JP7220664B2 - 液体医薬組成物 - Google Patents
液体医薬組成物 Download PDFInfo
- Publication number
- JP7220664B2 JP7220664B2 JP2019548458A JP2019548458A JP7220664B2 JP 7220664 B2 JP7220664 B2 JP 7220664B2 JP 2019548458 A JP2019548458 A JP 2019548458A JP 2019548458 A JP2019548458 A JP 2019548458A JP 7220664 B2 JP7220664 B2 JP 7220664B2
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- JP
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- Prior art keywords
- liquid pharmaceutical
- adalimumab
- pharmaceutical composition
- arginine
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
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- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17159458.3 | 2017-03-06 | ||
| EP17159458.3A EP3372241A1 (en) | 2017-03-06 | 2017-03-06 | Liquid pharmaceutical composition |
| PCT/EP2018/055509 WO2018162503A1 (en) | 2017-03-06 | 2018-03-06 | Liquid pharmaceutical composition |
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| JP2020511443A JP2020511443A (ja) | 2020-04-16 |
| JP2020511443A5 JP2020511443A5 (enExample) | 2021-04-08 |
| JP7220664B2 true JP7220664B2 (ja) | 2023-02-10 |
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| EP (2) | EP3372241A1 (enExample) |
| JP (1) | JP7220664B2 (enExample) |
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| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201703063D0 (en) * | 2017-02-24 | 2017-04-12 | Arecor Ltd | Stabilized antibody protein solutions |
| US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
| EP3372242A1 (en) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP3372241A1 (en) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| WO2020187760A1 (en) * | 2019-03-18 | 2020-09-24 | Alvotech Hf | Aqueous formulations of tnf-alpha antibodies in high concentrations |
| CN117120070B (zh) * | 2021-03-11 | 2024-11-15 | 89生物公司 | 包含突变型fgf-21肽peg化缀合物的液体制剂 |
| CA3211539A1 (en) | 2021-03-11 | 2022-09-15 | Boris Schwartsburd | Liquid formulations comprising mutant fgf-21 peptide pegylated conjugates |
| WO2023043232A1 (ko) * | 2021-09-16 | 2023-03-23 | 주식회사 에이프로젠 | 항-TNFα 항체를 포함하는 약제학적 조성물 |
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| JP2010505852A (ja) | 2006-10-06 | 2010-02-25 | アムジエン・インコーポレーテツド | 安定な抗体製剤 |
| JP2010529999A (ja) | 2007-06-14 | 2010-09-02 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗体製剤 |
| JP2014524748A (ja) | 2011-07-19 | 2014-09-25 | グラクソ グループ リミテッド | ＦｃＲｎ結合の増加したＴＮＦ−α抗原結合タンパク質 |
| JP2015509526A (ja) | 2012-03-07 | 2015-03-30 | カディラ ヘルスケア リミティド | 医薬製剤 |
| JP2015527402A (ja) | 2012-09-07 | 2015-09-17 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 安定水性アダリムマブ製剤 |
| JP2016505633A (ja) | 2013-01-24 | 2016-02-25 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | ＴＮＦα抗原結合性タンパク質 |
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| EP1441589B1 (en) | 2001-11-08 | 2012-05-09 | Abbott Biotherapeutics Corp. | Stable liquid pharmaceutical formulation of igg antibodies |
| PL215168B1 (pl) | 2002-02-27 | 2013-10-31 | Immunex Corp | Formulacja polipeptydowa |
| EP1539212A4 (en) | 2002-07-12 | 2007-05-02 | Medarex Inc | METHOD AND COMPOSITIONS FOR PREVENTING OXIDATIVE DEGRADATION OF PROTEINS |
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| BRPI0606867A2 (pt) | 2005-01-28 | 2009-07-21 | Wyeth Corp | formulação lìquida; forma de dosagem unitária farmacêutica; kit; recipiente; método para aumentar a estabilidade de um polipeptìdeo de ligação a antìgeno numa formulação; método para preparar uma forma de dosagem unitária farmacêutica; formulação estável; formulação; e produto terapêutico |
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| HUP1400510A1 (hu) * | 2014-10-28 | 2016-05-30 | Richter Gedeon Nyrt | Gyógyászati TNFalfa ellenes antitest készítmény |
| WO2016109822A1 (en) | 2014-12-31 | 2016-07-07 | Novelmed Therapeutics, Inc. | Formulation of aglycosylated therapeutic antibodies |
| TW201636047A (zh) * | 2015-01-28 | 2016-10-16 | 麥博賽恩斯有限公司 | 抗－ＴＮＦ－α抗體之醫藥調配物 |
| WO2016162819A1 (en) | 2015-04-07 | 2016-10-13 | Lupin Limited | Stable aqueous pharmaceutical composition of anti-tnf alpha antibody |
| GB201612317D0 (en) | 2016-07-15 | 2016-08-31 | Philogen Spa | Antibody compositions |
| US20200069799A1 (en) | 2018-08-28 | 2020-03-05 | Arecor Limited | Stabilized antibody protein solutions |
| GB201703062D0 (en) | 2017-02-24 | 2017-04-12 | Arecor Ltd | Stabilized antibody protein solutions |
| US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
| GB201703063D0 (en) | 2017-02-24 | 2017-04-12 | Arecor Ltd | Stabilized antibody protein solutions |
| EP3372241A1 (en) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP3372242A1 (en) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| WO2018184692A1 (en) | 2017-04-07 | 2018-10-11 | Ares Trading S.A. | Liquid pharmaceutical composition |
| WO2018184693A1 (en) | 2017-04-07 | 2018-10-11 | Ares Trading S.A. | Liquid pharmaceutical composition |
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2017
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2018
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2022
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010505852A (ja) | 2006-10-06 | 2010-02-25 | アムジエン・インコーポレーテツド | 安定な抗体製剤 |
| JP2010529999A (ja) | 2007-06-14 | 2010-09-02 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗体製剤 |
| JP2014524748A (ja) | 2011-07-19 | 2014-09-25 | グラクソ グループ リミテッド | ＦｃＲｎ結合の増加したＴＮＦ−α抗原結合タンパク質 |
| JP2015509526A (ja) | 2012-03-07 | 2015-03-30 | カディラ ヘルスケア リミティド | 医薬製剤 |
| JP2015527402A (ja) | 2012-09-07 | 2015-09-17 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 安定水性アダリムマブ製剤 |
| JP2016505633A (ja) | 2013-01-24 | 2016-02-25 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | ＴＮＦα抗原結合性タンパク質 |
| JP2016117732A (ja) | 2014-12-23 | 2016-06-30 | ファイザー・インク | 安定な水性抗体製剤 |
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| WO2018162503A1 (en) | 2018-09-13 |
| US20230233463A1 (en) | 2023-07-27 |
| JP2020511443A (ja) | 2020-04-16 |
| US20200016075A1 (en) | 2020-01-16 |
| EP3592385B1 (en) | 2022-05-04 |
| EP3592385A1 (en) | 2020-01-15 |
| EP3372241A1 (en) | 2018-09-12 |
| US11534403B2 (en) | 2022-12-27 |
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