JP7250808B2 - 抗がん剤としての環状ジヌクレオチド - Google Patents

抗がん剤としての環状ジヌクレオチド Download PDF

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JP7250808B2
JP7250808B2 JP2020546409A JP2020546409A JP7250808B2 JP 7250808 B2 JP7250808 B2 JP 7250808B2 JP 2020546409 A JP2020546409 A JP 2020546409A JP 2020546409 A JP2020546409 A JP 2020546409A JP 7250808 B2 JP7250808 B2 JP 7250808B2
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cancer
coor
pharmaceutically acceptable
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tautomer
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JP2021515016A (ja
JP2021515016A5 (enExample
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ブライアン・イー・フィンク
ジェミン・ルアン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020546409A 2018-03-08 2019-03-07 抗がん剤としての環状ジヌクレオチド Active JP7250808B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862640325P 2018-03-08 2018-03-08
US62/640,325 2018-03-08
PCT/US2019/021145 WO2019173587A1 (en) 2018-03-08 2019-03-07 Cyclic dinucleotides as anticancer agents

Publications (3)

Publication Number Publication Date
JP2021515016A JP2021515016A (ja) 2021-06-17
JP2021515016A5 JP2021515016A5 (enExample) 2022-02-17
JP7250808B2 true JP7250808B2 (ja) 2023-04-03

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JP2020546409A Active JP7250808B2 (ja) 2018-03-08 2019-03-07 抗がん剤としての環状ジヌクレオチド

Country Status (7)

Country Link
US (1) US11945834B2 (enExample)
EP (1) EP3762397B1 (enExample)
JP (1) JP7250808B2 (enExample)
KR (2) KR20250125433A (enExample)
CN (1) CN111801341B (enExample)
ES (1) ES2980374T3 (enExample)
WO (1) WO2019173587A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660311B2 (en) 2017-10-10 2023-05-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法

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WO2017123669A1 (en) 2016-01-11 2017-07-20 Gary Glick Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
WO2017161349A1 (en) 2016-03-18 2017-09-21 Immune Sensor, Llc Cyclic di-nucleotide compounds and methods of use
JP2020532529A (ja) 2017-08-31 2020-11-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗癌剤としての環状ジヌクレオチド
JP2020532539A (ja) 2017-08-31 2020-11-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗癌剤としての環状ジヌクレオチド
JP2020532585A (ja) 2017-08-30 2020-11-12 ベイジン シュエンイー ファーマサイエンシズ カンパニー， リミテッド インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド
JP2020536897A (ja) 2017-10-10 2020-12-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗がん剤としての環状ジヌクレオチド

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017027646A1 (en) 2015-08-13 2017-02-16 Merck Sharp & Dohme Corp. Cyclic di-nucleotide compounds as sting agonists
WO2017123669A1 (en) 2016-01-11 2017-07-20 Gary Glick Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
WO2017161349A1 (en) 2016-03-18 2017-09-21 Immune Sensor, Llc Cyclic di-nucleotide compounds and methods of use
JP2020532585A (ja) 2017-08-30 2020-11-12 ベイジン シュエンイー ファーマサイエンシズ カンパニー， リミテッド インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド
JP2020532529A (ja) 2017-08-31 2020-11-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗癌剤としての環状ジヌクレオチド
JP2020532539A (ja) 2017-08-31 2020-11-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗癌剤としての環状ジヌクレオチド
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Also Published As

Publication number Publication date
ES2980374T3 (es) 2024-10-01
JP2021515016A (ja) 2021-06-17
EP3762397B1 (en) 2024-05-01
KR20250125433A (ko) 2025-08-21
WO2019173587A1 (en) 2019-09-12
KR20200130362A (ko) 2020-11-18
US11945834B2 (en) 2024-04-02
US20210002323A1 (en) 2021-01-07
EP3762397A1 (en) 2021-01-13
CN111801341B (zh) 2023-10-24
CN111801341A (zh) 2020-10-20

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