JP7167509B2 - blood purifier - Google Patents

Description

The present invention relates to a blood purification device.

Japanese Unexamined Patent Publication No. 2007-135908 (Patent Document 1) is cited as a prior document disclosing the configuration of a blood purification device.

The blood purification apparatus described in Patent Document 1 is a blood purification apparatus for purifying blood taken from a living body, comprising an extracorporeal circulation circuit, a blood purification section provided in the extracorporeal circulation circuit, and a dialysate in the blood purification section. , a second flow path for supplying replacement fluid to the extracorporeal circulation circuit, a third flow path for discharging the filtrate from the blood purification unit, a measurement unit, and a flow path and a plurality of valves for switching. The valve guides the liquid flowing through at least one channel selected from the first channel, the second channel, and the third channel to the measurement unit, and the measurement unit controls the flow of the liquid flowing through the selected channel. Flow rate is measured.

JP-A-2007-135908

Blood purifiers are commonly used for dialysis patients, and miniaturization of the apparatus is always desired. Furthermore, there is always a demand for improved operability by medical personnel.

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and one object thereof is to provide a blood purification apparatus having a configuration that enables downsizing of the apparatus. Another object is to provide a blood purification apparatus having a configuration that enables improved operability by medical personnel.

This blood purification apparatus includes a blood purifier incorporated in a blood circuit in which blood flows from an upstream side to a downstream side, and a replacement fluid that supplies replacement fluid from the blood purifier to the upstream side or the downstream side of the blood circuit. a dialysate conduit for supplying dialysate into the blood purifier; a drain conduit for draining the waste fluid discharged from the blood purifier; a first supply source for supplying a first liquid, which is the dialysate, a first branch line connected to the replacement liquid line and the dialysate line through which the first liquid flows, and the first branch line a first liquid storage part connected to the channel, capable of temporarily storing the first liquid and delivering the stored first liquid; a two-branch pipeline, a second fluid storage unit connected to the second branch pipeline, temporarily storing the waste fluid, and capable of delivering the stored waste fluid, and the dialysate fluid pipeline a first pump provided in the dialysate pipe for sending out the dialysate flowing through the dialysate pipe; a second pump provided in the replacement fluid pipe for sending out the replacement fluid flowing in the replacement fluid pipe; and a third pump for pumping out the waste fluid flowing through the waste fluid conduit.

The dialysate line, the replacement liquid line and the drainage line are arranged in parallel, the first pump provided in the dialysate line, the second pump provided in the replacement liquid line and the drainage The third pumps provided in the pipeline are arranged side by side.

In another embodiment, a housing that accommodates the first pump, the second pump, and the third pump is included, and the housing includes a main body and a cover that can be opened and closed with respect to the main body. The dialysate line, the replacement liquid line, and the drainage line are arranged in parallel on the main body side, and the dialysis fluid can be removed from the main body by opening the cover with respect to the main body. The dialysate line, the replacement liquid line and the drainage line can be removed, and by closing the cover on the body, the dialysate line, the replacement fluid line and the drainage line can be connected to the body. The pipeline is fixed.

This blood purification device makes it possible to provide a blood purification device having a configuration that enables downsizing of the device. In addition, this blood purification device makes it possible to provide a blood purification device having a configuration that enables improved operability by medical personnel.

1 is a circuit diagram showing the configuration of a blood purification device according to an embodiment; FIG. FIG. 4 is a circuit diagram showing a state in which the fourth valve is closed and the first, second and third valves are open in the blood purification apparatus according to the embodiment; FIG. 4 is a circuit diagram showing a state in which the second and fourth valves are closed and the first and third valves are open in the blood purification apparatus according to the embodiment; FIG. 4 is a circuit diagram showing a state in which the first and fourth valves are closed and the second and third valves are open in the blood purification apparatus according to the embodiment; FIG. 4 is a circuit diagram showing a state in which the first and third valves are closed and the second and fourth valves are open in the blood purification apparatus according to the embodiment; FIG. 4 is a circuit diagram showing a state in which the first valve is closed and the second, third and fourth valves are open in the blood purification apparatus according to the embodiment; 4 is a flow chart showing steps for measuring water removal speed in the blood purification apparatus according to the embodiment. 1 is a front view of a rotary valve in which the valve according to the embodiment is in the first position; FIG. FIG. 4 is a side view of the rotary valve in the first position of the valve according to the embodiment; FIG. 4 is a side view of the rotary valve in the second position of the valve according to the embodiment; 1 is a perspective view showing the overall configuration of a liquid-sending pump unit according to an embodiment; FIG. FIG. 4 is a perspective view showing a state in which an opening/closing lever of the liquid-sending pump unit according to the embodiment is pulled up; FIG. 4 is a perspective view showing a state in which the door of the liquid-sending pump unit according to the embodiment is opened; 4 is a perspective view showing the structure of a liquid-sending pump provided inside the liquid-sending pump unit; FIG. FIG. 4 is a side view showing a liquid-sending pump provided inside the liquid-sending pump unit; FIG. 4 is a front view showing a liquid-sending pump provided inside the liquid-sending pump unit;

A blood purification apparatus according to an embodiment will be described below with reference to the drawings. In the following description of the embodiments, the same reference numerals are given to the same or corresponding parts in the drawings, and the description thereof will not be repeated. In the description of the embodiments below, a blood purification device used for Continuous Renal Replacement Therapy (CRRT) will be described as a blood purification device. However, the blood purification device can be used for continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), or continuous hemodialysis (CHD). It may be a blood purification device that can be used.

FIG. 1 is a circuit diagram showing the configuration of a blood purification apparatus according to this embodiment. As shown in FIG. 1, blood purification apparatus 100 according to the present embodiment includes blood purifier 120, replacement fluid line 131, dialysate line 141, drainage line 151, and first supply source 130. , first branch line 142 , first reservoir 140 , second branch line 152 , second reservoir 150 , first pump 160 , second pump 161 , and third pump 162 , a first valve 131 v , a second valve 142 v , a third valve 151 v , a fourth valve 152 v , and a scale 139 .

Blood purifier 120 contains a semi-permeable membrane made of, for example, a hollow fiber membrane. Blood purifier 120 has blood inlet 121 and blood outlet 122 . The upstream blood conduit 110 is connected to the blood inlet 121 . A downstream blood line 116 is connected to the blood outlet 122 .

A blood pump 111 for pumping blood is provided in the upstream blood line 110 . An arterial drip chamber 112 is provided in the middle of the upstream blood line 110 . The arterial drip chamber 112 is provided with an upstream pressure measuring device 113 that measures blood pressure. Blood collected from the patient's artery flows through the blood inlet 121 into the blood purifier 120 after having its pressure measured while passing through the arterial drip chamber 112 on the way through the upstream blood line 110 .

A venous drip chamber 114 is provided in the middle of the downstream blood line 116 . The venous drip chamber 114 is provided with a downstream pressure measuring device 115 that measures blood pressure. Blood purified by blood purifier 120 is pressure-measured as it passes through venous drip chamber 114 on its way through downstream blood line 116 before being returned to the patient's vein. Thus, blood purifier 120 is incorporated into the blood circuit. Blood flows from the upstream side to the downstream side of the blood circuit. The venous drip chamber 114 is connected to the replacement fluid line 131 . Note that the replacement fluid line 131 may be connected to the arterial drip chamber 112 instead of the venous drip chamber 114 .

Blood purifier 120 further has a dialysate inlet 124 and a drain outlet 123 . A dialysate line 141 is connected to the dialysate inlet 124 . A drainage conduit 151 is connected to the drainage outlet 123 .

The upstream end of the replacement fluid line 131 is connected to a first supply source 130 that supplies the first fluid 10, which is the replacement fluid and dialysate. A second pump 161 is connected to the replacement fluid line 131 to pump out the replacement fluid at a set flow rate Qs. A finger pump, which will be described later, is used for the second pump 161 . A first branch line 142 through which the first liquid 10 flows is connected to the replacement liquid line 131 . A first valve 131v for opening and closing the replacement fluid pipeline 131 is provided on the upstream side of the connection position with the first branch pipeline 142 in the replacement fluid pipeline 131 . A rotary valve, which will be described later, is used for the first valve 131v. A second heater 171 that heats the replacement fluid is provided downstream of the second pump 161 in the replacement fluid line 131 . Note that the second heater 171 may not be provided.

The replacement fluid that has flowed through the replacement fluid line 131 is supplied into the venous drip chamber 114 . That is, replacement fluid line 131 supplies replacement fluid to the downstream side of the blood circuit from blood purifier 120 . When the replacement fluid line 131 is connected to the arterial drip chamber 112 , the replacement fluid line 131 supplies replacement fluid to the upstream side of the blood circuit from the blood purifier 120 .

The upstream end of dialysate line 141 is connected to first branch line 142 . The dialysate line 141 is connected to a first pump 160 that pumps out the dialysate at a set flow rate Qd. A finger pump, which will be described later, is used for the first pump 160 . The dialysate that has flowed through the dialysate line 141 is supplied into the blood purifier 120 . A first heater 170 that heats the dialysate is provided downstream of the first pump 160 in the dialysate line 141 . Note that the first heater 170 may not be provided.

The first branch line 142 is connected to a first liquid storage section 140 that can temporarily store the first liquid 10 and deliver the stored first liquid 10 . In the first branch line 142, a second valve 142v for opening and closing the first branch line 142 is provided between the connection position with the replacement fluid line 131 and the connection position with the dialysate line 141. . A rotary valve, which will be described later, is used for the second valve 142v.

Drainage discharged from the blood purifier 120 is discharged from the downstream end of the drainage conduit 151 . A third pump 162 is connected to the drainage pipeline 151 to pump out the drainage flowing through the drainage pipeline 151 at a set flow rate Qu. A finger pump, which will be described later, is used for the third pump 162 .

A second branch pipeline 152 through which the drainage flows is connected to the drainage pipeline 151 . A third valve 151v for opening and closing the drainage pipeline 151 is provided on the downstream side of the connection position with the second branch pipeline 152 in the drainage pipeline 151 . A rotary valve, which will be described later, is used for the third valve 151v.

The second branch pipeline 152 is connected to a second liquid storage section 150 that can temporarily store the waste liquid and deliver the stored waste liquid. The second branch pipeline 152 is provided with a fourth valve 152v for opening and closing the second branch pipeline 152 . A rotary valve, which will be described later, is used for the fourth valve 152v.

First liquid storage section 140 and second liquid storage section 150 are housed in housing section 180 . The housing section 180 is connected to the measuring section of the scale 139 . In this embodiment, scale 139 is a load cell. However, the scale 139 is not limited to a load cell, and may be a spring scale or the like. Scale 139 measures the overall weight change of first reservoir 140 and second reservoir 150 .

Each of first liquid storage section 140 and second liquid storage section 150 may be bag-shaped or may be a rigid container. When each of first liquid reservoir 140 and second liquid reservoir 150 is a rigid container, the rigid container is provided with a vent hole. Also, each of the first liquid storage section 140 and the second liquid storage section 150 may be a deformable bellows-shaped soft container.

Hereinafter, in the blood purification apparatus 100 according to the present embodiment, by appropriately opening and closing the first valve 131v, the second valve 142v, the third valve 151v, and the fourth valve 152v, the water removal rate is measured. Operation will be explained.

FIG. 2 is a circuit diagram showing a first circuit state in which the fourth valve 152v is closed and the first valve 131v, the second valve 142v and the third valve 151v are opened in the blood purification apparatus 100, and FIG. 3 is a blood purification apparatus. 100, the circuit diagram shows the second circuit state in which the second valve 142v and the fourth valve 152v are closed and the first valve 131v and the third valve 151v are opened. 131v and the fourth valve 152v are closed and the second valve 142v and the third valve 151v are opened. FIG. is closed and the second valve 142v and the fourth valve 152v are opened. FIG. FIG. 7 is a circuit diagram showing a fifth circuit state in which valve 151v and fourth valve 152v are open, and FIG.

As shown in FIG. 7, the dialysate supply speed, the replacement fluid supply speed, the filtration speed and the water removal speed in the blood purifier 120 are set (S1). Next, the flow rate Qd of the first pump 160, the flow rate Qs of the second pump 161, and the flow rate Qs of the third pump 162 are adjusted so as to satisfy each of the set dialysate supply speed, replacement fluid supply speed, filtration speed, and water removal speed. Set each of the flow rates Qu.

Next, as shown in FIG. 2, with the fourth valve 152v closed and the first valve 131v, the second valve 142v and the third valve 151v open, the blood pump 111, the first pump 160, the 2 pump 161 and 3rd pump 162 are operated. As a result, the first liquid 10 supplied from the first supply source 130 is supplied from the replacement fluid duct 131 into the intravenous drip chamber 114 as a replacement fluid at a flow rate Qs, and is also supplied to the first branch duct 142 as the first fluid. Liquid 10 flows in. The replacement fluid is heated to a predetermined temperature by the second heater 171 .

A part of the first liquid 10 that has flowed into the first branch pipe 142 flows into the first liquid storage section 140 due to the pressure caused by the height difference between the first supply source 130 and the first liquid storage section 140 . is stored. The rest of the first liquid 10 that has flowed into the first branch line 142 flows into the dialysate line 141 . The first liquid 10 flowing into the dialysate line 141 is supplied as a dialysate from the dialysate line 141 into the blood purifier 120 at a flow rate Qd. The dialysate is heated to a predetermined temperature by the first heater 170 . The liquid discharged from the blood purifier 120 flows through the liquid discharge pipeline 151 at a flow rate Qu and is discharged to the outside.

For example, the first liquid 10 is allowed to flow into the first liquid storage section 140 until the estimated time when about 80% of the first liquid storage section 140 is filled with the first liquid 10 is reached. Therefore, the first reservoir 140 does not have to be manufactured precisely so that the volume is accurate.

Next, as shown in FIG. 3, the second valve 142v and the fourth valve 152v are closed and the first valve 131v and the third valve 151v are opened. As blood pump 111, first pump 160, second pump 161 and third pump 162 continue to operate, the inflow of first liquid 10 from replacement fluid conduit 131 to first branch conduit 142 is stopped and the first The first liquid 10 stored in the liquid storage part 140 is sent to the first branch pipeline 142 and further flows into the dialysate pipeline 141 at the flow rate Qd. Qd can be actually measured by measuring the change in weight of the accommodating portion 180 at this time with the scale 139 . Through this step, the dialysate supply rate is measured as shown in FIG. 7 (S2). After this step, the second valve 142v may be opened to restore the amount of the first liquid 10 stored in the first liquid reservoir 140 .

Next, as shown in FIG. 4, the first valve 131v and the fourth valve 152v are closed and the second valve 142v and the third valve 151v are opened. By continuing to operate blood pump 111, first pump 160, second pump 161, and third pump 162, first liquid 10 stops flowing from first supply source 130 to replacement fluid line 131, and the first reservoir is The first liquid 10 stored in the liquid section 140 is delivered to the first branch pipeline 142 . The first liquid 10 sent to the first branch line 142 flows into the replacement fluid line 131 at a flow rate Qs and into the dialysate line 141 at a flow rate Qd. (Qd+Qs) can be actually measured by measuring the change in weight of the accommodating portion 180 at this time with the scale 139 . By subtracting the measured value of Qd obtained in the previous step from the measured value of (Qd+Qs), the actual flow rate Qs can be calculated. Through this process, the replacement fluid supply rate is measured as shown in FIG. 7 (S3). After this step, the first valve 131v and the second valve 142v may be opened to recover the amount of the first liquid 10 stored in the first reservoir 140 .

Next, as shown in FIG. 5, the first valve 131v and the third valve 151v are closed, and the second valve 142v and the fourth valve 152v are opened. As blood pump 111 , first pump 160 , second pump 161 and third pump 162 continue to operate, drainage from the downstream end of drainage conduit 151 stops and is discharged to second branch conduit 152 . Drainage 20 flows in. The waste liquid 20 that has flowed into the second branch pipe 152 flows into the second liquid storage section 150 at a flow rate Qu and is stored therein.

Qu−(Qd+Qs) can be actually measured by measuring the change in weight of the containing portion 180 at this time with the balance 139 . Qu-(Qd+Qs) is the water removal rate. Since the actual flow rate Qd and the actual flow rate Qs have been calculated in the previous step, the flow rate Qu is calculated by adding the measured values of Qd and Qs to the measured value of Qu-(Qd+Qs). can be calculated. Qu is the filtration rate. Through this process, the filtration speed and water removal speed are measured as shown in FIG. 7 (S4).

For example, the waste liquid 20 is allowed to flow into the second reservoir 150 until the estimated time when the second reservoir 150 is filled with the waste liquid 20 is approximately 80%. Therefore, the second reservoir 150 need not be manufactured precisely so that the volume is accurate. The water removal amount can be accurately measured from the product of the operating time of the blood purification apparatus 100 and the actual water removal speed.

Next, as shown in FIG. 6, the first valve 131v is closed and the second valve 142v, the third valve 151v and the fourth valve 152v are opened. Blood pump 111 , first pump 160 , second pump 161 , and third pump 162 continue to operate, so that waste fluid 20 stored in second fluid reservoir 150 is sent to second branch pipeline 152 . . The drainage 20 sent to the second branch pipeline 152 flows into the drainage pipeline 151 and is discharged to the outside from the downstream end of the drainage pipeline 151 .

As a method for sending out the waste liquid 20 from the second liquid storage part 150, the waste liquid 20 is allowed to fall freely by gravity, the inside of the second liquid storage part 150 is pressurized by an air pump or the like, or the second liquid storage part 150 is discharged by a pressure device or the like. A method of crushing the second liquid storage part 150 by applying pressure to the second liquid storage part 150 from the outside of the liquid storage part 150 can be adopted.

After the drainage liquid 20 in the second liquid reservoir 150 is completely discharged, the fourth valve 152v is closed and the first valve 131v, the second valve 142v and the third valve 151v are opened. As a result, the state shown in FIG. 2 is restored.

As shown in FIG. 7, each speed is reset based on the measurement results of the dialysis supply speed, replacement fluid supply speed, filtration speed, and water removal speed obtained in steps S2 to S4 (S5).

If there is a difference between the actual dialysate feed rate measured in step S2 above and the dialysate feed rate set in step S1, the output of the first pump 160 is adjusted. Specifically, when the actual flow rate Qd is greater than the set flow rate Qd, the output of the first pump 160 is lowered. When the actual flow rate Qd is smaller than the set flow rate Qd, the output of the first pump 160 is increased.

If there is a difference between the actual replacement fluid supply speed measured in step S3 and the replacement fluid supply speed set in step S1, the output of the second pump 161 is adjusted. Specifically, when the actual flow rate Qs is larger than the set flow rate Qs, the output of the second pump 161 is lowered. If the actual flow rate Qs is smaller than the set flow rate Qs, the output of the second pump 161 is increased.

If there is a difference between the actual filtration rate measured in step S4 and the filtration rate set in step S1, the output of the third pump 162 is adjusted. Specifically, when the actual flow rate Qu is greater than the set flow rate Qu, the output of the third pump 162 is lowered. When the actual flow rate Qu is smaller than the set flow rate Qu, the output of the third pump 162 is increased.

As described above, by adjusting the measured values of the flow rate Qd, the flow rate Qs, and the flow rate Qu so as to approach the set value, the measured value of Qu-(Qd+Qs), which is the water removal rate, can be brought closer to the set value. can. By repeating the series of operations described above at regular intervals, the amount of water removed can be accurately maintained. Blood purification apparatus 100 preferably includes a control unit that performs feedback control as described above.

Blood purification apparatus 100 according to the present embodiment can accurately measure the amount of water removed only by measuring the change in weight of container 180 with scale 139, and therefore has a simple configuration. In addition, while the first pump 160, the second pump 161 and the third pump 162 are continuously operated, the delivery flow rate of each of the first pump 160, the second pump 161 and the third pump 162 can be measured. can.

Although the first supply source 130 is connected to the replacement fluid line 131 in this embodiment, the first supply source 130 may be connected to the dialysate line 141 .

(Rotary valve 1000)
Next, the configuration of the rotary valve 1000 used for the first valve 131v, the second valve 142v, the third valve 151v, and the fourth valve 152v will be described with reference to FIGS. 8 to 10. FIG. FIG. 8 is a front view of rotary valve 1000 with valve B1 in the first position, FIG. 9 is a side view of rotary valve 1000 with valve B1 in the first position, and FIG. 1000 is a side view of rotary valve 1000 in position. As an example, a case where this rotary valve 1000 is applied to the fourth valve 152v that opens and closes the second branch pipeline 152 is illustrated.

The rotary valve 1000 is a finger type valve and has a valve B1. Valve B1 includes valve head H1, shaft S1, and abutment roller R1. The side surface of the eccentric cam roller C1 is in contact with the contact roller R1. The rotational position of the eccentric cam roller C1 is directly controlled by the stepping motor M1.

A clamping base BS1 is provided at a position facing the valve head H1 with the second branch pipe 152 interposed therebetween.

The shaft S1 passes through a base plate BP1 fixed to the device, and a coil spring CB1 is mounted between the base plate BP1 and the contact roller R1. The valve B1 is always pressed toward the eccentric cam roller C1 by the biasing force that compresses the coil spring CB1.

The valve head H1 has a protrusion T1 that protrudes toward the sandwiching base BS1. Projection T1 has a top portion extending in a direction intersecting the direction in which second branch pipeline 152 extends. As a result, when the valve B1 is pressed toward the sandwiching base BS1 by the eccentric cam roller C1, the projecting portion T1 bites into the second branch pipeline 152 in a line-contact state, thereby securely closing the second branch pipeline 152. It can be deformed to make it possible to reliably adjust the closing pressure.

Here, the state in which the projecting portion T1 bites into the second branch pipeline 152 is described as a case of line contact as an example, but it is not limited to this state. As for the form of the projecting portion T1, it is preferable that the projecting portion T1 is a convex structure that is linearly symmetrical with respect to the upstream side and the downstream side of the second branch pipeline 152 with the projecting portion T1 interposed therebetween. As a result, even if the third pump 162 rotates forward or backward, the liquid feeding characteristics are the same, and the same control can be performed. Specifically, the liquid feed rate/rotation will be the same, and the same software can be used for motor drive in forward or reverse rotation. Furthermore, there is no need to provide a member such as an orifice for correcting the flow rate on the rotating side. The same applies to the projecting portion T1 in the following description.

The states shown in FIGS. 8 and 9 show a state in which the eccentric cam roller C1 moves the valve B1 to a position closest to the clamping base BS1 (so-called bottom dead center position). At this bottom dead center position, the second branch pipeline 152 is completely crushed by the valve head H1, and the second branch pipeline 152 is closed.

The state shown in FIG. 10 shows a state in which the eccentric cam roller C1 moves the valve B1 to a position (so-called top dead center position) where the valve B1 is farthest from the clamping base BS1. At this top dead center position, the second branch pipeline 152 is completely opened without being pushed by the valve head H1.

By controlling the rotational position of the eccentric cam roller C1 with the stepping motor M1, the position of the valve B1 can be controlled. As a result, the closing pressure of the valve head H1 of the second branch pipeline 152 is controlled, and the opening and closing of the second branch pipeline 152 can be easily controlled.

By using this rotary valve 1000, not only the fourth valve 152v but also the first valve 131v, the second valve 142v, and the third valve 151v can be similarly controlled to open and close. As a result, the operation for measuring the water removal speed described above can be easily realized. This makes it possible to improve the operability of the blood purification apparatus for medical personnel.

It is most preferable to adopt the above-described rotary valve 1000 for all of the first valve 131v, the second valve 142v, the third valve 151v, and the fourth valve 152v. The above-described rotary valve 1000 may be used for at least one of the third valve 151v and the fourth valve 152v.

(Liquid sending pump unit 1)
Next, the liquid-sending pump unit 1 employed in the blood purification apparatus 100 of this embodiment will be described. A schematic configuration of the liquid-sending pump unit 1 will be described with reference to FIGS. 11 to 13 . 11 is a perspective view showing the overall configuration of the liquid-sending pump unit 1, FIG. 12 is a perspective view showing a state in which the opening/closing lever 3 of the liquid-sending pump unit 1 is pulled up, and FIG. 2B is a perspective view showing a state in which 2B is opened; FIG.

Referring to FIG. 11 , liquid transfer pump unit 1 has housing 2 . A first pump 160 , a second pump 161 and a third pump 162 are housed inside the housing 2 . The housing 2 has a main body 2A and a cover 2B that can be opened and closed with respect to the main body 2A.

The liquid-sending pump unit 1 includes a dialysate line 141 whose liquid-feeding is controlled by a first pump 160, a replacement-fluid line 131 whose liquid-feeding is controlled by a second pump 161, and a liquid-feeding controlled by a third pump 162. A drainage pipe line 151 is detachably attached to the housing 2 .

A pair of channel holding plates 5 are provided on the main body 2A of the liquid-sending pump unit 1, and each channel holding plate 5 has a notch 5a for engaging and holding the dialysate channel 141, and a replacement fluid channel 131. , and a notch 5c for engaging and holding the drainage pipe line 151 are provided.

The state shown in FIG. 11 is a state in which the cover 2B is locked with respect to the main body 2A by the opening/closing lever 3. As shown in FIG. In this state, the dialysate line 141, the replacement liquid line 131, and the drain line 151 are securely held by the blood purification apparatus 100, and the first pump 160, the second pump 161, and the second pump 160 are held. Liquid transfer control by the 3-pump 162 is reliably performed.

The opening/closing operation of the cover 2B using the opening/closing lever 3 will be described with reference to FIGS. 12 and 13. FIG. The cover 2B is attached rotatably along the axis of a support shaft 2p provided on the main body 2A. The opening/closing lever 3 is rotatably attached along the axis of a support shaft 4p provided on the cover 2B.

The opening/closing lever 3 is provided with a pair of hook plates 3a that can be engaged with a lock shaft 2a provided on the main body 2A side. The hook plate 3a is provided with a hook groove 3b that engages with the lock shaft 2a.

As shown in FIG. 12, the opening/closing lever 3 is rotated in the arrow A direction. As a result, the hook plate 3a rotates together with the opening/closing lever 3. As shown in FIG. As a result, the lock shaft 2a is removed from the hook groove 3b of the hook plate 3a. As a result, as shown in FIG. 13, the open/close lever 3 can be opened around the support shaft 2p. This allows the dialysate line 141, the replacement liquid line 131, and the drainage line 151 to be attached to and removed from the main body 2A.

As shown in FIG. 13, on the inner surface of the cover 2B, sandwiching bases BS11 and BS12 having concave cross sections are provided at positions corresponding to the dialysate line 141, the replacement liquid line 131, and the drain line 151. , BS13 are provided. When the cover 2B is locked to the main body 2A (the state shown in FIG. 11), the bottom surface of each clamping base abuts against each pipeline, and each pipeline is sandwiched between the valve head and the clamping base, which will be described later. .

In order to lock the cover 2B to the main body 2A, as shown in FIG. 12, the dialysate line 141, the replacement liquid line 131, and the drain line 151 are attached to predetermined positions, and the cover 2B is closed. , the open/close lever 3 is rotated in the arrow B direction in the figure. At this time, since the hook groove 3b of the hook plate 3a draws an arc that gradually approaches the support shaft 4p, by rotating the open/close lever 3 in the direction B, the cover 2B gradually approaches the main body 2A side. , the cover 2B can be locked while being pressed against the main body 2A.

As a result, even when each pipeline is pressed by a valve head, which will be described later, each pipeline can be pressed in an appropriate state without the cover 2B moving.

In this way, by using one cover 2B, the dialysate line 141, the replacement liquid line 131, and the drain line 151 can be attached to the liquid feed pump unit 1 at the same time. , the work efficiency of medical staff can be improved.

(Specific configuration of liquid transfer pump)
Next, with reference to FIGS. 14 to 16, a specific configuration of the liquid-sending pump provided inside the liquid-sending pump unit 1 will be described. FIG. 14 is a perspective view showing the liquid-sending pumps 10A, 10B, and 10C provided inside the liquid-sending pump unit 1, and FIG. A front view and FIG. 16 are side views of the liquid-sending pumps 10A, 10B, and 10C provided inside the liquid-sending pump unit 1. FIG.

The liquid-sending pump 10A is a first pump 160 used for liquid-sending through the dialysate line 141 . The liquid-sending pump 10B is a second pump 161 used for liquid-sending of the replacement liquid line 131 . The liquid-sending pump 10</b>C is a third pump 162 that is used for liquid-sending in the drainage pipe 151 . Since the liquid-sending pumps 10A, 10B, and 10C all have the same configuration, only the configuration of the liquid-sending pump 10A will be described below.

The liquid-sending pump 10A is of a rotary valve type, and includes five finger-type valves B11, B12, B13, B14, and B15. The liquid-sending pump 10A is a so-called finger pump. The valve B11 includes a valve head H11, a shaft S11, and a contact roller R11. The side surface of the eccentric cam roller C11 is in contact with the contact roller R11. Valve B12 includes valve head H12, shaft S12, and contact roller R12. The side surface of the eccentric cam roller C12 is in contact with the contact roller R12.

Valve B13 includes valve head H13, shaft S13, and contact roller R13. The side surface of the eccentric cam roller C13 is in contact with the contact roller R13. Valve B14 includes valve head H14, shaft S14, and contact roller R14. The side surface of the eccentric cam roller C14 is in contact with the contact roller R14. Valve B15 includes valve head H15, shaft S15, and contact roller R15. The side surface of the eccentric cam roller C15 is in contact with the contact roller R15.

Eccentric cam roller C11, eccentric cam roller C12, eccentric cam roller C13, eccentric cam roller C14 and eccentric cam roller C15 are attached to the same rotating shaft A12. Each cam roller is mounted with a phase difference in the rotational direction with respect to the rotary shaft A12 by a predetermined rotational angle.

The eccentric cam roller C11 and the valve B11 constitute one finger pump. Similarly, the eccentric cam roller C12 and valve B12 constitute one finger pump, the eccentric cam roller C13 and valve B13 constitute one finger pump, and the eccentric cam roller C14 and valve B14 constitute one finger pump. , the eccentric cam roller C15 and the valve B15 constitute one finger pump. Therefore, the liquid feed pump 10A has a finger pump set FB10A including five finger pumps.

The liquid-sending pump 10B also has the same configuration as the liquid-sending pump 10A, and has a finger pump set FB10B including five finger pumps. The liquid-sending pump 10C also has the same configuration as the liquid-sending pump 10A, and has a finger pump set FB10C including five finger pumps.

A drive belt BL11 is wound between the drive shaft A11 of the stepping motor M11 and the rotary shaft A12. Rotation position control by the stepping motor M11 is transmitted to the rotation shaft A12 via the drive belt BL11.

By controlling the rotational positions of the eccentric cam rollers C11, C12, C13, C14 and C15 with the stepping motor M11, the positions of the valves B11, B12, B13, B14 and B15 are controlled. control can be exercised. Thus, by sequentially moving the valves B11, B12, B13, B14, and B15, it is possible to transfer the liquid in each pipe line. By selecting the order of movement of the valves B11, B12, B13, B14 and B15, the liquid in each pipe can be transferred in either direction.

The shaft S11 passes through a base plate BP11 fixed to the device, and a coil spring CB11 is mounted between the base plate BP11 and the contact roller R11. The valve B11 is always pressed toward the eccentric cam roller C11 by the biasing force that compresses the coil spring CB11.

The valve head H11 has a protrusion T11 that protrudes toward the sandwiching base BS11. The projecting portion T11 has a top extending in a direction intersecting the extending direction of the dialysate line 141 . As a result, when the valve B11 is pressed toward the pinching base BS11 by the eccentric cam roller C11, the projecting portion T1 bites into the dialysate line 141 while being in line contact with the dialysate line 141, thereby reliably deforming the dialysate line 141. .

The shaft S12 passes through a base plate BP11 fixed to the device, and a coil spring CB12 is mounted between the base plate BP11 and the contact roller R12. The valve B12 is always pressed toward the eccentric cam roller C12 by the biasing force that compresses the coil spring CB12.

The valve head H12 has a protrusion T12 that protrudes toward the sandwiching base BS11. The projecting portion T12 has a top extending in a direction intersecting the extending direction of the dialysate line 141 . As a result, when the valve B12 is pressed toward the sandwiching base BS11 by the eccentric cam roller C12, the projecting portion T12 bites into the dialysate line 141 in a line-contact state, thereby reliably deforming the dialysate line 141. .

The shaft S13 passes through a base plate BP11 fixed to the device, and a coil spring CB13 is mounted between the base plate BP11 and the contact roller R13. The valve B13 is always pressed toward the eccentric cam roller C13 by the biasing force that compresses the coil spring CB13.

The valve head H13 has a protrusion T13 that protrudes toward the sandwiching base BS11. The projecting portion T13 has a top extending in a direction intersecting the extending direction of the dialysate line 141 . As a result, when the valve B13 is pressed toward the sandwiching base BS11 by the eccentric cam roller C13, the projecting portion T13 bites into the dialysate line 141 in a line-contact state, thereby reliably deforming the dialysate line 141. .

The shaft S14 passes through a base plate BP11 fixed to the device, and a coil spring CB14 is mounted between the base plate BP11 and the contact roller R14. The valve B14 is always pressed toward the eccentric cam roller C14 by the biasing force that compresses the coil spring CB14.

The valve head H14 has a protrusion T14 that protrudes toward the sandwiching base BS11. The projecting portion T14 has a top extending in a direction intersecting the extending direction of the dialysate line 141 . As a result, when the valve B14 is pressed toward the sandwiching base BS11 by the eccentric cam roller C14, the projecting portion T14 bites into the dialysate line 141 in a line-contact state, thereby reliably deforming the dialysate line 141. .

The shaft S15 passes through a base plate BP11 fixed to the device, and a coil spring CB15 is mounted between the base plate BP11 and the contact roller R15. The valve B15 is always pressed toward the eccentric cam roller C15 by the biasing force that compresses the coil spring CB15.

The valve head H15 has a protrusion T15 that protrudes toward the sandwiching base BS11. The projecting portion T15 has a top extending in a direction intersecting the extending direction of the dialysate line 141 . As a result, when the valve B15 is pressed toward the sandwiching base BS11 by the eccentric cam roller C15, the projecting portion T15 bites into the dialysate line 141 in a line-contact state, thereby reliably deforming the dialysate line 141. .

As described above, the liquid-sending pump unit 1 in the present embodiment employs a triple arrangement structure in which the dialysate line 141, the replacement liquid line 131, and the drain line 151 are arranged in parallel. there is As a result, as shown in FIG. 14, it is possible to employ a configuration in which the liquid-sending pumps 10A, 10B, and 10C are arranged side by side, thereby making it possible to save the installation space.

Furthermore, by collecting the liquid-sending pumps 10A, 10B, and 10C in one place and making the cover 2B openable and closable with respect to the main body 2A, maintenance of each part can be easily performed when the cover 2B is open. can. In particular, as shown in FIG. 13, valve heads H11, H12, H13, H14, and H15 can be exposed, making it easy to clean each valve head. .

For example, by unitizing the valves B11, B12, B13, B14, and B15 in advance and making them detachable from the main body 2A, the unitized valves can be replaced efficiently at regular intervals. become.

Furthermore, as described above, the dialysate line 141, the replacement liquid line 131, and the drain line 151 can be attached to the liquid pump unit 1 at the same time. Work efficiency can be improved.

In the above embodiment, a case is described in which three pipelines are arranged in the order of dialysate pipeline 141, replacement fluid pipeline 131, and drainage fluid pipeline 151, but this order has a particular meaning. Instead, other arrangement orders may be adopted.

In the above embodiment, the finger pump set is used for all of the liquid-sending pumps 10A, 10B, and 10C, but any one of the liquid-sending pumps may be the finger-pump set.

In the above finger pump set, a case is described in which five finger pumps are provided, but the number is not limited to five, and liquid can be fed as long as the number of finger pumps is three or more.

It should be noted that the above-described embodiment disclosed this time is an example in all respects and does not serve as a basis for restrictive interpretation. Therefore, the technical scope of the present invention is not to be interpreted only by the above-described embodiments, but is defined based on the claims. In addition, all changes within the meaning and range of equivalents to the scope of claims are included.

1 liquid pump unit 2 housing 2A main body 2B cover 2a lock shaft 2p, 4p support shaft 3 opening/closing lever 3a hook plate 3b hook groove 5 pipe holding plate 5a, 5b, 5c notch Parts 10A, 10B, 10C Liquid-sending pump 100 Blood purification device 110 Upstream blood line 111 Blood pump 112 Arterial drip chamber 113 Upstream pressure measuring device 114 Venous drip chamber 115 Downstream pressure Measuring Device 116 Downstream Blood Line 120 Blood Purifier 121 Blood Inlet 122 Blood Outlet 123 Drain Outlet 124 Dialysate Inlet 130 First Supply Source 131 Replacement Fluid Line 131v First Valve 139 Balance, 140 first reservoir, 141 dialysate line, 142 first branch line, 142v second valve, 150 second reservoir, 151 drainage line, 151v third valve, 152 second branch line passage, 152v fourth valve, 160 first pump, 161 second pump, 162 third pump, 170 first heater, 171 second heater, 180 accommodating portion, 1000 rotary valve, A11 drive shaft, A12 rotating shaft, B1, B11, B12, B13, B14, B15 valve, BL11 drive belt, BP1, BP11 base plate, BS1, BS11, BS12, BS13 clamping base, C1, C11, C12, C13, C14, C15 eccentric cam roller, CB1, CB11, CB12 , CB13, CB14, CB15 coil spring, FB10A, FB10B, FB10C finger pump set, H1, H11, H12, H13, H14, H15 valve head, M1, M11 stepping motor, R1, R11, R12, R13, R14, R15 contact Roller, S1, S11, S12, S13, S14, S15 Shaft, T1, T11, T12, T13, T14, T15 Projection.

Claims (2)

a blood purifier incorporated in a blood circuit through which blood flows from the upstream side to the downstream side;
a replacement fluid conduit that supplies replacement fluid to the upstream side or the downstream side of the blood circuit from the blood purifier;
a dialysate line that supplies dialysate into the blood purifier;
a drainage conduit for flowing the drainage discharged from the blood purifier;
a first source connected to the replacement fluid line and supplying a first fluid, which is the replacement fluid and the dialysate;
a first branch conduit connected to the replacement fluid conduit and the dialysate conduit through which the first fluid flows;
a first liquid storage unit connected to the first branch pipeline, capable of temporarily storing the first liquid, and delivering the stored first liquid;
a second branch pipeline connected to the drainage pipeline through which the drainage flows;
a second liquid storage unit connected to the second branch pipeline, capable of temporarily storing the waste liquid, and delivering the stored waste liquid;
a first pump provided in the dialysate line for pumping out the dialysate flowing through the dialysate line;
a second pump that is provided in the replacement fluid pipeline and pumps out the replacement fluid that flows through the replacement fluid pipeline;
a third pump that is provided in the drainage pipeline and pumps out the drainage flowing through the drainage pipeline;
the dialysate line, the replacement fluid line and the drainage line are arranged in parallel;
The first pump provided in the dialysate line, the second pump provided in the replacement liquid line, and the third pump provided in the drainage line are arranged side by side ,
The first pump, the second pump and the third pump are all rotary valve type finger pump sets,
The finger pump set includes:
a drive shaft;
a rotating shaft to which the rotation of the drive shaft is transmitted;
a finger pump comprising an eccentric cam roller and a valve;
A plurality of the finger pumps are provided,
The valve is
a contact roller that contacts a side surface of the eccentric cam roller;
a shaft supporting the contact roller at one end;
a valve head supported on the other end of the shaft;
The plurality of eccentric cam rollers are mounted on the rotating shaft,
the drive shaft, the rotating shaft, and the plurality of shafts are arranged horizontally;
The plurality of valve heads are arranged in a horizontal direction,
Blood purifier. a housing containing the first pump, the second pump, and the third pump;
The housing has a main body and a cover that can be opened and closed with respect to the main body,
The dialysate line, the replacement liquid line, and the drainage line are arranged in parallel on the main body side,
By opening the cover with respect to the main body, it is possible to remove the dialysate line, the replacement liquid line, and the drainage line from the main body,
2. The blood purification apparatus according to claim 1, wherein said dialysate line, said replacement liquid line and said drain line are fixed to said body by closing said cover to said body.

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