JP7209097B2 - 歯の細管に深く入り閉塞し、バイオフィルムの形成を防止するための歯の脱感作剤 - Google Patents
歯の細管に深く入り閉塞し、バイオフィルムの形成を防止するための歯の脱感作剤 Download PDFInfo
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- JP7209097B2 JP7209097B2 JP2021538499A JP2021538499A JP7209097B2 JP 7209097 B2 JP7209097 B2 JP 7209097B2 JP 2021538499 A JP2021538499 A JP 2021538499A JP 2021538499 A JP2021538499 A JP 2021538499A JP 7209097 B2 JP7209097 B2 JP 7209097B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
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- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Description
Claims (4)
- 下記の重量部の比率の原料:
PEG化タンパク質を1~20部、
トリス(2-カルボキシエチル)ホスフィン塩酸塩を1~10部、
塩化カルシウムを1~3部、
pH調整剤を2~20部、
からなり、
前記pH調整剤は炭酸ナトリウム、重炭酸ナトリウム、炭酸カリウム、重炭酸カリウム、リン酸水素二カリウム、二塩基性リン酸ナトリウム、安息香酸ナトリウム、クエン酸ナトリウムのいずれかまたは複数であることを特徴とする、歯の細管に深く入り閉塞し、バイオフィルムの形成を防止するための歯の脱感作剤。 - 下記の重量部の比率の原料:
PEG化タンパク質を4~10部、
トリス(2-カルボキシエチル)ホスフィン塩酸塩を2~6部、
塩化カルシウムを1~2部、
pH調整剤を6~10部、
からなることを特徴とする請求項1に記載の歯の脱感作剤。 - 前記PEG化タンパク質のタンパク質がリゾチーム、ウシ血清アルブミン、インスリン及びα-ラクトアルブミンのいずれかまたは複数であることを特徴とする請求項1または2に記載の歯の脱感作剤。
- 前記PEG化タンパク質の中のポリエチレングリコールの数平均分子量が200~20000であることを特徴とする請求項1または2に記載の歯の脱感作剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811647134.7 | 2018-12-30 | ||
CN201811647134.7A CN109528498B (zh) | 2018-12-30 | 2018-12-30 | 一种用于深入封闭牙小管并防止生物膜形成的牙齿脱敏剂 |
PCT/CN2019/124585 WO2020140707A1 (zh) | 2018-12-30 | 2019-12-11 | 一种用于深入封闭牙小管并防止生物膜形成的牙齿脱敏剂 |
Publications (2)
Publication Number | Publication Date |
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JP2022516273A JP2022516273A (ja) | 2022-02-25 |
JP7209097B2 true JP7209097B2 (ja) | 2023-01-19 |
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Application Number | Title | Priority Date | Filing Date |
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JP2021538499A Active JP7209097B2 (ja) | 2018-12-30 | 2019-12-11 | 歯の細管に深く入り閉塞し、バイオフィルムの形成を防止するための歯の脱感作剤 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20210322284A1 (ja) |
JP (1) | JP7209097B2 (ja) |
CN (1) | CN109528498B (ja) |
DE (1) | DE112019006000T5 (ja) |
WO (1) | WO2020140707A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109528498B (zh) * | 2018-12-30 | 2021-05-18 | 美釉(西安)生物技术有限公司 | 一种用于深入封闭牙小管并防止生物膜形成的牙齿脱敏剂 |
CN113545996B (zh) * | 2020-02-29 | 2023-11-17 | 西安曼特思生物科技有限公司 | 一种可固定目标物并可按需清除的蛋白质产品 |
CN112716812B (zh) * | 2021-01-11 | 2023-03-10 | 天津医科大学口腔医院 | 一种用于根管冲洗和阻断治疗牙本质龋的抗生物膜-再矿化材料及其制备方法 |
CN114469750A (zh) * | 2022-01-28 | 2022-05-13 | 陕西师范大学 | 一种用于治疗牙敏感以及促进牙釉质外延生长的矿化材料及其应用 |
WO2023193538A1 (zh) * | 2022-04-07 | 2023-10-12 | 陕西师范大学 | 一种用于渗入封闭牙齿咬合面窝沟的窝沟封闭剂及其应用 |
CN116115823A (zh) * | 2023-02-08 | 2023-05-16 | 陕西师范大学 | 一种有机无机复合材料及其制备方法 |
CN117990728A (zh) * | 2024-04-07 | 2024-05-07 | 北京大学口腔医学院 | 蛋白质变性封堵型牙齿脱敏剂的体外功效评价装置和方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996017581A1 (fr) | 1994-12-07 | 1996-06-13 | Sun Medical Co., Ltd. | Composition dentaire contre l'hypersensibilite de la dentine |
US20020037260A1 (en) | 1997-10-16 | 2002-03-28 | Budny John A. | Compositions for treating biofilm |
JP2009143831A (ja) | 2007-12-12 | 2009-07-02 | Sunstar Inc | 口腔用組成物 |
JP2013067615A (ja) | 2011-09-23 | 2013-04-18 | Sancastle Worldwide Corp | 象牙質に関連する症状または疾患を予防または治療する組成物及び方法 |
CN107569395A (zh) | 2017-09-04 | 2018-01-12 | 天津医科大学口腔医院 | 一种用于封闭牙本质小管使牙齿脱敏的材料 |
Family Cites Families (7)
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JPH07196463A (ja) * | 1993-12-28 | 1995-08-01 | Lion Corp | 口腔用組成物 |
ITMI981148A1 (it) * | 1998-05-22 | 1999-11-22 | Therapicon Srl | Utilizzo di lisozima c modificato per preparare composizioni medicinali per il trattamento di alcune gravi malattie |
US20050089952A1 (en) * | 2003-10-22 | 2005-04-28 | Akzo Nobel N.V. | Apparatuses and processes for increasing protein PEGylation reaction yields |
EP1778120A4 (en) * | 2004-07-15 | 2009-07-08 | Dentigenix Inc | MINERALIZING COMPOSITE MATERIALS FOR RECONSTITUTION OF TEETH |
GB0428130D0 (en) * | 2004-12-22 | 2005-01-26 | Oxford Biosensors Ltd | Selective HDL cholesterol assay |
ITMI20052327A1 (it) * | 2005-12-06 | 2007-06-07 | Therapicon Srl | Lisozima umano ricombinante modificato |
CN109528498B (zh) * | 2018-12-30 | 2021-05-18 | 美釉(西安)生物技术有限公司 | 一种用于深入封闭牙小管并防止生物膜形成的牙齿脱敏剂 |
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2018
- 2018-12-30 CN CN201811647134.7A patent/CN109528498B/zh active Active
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2019
- 2019-12-11 WO PCT/CN2019/124585 patent/WO2020140707A1/zh active Application Filing
- 2019-12-11 JP JP2021538499A patent/JP7209097B2/ja active Active
- 2019-12-11 DE DE112019006000.7T patent/DE112019006000T5/de active Pending
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2021
- 2021-06-30 US US17/363,061 patent/US20210322284A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996017581A1 (fr) | 1994-12-07 | 1996-06-13 | Sun Medical Co., Ltd. | Composition dentaire contre l'hypersensibilite de la dentine |
US20020037260A1 (en) | 1997-10-16 | 2002-03-28 | Budny John A. | Compositions for treating biofilm |
JP2009143831A (ja) | 2007-12-12 | 2009-07-02 | Sunstar Inc | 口腔用組成物 |
JP2013067615A (ja) | 2011-09-23 | 2013-04-18 | Sancastle Worldwide Corp | 象牙質に関連する症状または疾患を予防または治療する組成物及び方法 |
CN107569395A (zh) | 2017-09-04 | 2018-01-12 | 天津医科大学口腔医院 | 一种用于封闭牙本质小管使牙齿脱敏的材料 |
Non-Patent Citations (1)
Title |
---|
今井庸二,5.生体機能材料、象牙質知覚過敏症の新しい処置法,口腔病学会雑誌,1991年,58巻、2号,584頁 |
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Publication number | Publication date |
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JP2022516273A (ja) | 2022-02-25 |
CN109528498B (zh) | 2021-05-18 |
WO2020140707A1 (zh) | 2020-07-09 |
CN109528498A (zh) | 2019-03-29 |
DE112019006000T5 (de) | 2021-12-09 |
US20210322284A1 (en) | 2021-10-21 |
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