JP6794713B2 - Blood purification device - Google Patents

Description

The present invention relates to a blood purification device.

As prior documents disclosing the configuration of the blood purification apparatus, there are Japanese Patent Application Laid-Open No. 2001-541 (Patent Document 1) and Japanese Patent Application Laid-Open No. 11-276578 (Patent Document 2).

The blood purification apparatus described in Patent Document 1 is a weight measuring means for measuring the total weight of the dialysate container and the filtrate container, and measuring the total weight of the dialysate container and the filtrate container measured by the weight measuring means. The filtrate is obtained by subtracting the initial total weight measurement value measured at the start of blood treatment from the value and the water removal target value that increases with the treatment time according to the set water removal amount until the difference between the two becomes zero. By providing a control device that increases or decreases the rotation of the pump, the control accuracy of the amount of water removed is improved. As the weight measuring means, two weight scales are used, one is a weight scale for measuring the weight of the dialysate container and the supplementary liquid container, and the other is a weight scale for measuring the weight of the filtrate container.

The blood purification apparatus described in Patent Document 2 includes a measuring container for dialysate, a measuring container for drainage, and a measuring container for replenishing liquid, each of which is manufactured by injection molding of plastic and has almost no error. .. The flow rates of dialysate, drainage and replacement fluid are measured by detecting that the liquid level has passed in front of the sensors provided at the top and bottom of each measuring container. By adjusting the rotation speed of the corresponding pump so that the obtained measured value and the set value match, the filtrate flow rate and the drainage flow rate are accurately maintained.

Japanese Unexamined Patent Publication No. 2001-541 Japanese Unexamined Patent Publication No. 11-276578

Since the blood purification apparatus described in Patent Document 1 uses two weighing scales, the difference in measurement accuracy between the two weighing scales hinders the improvement of the control accuracy of the amount of water removed.

In the blood purification device described in Patent Document 2, a measuring container with almost no manufacturing error must be used, and the blood purification device cannot be easily configured.

The present invention has been made in view of the above problems, and an object of the present invention is to provide a blood purification device capable of accurately measuring the amount of water removed with a simple configuration.

The blood purification device based on the first aspect of the present invention includes a blood purifier incorporated in a blood circuit in which blood flows from the upstream side to the downstream side, and a replenisher on the upstream side or the downstream side of the blood circuit from the blood purifier. It is connected to the replenishment line, the dialysate line that supplies the dialysate into the blood purifier, the drainage line that flows the drainage discharged from the blood purifier, and the replenishment line. The first supply source for supplying the first liquid, which is the dialysate, is connected to the replacement liquid line and the dialysate line, and is connected to the first branch line through which the first liquid flows and the first branch line. It is connected to the first liquid storage unit that can temporarily store the liquid and deliver the stored first liquid, to the second branch passage that is connected to the drainage pipe and allows the drainage to flow, and to the second branch passage. A second liquid storage unit capable of temporarily storing the drained liquid and sending out the stored drainage, and a first pump provided in the dialysate pipeline and sending out the dialysate flowing through the dialysate pipeline. , A second pump provided in the replenishment line and sending out the replenisher flowing through the replenishment line, a third pump provided in the drainage line and sending out the drainage flowing through the drainage line, and a first pump in the replenishment line. Between the first valve, which is provided on the upstream side of the connection position with the branch path and opens and closes the supplementary solution line, and the connection position with the supplementary solution line and the connection position with the dialysate line in the first branch line. A second valve that opens and closes the first branch line, and a third valve that opens and closes the drainage line on the downstream side of the connection position with the second branch line in the drainage line. It is provided in two branch paths and includes a fourth valve that opens and closes the second branch path, and a scale that measures the overall weight change of the first liquid storage section and the second liquid storage section.

The blood purifying device based on the second aspect of the present invention includes a blood purifier incorporated in a blood circuit in which blood flows from the upstream side to the downstream side, and a replenisher on the upstream side or the downstream side of the blood circuit from the blood purifier. The replacement fluid is connected to the replacement fluid conduit that supplies the dialysate, the dialysate pipeline that supplies the dialysate into the blood purifier, the drainage conduit that drains the drainage fluid discharged from the blood purifier, and the dialysate conduit. And the first supply source for supplying the first solution, which is the dialysate, is connected to the supplementary solution line and the dialysate line, and is connected to the first branch line and the first branch line through which the first liquid flows. In the first liquid storage section where one liquid is temporarily stored and the stored first liquid can be sent out, the second branch passage which is connected to the drainage pipeline and the drainage flows, and the second branch passage. A second reservoir that is connected and can temporarily store drainage and deliver the stored drainage, and a first pump that is provided in the dialysate conduit and sends out dialysate that flows through the dialysate conduit. In the second pump provided in the replenishing pipeline and sending out the replenishing liquid flowing through the replenishing conduit, the third pump provided in the drainage conduit and sending out the drainage flowing through the drainage conduit, and the dialysate conduit. A first valve provided upstream from the connection position with the first branch line to open and close the dialysate line, a connection position with the supplementary solution line in the first branch line, and a connection position with the dialysate line. A second valve that opens and closes the first branch path is provided between the two, and a third valve that is provided downstream from the connection position with the second branch path in the drainage pipeline and opens and closes the drainage pipeline. A fourth valve provided in the second branch path to open and close the second branch path, and a scale for measuring the total weight change of the first liquid storage section and the second liquid storage section are provided.

The blood purifying device based on the third aspect of the present invention includes a blood purifier incorporated in a blood circuit in which blood flows from the upstream side to the downstream side, and a replenisher on the upstream side or the downstream side of the blood circuit from the blood purifier. It is connected to the replenisher conduit that supplies the dialysate, the dialysate conduit that supplies the dialysate into the blood purifier, the drainage conduit that drains the drainage discharged from the blood purifier, and the replenisher conduit. A first supply source that supplies a certain first liquid, a second supply source that is connected to the dialysate pipeline and supplies the second liquid that is the dialysate, and a second supply source that is connected to the supplementary liquid conduit and the first liquid flows. It is connected to the 1-branch path and the 1st branch path, temporarily stores the 1st liquid, and is connected to the 1st liquid storage unit capable of delivering the stored 1st liquid, and is connected to the drainage pipeline to drain the liquid. It is connected to the second branch passage through which the liquid flows and the second branch passage, and is connected to the dialysate pipeline and the second liquid storage unit which is connected to the second branch passage and can temporarily store the drainage liquid and send out the stored liquid drainage. , A third branch passage through which the second liquid flows, a third liquid storage unit which is connected to the third branch passage, can temporarily store the second liquid, and can deliver the stored second liquid, and a dialysate. A first pump provided in the conduit and sending out dialysate flowing through the dialysate conduit, a second pump provided in the supplementary conduit and sending out supplementary fluid flowing through the replacement conduit, and a second pump provided in the drainage conduit for drainage. A third pump that sends out the drainage flowing through the liquid conduit, a first valve that is provided upstream from the connection position with the first branch in the supplementary conduit and opens and closes the supplementary conduit, and a first branch. A second valve that opens and closes the first branch path, and a third valve that opens and closes the drainage line, which is provided downstream from the connection position with the second branch line in the drainage line, and a second branch. A fourth valve provided on the road to open and close the second branch, a fifth valve provided on the upstream side of the connection position with the third branch in the dialysate pipeline and open and close the dialysate conduit, and a third valve. It is provided with a scale for measuring the total weight change of one liquid storage unit, the second liquid storage unit, and the third liquid storage unit.

In one embodiment of the invention, the scale is a load cell.

According to the present invention, the amount of water removed can be accurately measured with a simple configuration.

It is a circuit diagram which shows the structure of the blood purification apparatus which concerns on Embodiment 1 of this invention. It is a circuit diagram which shows the state which closed the 4th valve and opened the 1st valve, the 2nd valve and the 3rd valve in the blood purification apparatus which concerns on Embodiment 1 of this invention. FIG. 5 is a circuit diagram showing a state in which the second valve and the fourth valve are closed and the first valve and the third valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 5 is a circuit diagram showing a state in which the first valve and the fourth valve are closed and the second valve and the third valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 5 is a circuit diagram showing a state in which the first valve and the third valve are closed and the second valve and the fourth valve are opened in the blood purification device according to the first embodiment of the present invention. It is a circuit diagram which shows the state which closed the 1st valve and opened the 2nd valve, the 3rd valve and the 4th valve in the blood purification apparatus which concerns on Embodiment 1 of this invention. It is a flowchart which shows the process for measuring the water removal rate in the blood purification apparatus which concerns on Embodiment 1 of this invention. It is a circuit diagram which shows the structure of the blood purification apparatus which concerns on the modification of Embodiment 1 of this invention. It is a circuit diagram which shows the state which closed the 4th valve, and opened the 1st valve, the 2nd valve and the 3rd valve in the blood purification apparatus which concerns on the modification of Embodiment 1 of this invention. It is a circuit diagram which shows the state which the 2nd valve and the 4th valve were closed, and the 1st valve and the 3rd valve were opened in the blood purification apparatus which concerns on the modification of Embodiment 1 of this invention. It is a circuit diagram which shows the state which the 1st valve and the 4th valve were closed, and the 2nd valve and the 3rd valve were opened in the blood purification apparatus which concerns on the modification of Embodiment 1 of this invention. It is a circuit diagram which shows the state which the 1st valve and the 3rd valve were closed, and the 2nd valve and the 4th valve were opened in the blood purification apparatus which concerns on the modification of Embodiment 1 of this invention. It is a circuit diagram which shows the state which the 1st valve was closed and the 2nd valve, the 3rd valve and the 4th valve were opened in the blood purification apparatus which concerns on the modification of Embodiment 1 of this invention. It is a circuit diagram which shows the structure of the blood purification apparatus which concerns on Embodiment 2 of this invention. It is a circuit diagram which shows the state which closed the 4th valve and opened the 1st valve, the 2nd valve, the 3rd valve and the 5th valve in the blood purification apparatus which concerns on Embodiment 2 of this invention. It is a circuit diagram which shows the state which the 2nd valve, the 4th valve and the 5th valve were closed and the 1st valve and the 3rd valve were opened in the blood purification apparatus which concerns on Embodiment 2 of this invention. FIG. 5 is a circuit diagram showing a state in which the first valve, the fourth valve, and the fifth valve are closed and the second valve and the third valve are opened in the blood purification device according to the second embodiment of the present invention. FIG. 5 is a circuit diagram showing a state in which the first valve, the third valve, and the fifth valve are closed and the second valve and the fourth valve are opened in the blood purification device according to the second embodiment of the present invention. FIG. 5 is a circuit diagram showing a state in which the first valve and the fifth valve are closed and the second valve, the third valve, and the fourth valve are opened in the blood purification device according to the second embodiment of the present invention. It is a flowchart which shows the operation cycle of the blood purification apparatus which concerns on Embodiment 2 of this invention.

Hereinafter, the blood purification apparatus according to each embodiment of the present invention will be described with reference to the drawings. In the following description of the embodiment, the same or corresponding parts in the drawings are designated by the same reference numerals, and the description will not be repeated. In the following description of the embodiment, the blood purification device used for continuous renal replacement therapy (CRRT) as a blood purification device will be described. However, the blood purification device is used for any of continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), and continuous hemodialysis (CHD). It may be a hemodiafiltration device.

(Embodiment 1)
FIG. 1 is a circuit diagram showing a configuration of a blood purification device according to a first embodiment of the present invention. As shown in FIG. 1, the blood purifying device 100 according to the first embodiment of the present invention includes a blood purifying device 120, a replenishing fluid line 131, a dialysate line 141, a drainage line 151, and a first supply. The source 130, the first branch path 142, the first liquid storage section 140, the second branch path 152, the second liquid storage section 150, the first pump 160, the second pump 161 and the third pump 162. A first valve 131v, a second valve 142v, a third valve 151v, a fourth valve 152v, and a scale 139 are provided.

The blood purifier 120 contains, for example, a semipermeable membrane made of a hollow fiber membrane. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. An upstream blood duct 110 is connected to the blood inlet 121. A downstream blood duct 116 is connected to the blood outlet 122.

A blood pump 111 that pumps blood is provided in the upstream blood duct 110. An arterial drip chamber 112 is provided in the middle of the upstream blood vessel 110. The arterial drip chamber 112 is provided with an upstream pressure measuring device 113 for measuring blood pressure. The blood collected from the patient's artery flows into the blood purifier 120 from the blood inlet 121 after the pressure is measured as it passes through the arterial drip chamber 112 on the way through the upstream blood line 110.

A venous drip chamber 114 is provided in the middle of the downstream blood vessel 116. The venous drip chamber 114 is provided with a downstream pressure measuring device 115 for measuring blood pressure. The blood purified by the blood purifier 120 is returned to the patient's vein after the pressure is measured as it passes through the venous drip chamber 114 on the way through the downstream blood duct 116. As described above, the blood purifier 120 is incorporated in the blood circuit. Blood flows from the upstream side to the downstream side of the blood circuit. The venous drip chamber 114 is connected to the replacement fluid line 131. The fluid replacement line 131 may be connected to the arterial drip chamber 112 instead of the venous drip chamber 114.

The blood purifier 120 further includes a dialysate inlet 124 and a drainage outlet 123. A dialysate conduit 141 is connected to the dialysate inlet 124. A drainage pipe line 151 is connected to the drainage outlet 123.

The upstream end of the replacement fluid line 131 is connected to a first supply source 130 that supplies the first fluid 10, which is the replacement fluid and dialysate. A second pump 161 that delivers the replacement fluid at a set flow rate Qs is connected to the replacement fluid line 131. The second pump 161 is a veristaltic type pump, but may be a roller type pump. A first branch path 142 through which the first liquid 10 flows is connected to the replacement fluid line 131. A first valve 131v for opening and closing the replacement fluid line 131 is provided on the upstream side of the connection position with the first branch line 142 in the replacement fluid line 131. A second heater 171 for heating the replacement fluid is provided on the downstream side of the second pump 161 in the replacement fluid line 131. The second heater 171 may not be provided.

The replacement fluid that has flowed through the replacement fluid line 131 is supplied into the venous drip chamber 114. That is, the replacement fluid line 131 supplies the replacement fluid to the downstream side of the blood circuit from the blood purifier 120. When the replacement fluid line 131 is connected to the arterial side drip chamber 112, the replacement fluid line 131 supplies the replacement fluid from the blood purifier 120 to the upstream side of the blood circuit.

The upstream end of the dialysate line 141 is connected to the first branch line 142. A first pump 160 that delivers dialysate at a set flow rate Qd is connected to the dialysate line 141. The first pump 160 is a veristaltic type pump, but may be a roller type pump. The dialysate that has flowed through the dialysate line 141 is supplied into the blood purifier 120. A first heater 170 for heating the dialysate is provided on the downstream side of the first pump 160 in the dialysate line 141. The first heater 170 may not be provided.

The first branch path 142 is connected to a first liquid storage unit 140 capable of temporarily storing the first liquid 10 and delivering the stored first liquid 10. In the first branch line 142, a second valve 142v for opening and closing the first branch line 142 is provided between the connection position with the replacement fluid line 131 and the connection position with the dialysate line 141.

The drainage discharged from the blood purifier 120 is discharged from the downstream end of the drainage pipe line 151. A third pump 162 that sends out the drainage flowing through the drainage pipe line 151 at a set flow rate Qu is connected to the drainage pipe line 151. The third pump 162 is a veristaltic type pump, but may be a roller type pump.

A second branch path 152 through which drainage flows is connected to the drainage pipe line 151. In the drainage pipe line 151, a third valve 151v for opening and closing the drainage pipe line 151 is provided on the downstream side from the connection position with the second branch line 152.

The second branch path 152 is connected to a second liquid storage unit 150 capable of temporarily storing the drainage and delivering the stored drainage. The second branch path 152 is provided with a fourth valve 152v that opens and closes the second branch path 152.

The first liquid storage unit 140 and the second liquid storage unit 150 are housed in the storage unit 180. The accommodating unit 180 is connected to the measuring unit of the scale 139. In this embodiment, the scale 139 is a load cell. However, the scale 139 is not limited to the load cell, and may be only a spring or the like. The scale 139 measures the total weight change of the first liquid storage unit 140 and the second liquid storage unit 150.

Each of the first liquid storage unit 140 and the second liquid storage unit 150 may be in the shape of a bag or may be a hard container. When each of the first liquid storage unit 140 and the second liquid storage unit 150 is a hard container, the hard container is provided with a ventilation hole. Further, each of the first liquid storage unit 140 and the second liquid storage unit 150 may be a deformable bellows-shaped soft container.

Hereinafter, the operation for measuring the water removal rate in the blood purification device 100 according to the present embodiment will be described.

FIG. 2 is a circuit diagram showing a state in which the fourth valve is closed and the first valve, the second valve, and the third valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 3 is a circuit diagram showing a state in which the second valve and the fourth valve are closed and the first valve and the third valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 4 is a circuit diagram showing a state in which the first valve and the fourth valve are closed and the second valve and the third valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 5 is a circuit diagram showing a state in which the first valve and the third valve are closed and the second valve and the fourth valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 6 is a circuit diagram showing a state in which the first valve is closed and the second valve, the third valve, and the fourth valve are opened in the blood purification device according to the first embodiment of the present invention. FIG. 7 is a flowchart showing a step for measuring the water removal rate in the blood purification device according to the first embodiment of the present invention.

First, as shown in FIG. 7, the dialysate supply rate, the replacement fluid supply rate, the filtration rate in the blood purifier 120, and the water removal rate are set (S1). Next, the flow rate Qd of the first pump 160, the flow rate Qs of the second pump 161 and the flow rate Qs of the third pump 162 so as to satisfy each of the set dialysate supply rate, replacement solution supply rate, filtration rate and water removal rate. Each of the flow rates Qu is set.

Next, as shown in FIG. 2, with the fourth valve 152v closed and the first valve 131v, the second valve 142v, and the third valve 151v open, the blood pump 111, the first pump 160, and the first The two pumps 161 and the third pump 162 are operated. As a result, the first liquid 10 supplied from the first supply source 130 is supplied as a replacement fluid from the replacement fluid line 131 into the venous drip chamber 114 at a flow rate of Qs, and the first liquid is also supplied to the first branch passage 142. 10 flows in. The replacement fluid is in a state of being heated to a predetermined temperature by the second heater 171.

A part of the first liquid 10 that has flowed into the first branch passage 142 flows into the first liquid storage unit 140 due to the pressure due to the height difference between the arrangement of the first supply source 130 and the first liquid storage unit 140. The liquid is stored. The rest of the first liquid 10 that has flowed into the first branch road 142 flows into the dialysate pipe line 141. The first liquid 10 that has flowed into the dialysate line 141 is supplied as a dialysate from the dialysate line 141 into the blood purifier 120 at a flow rate of Qd. The dialysate is in a state of being heated to a predetermined temperature by the first heater 170. The drainage discharged from the blood purifier 120 flows through the drainage pipe line 151 at a flow rate of Qu and is discharged to the outside.

For example, the first liquid 10 is allowed to flow into the first liquid storage unit 140 until about 80% of the first liquid storage unit 140 is filled with the first liquid 10. Therefore, the first liquid storage unit 140 does not need to be precisely manufactured so that the capacity is accurate.

Next, as shown in FIG. 3, the second valve 142v and the fourth valve 152v are closed, and the first valve 131v and the third valve 151v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the inflow of the first liquid 10 from the replacement fluid line 131 to the first branch line 142 is stopped, and the first storage The first liquid 10 stored in the liquid unit 140 is sent out to the first branch passage 142, and further flows into the dialysate pipeline 141 at a flow rate of Qd. Qd can be actually measured by measuring the weight change of the accommodating portion 180 at this time with the scale 139. By this step, as shown in FIG. 7, the dialysate supply rate is measured (S2). After this step, the second valve 142v may be opened to restore the stored amount of the first liquid 10 of the first liquid storage unit 140.

Next, as shown in FIG. 4, the first valve 131v and the fourth valve 152v are closed, and the second valve 142v and the third valve 151v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the inflow of the first liquid 10 from the first supply source 130 to the replacement fluid line 131 is stopped, and the first storage The first liquid 10 stored in the liquid unit 140 is sent out to the first branch path 142. The first liquid 10 sent out to the first branch line 142 flows into the replacement fluid line 131 at a flow rate of Qs and flows into the dialysate line 141 at a flow rate of Qd. By measuring the weight change of the accommodating portion 180 at this time with the scale 139, (Qd + Qs) can be actually measured. The actual flow rate Qs can be calculated by subtracting the measured value of Qd obtained in the previous step from the measured value of (Qd + Qs). By this step, as shown in FIG. 7, the replacement fluid supply rate is measured (S3). After this step, the first valve 131v and the second valve 142v may be opened to recover the amount of the first liquid 10 of the first liquid storage unit 140.

Next, as shown in FIG. 5, the first valve 131v and the third valve 151v are closed, and the second valve 142v and the fourth valve 152v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the drainage of the drainage from the downstream end of the drainage pipe line 151 is stopped, and the drainage is discharged to the second branch passage 152. The liquid 20 flows in. The drainage 20 that has flowed into the second branch path 152 flows into the second liquid storage unit 150 at a flow rate of Qu and is stored.

Qu− (Qd + Qs) can be actually measured by measuring the weight change of the accommodating portion 180 at this time with the scale 139. Qu− (Qd + Qs) is the water removal rate. Since the actual flow rate Qd and the actual flow rate Qs are calculated in the previous step, the flow rate Qu can be calculated by adding the measured value of Qd and the measured value of Qs to the measured value of Qu− (Qd + Qs). Can be calculated. Qu is the filtration rate. By this step, as shown in FIG. 7, the filtration rate and the water removal rate are measured (S4).

For example, the drainage 20 is allowed to flow into the second liquid storage unit 150 until the predicted time is reached in which about 80% of the second liquid storage unit 150 is filled with the drainage 20. Therefore, the second liquid storage unit 150 does not need to be precisely manufactured so that the capacity is accurate. The amount of water removed can be accurately measured from the product of the operating time of the blood purification device 100 and the actual water removal rate.

Next, as shown in FIG. 6, the first valve 131v is closed, and the second valve 142v, the third valve 151v, and the fourth valve 152v are opened. When the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the drainage 20 stored in the second liquid storage unit 150 is sent out to the second branch path 152. The drainage 20 sent out to the second branch passage 152 flows into the drainage pipe line 151 and is discharged to the outside from the downstream end of the drainage pipe line 151.

As a method of sending the drainage 20 from the second liquid storage unit 150, the drainage 20 is freely dropped by gravity, the inside of the second liquid storage unit 150 is pressurized by an air pump or the like, or a second pressure device or the like is used. A method such as applying pressure to the second liquid storage unit 150 from the outside of the liquid storage unit 150 to crush the second liquid storage unit 150 can be adopted.

After all the drainage 20 in the second liquid storage unit 150 is drained, the fourth valve 152v is closed to open the first valve 131v, the second valve 142v, and the third valve 151v. As a result, the state returns to the state shown in FIG.

As shown in FIG. 7, each rate is reset based on the measurement results of the dialysis supply rate, the replacement fluid supply rate, the filtration rate, and the water removal rate obtained in the above steps S2 to S4 (S5).

If there is a difference between the actual dialysate supply rate measured in step S2 and the dialysate supply rate set in step S1, the output of the first pump 160 is adjusted. Specifically, when the actual flow rate Qd is larger than the set flow rate Qd, the output of the first pump 160 is lowered. When the actual flow rate Qd is smaller than the set flow rate Qd, the output of the first pump 160 is increased.

If there is a difference between the actual replacement fluid supply speed measured in step S3 and the replacement fluid supply speed set in step S1, the output of the second pump 161 is adjusted. Specifically, when the actual flow rate Qs is larger than the set flow rate Qs, the output of the second pump 161 is lowered. When the actual flow rate Qs is smaller than the set flow rate Qs, the output of the second pump 161 is increased.

If there is a difference between the actual filtration rate measured in step S4 and the filtration rate set in step S1, the output of the third pump 162 is adjusted. Specifically, when the actual flow rate Qu is larger than the set flow rate Qu, the output of the third pump 162 is lowered. When the actual flow rate Qu is smaller than the set flow rate Qu, the output of the third pump 162 is increased.

As described above, by adjusting the measured values of each of the flow rate Qd, the flow rate Qs, and the flow rate Qu so as to be close to the set value, the measured value of the water removal rate Qu− (Qd + Qs) can be brought close to the set value. it can. By repeating the above series of operations at regular intervals, the amount of water removed can be maintained accurately. It is preferable that the blood purification device 100 is provided with a control unit that performs the feedback control as described above.

The blood purification device 100 according to the present embodiment has a simple configuration because the amount of water removed can be accurately measured only by measuring the weight change of the accommodating portion 180 with the scale 139. Further, the delivery flow rates of the first pump 160, the second pump 161 and the third pump 162 can be measured while the first pump 160, the second pump 161 and the third pump 162 are continuously operated. it can.

In the present embodiment, the first supply source 130 is connected to the replacement fluid line 131, but the first supply source 130 may be connected to the dialysate line 141. Hereinafter, the blood purification device according to the modified example of the first embodiment of the present invention in which the first supply source 130 is connected to the dialysate pipeline 141 will be described. The description of the configuration similar to that of the blood purification device 100 according to the first embodiment of the present invention will not be repeated.

FIG. 8 is a circuit diagram showing a configuration of a blood purification device according to a modified example of the first embodiment of the present invention. As shown in FIG. 8, in the blood purification device 100a according to the modified example of the present embodiment, the upstream end of the dialysate conduit 141 is a first supply source for supplying the first liquid 10 which is a replacement fluid and a dialysate. It is connected to 130. A first branch passage 142 through which the first liquid 10 flows is connected to the dialysate pipe line 141. A first valve 131v for opening and closing the dialysate pipeline 141 is provided upstream of the connection position with the first branch passage 142 in the dialysate pipeline 141. The upstream end of the replacement fluid line 131 is connected to the first branch line 142.

Hereinafter, the operation for measuring the water removal rate in the blood purification device 100a according to the modified example of the present embodiment will be described.

FIG. 9 is a circuit diagram showing a state in which the fourth valve is closed and the first valve, the second valve, and the third valve are opened in the blood purification device according to the modified example of the first embodiment of the present invention. FIG. 10 is a circuit diagram showing a state in which the second valve and the fourth valve are closed and the first valve and the third valve are opened in the blood purification device according to the modified example of the first embodiment of the present invention. FIG. 11 is a circuit diagram showing a state in which the first valve and the fourth valve are closed and the second valve and the third valve are opened in the blood purification device according to the modified example of the first embodiment of the present invention. FIG. 12 is a circuit diagram showing a state in which the first valve and the third valve are closed and the second valve and the fourth valve are opened in the blood purification device according to the modified example of the first embodiment of the present invention. FIG. 13 is a circuit diagram showing a state in which the first valve is closed and the second valve, the third valve, and the fourth valve are opened in the blood purification device according to the modified example of the first embodiment of the present invention.

First, the dialysate supply rate, the replacement fluid supply rate, the filtration rate in the blood purifier 120, and the water removal rate are set. Next, the flow rate Qd of the first pump 160, the flow rate Qs of the second pump 161 and the flow rate Qs of the third pump 162 so as to satisfy each of the set dialysate supply rate, replacement solution supply rate, filtration rate and water removal rate. Each of the flow rates Qu is set.

Next, as shown in FIG. 9, with the fourth valve 152v closed and the first valve 131v, the second valve 142v, and the third valve 151v open, the blood pump 111, the first pump 160, and the first The two pumps 161 and the third pump 162 are operated. As a result, the first liquid 10 supplied from the first supply source 130 is supplied as dialysate from the dialysate pipe line 141 into the blood purifier 120 at a flow rate of Qd, and is also supplied to the first branch passage 142 as the first liquid. The liquid 10 flows in. The dialysate is in a state of being heated to a predetermined temperature by the first heater 170. The drainage discharged from the blood purifier 120 flows through the drainage pipe line 151 at a flow rate of Qu and is discharged to the outside.

A part of the first liquid 10 that has flowed into the first branch passage 142 flows into the first liquid storage unit 140 due to the pressure due to the height difference between the arrangement of the first supply source 130 and the first liquid storage unit 140. The liquid is stored. The rest of the first liquid 10 that has flowed into the first branch passage 142 flows into the replacement fluid line 131. The first liquid 10 that has flowed into the replacement fluid line 131 is supplied as a replacement fluid from the replacement fluid line 131 into the venous drip chamber 114 at a flow rate of Qs. The replacement fluid is in a state of being heated to a predetermined temperature by the second heater 171.

Next, as shown in FIG. 10, the second valve 142v and the fourth valve 152v are closed, and the first valve 131v and the third valve 151v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the inflow of the first liquid 10 from the dialysate pipe line 141 to the first branch line 142 is stopped, and the first The first liquid 10 stored in the liquid storage unit 140 is sent out to the first branch path 142, and further flows into the replacement fluid line 131 at a flow rate of Qs. Qs can be actually measured by measuring the weight change of the accommodating portion 180 at this time with the scale 139. By this step, the replacement fluid supply rate is measured. After this step, the second valve 142v may be opened to restore the stored amount of the first liquid 10 of the first liquid storage unit 140.

Next, as shown in FIG. 11, the first valve 131v and the fourth valve 152v are closed, and the second valve 142v and the third valve 151v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the inflow of the first liquid 10 from the first supply source 130 into the dialysate pipe 141 is stopped, and the first The first liquid 10 stored in the liquid storage unit 140 is sent out to the first branch path 142. The first liquid 10 sent out to the first branch line 142 flows into the replacement fluid line 131 at a flow rate of Qs and flows into the dialysate line 141 at a flow rate of Qd. By measuring the weight change of the accommodating portion 180 at this time with the scale 139, (Qd + Qs) can be actually measured. The actual flow rate Qd can be calculated by subtracting the measured value of Qs obtained in the previous step from the measured value of (Qd + Qs). By this step, the dialysate supply rate is measured. After this step, the first valve 131v and the second valve 142v may be opened to recover the amount of the first liquid 10 of the first liquid storage unit 140.

Next, as shown in FIG. 12, the first valve 131v and the third valve 151v are closed, and the second valve 142v and the fourth valve 152v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the drainage of the drainage from the downstream end of the drainage pipe line 151 is stopped, and the drainage is discharged to the second branch passage 152. The liquid 20 flows in. The drainage 20 that has flowed into the second branch path 152 flows into the second liquid storage unit 150 at a flow rate of Qu and is stored.

Qu− (Qd + Qs) can be actually measured by measuring the weight change of the accommodating portion 180 at this time with the scale 139. Qu− (Qd + Qs) is the water removal rate. Since the actual flow rate Qd and the actual flow rate Qs are calculated in the previous step, the flow rate Qu can be calculated by adding the measured value of Qd and the measured value of Qs to the measured value of Qu− (Qd + Qs). Can be calculated. Qu is the filtration rate. By this step, the filtration rate and the water removal rate are measured.

Next, as shown in FIG. 13, the first valve 131v is closed, and the second valve 142v, the third valve 151v, and the fourth valve 152v are opened. When the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the drainage 20 stored in the second liquid storage unit 150 is sent out to the second branch path 152. The drainage 20 sent out to the second branch passage 152 flows into the drainage pipe line 151 and is discharged to the outside from the downstream end of the drainage pipe line 151.

After all the drainage 20 in the second liquid storage unit 150 is drained, the fourth valve 152v is closed to open the first valve 131v, the second valve 142v, and the third valve 151v. As a result, the state returns to the state shown in FIG.

Each rate is reset based on the measurement results of the dialysis supply rate, the replacement fluid supply rate, the filtration rate, and the water removal rate obtained by the above steps.

The blood purification device 100a according to the modified example of the present embodiment also has a simple configuration because the amount of water removed can be accurately measured only by measuring the weight change of the accommodating portion 180 with the scale 139. Further, the delivery flow rates of the first pump 160, the second pump 161 and the third pump 162 can be measured while the first pump 160, the second pump 161 and the third pump 162 are continuously operated. it can.

(Embodiment 2)
Hereinafter, the blood purification apparatus according to the second embodiment of the present invention will be described with reference to the drawings. The blood purification device according to the second embodiment of the present invention mainly uses the second liquid as a dialysate separately from the first liquid as a replacement fluid, and the blood purification device 100 according to the first embodiment of the present invention. Therefore, the description of the same configuration as that of the blood purification device 100 according to the first embodiment of the present invention will not be repeated.

FIG. 14 is a circuit diagram showing the configuration of the blood purification device according to the second embodiment of the present invention. As shown in FIG. 14, the blood purifying device 200 according to the second embodiment of the present invention includes a blood purifying device 120, a replenishing fluid line 131, a dialysate line 141, a drainage line 151, and a first supply. Source 130, second supply source 230, first branch path 142, first liquid storage section 140, second branch path 152, second liquid storage section 150, third branch path 242, and third. Liquid storage unit 240, first pump 160, second pump 161 and third pump 162, first valve 131v, second valve 142v, third valve 151v, fourth valve 152v, and fifth. It includes a valve 141v and a scale 139.

When the blood purification device 200 is used for CHD, the blood purification device 200 includes a replacement fluid line 131, a first supply source 130, a second pump 161 and a first branch line 142, a first liquid storage unit 140, and a first liquid storage device 200. Does not include valve 131v. When the blood purification device 200 is used for CHF, the blood purification device 200 includes a dialysate pipe line 141, a second supply source 230, a first pump 160, a third branch line 242, a third liquid storage unit 240, and a fifth valve. Does not include 141v.

In this embodiment, the first liquid 10 is a replacement fluid. The upstream end of the dialysate line 141 is connected to a second supply source 230 for supplying the second liquid 30 which is the dialysate. A third branch passage 242 through which the second liquid 30 flows is connected to the dialysate pipe line 141. A fifth valve 141v for opening and closing the dialysate pipeline 141 is provided upstream of the connection position with the third branch passage 242 in the dialysate pipeline 141.

The third branch path 242 is connected to a third liquid storage unit 240 capable of temporarily storing the second liquid 30 and delivering the stored second liquid 30. The first liquid storage unit 140, the second liquid storage unit 150, and the third liquid storage unit 240 are housed in the storage unit 180. The scale 139 measures the total weight change of the first liquid storage unit 140, the second liquid storage unit 150, and the third liquid storage unit 240.

The third liquid storage unit 240 may have a bag shape or a hard container. When the third liquid storage unit 240 is a hard container, the hard container is provided with a ventilation hole. Further, the third liquid storage unit 240 may be a deformable bellows-shaped soft container.

Hereinafter, the operation for measuring the water removal rate in the blood purification device 200 according to the present embodiment will be described.

FIG. 15 is a circuit diagram showing a state in which the fourth valve is closed and the first valve, the second valve, the third valve, and the fifth valve are opened in the blood purification device according to the second embodiment of the present invention. FIG. 16 is a circuit diagram showing a state in which the second valve, the fourth valve, and the fifth valve are closed and the first valve and the third valve are opened in the blood purification device according to the second embodiment of the present invention. FIG. 17 is a circuit diagram showing a state in which the first valve, the fourth valve, and the fifth valve are closed and the second valve and the third valve are opened in the blood purification device according to the second embodiment of the present invention. FIG. 18 is a circuit diagram showing a state in which the first valve, the third valve, and the fifth valve are closed and the second valve and the fourth valve are opened in the blood purification device according to the second embodiment of the present invention. FIG. 19 is a circuit diagram showing a state in which the first valve and the fifth valve are closed and the second valve, the third valve, and the fourth valve are opened in the blood purification device according to the second embodiment of the present invention.

First, as shown in FIG. 7, the dialysate supply rate, the replacement fluid supply rate, the filtration rate in the blood purifier 120, and the water removal rate are set (S1). Next, the flow rate Qd of the first pump 160, the flow rate Qs of the second pump 161 and the flow rate Qs of the third pump 162 so as to satisfy each of the set dialysate supply rate, replacement solution supply rate, filtration rate and water removal rate. Each of the flow rates Qu is set.

Next, as shown in FIG. 15, with the fourth valve 152v closed and the first valve 131v, the second valve 142v, the third valve 151v, and the fifth valve 141v open, the blood pump 111, the first The 1st pump 160, the 2nd pump 161 and the 3rd pump 162 are operated. As a result, the first liquid 10 supplied from the first supply source 130 is supplied as a replacement fluid from the replacement fluid line 131 into the venous drip chamber 114 at a flow rate of Qs, and the first liquid is also supplied to the first branch passage 142. 10 flows in. The replacement fluid is in a state of being heated to a predetermined temperature by the second heater 171. The first liquid 10 that has flowed into the first branch path 142 flows into the first liquid storage unit 140 and is stored due to the pressure due to the height difference between the arrangement of the first supply source 130 and the first liquid storage unit 140. To.

The second liquid 30 supplied from the second supply source 230 is supplied as a dialysate from the dialysate pipe line 141 into the blood purifier 120 at a flow rate of Qd, and the second liquid 30 is also supplied to the third branch line 242. Inflow. The dialysate is in a state of being heated to a predetermined temperature by the first heater 170. The second liquid 30 that has flowed into the third branch path 242 flows into the third liquid storage unit 240 and is stored due to the pressure due to the height difference between the arrangement of the second supply source 230 and the third liquid storage unit 240. To. The drainage discharged from the blood purifier 120 flows through the drainage pipe line 151 at a flow rate of Qu and is discharged to the outside.

For example, the first liquid 10 is allowed to flow into the first liquid storage unit 140 until about 80% of the first liquid storage unit 140 is filled with the first liquid 10. Therefore, the first liquid storage unit 140 does not need to be precisely manufactured so that the capacity is accurate. Similarly, the second liquid 30 is allowed to flow into the third liquid storage unit 240 until about 80% of the third liquid storage unit 240 is filled with the second liquid 30 at the predicted time. Therefore, the third liquid storage unit 240 does not need to be precisely manufactured so that the capacity is accurate.

Next, as shown in FIG. 16, the second valve 142v, the fourth valve 152v, and the fifth valve 141v are closed, and the first valve 131v and the third valve 151v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the inflow of the second liquid 30 from the second supply source 230 into the dialysate line 141 is stopped, and the third The second liquid 30 stored in the liquid storage unit 240 is sent out to the third branch passage 242, and further flows into the dialysate pipe line 141 at a flow rate of Qd. Qd can be actually measured by measuring the weight change of the accommodating portion 180 at this time with the scale 139. By this step, as shown in FIG. 7, the dialysate supply rate is measured (S2). After this step, the fifth valve 141v may be opened to recover the amount of the second liquid 30 of the third liquid storage unit 240.

Next, as shown in FIG. 17, the first valve 131v, the fourth valve 152v and the fifth valve 141v are closed, and the second valve 142v and the third valve 151v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the inflow of the first liquid 10 from the first supply source 130 to the replacement fluid line 131 is stopped, and the first storage The first liquid 10 stored in the liquid unit 140 is sent out to the first branch path 142. The first liquid 10 sent out to the first branch passage 142 flows into the replacement fluid line 131 at a flow rate of Qs. By measuring the weight change of the accommodating portion 180 at this time with the scale 139, (Qd + Qs) can be actually measured. The actual flow rate Qs can be calculated by subtracting the measured value of Qd obtained in the previous step from the measured value of (Qd + Qs). By this step, as shown in FIG. 7, the replacement fluid supply rate is measured (S3). After this step, at least one of the first valve 131v and the fifth valve 141v is opened to store the amount of the first liquid 10 in the first liquid storage unit 140 and the second liquid 30 in the third liquid storage unit 240. At least one of the stored liquid volume of the liquid may be restored.

Next, as shown in FIG. 18, the first valve 131v, the third valve 151v and the fifth valve 141v are closed, and the second valve 142v and the fourth valve 152v are opened. As the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the drainage of the drainage from the downstream end of the drainage pipe line 151 is stopped, and the drainage is discharged to the second branch passage 152. The liquid 20 flows in. The drainage 20 that has flowed into the second branch path 152 flows into the second liquid storage unit 150 at a flow rate of Qu and is stored.

Qu− (Qd + Qs) can be actually measured by measuring the weight change of the accommodating portion 180 at this time with the scale 139. Qu− (Qd + Qs) is the water removal rate. Since the actual flow rate Qd and the actual flow rate Qs are calculated in the previous step, the flow rate Qu can be calculated by adding the measured value of Qd and the measured value of Qs to the measured value of Qu− (Qd + Qs). Can be calculated. Qu is the filtration rate. By this step, as shown in FIG. 7, the filtration rate and the water removal rate are measured (S4).

For example, the drainage 20 is allowed to flow into the second liquid storage unit 150 until the predicted time is reached in which about 80% of the second liquid storage unit 150 is filled with the drainage 20. Therefore, the second liquid storage unit 150 does not need to be precisely manufactured so that the capacity is accurate. The amount of water removed can be accurately measured from the product of the operating time of the blood purification device 200 and the actual water removal rate.

Next, as shown in FIG. 19, the first valve 131v and the fifth valve 141v are closed, and the second valve 142v, the third valve 151v, and the fourth valve 152v are opened. When the blood pump 111, the first pump 160, the second pump 161 and the third pump 162 continue to operate, the drainage 20 stored in the second liquid storage unit 150 is sent out to the second branch path 152. The drainage 20 sent out to the second branch passage 152 flows into the drainage pipe line 151 and is discharged to the outside from the downstream end of the drainage pipe line 151.

After all the drainage 20 in the second liquid storage unit 150 is discharged, the fourth valve 152v is closed and the first valve 131v, the second valve 142v, the third valve 151v and the fifth valve 141v are opened. To do. As a result, the state returns to the state shown in FIG.

As shown in FIG. 7, each rate is reset based on the measurement results of the dialysis supply rate, the replacement fluid supply rate, the filtration rate, and the water removal rate obtained in the above steps S2 to S4 (S5).

If there is a difference between the actual dialysate supply rate measured in step S2 and the dialysate supply rate set in step S1, the output of the first pump 160 is adjusted. Specifically, when the actual flow rate Qd is larger than the set flow rate Qd, the output of the first pump 160 is lowered. When the actual flow rate Qd is smaller than the set flow rate Qd, the output of the first pump 160 is increased.

If there is a difference between the actual replacement fluid supply speed measured in step S3 and the replacement fluid supply speed set in step S1, the output of the second pump 161 is adjusted. Specifically, when the actual flow rate Qs is larger than the set flow rate Qs, the output of the second pump 161 is lowered. When the actual flow rate Qs is smaller than the set flow rate Qs, the output of the second pump 161 is increased.

If there is a difference between the actual filtration rate measured in step S4 and the filtration rate set in step S1, the output of the third pump 162 is adjusted. Specifically, when the actual flow rate Qu is larger than the set flow rate Qu, the output of the third pump 162 is lowered. When the actual flow rate Qu is smaller than the set flow rate Qu, the output of the third pump 162 is increased.

As described above, by adjusting the measured values of each of the flow rate Qd, the flow rate Qs, and the flow rate Qu so as to be close to the set value, the measured value of the water removal rate Qu− (Qd + Qs) can be brought close to the set value. it can. By repeating the above series of operations at regular intervals, the amount of water removed can be maintained accurately. It is preferable that the blood purification device 200 is provided with a control unit that performs the feedback control as described above.

The blood purification device 200 according to the present embodiment has a simple configuration because the amount of water removed can be accurately measured only by measuring the weight change of the accommodating portion 180 with the scale 139. Further, the delivery flow rates of the first pump 160, the second pump 161 and the third pump 162 can be measured while the first pump 160, the second pump 161 and the third pump 162 are continuously operated. it can. In the blood purification device 200 according to the present embodiment, the replacement fluid and the dialysate can be liquids having different components.

Here, an example of the operation cycle of the blood purification device will be described. FIG. 20 is a flowchart showing an operation cycle of the blood purification device according to the second embodiment of the present invention. As shown in FIG. 20, the water removal rate is measured in the blood purification device 200 (S11). Next, it is determined whether the measured water removal rate is within the permissible range (S12). If the water removal rate is not within the permissible range, the water removal rate is feedback-controlled (S13). After that, the process returns to step S11.

When the water removal rate is within the permissible range, the dialysate supply rate is measured at regular intervals or when the measurement start signal is received (S23). Next, the replacement fluid supply rate is measured (S24). Next, the filtration rate is measured (S25). Next, each rate is feedback-controlled based on the measurement results of the dialysate supply rate, the replacement fluid supply rate, and the filtration rate (S26). After that, the process returns to step S11.

By operating the blood purification device 200 in the above series of operation cycles, the water removal rate can be stably maintained. The above operation cycle may be applied to the blood purification device 100 of the first embodiment.

It should be noted that the above-described embodiment disclosed this time is an example in all respects and does not serve as a basis for a limited interpretation. Therefore, the technical scope of the present invention is not construed solely by the above-described embodiments, but is defined based on the description of the claims. It also includes all changes within the meaning and scope of the claims.

10 1st solution, 20 drainage, 30 2nd solution, 100,200 Blood purification device, 110 upstream blood duct, 111 blood pump, 112 arterial drip chamber, 113 upstream pressure measuring device, 114 venous drip chamber , 115 downstream pressure measuring device, 116 downstream blood conduit, 120 blood purifier, 121 blood inlet, 122 blood outlet, 123 drain outlet, 124 dialysate inlet, 130 first source, 131 replacement fluid inlet, 131v 1st valve, 139 scale, 140 1st liquid storage section, 141 dialysate pipeline, 141v 5th valve, 142 1st branch path, 142v 2nd valve, 150 2nd liquid storage section, 151 drainage pipeline, 151v 3rd valve, 152 2nd branch, 152v 4th valve, 160 1st pump, 161 2nd pump, 162 3rd pump, 170 1st heater, 171 2nd heater, 180 accommodation, 230 2nd source, 240 3rd liquid storage unit, 242 3rd branch road.

Claims (3)

A blood purifier built into the blood circuit that allows blood to flow from the upstream side to the downstream side,
A fluid replacement line that supplies fluid replacement to the upstream side or the downstream side of the blood circuit from the blood purifier, and
A dialysate pipeline that supplies dialysate into the blood purifier,
A drainage pipe for flowing the drainage discharged from the blood purifier, and
A first supply source connected to the replacement fluid line and supplying the first fluid, which is the replacement fluid and the dialysate,
A first branch line connected to the replacement fluid line and the dialysate line and through which the first solution flows,
A first liquid storage unit that is connected to the first branch path, temporarily stores the first liquid, and can deliver the stored first liquid.
A second branch path connected to the drainage pipe and through which the drainage flows,
A second liquid storage unit that is connected to the second branch path, temporarily stores the drainage, and can deliver the stored drainage.
A first pump provided in the dialysate line and delivering the dialysate flowing through the dialysate line.
A second pump provided in the replacement fluid line and delivering the replacement fluid flowing through the replacement fluid line,
A third pump provided in the drainage pipe and delivering the drainage flowing through the drainage pipe, and a third pump.
A first valve provided on the upstream side of the connection position with the first branch line in the fluid replacement line and opens and closes the fluid replacement line.
In the first branch line, a second valve provided between the connection position with the replacement fluid line and the connection position with the dialysate line and opens and closes the first branch line.
In the drainage pipe, a third valve provided on the downstream side from the connection position with the second branch passage to open and close the drainage pipe, and
A fourth valve provided in the second branch path to open and close the second branch path,
A blood purification device including a scale for measuring an overall weight change of the first liquid storage unit and the second liquid storage unit. A blood purifier built into the blood circuit that allows blood to flow from the upstream side to the downstream side,
A fluid replacement line that supplies fluid replacement to the upstream side or the downstream side of the blood circuit from the blood purifier, and
A dialysate pipeline that supplies dialysate into the blood purifier,
A drainage pipe for flowing the drainage discharged from the blood purifier, and
A first supply source connected to the dialysate line and supplying the first fluid, which is the replacement fluid and the dialysate,
A first branch line connected to the replacement fluid line and the dialysate line and through which the first solution flows,
A first liquid storage unit that is connected to the first branch path, temporarily stores the first liquid, and can deliver the stored first liquid.
A second branch path connected to the drainage pipe and through which the drainage flows,
A second liquid storage unit that is connected to the second branch path, temporarily stores the drainage, and can deliver the stored drainage.
A first pump provided in the dialysate line and delivering the dialysate flowing through the dialysate line.
A second pump provided in the replacement fluid line and delivering the replacement fluid flowing through the replacement fluid line,
A third pump provided in the drainage pipe and delivering the drainage flowing through the drainage pipe, and a third pump.
A first valve provided on the upstream side of the connection position with the first branch line in the dialysate line and opens and closes the dialysate line.
In the first branch line, a second valve provided between the connection position with the replacement fluid line and the connection position with the dialysate line and opens and closes the first branch line.
In the drainage pipe, a third valve provided on the downstream side from the connection position with the second branch passage to open and close the drainage pipe, and
A fourth valve provided in the second branch path to open and close the second branch path,
A blood purification device including a scale for measuring an overall weight change of the first liquid storage unit and the second liquid storage unit. The blood purification apparatus according to claim 1 or 2 , wherein the scale is a load cell.

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