JP7261591B2 - Hair composition and hair treatment method - Google Patents

Description

The present invention relates to a composition for hair and a method of treating hair using this composition.

Peptides obtained by hydrolyzing proteins are incorporated into compositions intended for use in hair, in anticipation of hair repairing and conditioning effects. Research and development aimed at improving the effects of such peptides and adding functions are being carried out, and cationized, acylated or silylated peptide derivatives are known.

Further, Patent Document 1 discloses a modified peptide obtained by introducing a carboxymethyl disulfide group into a peptide using thioglycolate as a peptide derivative expected to have a repairing effect in hair. Furthermore, in Patent Document 2, a hair treatment agent with a pH of 3.5 or more and 5.5 or less, which contains the modified peptide of Patent Document 1 or a predetermined modified peptide other than the modified peptide, also contains an anionic surfactant. It is disclosed that the penetration of the modified peptide into the hair is improved by doing so.

JP 2011-144127 A JP 2017-57149 A

By the way, the above-mentioned Patent Document 2 merely discloses a technique relating to a modified peptide in a composition having a pH of 3.5 or more and 5.5 or less, and does not disclose other effective hair repairing methods using the modified peptide.

In view of the above circumstances, an object of the present invention is to provide a hair composition that enables effective hair repair with a given modified peptide, and a hair treatment method using the composition.

As a result of intensive studies by the present inventors, it was found that if the pH of a composition containing a predetermined modified peptide is set to less than 3.5, hair repair with excellent hair density improvement is possible, and the present invention has been developed. Completed.

That is, the composition for hair according to the present invention has a pH of less than 3.5 and a side chain having a unit selected from structures represented by the following formulas (I) to (III) and salts of these structures Modified peptides having one or more groups are blended.
—S—S—(CH ₂ )n—COOH (I)
(In formula (I), n is 1 or 2.)
—S—S—CH(CH ₃ )—COOH (II)
—S—S—CH(COOH)—CH ₂ —COOH (III)

The pH of the hair composition according to the present invention is preferably less than 3.0. If the pH is less than 3.0, the denatured peptide is excellent in dispersibility in water, and an improvement in penetration into the hair is expected.

In the composition for hair according to the present invention, it is preferable that the anionic surfactant is blended in an amount of 1% by mass or less or not blended. If it is 1% by mass or less or if it is not blended, it is expected that the fixation of the denatured peptide into the hair will be improved.

The composition for hair according to the present invention preferably contains an acid dye. Since the pH of the hair composition of the present invention is less than 3.5, the acid dye has excellent hair dyeing properties.

In the hair treatment method according to the present invention, after applying the hair composition according to the present invention to the hair, water or a composition having a pH of 3.5 or higher is brought into contact with the hair. The modified peptide in the composition for hair according to the present invention has excellent dispersibility in water at a pH of less than 3.5, so that it penetrates into the hair at a high level. Aggregation is thought to improve fixation of the denatured peptide and increase hair density.

According to the composition for hair according to the present invention, since the pH is set to less than 3.5, the hair density is excellently improved by the predetermined modified peptide.

Moreover, according to the hair treatment method of the present invention, the pH of the hair composition containing the predetermined modified peptide is set to be less than 3.5, so that the hair density is excellently improved.

4 is a graph showing calculated values of hair density ratios in Examples and Comparative Examples.

The present invention will be described below based on the embodiments of the present invention.
(Composition for hair)
The composition for hair according to the present embodiment has a predetermined pH and contains water and a predetermined modified peptide (the amount of water is, for example, 70% by mass or more). In addition, the composition for hair according to the present embodiment is optionally blended with known ingredients for the composition for hair according to the purpose of use.

pH
The pH of the hair composition of the present embodiment is less than 3.5, preferably less than 3.0, preferably less than 2.8, more preferably less than 2.6, and less than 2.5 at 25°C. More preferred. If it is less than 3.5, it is excellent in hair density improvement by the predetermined modified peptide to be blended. This increase in density is considered to be due to the fact that when the pH is less than 3.5, the dispersibility of a given modified peptide in water increases, and the modified peptide easily penetrates into the hair. The lower limit of the pH of the hair composition of the present embodiment is not particularly limited, but is, for example, 2.0.

Modified Peptide The hair composition of the present embodiment contains a predetermined modified peptide. The modified peptide comprises a backbone formed by peptide bonds of two or more amino acids and side groups attached to the backbone.

The main chain of the modified peptide of this embodiment is not particularly limited. An example of this main chain is the same as the main chain of peptides in which cysteine is one of the constituent amino acids. Examples of peptides containing cysteine as one of the constituent amino acids include keratin and casein. Keratin is known to have a high cysteine ratio among peptides derived from natural products, and is a raw material from which the modified peptide can be efficiently obtained. From this point of view, the main chain of the modified peptide is preferably the same as that of keratin.

The modified peptide has a side chain group having a structure represented by the following formula (I), a side chain group having a salt having a structure represented by the following formula (I), and a structure represented by the following formula (II). a side chain group having a salt of the structure represented by the following formula (II), a side chain group having a structure represented by the following formula (III), a structure represented by the following formula (III) One or two or more side chain groups selected from salt-containing side chain groups are provided.
—S—S—(CH ₂ )n—COOH (I)
(In formula (I), n is 1 or 2.)
—S—S—CH(CH ₃ )—COOH (II)
—S—S—CH(COOH)—CH ₂ —COOH (III)

The salt having the structure represented by formula (I), the salt having the structure represented by formula (II), and the salt having the structure represented by formula (III) are each an ionic combination of a carboxylate anion and a cation. is. Examples of units that become cations include ammonium such as _NH4 ; metal atoms such as Na and K;

The penetrability of the modified peptide into the inside of the hair is higher when the molecular weight is smaller, and lower when the molecular weight is higher. From this point of view, the molecular weight of the modified peptide is preferably 70,000 or less, preferably 50,000 or less, and more preferably 30,000 or less. Although the lower limit of the molecular weight is not particularly limited, it is 10,000, for example. Here, the molecular weight of the denatured peptide is calculated from the relative distance between the denatured peptide band and the molecular weight marker band by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE method). considered and adopted.

The lower limit of the content of the modified peptide in the composition for hair of the present embodiment is not particularly limited, but from the viewpoint of improving hair density by the modified peptide, it is preferably 0.001% by mass, preferably 0.005% by mass. , more preferably 0.01% by mass, and even more preferably 0.1% by mass. On the other hand, the upper limit of the modified peptide content is preferably 5% by mass, preferably 3% by mass, more preferably 2% by mass, and still more preferably 0.5% by mass, from the viewpoint of suppressing cost increases due to blending in a large amount.

The modified peptide of the present embodiment can be produced by a known production method such as that disclosed in Japanese Patent No. 5798741, for example.

Optional Ingredients As described above, the hair composition of the present embodiment is arbitrarily blended with known hair composition ingredients depending on the purpose of use. The optional raw materials include anionic surfactants, cationic surfactants, amphoteric surfactants, alcohols, polyhydric alcohols, sugars, ester oils, fats and oils, fatty acids, hydrocarbons, waxes, silicones, polymer compounds, amino acids, animal and plant extracts. substances, substances derived from microorganisms, inorganic compounds, dyes, fragrances, preservatives, sequestering agents, ultraviolet absorbers, and the like.

When blending an anionic surfactant in the composition for hair of the present embodiment, carboxylic acid-based anionic surfactants, sulfonic acid-based anionic surfactants, sulfate-based anionic surfactants, phosphoric acid-based anionic surfactants, etc. One or two or more selected from known anionic surfactants are blended. The content of the anionic surfactant in the hair composition of the present embodiment is preferably 1% by mass or less, preferably 0.5% by mass or less, more preferably 0.1% by mass or less, and 0.05% by mass or less. is more preferred. Since the modified peptide of the present embodiment easily aggregates at pH 3.5 or higher, if water or a composition having a pH of 3.5 or higher is brought into contact with the hair after application of the hair composition of the present embodiment, However, since the anionic surfactant may inhibit the aggregation, the content of the anionic surfactant in the hair composition of the present embodiment should be 1% by mass or less. Good.

Since the hair dyeing property with an acid dye is good at a pH of less than 3.5, it is preferable to mix an acid dye with the hair composition of the present embodiment and use it as a hair dye. The acid dyes include, for example, Red No. 2 (Amaranth), Red No. 3 (Erythrosine), Red No. 102 (New Coccine), Red No. 104 (1) (Phloxine B), Red No. 105 (1) ( Rose Bengal), Red No. 106 (Acid Red), Red No. 201 (Lithol Rubine B), Red No. 227 (Fast Acid Magenta), Red No. 230 (1) (Eosine YS), Red No. 230 (2) ( Eosine YSK), Red No. 231 (Phloxine BK), Red No. 232 (Rose Bengal K), Red No. 401 (Violamine R), Red No. 502 (Ponceau 3R), Red No. 503 (Ponceau R), Red No. 504 (Ponceau) SX), Red No. 506 (Fast Red S), Yellow No. 4 (Tartrazine), Yellow No. 5 (Sunset Yellow FCF), Yellow No. 202 (1) (Uranine), Yellow No. 202 (2) (Uranine K) , Yellow No. 203 (Quinoline Yellow WS), Yellow No. 402 (Polar Yellow 5G), Yellow No. 403 (1) (Naphthol Yellow S), Yellow No. 406 (Metanil Yellow), Yellow No. 407 (Fast Light Yellow 3G), Orange No. 205 (Orange II), Orange No. 207 (Erythrosine Yellowish NA), Orange No. 402 (Orange I), Green No. 3 (Fast Green FCF), Green No. 204 (Pyranine Conc), Green No. 205 (Light Green SF Yellowish) ), Green No. 401 (Naphthol Green B), Green No. 402 (Guinea Green B), Purple No. 401 (Alizurol Purple), Blue No. 1 (Brilliant Blue FCF), Blue No. 2 (Indigo Carmine), Blue No. 202 (Patent Blue NA), Blue No. 203 (Patent Blue CA), Blue No. 205 (Alphazurine FG), Brown No. 201 (Rezorich Brown), and Black No. 401 (Naphthol Blue Black). The content of the acid dye in the hair composition of the present embodiment is not particularly limited, but is, for example, 0.01 to 5% by mass.

Dosage form The dosage form of the composition for hair is not particularly limited, and examples thereof include liquid, milky lotion, lotion, cream, wax, gel, solid, foam (foam), and mist. is mentioned.

(Hair treatment method)
In the hair treatment method of the present embodiment, after the hair composition of the present embodiment is applied to the hair, water or a composition having a pH of 3.5 or more (the amount of water in the composition) is applied to the hair after application. is, for example, 60% by mass or more). It is believed that the increase in pH due to this contact promotes aggregation of the denatured peptide and, as a result, enhances fixation of the denatured peptide on the hair.

Examples of contact with water or a composition with a pH of 3.5 or higher include continuous application of water or a composition with a pH of 3.5 or higher by spraying, and removal of the hair composition of the present embodiment by washing with water.

EXAMPLES The present invention will be described in detail below based on examples, but the present invention is not limitedly interpreted based on the description of these examples.

After the hair compositions of Examples and Comparative Examples were produced and hair was treated with these hair compositions, the hair density was measured. Details are as follows.

(Composition for hair)
Liquid hair compositions of Example 1 and Comparative Examples 1a to 1d having the components and their blending amounts as shown in Table 1 below were produced (the "remainder" in Table 1 means the total amount of 100% by mass). quantity.).

Modified peptide (I) in Table 1 was obtained as a transparent modified peptide (I) solution in which modified peptides having a side chain group (n=1) represented by the above formula (I) were dispersed. A modified peptide (I) solution was produced according to the following reduction step, oxidant mixing step, solid-liquid separation step, recovery step, and hydrolysis step.

Reduction process:
Merino wool washed with a neutral detergent and dried was cut into pieces of about 5 mm. 5.0 parts by mass of this wool, 15.4 parts by mass of a 30% by mass sodium thioglycolate aqueous solution and 8.5 parts by mass of a 6 mol/L sodium hydroxide aqueous solution were mixed, and further mixed with water to give a total amount of 150 parts by mass and a pH of 11. was prepared. This liquid to be treated was stirred at 45° C. for 1 hour. Next, water was further mixed to make the total amount 200 parts by mass, left at 45° C. for 2 hours, and then naturally cooled until the liquid temperature reached normal temperature.

Oxidant mixing process:
While stirring the liquid to be treated after the reduction step, 178 parts by mass of an aqueous solution containing 15.26 parts by mass of 35% by mass hydrogen peroxide solution was mixed with the liquid over about 30 minutes with stirring (peroxidation The pH of the liquid to be treated rises with the mixing of hydrogen water, and the rise was adjusted to a range of pH 10 or more and 11 or less by mixing about 20 mass % acetic acid aqueous solution.). After that, about 20% by mass of acetic acid aqueous solution was gradually mixed, and the pH of the liquid to be treated was gradually adjusted from 11 to 7.

Solid-liquid separation step and recovery step:
The liquid obtained in the oxidizing agent mixing step was filtered to remove insoluble matter from the liquid. After that, 160 parts by mass of an aqueous solution containing 97.2 parts by mass of a 36% by mass hydrochloric acid aqueous solution was added to the collected liquid portion (filtrate) to adjust the pH of the liquid from 7 to 3.8, thereby obtaining a modified peptide (I ) resulted in precipitation. This precipitate was collected and washed with water to obtain a solid denatured peptide (I).

Hydrolysis step:
An aqueous solution containing the solid modified peptide (I) obtained in the recovery step and adjusted to pH 10.5 with 2-amino-2-methyl-1-propanol was heated at 80° C. for 2 hours. The heated aqueous solution was filtered to obtain a filtrate as a modified peptide (I) solution. Denatured peptide (I) in the denatured peptide (I) solution was found to have a denatured peptide (I) band with a molecular weight of 44,000 in the SDS-PAGE method.

(hair treatment)
Hair was collected from three Japanese women in their 50s (Female A, Female B, and Female C), washed with Milbon's shampoo "Deese's Neu Willow Luxe Shampoo", and then dried. Nine hairs of each woman after drying (three hairs of woman A, three hairs of woman B, and three hairs of woman C) were soaked in each of the hair compositions of Examples and Comparative Examples for 30 minutes. After the soaked hair was rinsed with purified water, it was naturally dried under the conditions of 25° C. and 50% humidity. After cutting these hairs into pieces of about 0.5 mm, the hair density was measured as described below.

(Measurement of hair density)
The hair density was measured on 30 pieces of hair after each hair treatment (hair of female A: 10 pieces, hair of female B: 10 pieces, hair of female C: 10 pieces). As the measurement method, a method using a density gradient liquid was used as in the example of JP-A-2016-61664.

Table 1 below shows the components and blending amounts of the hair compositions of Examples and Comparative Examples, the measurement results of hair density, and the hair density ratio (the ratio when the hair of Comparative Example 1a is taken as 100). Further, FIG. 1 shows a graph showing calculated values of the hair density ratio.

In Table 1, the following (1) to (3) can be confirmed.
(1) By comparing Example 1 and Comparative Example 1b, it was found that Example 1, in which the pH was less than 3, was superior to Comparative Example 1b, in which the pH was 3 or more, in terms of hair density ratio. In both the hair compositions of Example 1 and Comparative Example 1b, modified peptide (I) was dispersed and there was no aggregation of modified peptide (I).).
(2) By comparing Example 1 with Comparative Example 1c, which has a lower hair density ratio, the lactic acid used to make the pH less than 3.0 did not cause a difference in the hair density ratio.
(3) By comparing Example 1 containing modified peptide (I) and Comparative Example 1d containing wool-derived hydrolyzed keratin, Example 1 has a higher hair density ratio, and therefore, it is unique to modified peptide (I). (In addition, aggregation of wool-derived hydrolyzed keratin was observed in the hair composition of Comparative Example 1d.).

Claims (5)

A modified peptide having a pH of less than 3.0 and having one or more side chain groups having units selected from the structures represented by the following formulas (I) to (III) and salts of these structures is blended. A hair composition that is applied to the treated hair .
—S—S—(CH ₂ )n—COOH (I)
(In formula (I), n is 1 or 2.)
—S—S—CH(CH ₃ )—COOH (II)
—S—S—CH(COOH)—CH ₂ —COOH (III) 2. The composition for hair according to claim 1, wherein the anionic surfactant is blended in an amount of 1% by mass or less. 2. The composition for hair according to claim 1, which contains no anionic surfactant. The composition for hair according to any one of claims 1 to 3 , which contains an acid dye. A hair treatment method comprising applying the composition for hair according to any one of claims 1 to 4 to the hair, and then contacting the hair with water or a composition having a pH of 3.5 or higher.

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