JP7148642B2 - 安定したアザシチジン含有医薬組成物の製造方法 - Google Patents
安定したアザシチジン含有医薬組成物の製造方法 Download PDFInfo
- Publication number
- JP7148642B2 JP7148642B2 JP2020566917A JP2020566917A JP7148642B2 JP 7148642 B2 JP7148642 B2 JP 7148642B2 JP 2020566917 A JP2020566917 A JP 2020566917A JP 2020566917 A JP2020566917 A JP 2020566917A JP 7148642 B2 JP7148642 B2 JP 7148642B2
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- JP
- Japan
- Prior art keywords
- azacitidine
- pharmaceutical composition
- solution
- temperature
- acetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022152920A JP2022185009A (ja) | 2018-05-30 | 2022-09-26 | 安定したアザシチジン含有医薬組成物の製造方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2018-0061784 | 2018-05-30 | ||
KR1020180061784A KR20190136284A (ko) | 2018-05-30 | 2018-05-30 | 안정한 아자시티딘-함유 약제학적 조성물의 제조방법 |
PCT/KR2019/006415 WO2019231225A1 (ko) | 2018-05-30 | 2019-05-29 | 안정한 아자시티딘-함유 약제학적 조성물의 제조방법 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022152920A Division JP2022185009A (ja) | 2018-05-30 | 2022-09-26 | 安定したアザシチジン含有医薬組成物の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022500350A JP2022500350A (ja) | 2022-01-04 |
JP7148642B2 true JP7148642B2 (ja) | 2022-10-05 |
Family
ID=68698347
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020566917A Active JP7148642B2 (ja) | 2018-05-30 | 2019-05-29 | 安定したアザシチジン含有医薬組成物の製造方法 |
JP2022152920A Pending JP2022185009A (ja) | 2018-05-30 | 2022-09-26 | 安定したアザシチジン含有医薬組成物の製造方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022152920A Pending JP2022185009A (ja) | 2018-05-30 | 2022-09-26 | 安定したアザシチジン含有医薬組成物の製造方法 |
Country Status (3)
Country | Link |
---|---|
JP (2) | JP7148642B2 (ko) |
KR (2) | KR20190136284A (ko) |
WO (1) | WO2019231225A1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110042247A1 (en) | 2009-06-25 | 2011-02-24 | Chandrasekhar Kocherlakota | Formulations of azacitidine and its derivatives |
WO2013117969A1 (en) | 2012-02-06 | 2013-08-15 | Fresenius Kabi Oncology Ltd. | Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis |
JP2014510755A (ja) | 2011-03-31 | 2014-05-01 | セルジーン インターナショナル サルル | 5−アザシチジンの合成 |
WO2014076616A2 (en) | 2012-11-19 | 2014-05-22 | Shilpa Medicare Limited | Formulations of 5-azacytidine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101286802B1 (ko) * | 2011-07-15 | 2013-07-23 | 보령제약 주식회사 | 아자시티딘의 전―동결건조 제제, 아자시티딘의 동결건조 제제 및 이의 제조방법 |
-
2018
- 2018-05-30 KR KR1020180061784A patent/KR20190136284A/ko active Application Filing
-
2019
- 2019-05-29 JP JP2020566917A patent/JP7148642B2/ja active Active
- 2019-05-29 WO PCT/KR2019/006415 patent/WO2019231225A1/ko active Application Filing
-
2021
- 2021-06-21 KR KR1020210079877A patent/KR20210078462A/ko not_active Application Discontinuation
-
2022
- 2022-09-26 JP JP2022152920A patent/JP2022185009A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110042247A1 (en) | 2009-06-25 | 2011-02-24 | Chandrasekhar Kocherlakota | Formulations of azacitidine and its derivatives |
JP2014510755A (ja) | 2011-03-31 | 2014-05-01 | セルジーン インターナショナル サルル | 5−アザシチジンの合成 |
WO2013117969A1 (en) | 2012-02-06 | 2013-08-15 | Fresenius Kabi Oncology Ltd. | Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis |
WO2014076616A2 (en) | 2012-11-19 | 2014-05-22 | Shilpa Medicare Limited | Formulations of 5-azacytidine |
Also Published As
Publication number | Publication date |
---|---|
KR20190136284A (ko) | 2019-12-10 |
WO2019231225A1 (ko) | 2019-12-05 |
KR20210078462A (ko) | 2021-06-28 |
JP2022185009A (ja) | 2022-12-13 |
JP2022500350A (ja) | 2022-01-04 |
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