A1 (en) | 1998-03-27 | 2003-05-15 | Cima Labs Inc. | Sublingual buccal effervescent |
| US6730330B2 (en) | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
| WO2003074029A1 (en) * | 2002-03-07 | 2003-09-12 | Vectura Limited | Fast melt multiparticulate formulations for oral delivery |
| CA2551637A1 (en) | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
| JP5179757B2 (ja) | 2004-02-17 | 2013-04-10 | トランセプト ファーマシューティカルズ， インコーポレイティド | 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法 |
| US20090047347A1 (en) | 2005-07-29 | 2009-02-19 | Aegis Therapeutics, Inc. | Compositions for Drug Administration |
| CA2582299A1 (en) | 2004-10-05 | 2006-04-13 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
| CN101132769A (zh) * | 2005-02-10 | 2008-02-27 | 奥瑞克索股份公司 | 用于药物的跨黏膜给药的药物组合物 |
| JP2009527504A (ja) | 2006-02-23 | 2009-07-30 | イオメディックス スリープ インターナショナル エスアールエル | 良質な睡眠の誘導および維持のための組成物および方法 |
| IL175338A0 (en) * | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| US20080171085A1 (en) | 2007-01-11 | 2008-07-17 | Natrol, Inc. | Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| CA2685591A1 (en) | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| KR100905027B1 (ko) | 2007-10-03 | 2009-06-30 | (주)씨엘팜 | 식용 필름 |
| EP2265259A1 (en) * | 2008-04-25 | 2010-12-29 | Cadila Healthcare Limited | Rapidly disintegrating oral compositions of tramadol |
| US20120213855A1 (en) | 2011-02-17 | 2012-08-23 | Cima Labs Inc. | Dosage forms for weakly ionizable compounds |
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| SG11201912172YA (en) * | 2017-06-20 | 2020-01-30 | Physicians Seal Llc | Orally dissolving melatonin formulation with acidifying agent that renders melatonin soluble in saliva |
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2018
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- 2018-06-15 MX MX2019015733A patent/MX2019015733A/es unknown
- 2018-06-15 BR BR122021012549A patent/BR122021012549B8/pt active IP Right Grant
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- 2018-06-15 CA CA3067822A patent/CA3067822C/en active Active
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| JP2014237700A (ja) | 2007-04-11 | 2014-12-18 | ファーマシューティカル プロダクションズ， インコーポレイテッド | メラトニンタブレットならびに調剤及び使用方法 |
| US20120195968A1 (en) | 2011-01-28 | 2012-08-02 | Shah Syed M | Controlled-release melatonin compositions and related methods |
| US20130052234A1 (en) | 2011-08-25 | 2013-02-28 | Purebrands LLC | Edible strips |
| US20140303227A1 (en) | 2013-03-14 | 2014-10-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| WO2016141069A1 (en) | 2015-03-02 | 2016-09-09 | Medlab Clinical U.S., Inc. | Transmucosal and transdermal delivery systems |
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| US10500280B2 (en) | 2019-12-10 |
| EP3641759B1 (en) | 2024-04-03 |
| CN110913853A (zh) | 2020-03-24 |
| KR20200018652A (ko) | 2020-02-19 |
| ES2979335T3 (es) | 2024-09-25 |
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| BR112019027286B1 (pt) | 2022-02-22 |
| US11224657B2 (en) | 2022-01-18 |
| BR122021012549B8 (pt) | 2022-10-25 |
| US20180360967A1 (en) | 2018-12-20 |
| WO2018236678A1 (en) | 2018-12-27 |
| CA3067822C (en) | 2022-08-30 |
| SG11201912172YA (en) | 2020-01-30 |
| RU2020101742A (ru) | 2021-07-20 |
| EP3641759A1 (en) | 2020-04-29 |
| JP2020524162A (ja) | 2020-08-13 |
| CA3067822A1 (en) | 2018-12-27 |
| US20200268886A1 (en) | 2020-08-27 |
| BR112019027286A2 (pt) | 2020-07-21 |
| EP3641759A4 (en) | 2021-03-24 |
| BR122021012549B1 (pt) | 2022-02-22 |
| US10960075B2 (en) | 2021-03-30 |
| AU2018289284A1 (en) | 2020-01-16 |
| MX2019015733A (es) | 2020-02-20 |
| US20200069803A1 (en) | 2020-03-05 |
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