JP6961879B2 - 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 - Google Patents

変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 Download PDF

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JP6961879B2
JP6961879B2 JP2018534683A JP2018534683A JP6961879B2 JP 6961879 B2 JP6961879 B2 JP 6961879B2 JP 2018534683 A JP2018534683 A JP 2018534683A JP 2018534683 A JP2018534683 A JP 2018534683A JP 6961879 B2 JP6961879 B2 JP 6961879B2
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protein
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cancer
idh
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JP2019506380A (ja
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シ，ヤガン
キーナン，マリー・シー
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レ ラボラトワール セルヴィエ ソシエテ・パール・アクシオンス・サンプリフィエ
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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JP2018534683A 2015-12-30 2016-12-29 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 Expired - Fee Related JP6961879B2 (ja)

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US201562273135P 2015-12-30 2015-12-30
US62/273,135 2015-12-30
PCT/US2016/069161 WO2017117372A1 (en) 2015-12-30 2016-12-29 Treatment of tumors incorporating mutant isocitrate dehydrogenase

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JP2019506380A JP2019506380A (ja) 2019-03-07
JP2019506380A5 JP2019506380A5 (enExample) 2020-02-06
JP6961879B2 true JP6961879B2 (ja) 2021-11-05

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US (2) US20190025313A1 (enExample)
EP (1) EP3397625A4 (enExample)
JP (1) JP6961879B2 (enExample)
KR (1) KR20180102105A (enExample)
CN (1) CN108699023A (enExample)
AU (1) AU2016380280B2 (enExample)
CA (1) CA3009826A1 (enExample)
IL (1) IL260326A (enExample)
MX (1) MX2018008169A (enExample)
WO (1) WO2017117372A1 (enExample)

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CN106572968A (zh) 2014-05-08 2017-04-19 帕诺泰斯制药有限公司 用于治疗眼科疾病和障碍的化合物
SMT202100553T1 (it) 2017-04-24 2021-11-12 Aurigene Discovery Tech Ltd Metodi d'uso per derivati benzotriazolici trisostituiti come inibitori di diidroorotato ossigenasi
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
US11717512B2 (en) 2018-02-20 2023-08-08 Servier Pharmaceuticals Llc Methods of use for trisubstituted benzotriazole derivatives
EP3761960B1 (en) 2018-03-09 2023-11-22 Kiora Pharmaceuticals GmbH Ophthalmic formulation
KR102764121B1 (ko) * 2018-03-16 2025-02-05 이뮤닉 아게 항-염증제, 면역조절제 및 항-증식제로서의 신규한 칼슘 염 다형체
US10889548B2 (en) 2018-03-26 2021-01-12 Clear Creek Bio, Inc. Compositions and methods for inhibiting dihydroorotate dehydrogenase
JP7126556B2 (ja) 2018-09-28 2022-08-26 富士フイルム株式会社 シタラビンを含む抗腫瘍剤、シタラビンと併用される抗腫瘍効果増強剤、抗腫瘍用キット、およびシタラビンと併用される抗腫瘍剤
US20200171001A1 (en) * 2018-11-30 2020-06-04 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
EP3898597A1 (en) 2018-12-21 2021-10-27 Les Laboratoires Servier SAS Crystalline and salt forms of an organic compound and pharmaceutical compositions thereof
EP3750892A1 (en) 2019-06-14 2020-12-16 Yerevan State University Novel 5-cyclopropyl-furo[3,4-c]pyridine-3,4(1h,5h)-dione 1,1' substituted derivatives and their uses
US11228361B2 (en) 2019-10-25 2022-01-18 Atlas Space Operations, Inc. System and method for configuring a communications device for space-terrestrial communications
AU2020412805A1 (en) * 2019-12-26 2022-07-14 Hendrix College Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-CD38 therapeutic agent
US20210315880A1 (en) 2020-03-20 2021-10-14 Clear Creek Bio, Inc. Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
WO2022167402A1 (en) * 2021-02-02 2022-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of therapy comprising administering a therapeutically effective combination comprising a dhodh inhibitor and an idh inhibitor
MX2023009685A (es) 2021-02-19 2023-10-30 Sudo Biosciences Ltd Inhibidores de tyk2 y sus usos.
WO2022175747A1 (en) 2021-02-19 2022-08-25 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
EP4319766A4 (en) * 2021-04-08 2025-05-28 Memorial Sloan Kettering Cancer Center NADK2 INHIBITION IN CANCER AND FIBROTIC DISEASES
KR20250007508A (ko) 2022-03-09 2025-01-14 키오라 파마슈티칼스 게엠베하 디하이드로오로테이트 탈수소효소(dhod) 억제제의 다형체

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WO2003006424A1 (en) * 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US9316632B2 (en) * 2009-03-17 2016-04-19 Marshall University Research Corporation Methods of screening chemotherapeutic agents and treating cancer
JP5967827B2 (ja) * 2009-12-09 2016-08-10 アジオス ファーマシューティカルズ， インコーポレイテッド Ｉｄｈ変異体をもつことを特徴とする癌治療用の治療的活性化合物
WO2013049112A1 (en) * 2011-09-27 2013-04-04 Emory University Detection of biomarkers using magnetic resonance
CN106572968A (zh) * 2014-05-08 2017-04-19 帕诺泰斯制药有限公司 用于治疗眼科疾病和障碍的化合物
WO2017037022A1 (en) * 2015-09-01 2017-03-09 Bayer Pharma Aktiengesellschaft Compounds and methods useful for treating or preventing hematological cancers

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US20210088520A1 (en) 2021-03-25
WO2017117372A1 (en) 2017-07-06
EP3397625A1 (en) 2018-11-07
AU2016380280A1 (en) 2018-07-12
MX2018008169A (es) 2019-02-20
KR20180102105A (ko) 2018-09-14
CN108699023A (zh) 2018-10-23
JP2019506380A (ja) 2019-03-07
IL260326A (en) 2018-08-30
CA3009826A1 (en) 2017-07-06
AU2016380280B2 (en) 2021-09-23
EP3397625A4 (en) 2019-12-25
US20190025313A1 (en) 2019-01-24

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