JP7036594B2 - Braf陽性癌を患っている患者を、braf阻害剤に対する非レスポンダーであると及びmapk/erk阻害剤に対するレスポンダーであると同定する手段及び方法 - Google Patents

Braf陽性癌を患っている患者を、braf阻害剤に対する非レスポンダーであると及びmapk/erk阻害剤に対するレスポンダーであると同定する手段及び方法 Download PDF

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JP7036594B2
JP7036594B2 JP2017522732A JP2017522732A JP7036594B2 JP 7036594 B2 JP7036594 B2 JP 7036594B2 JP 2017522732 A JP2017522732 A JP 2017522732A JP 2017522732 A JP2017522732 A JP 2017522732A JP 7036594 B2 JP7036594 B2 JP 7036594B2
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パウル レベック ミッチェル
ドゥンマー ラインハルト
ビドマー ダニエル
イネケ ゲールトチェス ラアイマケルス マリーケ
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JP2017522732A 2014-07-14 2015-07-13 Braf陽性癌を患っている患者を、braf阻害剤に対する非レスポンダーであると及びmapk/erk阻害剤に対するレスポンダーであると同定する手段及び方法 Active JP7036594B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14176944.8 2014-07-14
EP14176944 2014-07-14
PCT/EP2015/065986 WO2016008853A1 (en) 2014-07-14 2015-07-13 Means and methods for identifying a patient having a braf-positive cancer as a non-responder to a braf inhibitor and as a responder to an mapk/erk inhibitor

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JP2017529094A JP2017529094A (ja) 2017-10-05
JP2017529094A5 JP2017529094A5 (enExample) 2018-07-05
JP7036594B2 true JP7036594B2 (ja) 2022-03-15

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US (1) US20190194757A1 (enExample)
EP (1) EP3169797B2 (enExample)
JP (1) JP7036594B2 (enExample)
CN (1) CN107148481A (enExample)
CA (1) CA2953732C (enExample)
ES (1) ES2751925T5 (enExample)
WO (1) WO2016008853A1 (enExample)

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MX393780B (es) 2017-01-17 2025-03-24 Heparegenix Gmbh Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos
WO2018213302A1 (en) * 2017-05-16 2018-11-22 Biomed Valley Discoveries, Inc. Compositions and methods for treating cancer with atypical braf mutations
CN112795647B (zh) * 2019-11-14 2022-08-16 北京肿瘤医院(北京大学肿瘤医院) 一种肿瘤标志物及其应用
CN111020033A (zh) * 2019-12-24 2020-04-17 中山大学达安基因股份有限公司 多重检测braf基因突变的试剂盒及方法
EP4359781A4 (en) * 2021-06-23 2025-05-14 Royal Melbourne Institute of Technology CONDUCTOMETRIC SENSOR FOR DETECTING A NUCLEIC ACID AND ITS DETECTION METHOD

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2012068562A2 (en) 2010-11-19 2012-05-24 The Regents Of The University Of California Compositions and methods for detection and treatment of b-raf inhibitor-resistant melanomas
JP2013543008A (ja) 2010-11-19 2013-11-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッド Braf阻害剤による治療方法

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US20120252015A1 (en) * 2011-02-18 2012-10-04 Bio-Rad Laboratories Methods and compositions for detecting genetic material
CN103911428B (zh) * 2009-03-27 2016-02-24 生命技术公司 用于检测等位基因变体的方法、组合物和试剂盒
US20130315934A1 (en) * 2010-10-28 2013-11-28 Yale University Methods and Compositions for Assessing and Treating Cancer
WO2012061683A2 (en) 2010-11-05 2012-05-10 Glaxosmithkline Llc Methods for treating cancer
WO2014009318A1 (en) * 2012-07-11 2014-01-16 Boehringer Ingelheim International Gmbh 3-{3-[1 -(4-dimethylaminomethyl-phenylamino)-1 -phenyl-meth-(z)-ylidene]-2-oxo-2,3-dihydro-1 h-indol-6-yll-propynoic acid ethylamide and its use in the treatment of cancer
WO2014009319A1 (en) * 2012-07-11 2014-01-16 Boehringer Ingelheim International Gmbh Indolinone derivatives anticancer compounds
WO2014052613A2 (en) 2012-09-26 2014-04-03 Insight Genetics, Inc. Methods and compositions relating to next generation sequencing for genetic testing in alk related cancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068562A2 (en) 2010-11-19 2012-05-24 The Regents Of The University Of California Compositions and methods for detection and treatment of b-raf inhibitor-resistant melanomas
JP2013543008A (ja) 2010-11-19 2013-11-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッド Braf阻害剤による治療方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cancer Res.,2003年,Vol.63,No.15,pp.4561-4567
J.Mol.Diagn.,2013年,Vol.15,No.1,pp.94-100
MOLECULAR CANCER THERAPEUTICS,2012年4月1日,Vol.11,No.4,pp.909-920
Nature,2010年,Vol.468,No.7326,pp.973-977

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CA2953732A1 (en) 2016-01-21
JP2017529094A (ja) 2017-10-05
EP3169797A1 (en) 2017-05-24
EP3169797B2 (en) 2025-02-19
ES2751925T5 (en) 2025-05-13
ES2751925T3 (es) 2020-04-02
US20190194757A1 (en) 2019-06-27
EP3169797B1 (en) 2019-08-21
CA2953732C (en) 2023-09-26
CN107148481A (zh) 2017-09-08

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