JP7062050B2 - 老化の徴候を示す皮膚の診断方法 - Google Patents
老化の徴候を示す皮膚の診断方法 Download PDFInfo
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Description
a)前記対象の皮膚試料におけるIDEをコードする遺伝子の発現レベルを測定する工程
を含む方法を有する。
b)工程a)で測定したIDEをコードする遺伝子の発現レベルに基づいて、前記対象の皮膚が老化の徴候を有するかどうかを判定する工程
を含む。
a)前記対象の皮膚試料におけるIDEをコードする遺伝子の発現レベルを測定する工程、
b)工程a)から、前記対象の皮膚が老化の徴候を有するかどうかを推定する工程、及び
c)工程b)において、前記皮膚が老化の徴候を有するとされた場合、前記皮膚を、皮膚の老化の徴候の進行を低減及び/又は遅延させる化粧品組成物で処置する工程
を含む方法に関する。
a)候補化合物に曝露した皮膚試料においてIDEをコードする遺伝子の発現レベルを測定する工程、
b)前記発現レベルを前記化合物に曝露していない前記皮膚の試料における発現レベルと比較する工程、
c)候補化合物に曝露していない皮膚試料におけるIDEをコードする遺伝子の発現レベルに対して、前記候補化合物に曝露した皮膚試料におけるIDEをコードする遺伝子の発現レベルの増加が検出されたとき、前記候補化合物を皮膚の老化の徴候の進行を低減及び/又は遅延させるのに適切な化合物として同定する工程
を含む方法に関する。
a)皮膚試料においてIDEをコードする遺伝子の発現レベルを測定する手段、及び
b)使用説明書
を含むキットに関する。
Claims (5)
- 対象の皮膚における老化の徴候を検出する方法であって、
a)前記対象の皮膚試料におけるインスリン分解酵素(IDE)をコードする遺伝子の発現レベルを測定する工程を含み、
検出される皮膚の老化の徴候は、皮膚の著しいマイクロレリーフ、細かい線条、皺の出現及び弾力性の低下である、方法。 - 対象における老化の徴候を有する皮膚の美容的処置の方法であって、
a)前記対象の皮膚試料におけるIDEをコードする遺伝子の発現レベルを測定する工程、
b)工程a)から、前記対象の皮膚が老化の徴候を有するかどうかを推定する工程、及び
c)工程b)において、皮膚が老化の徴候を有するとされた場合、前記皮膚を、皮膚の老化の徴候の進行を低減及び/又は遅延させる化粧品組成物で処置する工程
を含み、
処置される皮膚の老化の徴候は、皮膚の著しいマイクロレリーフ、細かい線条、皺の出現及び弾力性の低下である、方法。 - 皮膚試料が、皮膚表面をこすることによって、又は粘着表面を使用して採取される、請求項1又は2に記載の方法。
- IDEをコードする遺伝子の発現レベルが、前記遺伝子のmRNAの発現レベルによって、又は前記遺伝子によってコードされるタンパク質の発現レベルの測定によって判定される、請求項1から3のいずれか一項に記載の方法。
- IDEをコードする遺伝子によってコードされるタンパク質の発現レベルが、IDEタンパク質の少なくとも1つの特異的リガンドを使用して測定される、請求項4に記載の方法。
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JP2022016295A JP2022069443A (ja) | 2017-08-23 | 2022-02-04 | 老化の徴候を示す皮膚の診断方法 |
Applications Claiming Priority (3)
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FR1757817A FR3070494B1 (fr) | 2017-08-23 | 2017-08-23 | Methode de diagnostic d'une peau presentant des signes de vieillissement |
FR1757817 | 2017-08-23 | ||
PCT/EP2018/072569 WO2019038290A1 (en) | 2017-08-23 | 2018-08-21 | DIAGNOSTIC METHOD FOR SKIN HAVING AGING SIGNS |
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JP2022016295A Division JP2022069443A (ja) | 2017-08-23 | 2022-02-04 | 老化の徴候を示す皮膚の診断方法 |
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JP2020531027A JP2020531027A (ja) | 2020-11-05 |
JP7062050B2 true JP7062050B2 (ja) | 2022-05-02 |
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JP2020511320A Active JP7062050B2 (ja) | 2017-08-23 | 2018-08-21 | 老化の徴候を示す皮膚の診断方法 |
JP2022016295A Pending JP2022069443A (ja) | 2017-08-23 | 2022-02-04 | 老化の徴候を示す皮膚の診断方法 |
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US (1) | US20200363428A1 (ja) |
EP (1) | EP3673270A1 (ja) |
JP (2) | JP7062050B2 (ja) |
KR (1) | KR102368508B1 (ja) |
FR (1) | FR3070494B1 (ja) |
WO (1) | WO2019038290A1 (ja) |
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US11127176B2 (en) | 2019-01-31 | 2021-09-21 | L'oreal | Systems and methods for visualizing future skin trends based on biomarker analysis |
US11501356B2 (en) | 2019-07-31 | 2022-11-15 | L'oreal | Systems and methods for generating personalized skincare formulations based on biomarker analysis |
US11741523B2 (en) | 2019-07-31 | 2023-08-29 | L'oreal | Personalized skincare recommendations based on biomarker analysis |
FR3100452B1 (fr) * | 2019-09-05 | 2021-09-17 | Oreal | Méthode de diagnostic de peaux agées |
Citations (1)
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US20130337085A1 (en) | 2010-12-13 | 2013-12-19 | L'oreal | Use of ide as a biomarker for a scalp condition |
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FR2667778B1 (fr) | 1990-10-16 | 1995-05-12 | Oreal | Cellule permettant de collecter sur la peau, par circulation de liquide, au moins un compose a doser. |
KR100961874B1 (ko) | 2010-04-05 | 2010-06-09 | 주식회사 나노엔텍 | 외부동력 없이 유체가 이동하는 유체분석용 칩 |
WO2012038929A1 (fr) * | 2010-09-24 | 2012-03-29 | L'oreal | Utilisation cosmetique de la dermcidine, analogues ou fragments de celle-ci |
KR101507234B1 (ko) | 2013-07-17 | 2015-03-31 | 로레알 | 생분자 추출기 및 생분자 추출방법 |
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2017
- 2017-08-23 FR FR1757817A patent/FR3070494B1/fr active Active
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- 2018-08-21 JP JP2020511320A patent/JP7062050B2/ja active Active
- 2018-08-21 US US16/638,878 patent/US20200363428A1/en active Pending
- 2018-08-21 EP EP18756245.9A patent/EP3673270A1/en active Pending
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Patent Citations (1)
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US20130337085A1 (en) | 2010-12-13 | 2013-12-19 | L'oreal | Use of ide as a biomarker for a scalp condition |
Non-Patent Citations (1)
Title |
---|
Hardman M J and Ashcroft G S,Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly,Genome biology,2008年,9(5), R80,1-17 |
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Publication number | Publication date |
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US20200363428A1 (en) | 2020-11-19 |
WO2019038290A1 (en) | 2019-02-28 |
JP2022069443A (ja) | 2022-05-11 |
FR3070494A1 (fr) | 2019-03-01 |
JP2020531027A (ja) | 2020-11-05 |
KR20200041971A (ko) | 2020-04-22 |
EP3673270A1 (en) | 2020-07-01 |
FR3070494B1 (fr) | 2022-07-01 |
KR102368508B1 (ko) | 2022-02-25 |
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