JP7169633B2 - 表面麻酔剤 - Google Patents
表面麻酔剤 Download PDFInfo
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- JP7169633B2 JP7169633B2 JP2018162980A JP2018162980A JP7169633B2 JP 7169633 B2 JP7169633 B2 JP 7169633B2 JP 2018162980 A JP2018162980 A JP 2018162980A JP 2018162980 A JP2018162980 A JP 2018162980A JP 7169633 B2 JP7169633 B2 JP 7169633B2
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- anesthetic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
[1]麻酔成分とテルペノイドとを含むことを特徴とする表面麻酔剤。
[2]さらに、イソプロピルアルコールを含むことを特徴とする上記[1]記載の表面麻酔剤。
[3]テルペノイドが、表面麻酔剤中、0.000001~2質量%含まれることを特徴とする上記[1]又は[2]記載の表面麻酔剤。
[4]テルペノイドが、ゲラニオールであることを特徴とする上記[1]~[3]のいずれか記載の表面麻酔剤。
[5]皮膚又は粘膜に適用されることを特徴とする上記[1]~[4]のいずれか記載の表面麻酔剤。
[6]口腔内組織への外科的処置に用いられることを特徴とする上記[1]~[5]のいずれか記載の表面麻酔剤。
[7]皮膚への外科的処置に用いられることを特徴とする上記[1]~[5]のいずれか記載の表面麻酔剤。
[8]口腔内組織への注射前に用いられることを特徴とする上記[6]記載の表面麻酔剤。
[9]皮膚への注射前に用いられることを特徴とする上記[7]記載の表面麻酔剤。
本発明の表面麻酔剤は、除痛効果が高く、例えば、針の刺入前に適用することにより、鈍針に対して無痛状態とすることができる。したがって、痛みに感受性の高い患者に対して特に有効である。
[実施例1]
室温にてボルテックスにより、予めごく少量のエタノールに溶解したリドカインと、イソプロピルアルコールと、ゲラニオールとを混合し、リドカイン濃度20質量%の実施例に係る表面麻酔剤(LD20%+IPA/GL)を得た。なお、表面麻酔剤中のゲラニオールの含有量は0.0001質量%とした。
ゲラニオールの含有量(0.00001~0.1質量%)を変化させる以外は実施例1と同様にして、実施例に係る表面麻酔剤(LD20%+IPA/GL)を調製した。なお、ゲラニオールを配合しない比較例に係る表面麻酔剤(LD20%+IPA)も調製した。
実施例2において、麻酔成分であるリドカインをテトラカインに変更した以外は、同様にして、表面麻酔剤塗布後13分経過後の鈍針の痛みの程度について評価した。
麻酔成分であるリドカインの含有量(1~30質量%)を変化させる以外は実施例1と同様にして、実施例に係る表面麻酔剤(LD+IPA/GL)を調製した。また、実施例1と同様にして、リドカインをエタノールに溶解した比較例に係る表面麻酔剤(LD)を調製した。
Claims (5)
- 局所麻酔成分とゲラニオールとイソプロピルアルコールとを含むことを特徴とする表面麻酔剤。
- ゲラニオールが、0.000001~2質量%含まれることを特徴とする請求項1記載の表面麻酔剤。
- 皮膚又は粘膜に適用されることを特徴とする請求項1又は2記載の表面麻酔剤。
- 口腔内組織への外科的処置に用いられることを特徴とする請求項1~3のいずれか記載の表面麻酔剤。
- 皮膚への外科的処置に用いられることを特徴とする請求項1~3のいずれか記載の表面麻酔剤。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018162980A JP7169633B2 (ja) | 2018-08-31 | 2018-08-31 | 表面麻酔剤 |
PCT/JP2019/033959 WO2020045581A1 (ja) | 2018-08-31 | 2019-08-29 | 表面麻酔剤 |
Applications Claiming Priority (1)
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JP2018162980A JP7169633B2 (ja) | 2018-08-31 | 2018-08-31 | 表面麻酔剤 |
Publications (2)
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JP2020033321A JP2020033321A (ja) | 2020-03-05 |
JP7169633B2 true JP7169633B2 (ja) | 2022-11-11 |
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JP2018162980A Active JP7169633B2 (ja) | 2018-08-31 | 2018-08-31 | 表面麻酔剤 |
Country Status (2)
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JP (1) | JP7169633B2 (ja) |
WO (1) | WO2020045581A1 (ja) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001512415A (ja) | 1997-05-20 | 2001-08-21 | ジェイ. カルドウェル,ラリー | 局所的局所麻酔薬組成物を用いる頭痛の痛みを処置するための方法 |
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2018
- 2018-08-31 JP JP2018162980A patent/JP7169633B2/ja active Active
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2019
- 2019-08-29 WO PCT/JP2019/033959 patent/WO2020045581A1/ja active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001512415A (ja) | 1997-05-20 | 2001-08-21 | ジェイ. カルドウェル,ラリー | 局所的局所麻酔薬組成物を用いる頭痛の痛みを処置するための方法 |
Non-Patent Citations (5)
Title |
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CASTRO, E. et al.,A comparison of transdermal over-the-counter lidocaine 3.6% menthol 1.25%, Rx lidocaine 5% and place,Pain management,2017年,Vol.7, No.6,p.489-498,ISSN 1758-1869 |
GODWIN, D.A. et al.,Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers,Drug Development and Industrial Pharmacy,1999年,Vol.25, No.8,p.905-915,ISSN 0363-9045 |
LIU, Y. et al.,Menthol facilitates the skin analgesic effect of tetracaine gel,International Journal of Pharmaceutics,2005年,Vol.305,p.31-36,ISSN 0378-5173 |
NORTIER, Y.L.M. et al.,Preparation and stability testing of a hydrogel for topical analgesia,Pharmacy World & Science,1995年,Vol.17, No.6,p.214-217,ISSN 0928-1231 |
SONG, Y.H. et al.,The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches,Drug Delivery,2009年,Vol.16, No.2,p.75-81,ISSN 1071-7544 |
Also Published As
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JP2020033321A (ja) | 2020-03-05 |
WO2020045581A1 (ja) | 2020-03-05 |
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