JP6963560B2 - Ｔ細胞の拡張及び活性化の方法 - Google Patents

Ｔ細胞の拡張及び活性化の方法 Download PDF

Info

Publication number
JP6963560B2
JP6963560B2 JP2018548805A JP2018548805A JP6963560B2 JP 6963560 B2 JP6963560 B2 JP 6963560B2 JP 2018548805 A JP2018548805 A JP 2018548805A JP 2018548805 A JP2018548805 A JP 2018548805A JP 6963560 B2 JP6963560 B2 JP 6963560B2
Authority
JP
Japan
Prior art keywords
cells
cell
baff
activated
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018548805A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019508056A (ja
JP2019508056A5 (https=
Inventor
ペイマン ヘマッティ
デブラ ブルーム
Original Assignee
ウィスコンシン アラムニ リサーチ ファンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウィスコンシン アラムニ リサーチ ファンデーション filed Critical ウィスコンシン アラムニ リサーチ ファンデーション
Publication of JP2019508056A publication Critical patent/JP2019508056A/ja
Publication of JP2019508056A5 publication Critical patent/JP2019508056A5/ja
Priority to JP2021169476A priority Critical patent/JP2022023136A/ja
Application granted granted Critical
Publication of JP6963560B2 publication Critical patent/JP6963560B2/ja
Priority to JP2024063798A priority patent/JP2024091728A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Hospice & Palliative Care (AREA)
JP2018548805A 2016-03-14 2017-03-14 Ｔ細胞の拡張及び活性化の方法 Active JP6963560B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021169476A JP2022023136A (ja) 2016-03-14 2021-10-15 Ｔ細胞の拡張及び活性化の方法
JP2024063798A JP2024091728A (ja) 2016-03-14 2024-04-11 Ｔ細胞の拡張及び活性化の方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662307989P 2016-03-14 2016-03-14
US62/307,989 2016-03-14
PCT/US2017/022260 WO2017160806A1 (en) 2016-03-14 2017-03-14 Methods of t cell expansion and activation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021169476A Division JP2022023136A (ja) 2016-03-14 2021-10-15 Ｔ細胞の拡張及び活性化の方法

Publications (3)

Publication Number Publication Date
JP2019508056A JP2019508056A (ja) 2019-03-28
JP2019508056A5 JP2019508056A5 (https=) 2020-04-23
JP6963560B2 true JP6963560B2 (ja) 2021-11-10

Family

ID=58461445

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018548805A Active JP6963560B2 (ja) 2016-03-14 2017-03-14 Ｔ細胞の拡張及び活性化の方法
JP2021169476A Pending JP2022023136A (ja) 2016-03-14 2021-10-15 Ｔ細胞の拡張及び活性化の方法
JP2024063798A Pending JP2024091728A (ja) 2016-03-14 2024-04-11 Ｔ細胞の拡張及び活性化の方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021169476A Pending JP2022023136A (ja) 2016-03-14 2021-10-15 Ｔ細胞の拡張及び活性化の方法
JP2024063798A Pending JP2024091728A (ja) 2016-03-14 2024-04-11 Ｔ細胞の拡張及び活性化の方法

Country Status (4)

Country Link
US (3) US10563172B2 (https=)
EP (1) EP3430130B1 (https=)
JP (3) JP6963560B2 (https=)
WO (1) WO2017160806A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10563172B2 (en) * 2016-03-14 2020-02-18 Wisconsin Alumni Research Foundation Methods of T cell expansion and activation
EP4501408A3 (en) * 2017-11-17 2025-04-09 Iovance Biotherapeutics, Inc. Til expansion from fine needle aspirates and small biopsies
WO2025212837A1 (en) * 2024-04-04 2025-10-09 The Regents Of The University Of Michigan Enhanced anti-cancer t-cell therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003534283A (ja) 2000-05-25 2003-11-18 エクサイト セラピーズ， インコーポレイテッド 天然で誘導されたかまたは人工的に誘導された免疫抑制後にｔ細胞免疫サーベイランスを回復もしくは増強するための方法
WO2004094620A2 (en) * 2003-03-28 2004-11-04 Biogen Idec Ma Inc. Truncated baff receptors
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
CA2920377A1 (en) 2013-08-05 2015-02-12 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy
US11028143B2 (en) * 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
US10563172B2 (en) * 2016-03-14 2020-02-18 Wisconsin Alumni Research Foundation Methods of T cell expansion and activation

Also Published As

Publication number Publication date
JP2019508056A (ja) 2019-03-28
US12037606B2 (en) 2024-07-16
JP2024091728A (ja) 2024-07-05
EP3430130A1 (en) 2019-01-23
US20170260506A1 (en) 2017-09-14
US20200149010A1 (en) 2020-05-14
WO2017160806A1 (en) 2017-09-21
US20240398695A1 (en) 2024-12-05
CA3017603A1 (en) 2017-09-21
EP3430130B1 (en) 2023-01-04
US10563172B2 (en) 2020-02-18
JP2022023136A (ja) 2022-02-07

Similar Documents

Publication Publication Date Title
Klingemann The NK-92 cell line—30 years later: its impact on natural killer cell research and treatment of cancer
Wardell et al. Harnessing the biology of regulatory T cells to treat disease
US11730761B2 (en) Combination immune therapy and cytokine control therapy for cancer treatment
JP6858128B2 (ja) 癌治療のための免疫療法とサイトカイン制御療法との組み合わせ
RU2739770C2 (ru) Экспансия лимфоцитов с использованием композиции цитокинов для активной клеточной иммунотерапии
ES2765884T3 (es) Métodos de expansión y evaluación de linfocitos B y uso de linfocitos B expandidos para el tratamiento de enfermedades
CN112534044A (zh) 经修饰的多能干细胞及制备和使用方法
US20240398695A1 (en) Methods of T Cell Expansion and Activation
JP2020526194A (ja) 免疫療法薬と関連する毒性を評価するためのマウスモデル
WO2018229163A1 (en) Methods of activating v delta 2 negative gamma delta t cells
US20230312671A1 (en) Grp78 targeted adoptive cell therapy
Dwyer et al. IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
US12496298B2 (en) Natural killer cells
EP3834849A1 (en) Method for treating tumor using immune effector cell
Canto et al. Distinctive response of naive lymphocytes from cord blood to primary activation via TCR
US12325734B2 (en) Human immunodeficiency virus-specific T cell receptors
US20240226166A1 (en) CD8(+) Stem-Like Chronic Memory Cell Based Therapies and Compositions Related Thereto
EP3789485A1 (en) Cellular therapies for cancer
CN110337446B (zh) 过继细胞疗法中ccr2+造血干细胞介导的t细胞激活
US20240216427A1 (en) Chimeric antigen receptors targeting splice variants of the extracellular matrix proteins tenascin c (tnc) and procollagen 11a1 (col11a1)
CA3017603C (en) Methods of t cell expansion and activation
Bloom c12) United States Patent
Preece et al. Allo-defensive, multiplex base-edited, anti-CD38 CAR T cells for ‘off-the-shelf’Immunotherapy
JP2004315381A (ja) ナチュラルキラーＴ細胞のインターロイキン１８による刺激を利用した免疫疾患治療薬剤および治療キット、並びにＩｇＥ産生の制御方法
Janelle et al. T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies. Cancers 2021, 13, 598

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200311

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200311

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210208

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210218

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210518

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210715

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210915

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20211015

R150 Certificate of patent or registration of utility model

Ref document number: 6963560

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250