JP7246320B2 - ヒト抗セマフォリン4d抗体 - Google Patents

ヒト抗セマフォリン4d抗体 Download PDF

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JP7246320B2
JP7246320B2 JP2019560083A JP2019560083A JP7246320B2 JP 7246320 B2 JP7246320 B2 JP 7246320B2 JP 2019560083 A JP2019560083 A JP 2019560083A JP 2019560083 A JP2019560083 A JP 2019560083A JP 7246320 B2 JP7246320 B2 JP 7246320B2
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antibody
sema4d
antigen
fragment
binding
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JP2020518248A (ja
JP2020518248A5 (enExample
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アーネスト エス. スミス
アンジェリカ コーネリソン
マリア ジー.エム. スクライヴンス
マーク パリス
モーリス ザウデラー
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バクシネックス インコーポレーティッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019560083A 2017-05-05 2018-05-04 ヒト抗セマフォリン4d抗体 Active JP7246320B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023039438A JP7460819B2 (ja) 2017-05-05 2023-03-14 ヒト抗セマフォリン4d抗体
JP2024044422A JP2024081694A (ja) 2017-05-05 2024-03-21 ヒト抗セマフォリン4d抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762501981P 2017-05-05 2017-05-05
US62/501,981 2017-05-05
PCT/US2018/031263 WO2018204895A1 (en) 2017-05-05 2018-05-04 Human anti-semaphorin 4d antibody

Related Child Applications (1)

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JP2023039438A Division JP7460819B2 (ja) 2017-05-05 2023-03-14 ヒト抗セマフォリン4d抗体

Publications (3)

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JP2020518248A JP2020518248A (ja) 2020-06-25
JP2020518248A5 JP2020518248A5 (enExample) 2021-05-13
JP7246320B2 true JP7246320B2 (ja) 2023-03-27

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JP2019560083A Active JP7246320B2 (ja) 2017-05-05 2018-05-04 ヒト抗セマフォリン4d抗体
JP2023039438A Active JP7460819B2 (ja) 2017-05-05 2023-03-14 ヒト抗セマフォリン4d抗体
JP2024044422A Pending JP2024081694A (ja) 2017-05-05 2024-03-21 ヒト抗セマフォリン4d抗体

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JP2023039438A Active JP7460819B2 (ja) 2017-05-05 2023-03-14 ヒト抗セマフォリン4d抗体
JP2024044422A Pending JP2024081694A (ja) 2017-05-05 2024-03-21 ヒト抗セマフォリン4d抗体

Country Status (14)

Country Link
US (3) US11427634B2 (enExample)
EP (1) EP3618865A4 (enExample)
JP (3) JP7246320B2 (enExample)
KR (1) KR102680924B1 (enExample)
CN (1) CN110636858B (enExample)
AU (2) AU2018261947B2 (enExample)
BR (1) BR112019023138A2 (enExample)
CA (1) CA3061963A1 (enExample)
IL (1) IL270244B2 (enExample)
MX (2) MX2019013110A (enExample)
NZ (1) NZ758300A (enExample)
SG (1) SG11201909466RA (enExample)
WO (1) WO2018204895A1 (enExample)
ZA (1) ZA201907148B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2024081694A (ja) * 2017-05-05 2024-06-18 バクシネックス インコーポレーティッド ヒト抗セマフォリン4d抗体

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US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
BR112018071686A2 (pt) 2016-04-22 2019-02-19 Vaccinex, Inc. exibição de proteínas integrais de membrana em vírions extracelulares envelopados de poxvírus
WO2018026715A1 (en) 2016-08-02 2018-02-08 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
US20210032322A1 (en) 2019-08-01 2021-02-04 Vaccinex, Inc. Combined inhibition of semaphorin-4d and tgf-beta and compositions therefor
CN117597360A (zh) * 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
CA3231551A1 (en) 2021-09-27 2023-03-30 Maurice Zauderer Predictive outcome profiling for use of an anti-semaphorin-4d binding molecule to treat neurodegenerative disorders
US20230331863A1 (en) 2022-02-13 2023-10-19 Vaccinex, Inc. Combination therapy with semaphorin-4d blockade and htt-lowering agent for treatment of huntington's disease
KR102875105B1 (ko) * 2023-04-03 2025-10-21 주식회사 사이알바이오 재조합 세마포린 4d 차단항체를 유효성분으로 포함하는 쇼그렌 증후군 예방 또는 치료용 약학 조성물
CN117924494B (zh) * 2024-01-23 2025-02-25 首都医科大学附属北京积水潭医院 特异性结合sema4d的抗原结合蛋白及其应用

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Cited By (1)

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JP2024081694A (ja) * 2017-05-05 2024-06-18 バクシネックス インコーポレーティッド ヒト抗セマフォリン4d抗体

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SG11201909466RA (en) 2019-11-28
US11427634B2 (en) 2022-08-30
IL270244A (en) 2019-12-31
ZA201907148B (en) 2025-06-25
EP3618865A1 (en) 2020-03-11
JP2020518248A (ja) 2020-06-25
MX2023003519A (es) 2023-04-19
JP7460819B2 (ja) 2024-04-02
CA3061963A1 (en) 2018-11-08
US20240309091A1 (en) 2024-09-19
CN110636858A (zh) 2019-12-31
JP2024081694A (ja) 2024-06-18
KR102680924B1 (ko) 2024-07-02
MX2019013110A (es) 2019-12-16
JP2023075271A (ja) 2023-05-30
WO2018204895A1 (en) 2018-11-08
RU2019131732A3 (enExample) 2021-09-28
RU2019131732A (ru) 2021-06-07
BR112019023138A2 (pt) 2020-07-28
AU2018261947B2 (en) 2024-06-13
US20220356249A1 (en) 2022-11-10
KR20200004324A (ko) 2020-01-13
AU2018261947A1 (en) 2019-11-07
AU2024204752A1 (en) 2024-08-01
US20210032329A1 (en) 2021-02-04
EP3618865A4 (en) 2021-05-05
CN110636858B (zh) 2024-03-19
NZ758300A (en) 2025-11-28
IL270244B1 (en) 2024-09-01
US12006365B2 (en) 2024-06-11
IL270244B2 (en) 2025-01-01

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