JP7008920B2 - 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用 - Google Patents

血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用 Download PDF

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JP7008920B2
JP7008920B2 JP2017549388A JP2017549388A JP7008920B2 JP 7008920 B2 JP7008920 B2 JP 7008920B2 JP 2017549388 A JP2017549388 A JP 2017549388A JP 2017549388 A JP2017549388 A JP 2017549388A JP 7008920 B2 JP7008920 B2 JP 7008920B2
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antibody
hae
pharmaceutical composition
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JP2018514510A5 (enExample
JP2018514510A (ja
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チユン，ヤン
アデルマン，ブルト
ジェイ． セクストン，ダニエル
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017549388A 2015-03-30 2016-03-30 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用 Active JP7008920B2 (ja)

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JP2021204200A JP7309836B2 (ja) 2015-03-30 2021-12-16 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用
JP2023110592A JP2023130442A (ja) 2015-03-30 2023-07-05 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562140277P 2015-03-30 2015-03-30
US201562140289P 2015-03-30 2015-03-30
US62/140,289 2015-03-30
US62/140,277 2015-03-30
US201562214293P 2015-09-04 2015-09-04
US62/214,293 2015-09-04
PCT/US2016/024921 WO2016160926A1 (en) 2015-03-30 2016-03-30 Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack

Related Child Applications (1)

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JP2021204200A Division JP7309836B2 (ja) 2015-03-30 2021-12-16 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用

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JP2018514510A JP2018514510A (ja) 2018-06-07
JP2018514510A5 JP2018514510A5 (enExample) 2019-05-09
JP7008920B2 true JP7008920B2 (ja) 2022-01-25

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JP2017549388A Active JP7008920B2 (ja) 2015-03-30 2016-03-30 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用
JP2021204200A Active JP7309836B2 (ja) 2015-03-30 2021-12-16 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用
JP2023110592A Pending JP2023130442A (ja) 2015-03-30 2023-07-05 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用

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JP2023110592A Pending JP2023130442A (ja) 2015-03-30 2023-07-05 血漿カリクレイン阻害剤および遺伝性血管浮腫発作を予防するためのその使用

Country Status (14)

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US (2) US20180298110A1 (enExample)
EP (2) EP3286226A4 (enExample)
JP (3) JP7008920B2 (enExample)
KR (3) KR102799778B1 (enExample)
CN (1) CN107614532A (enExample)
AU (2) AU2016243160B2 (enExample)
BR (1) BR112017020864A2 (enExample)
CA (1) CA2979713A1 (enExample)
CO (1) CO2017009404A2 (enExample)
EA (1) EA201792161A1 (enExample)
HK (1) HK1250995A1 (enExample)
IL (2) IL305207A (enExample)
MX (2) MX2017012423A (enExample)
WO (1) WO2016160926A1 (enExample)

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ES2905545T3 (es) 2010-01-06 2022-04-11 Takeda Pharmaceuticals Co Proteínas de unión a calicreína plasmática
IL269565B2 (en) 2011-01-06 2024-06-01 Dyax Corp Plasma kallikrein binding proteins
EP2970502A4 (en) 2013-03-15 2016-11-30 Dyax Corp ANTI-PLASMA KALLIKREIN ANTIBODY
KR102424183B1 (ko) 2014-01-21 2022-07-26 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도
EP3122782A4 (en) 2014-03-27 2017-09-13 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
CN116077648A (zh) * 2015-12-11 2023-05-09 武田药品工业株式会社 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
MX2019002918A (es) 2016-09-16 2019-07-18 Dyax Corp Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activacion por contacto.
AU2018311976B2 (en) * 2017-08-04 2022-10-13 Takeda Pharmaceutical Company Limited Inhibitors of Plasma Kallikrein and uses thereof
WO2019166572A1 (en) * 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
JP2021515761A (ja) * 2018-02-28 2021-06-24 ライフサイ ファーマシューティカルズ，インク． 遺伝性血管浮腫の治療
CA3110689A1 (en) * 2018-08-30 2020-03-05 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
CN114166924B (zh) * 2021-12-03 2024-11-22 中国医学科学院北京协和医院 尿液蛋白标志物在诊断遗传性血管水肿中的用途

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WO2013186700A1 (en) 2012-06-12 2013-12-19 Novartis Ag Antibody formulation
JP2014515763A (ja) 2011-05-02 2014-07-03 ミレニアム ファーマシューティカルズ， インコーポレイテッド 抗α４β７抗体のための製剤
WO2014152232A2 (en) 2013-03-15 2014-09-25 Dyax Corp. Anti-plasma kallikrein antibodies

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KR102424183B1 (ko) * 2014-01-21 2022-07-26 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도

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JP2006501168A (ja) 2002-06-14 2006-01-12 メディミューン，インコーポレイテッド 安定化した抗ｒｓｖ抗体液体製剤
JP2014515763A (ja) 2011-05-02 2014-07-03 ミレニアム ファーマシューティカルズ， インコーポレイテッド 抗α４β７抗体のための製剤
WO2013186700A1 (en) 2012-06-12 2013-12-19 Novartis Ag Antibody formulation
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Also Published As

Publication number Publication date
EA201792161A1 (ru) 2018-04-30
IL305207A (en) 2023-10-01
KR20170135885A (ko) 2017-12-08
MX2023010206A (es) 2023-09-11
HK1250995A1 (zh) 2019-01-18
AU2016243160A1 (en) 2017-10-05
NZ735659A (en) 2023-08-25
MX2017012423A (es) 2018-01-26
AU2016243160B2 (en) 2022-02-24
JP2023130442A (ja) 2023-09-20
EP3916020A1 (en) 2021-12-01
EP3286226A1 (en) 2018-02-28
EP3286226A4 (en) 2018-12-05
JP7309836B2 (ja) 2023-07-18
NZ774543A (en) 2024-04-26
BR112017020864A2 (en) 2018-07-10
IL254292B1 (en) 2025-09-01
AU2022203180B2 (en) 2025-09-11
CO2017009404A2 (es) 2018-03-09
KR102799778B1 (ko) 2025-04-28
US20220169749A1 (en) 2022-06-02
JP2018514510A (ja) 2018-06-07
KR20250057946A (ko) 2025-04-29
CN107614532A (zh) 2018-01-19
KR102607829B1 (ko) 2023-12-01
IL254292A0 (en) 2017-10-31
JP2022037131A (ja) 2022-03-08
WO2016160926A1 (en) 2016-10-06
US20180298110A1 (en) 2018-10-18
KR20230164767A (ko) 2023-12-04
CA2979713A1 (en) 2016-10-06
AU2022203180A1 (en) 2022-06-02

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