JP6971986B2 - 免疫療法の抗腫瘍活性を高めるための間葉系幹細胞 - Google Patents

免疫療法の抗腫瘍活性を高めるための間葉系幹細胞 Download PDF

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JP6971986B2
JP6971986B2 JP2018534792A JP2018534792A JP6971986B2 JP 6971986 B2 JP6971986 B2 JP 6971986B2 JP 2018534792 A JP2018534792 A JP 2018534792A JP 2018534792 A JP2018534792 A JP 2018534792A JP 6971986 B2 JP6971986 B2 JP 6971986B2
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msc
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JP2019509715A (ja
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ヘルマン，フェリクス
ギュンター，クリスチーネ
ゲウマン，ウルフ
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アプセト ゲーエムベーハー アンド ツェーオー．カーゲー
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/54—Pancreas
    • A—HUMAN NECESSITIES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2018534792A 2016-04-01 2017-03-31 免疫療法の抗腫瘍活性を高めるための間葉系幹細胞 Active JP6971986B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16163557.8 2016-04-01
EP16163557 2016-04-01
EP16176185 2016-06-24
EP16176185.3 2016-06-24
PCT/EP2017/057679 WO2017167959A1 (en) 2016-04-01 2017-03-31 Mesenchymal stem cells to enhance anti-tumor activity of immunotherapy

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JP2019509715A JP2019509715A (ja) 2019-04-11
JP2019509715A5 JP2019509715A5 (enExample) 2020-05-07
JP6971986B2 true JP6971986B2 (ja) 2021-11-24

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US (2) US20190030152A1 (enExample)
EP (2) EP3730607A1 (enExample)
JP (1) JP6971986B2 (enExample)
KR (1) KR20190003456A (enExample)
CN (1) CN108884440A (enExample)
AU (2) AU2017242899A1 (enExample)
CA (1) CA3008352A1 (enExample)
ES (1) ES2823162T3 (enExample)
PL (1) PL3411473T3 (enExample)
WO (1) WO2017167959A1 (enExample)

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EP3606540A1 (en) * 2017-04-07 2020-02-12 Cynata Therapeutics Limited Method for treating a side effect of chimeric antigen receptor (car) t cell therapy
AU2018285953A1 (en) * 2017-06-16 2020-01-16 Cynata Therapeutics Limited Method for treating a side effect of immunotherapy
WO2019104037A1 (en) * 2017-11-22 2019-05-31 The Brigham And Women's Hospital, Inc. Msc-expressed immunomodulators in combination with car-t for cancer therapy
US20220133791A1 (en) * 2019-01-23 2022-05-05 Miltenyi Biotec B.V. & Co. KG A Combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject
KR20220137630A (ko) * 2020-02-05 2022-10-12 워싱턴 유니버시티 Il-7 단백질과 car-보유 면역 세포의 조합물로 고형 종양을 치료하는 방법
WO2022155585A2 (en) * 2021-01-15 2022-07-21 City Of Hope Methods of preparing and expanding type i innate lymphoid cells and therapeutic uses thereof
CN112980888B (zh) * 2021-02-22 2023-04-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 分泌il-6抗体/cd20抗体的间充质干细胞、构建方法及其应用
EP4180049A1 (en) * 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
CN115463155B (zh) * 2022-11-01 2023-05-23 卡瑞济(北京)生命科技有限公司 间充质干细胞的用途

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EP1757703A3 (en) 2005-08-24 2007-12-05 Medizinische Hochschule Hannover Self-inactivating retroviral vector
KR101022401B1 (ko) * 2005-09-29 2011-03-15 아주대학교산학협력단 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물
BRPI0811906A2 (pt) 2007-05-24 2014-11-18 Apceth Gmbh & Co Kg Composições e métodos relacionados a célula-tronco cd34
US8557578B2 (en) 2009-12-23 2013-10-15 Apceth Gmbh & Co. Kg Expansion medium for CD34-negative stem cells
CN102641298B (zh) * 2012-05-15 2014-03-05 祁岩超 一种预防和治疗肿瘤的效应细胞组合及其制备方法
WO2014087217A1 (en) * 2012-12-03 2014-06-12 Subhadra Dravida Allogenic mesendritic vector for ovarian cancer
AU2013370932B2 (en) * 2012-12-24 2019-02-21 Cell Ideas Pty Ltd Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy
CA2956987C (en) * 2014-08-18 2023-03-21 Apceth Gmbh & Co. Kg Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells
TW201619133A (zh) * 2014-08-21 2016-06-01 裘拉德製藥私人有限公司 新穎亞氨腈（ｉｍｉｎｏｎｉｔｒｉｌｅ）衍生物

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EP3730607A1 (en) 2020-10-28
ES2823162T3 (es) 2021-05-06
AU2023237078A1 (en) 2023-10-12
CA3008352A1 (en) 2017-10-05
AU2017242899A1 (en) 2018-07-05
PL3411473T3 (pl) 2021-05-04
JP2019509715A (ja) 2019-04-11
US20190030152A1 (en) 2019-01-31
CN108884440A (zh) 2018-11-23
US20230063829A1 (en) 2023-03-02
EP3411473B1 (en) 2020-07-08
EP3411473A1 (en) 2018-12-12
KR20190003456A (ko) 2019-01-09
WO2017167959A1 (en) 2017-10-05

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