JP7229656B2 - カテーテルおよび医療装置 - Google Patents
カテーテルおよび医療装置 Download PDFInfo
- Publication number
- JP7229656B2 JP7229656B2 JP2017113535A JP2017113535A JP7229656B2 JP 7229656 B2 JP7229656 B2 JP 7229656B2 JP 2017113535 A JP2017113535 A JP 2017113535A JP 2017113535 A JP2017113535 A JP 2017113535A JP 7229656 B2 JP7229656 B2 JP 7229656B2
- Authority
- JP
- Japan
- Prior art keywords
- voltage
- output
- conductive element
- catheter
- ecg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6853—Catheters with a balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
- A61B5/062—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
- A61B5/287—Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6858—Catheters with a distal basket, e.g. expandable basket
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6869—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient; User input means
- A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
- A61B5/7445—Display arrangements, e.g. multiple display units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Human Computer Interaction (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/177,775 | 2016-06-09 | ||
| US15/177,775 US20170354338A1 (en) | 2016-06-09 | 2016-06-09 | Dual-function sensors for a basket catheter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017217484A JP2017217484A (ja) | 2017-12-14 |
| JP7229656B2 true JP7229656B2 (ja) | 2023-02-28 |
Family
ID=59055007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017113535A Active JP7229656B2 (ja) | 2016-06-09 | 2017-06-08 | カテーテルおよび医療装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20170354338A1 (de) |
| EP (3) | EP3254613A3 (de) |
| JP (1) | JP7229656B2 (de) |
| CN (1) | CN107485388B (de) |
| AU (1) | AU2017203843A1 (de) |
| CA (1) | CA2970090A1 (de) |
| IL (1) | IL252383B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10905329B2 (en) | 2016-06-09 | 2021-02-02 | Biosense Webster (Israel) Ltd. | Multi-function conducting elements for a catheter |
| US12029545B2 (en) | 2017-05-30 | 2024-07-09 | Biosense Webster (Israel) Ltd. | Catheter splines as location sensors |
| US11000220B2 (en) | 2018-03-13 | 2021-05-11 | Biosense Webster (Israel) Ltd. | SNR of intracardiac signals |
| US20190314083A1 (en) | 2018-04-11 | 2019-10-17 | Biosense Webster (Israel) Ltd. | Flexible Multi-Arm Catheter with Diametrically Opposed Sensing Electrodes |
| US10799147B2 (en) * | 2018-06-26 | 2020-10-13 | Biosense Webster (Israel) Ltd. | Magnetic pickup cancellation by compensation leads |
| US11246505B2 (en) | 2018-11-01 | 2022-02-15 | Biosense Webster (Israel) Ltd. | Using radiofrequency (RF) transmission system to find opening in tissue wall |
| US11045628B2 (en) | 2018-12-11 | 2021-06-29 | Biosense Webster (Israel) Ltd. | Balloon catheter with high articulation |
| CN111345909B (zh) * | 2018-12-20 | 2021-11-02 | 四川锦江电子科技有限公司 | 一种用于确定磁电映射关系的方法和装置 |
| US11207016B2 (en) | 2018-12-28 | 2021-12-28 | Biosense Webster (Israel) Ltd. | Mapping ECG signals using a multipole electrode assembly |
| US11850051B2 (en) | 2019-04-30 | 2023-12-26 | Biosense Webster (Israel) Ltd. | Mapping grid with high density electrode array |
| US11712172B2 (en) | 2019-07-18 | 2023-08-01 | Biosense Webster (Israel) Ltd. | Visual guidance for positioning a distal end of a medical probe |
| US11759150B2 (en) | 2019-08-27 | 2023-09-19 | Biosense Webster (Israel) Ltd. | Accurate basket catheter tracking |
| US11950930B2 (en) | 2019-12-12 | 2024-04-09 | Biosense Webster (Israel) Ltd. | Multi-dimensional acquisition of bipolar signals from a catheter |
| US11517218B2 (en) | 2019-12-20 | 2022-12-06 | Biosense Webster (Israel) Ltd. | Selective graphical presentation of electrophysiological parameters |
| US20210369132A1 (en) | 2020-05-29 | 2021-12-02 | Biosense Webster (Israel) Ltd. | Intraluminal reference electrode for cardiovascular treatment apparatus |
| US11987017B2 (en) | 2020-06-08 | 2024-05-21 | Biosense Webster (Israel) Ltd. | Features to assist in assembly and testing of devices |
| US12048479B2 (en) | 2020-09-10 | 2024-07-30 | Biosense Webster (Israel) Ltd. | Surface mounted electrode catheter |
| US11950840B2 (en) | 2020-09-22 | 2024-04-09 | Biosense Webster (Israel) Ltd. | Basket catheter having insulated ablation electrodes |
| US11950841B2 (en) | 2020-09-22 | 2024-04-09 | Biosense Webster (Israel) Ltd. | Basket catheter having insulated ablation electrodes and diagnostic electrodes |
| US12082875B2 (en) | 2020-09-24 | 2024-09-10 | Biosense Webster (Israel) Ltd | Balloon catheter having a coil for sensing tissue temperature and position of the balloon |
| US11974803B2 (en) | 2020-10-12 | 2024-05-07 | Biosense Webster (Israel) Ltd. | Basket catheter with balloon |
| US12201786B2 (en) | 2020-12-17 | 2025-01-21 | Biosense Webster (Israel) Ltd. | Measurement of distal end dimension of catheters using magnetic fields |
| US11918383B2 (en) | 2020-12-21 | 2024-03-05 | Biosense Webster (Israel) Ltd. | Visualizing performance of catheter electrodes |
| US12064170B2 (en) | 2021-05-13 | 2024-08-20 | Biosense Webster (Israel) Ltd. | Distal assembly for catheter with lumens running along spines |
| US12364426B2 (en) | 2021-08-12 | 2025-07-22 | Biosense Webster (Israel) Ltd. | Electro-anatomical mapping and annotation presented in electrophysiological procedures |
| US12004804B2 (en) | 2021-09-09 | 2024-06-11 | Biosense Webster (Israel) Ltd. | Basket catheter with mushroom shape distal tip |
| US12478424B2 (en) | 2021-09-10 | 2025-11-25 | Biosense Webster (Israel) Ltd. | Staggered pairs of biased ablation electrodes on basket catheter |
| US12011280B2 (en) | 2021-10-04 | 2024-06-18 | Biosense Webster (Israel) Ltd. | Electrophysiological mapping in the presence of injury current |
| US12533489B2 (en) | 2021-10-08 | 2026-01-27 | Biosense Webster (Israel) Ltd. | Measuring tissue proximity for multi-electrode catheter |
| US12419683B2 (en) | 2021-12-22 | 2025-09-23 | Biosense Webster (Israel) Ltd. | Irreversible electroporation with shorted electrodes |
| US12446946B2 (en) | 2022-01-20 | 2025-10-21 | Biosense Webster (Israel) Ltd. | Systems and methods for a single spiral electrode assembly forming a spherical basket for improved tissue contact and current delivery |
| US12484961B2 (en) | 2022-01-20 | 2025-12-02 | Biosense Webster (Israel) Ltd. | Mechanical retainer systems for electrodes of a basket catheter, and methods of the same |
| US12440263B2 (en) | 2022-01-20 | 2025-10-14 | Biosense Webster (Israel) Ltd. | Systems and methods for tripodic spines forming a spherical basket for improved tissue contact and current delivery |
| CN114668482A (zh) * | 2022-01-28 | 2022-06-28 | 心航路医学科技(广州)有限公司 | 双层网篮导管装置 |
| US12471989B2 (en) | 2022-04-28 | 2025-11-18 | Biosense Webster (Israel) Ltd. | Strengthened expandable baskets for medical probes and medical probes containing strengthen expandable baskets |
| US12533185B2 (en) | 2022-12-28 | 2026-01-27 | Biosense Webster (Israel) Ltd. | Basket end effector with distal position sensor |
| US12521035B2 (en) | 2022-12-29 | 2026-01-13 | Biosense Webster (Israel) Ltd. | Cylindrical cage systems and methods for distributed tissue contact for mapping and ablation |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005525162A (ja) | 2002-05-13 | 2005-08-25 | カソリックス ピーティーワイ リミテッド | 多重電極リード |
| JP2006511296A (ja) | 2002-12-18 | 2006-04-06 | ボストン サイエンティフィック リミテッド | 登録した画像を用いたカテーテル案内システム |
| JP2010522623A (ja) | 2007-03-26 | 2010-07-08 | ボストン サイエンティフィック リミテッド | 高解像度電気生理学カテーテル |
| JP2011500172A (ja) | 2007-10-12 | 2011-01-06 | コンメッド コーポレーション | 心拍出量測定装置および方法 |
| JP2011152430A (ja) | 2000-07-07 | 2011-08-11 | Biosense Webster Inc | 電極−目的物間の接触検出用の方法 |
| US20110264000A1 (en) | 2007-12-28 | 2011-10-27 | Saurav Paul | System and method for determining tissue type and mapping tissue morphology |
| JP2014506171A (ja) | 2010-12-30 | 2014-03-13 | セント・ジュード・メディカル・エイトリアル・フィブリレーション・ディヴィジョン・インコーポレーテッド | 不整脈の診断及びカテーテル治療のためのシステム及び方法 |
| US20150119670A1 (en) | 2013-10-30 | 2015-04-30 | The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System | Devices, systems, and methods for treating cardiac arrhythmias |
| JP2015134166A (ja) | 2014-01-17 | 2015-07-27 | バイオセンス・ウエブスター・(イスラエル)・リミテッドBiosense Webster (Israel), Ltd. | カテーテル編組ワイヤを使用する信号伝送 |
| JP2015139707A (ja) | 2014-01-29 | 2015-08-03 | バイオセンス・ウエブスター・(イスラエル)・リミテッドBiosense Webster (Israel), Ltd. | 心房細動アノテーションのための二重双極構成 |
| JP2015167864A (ja) | 2014-03-05 | 2015-09-28 | バイオセンス・ウエブスター・(イスラエル)・リミテッドBiosense Webster (Israel), Ltd. | 編組ワイヤを介した信号伝送を備えるマルチアーム・カテーテル |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411025A (en) * | 1992-06-30 | 1995-05-02 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array |
| US8728065B2 (en) * | 2009-07-02 | 2014-05-20 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Apparatus and methods for contactless electrophysiology studies |
| SI0901341T1 (en) | 1997-01-03 | 2005-04-30 | Biosense Webster, Inc. | Bend-responsive catheter |
| US6050267A (en) * | 1997-04-28 | 2000-04-18 | American Cardiac Ablation Co. Inc. | Catheter positioning system |
| US8239001B2 (en) | 2003-10-17 | 2012-08-07 | Medtronic Navigation, Inc. | Method and apparatus for surgical navigation |
| US6892091B1 (en) | 2000-02-18 | 2005-05-10 | Biosense, Inc. | Catheter, method and apparatus for generating an electrical map of a chamber of the heart |
| US20030093067A1 (en) | 2001-11-09 | 2003-05-15 | Scimed Life Systems, Inc. | Systems and methods for guiding catheters using registered images |
| US7684850B2 (en) * | 2005-01-07 | 2010-03-23 | Biosense Webster, Inc. | Reference catheter for impedance calibration |
| US8926511B2 (en) * | 2008-02-29 | 2015-01-06 | Biosense Webster, Inc. | Location system with virtual touch screen |
| US8494608B2 (en) * | 2008-04-18 | 2013-07-23 | Medtronic, Inc. | Method and apparatus for mapping a structure |
| EP2313143B1 (de) * | 2008-08-22 | 2014-09-24 | C.R. Bard, Inc. | Katheteranordnung mit ekg-sensor und magnetischen baugruppen |
| US8097926B2 (en) * | 2008-10-07 | 2012-01-17 | Mc10, Inc. | Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy |
| US20110118590A1 (en) * | 2009-11-18 | 2011-05-19 | Siemens Medical Solutions Usa, Inc. | System For Continuous Cardiac Imaging And Mapping |
| US8380289B2 (en) * | 2010-11-18 | 2013-02-19 | Robert D. Zellers | Medical device location systems, devices and methods |
| US9861293B2 (en) * | 2011-04-28 | 2018-01-09 | Myolex Inc. | Sensors, including disposable sensors, for measuring tissue |
| JP5911570B2 (ja) * | 2011-06-13 | 2016-04-27 | アンジオメトリックス コーポレーション | 解剖学的および機能的パラメータ分析のための多機能誘導ワイヤアセンブリおよびシステム |
| US20150057519A1 (en) * | 2012-03-15 | 2015-02-26 | Gema Medical Ltd. | Sensing system, device and methods for gastroparesis monitoring |
| US9883906B2 (en) * | 2012-04-22 | 2018-02-06 | Newuro, B.V. | Bladder tissue modification for overactive bladder disorders |
| EP2682157A1 (de) * | 2012-07-06 | 2014-01-08 | Peter Osypka Stiftung | Mapping Elektrode für den linken Vorhof des Herzens |
| US20140107453A1 (en) * | 2012-10-15 | 2014-04-17 | Boston Scientific Scimed Inc. | Real-time signal comparison to guide ablation catheter to the target location |
| JP6144360B2 (ja) * | 2012-12-27 | 2017-06-07 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 電気生理学的マッピング中に遠距離場活動を抑制するためのアーティファクト除去に用いるカテーテルシステム |
| US9179971B2 (en) * | 2013-02-11 | 2015-11-10 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Printed electrode catheter |
-
2016
- 2016-06-09 US US15/177,775 patent/US20170354338A1/en not_active Abandoned
-
2017
- 2017-05-18 IL IL252383A patent/IL252383B/en active IP Right Grant
- 2017-06-07 AU AU2017203843A patent/AU2017203843A1/en not_active Abandoned
- 2017-06-08 CA CA2970090A patent/CA2970090A1/en not_active Abandoned
- 2017-06-08 EP EP17174936.9A patent/EP3254613A3/de not_active Withdrawn
- 2017-06-08 JP JP2017113535A patent/JP7229656B2/ja active Active
- 2017-06-08 EP EP18192797.1A patent/EP3434180B1/de active Active
- 2017-06-08 EP EP20150359.6A patent/EP3689232B1/de active Active
- 2017-06-09 CN CN201710433124.2A patent/CN107485388B/zh active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011152430A (ja) | 2000-07-07 | 2011-08-11 | Biosense Webster Inc | 電極−目的物間の接触検出用の方法 |
| JP2005525162A (ja) | 2002-05-13 | 2005-08-25 | カソリックス ピーティーワイ リミテッド | 多重電極リード |
| JP2006511296A (ja) | 2002-12-18 | 2006-04-06 | ボストン サイエンティフィック リミテッド | 登録した画像を用いたカテーテル案内システム |
| JP2010522623A (ja) | 2007-03-26 | 2010-07-08 | ボストン サイエンティフィック リミテッド | 高解像度電気生理学カテーテル |
| JP2011500172A (ja) | 2007-10-12 | 2011-01-06 | コンメッド コーポレーション | 心拍出量測定装置および方法 |
| US20110264000A1 (en) | 2007-12-28 | 2011-10-27 | Saurav Paul | System and method for determining tissue type and mapping tissue morphology |
| JP2014506171A (ja) | 2010-12-30 | 2014-03-13 | セント・ジュード・メディカル・エイトリアル・フィブリレーション・ディヴィジョン・インコーポレーテッド | 不整脈の診断及びカテーテル治療のためのシステム及び方法 |
| US20150119670A1 (en) | 2013-10-30 | 2015-04-30 | The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System | Devices, systems, and methods for treating cardiac arrhythmias |
| JP2015134166A (ja) | 2014-01-17 | 2015-07-27 | バイオセンス・ウエブスター・(イスラエル)・リミテッドBiosense Webster (Israel), Ltd. | カテーテル編組ワイヤを使用する信号伝送 |
| JP2015139707A (ja) | 2014-01-29 | 2015-08-03 | バイオセンス・ウエブスター・(イスラエル)・リミテッドBiosense Webster (Israel), Ltd. | 心房細動アノテーションのための二重双極構成 |
| JP2015167864A (ja) | 2014-03-05 | 2015-09-28 | バイオセンス・ウエブスター・(イスラエル)・リミテッドBiosense Webster (Israel), Ltd. | 編組ワイヤを介した信号伝送を備えるマルチアーム・カテーテル |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017217484A (ja) | 2017-12-14 |
| EP3434180A1 (de) | 2019-01-30 |
| EP3689232C0 (de) | 2024-02-07 |
| EP3254613A2 (de) | 2017-12-13 |
| CN107485388A (zh) | 2017-12-19 |
| US20170354338A1 (en) | 2017-12-14 |
| AU2017203843A1 (en) | 2018-01-04 |
| EP3434180B1 (de) | 2020-01-08 |
| CA2970090A1 (en) | 2017-12-09 |
| EP3689232A1 (de) | 2020-08-05 |
| IL252383A0 (en) | 2017-07-31 |
| EP3254613A3 (de) | 2018-03-07 |
| IL252383B (en) | 2020-09-30 |
| CN107485388B (zh) | 2022-10-25 |
| EP3689232B1 (de) | 2024-02-07 |
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