JP7184775B2 - 黄体化ホルモン放出ホルモン受容体（ｌｈｒｈ－ｒ）コンジュゲートおよびその使用 - Google Patents

黄体化ホルモン放出ホルモン受容体（ｌｈｒｈ－ｒ）コンジュゲートおよびその使用 Download PDF

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JP7184775B2
JP7184775B2 JP2019531800A JP2019531800A JP7184775B2 JP 7184775 B2 JP7184775 B2 JP 7184775B2 JP 2019531800 A JP2019531800 A JP 2019531800A JP 2019531800 A JP2019531800 A JP 2019531800A JP 7184775 B2 JP7184775 B2 JP 7184775B2
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conjugate
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JP2020502131A (ja
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フィリップ・ステュワート・ロウ
ジョティ・ロイ
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    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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JP2019531800A 2016-12-14 2017-12-13 黄体化ホルモン放出ホルモン受容体（ｌｈｒｈ－ｒ）コンジュゲートおよびその使用 Active JP7184775B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434383P 2016-12-14 2016-12-14
US62/434,383 2016-12-14
US201762467297P 2017-03-06 2017-03-06
US62/467,297 2017-03-06
PCT/US2017/065996 WO2018111990A1 (en) 2016-12-14 2017-12-13 Luteinizing hormone-releasing hormone receptor (lhrh-r) conjugates and uses thereof

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JP2020502131A JP2020502131A (ja) 2020-01-23
JP2020502131A5 JP2020502131A5 (enExample) 2021-01-28
JP7184775B2 true JP7184775B2 (ja) 2022-12-06

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US (3) US10821188B2 (enExample)
EP (1) EP3554526B1 (enExample)
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CN (1) CN110312517A (enExample)
ES (1) ES2983735T3 (enExample)
WO (1) WO2018111990A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN110312517A (zh) * 2016-12-14 2019-10-08 普渡研究基金会 促黄体激素释放激素受体(lhrh-r)缀合物及其用途
US20190375732A1 (en) 2018-05-14 2019-12-12 David Hung Anti-cancer nuclear hormone receptor-targeting compounds
KR20220008869A (ko) 2019-05-14 2022-01-21 누베이션 바이오 인크. 항암 핵 호르몬 수용체-표적화 화합물
TW202131930A (zh) 2019-11-13 2021-09-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
BR112023019420A2 (pt) 2021-03-23 2023-10-24 Nuvation Bio Inc Compostos de direcionamento ao receptor de hormônio nuclear anticâncer
EP4334314A1 (en) 2021-05-03 2024-03-13 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CN114214061B (zh) * 2022-02-22 2022-05-17 北京大学 一种聚乙二醇修饰的两性离子化荧光探针、制剂及其应用
GB2623090A (en) 2022-10-04 2024-04-10 Sublino Ltd Method of colouring

Citations (1)

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JP2006522085A (ja) 2003-04-04 2006-09-28 アーダナ バイオサイエンス リミテッド ステロイドホルモンとの性腺刺激ホルモン放出ホルモン類似体結合体

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US5780435A (en) * 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US8962558B2 (en) * 1997-07-04 2015-02-24 Johannes C. van Groeninghen Methods for reducing GnRH-positive tumor cell proliferation using the GnRH antagonist IN3
WO2005007165A1 (en) * 2003-07-07 2005-01-27 Neurocrine Biosciences, Inc. Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists
EP2095818A1 (en) * 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
CN110312517A (zh) * 2016-12-14 2019-10-08 普渡研究基金会 促黄体激素释放激素受体(lhrh-r)缀合物及其用途

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2006522085A (ja) 2003-04-04 2006-09-28 アーダナ バイオサイエンス リミテッド ステロイドホルモンとの性腺刺激ホルモン放出ホルモン類似体結合体

Non-Patent Citations (3)

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Title
Amino Acids，2015年，Vol.47，pp.2359-2366
Bioorganic & Medicinal Chemistry Letters，2014年，Vol.24，pp.1846-1850
Endocrinology，2007年，Vol.148, No.2，pp.857-867

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EP3554526B1 (en) 2024-05-08
US20210290767A1 (en) 2021-09-23
US10821188B2 (en) 2020-11-03
JP2020502131A (ja) 2020-01-23
US11883498B2 (en) 2024-01-30
CN110312517A (zh) 2019-10-08
WO2018111990A1 (en) 2018-06-21
EP3554526A4 (en) 2020-05-27
EP3554526A1 (en) 2019-10-23
US20190365904A1 (en) 2019-12-05
US20240173417A1 (en) 2024-05-30
ES2983735T3 (es) 2024-10-24

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