JP6960856B2 - ヒト化インフルエンザモノクローナル抗体およびその使用方法 - Google Patents

ヒト化インフルエンザモノクローナル抗体およびその使用方法 Download PDF

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JP6960856B2
JP6960856B2 JP2017553107A JP2017553107A JP6960856B2 JP 6960856 B2 JP6960856 B2 JP 6960856B2 JP 2017553107 A JP2017553107 A JP 2017553107A JP 2017553107 A JP2017553107 A JP 2017553107A JP 6960856 B2 JP6960856 B2 JP 6960856B2
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antibody
acid sequence
seq
binding
amino acid
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JP2018518940A5 (OSRAM
JP2018518940A (ja
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ウェイン エイ． マラスコ
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デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017553107A 2015-04-08 2016-04-08 ヒト化インフルエンザモノクローナル抗体およびその使用方法 Active JP6960856B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021083700A JP2021121204A (ja) 2015-04-08 2021-05-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2023116535A JP2023130499A (ja) 2015-04-08 2023-07-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562144729P 2015-04-08 2015-04-08
US62/144,729 2015-04-08
PCT/US2016/026800 WO2016164835A1 (en) 2015-04-08 2016-04-08 Humanized influenza monoclonal antibodies and methods of use thereof

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JP2021083700A Division JP2021121204A (ja) 2015-04-08 2021-05-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

Publications (3)

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JP2018518940A JP2018518940A (ja) 2018-07-19
JP2018518940A5 JP2018518940A5 (OSRAM) 2019-05-16
JP6960856B2 true JP6960856B2 (ja) 2021-11-05

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JP2017553107A Active JP6960856B2 (ja) 2015-04-08 2016-04-08 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2021083700A Pending JP2021121204A (ja) 2015-04-08 2021-05-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2023116535A Withdrawn JP2023130499A (ja) 2015-04-08 2023-07-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

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JP2021083700A Pending JP2021121204A (ja) 2015-04-08 2021-05-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2023116535A Withdrawn JP2023130499A (ja) 2015-04-08 2023-07-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

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US (2) US11135282B2 (OSRAM)
EP (1) EP3280730B1 (OSRAM)
JP (3) JP6960856B2 (OSRAM)
KR (1) KR102668588B1 (OSRAM)
CN (1) CN107750253B (OSRAM)
AU (2) AU2016246065B2 (OSRAM)
CA (1) CA2981969C (OSRAM)
IL (2) IL254951B (OSRAM)
WO (1) WO2016164835A1 (OSRAM)

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JP2021534393A (ja) 2018-08-13 2021-12-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 疑似インビボ条件での治療用タンパク質の選択
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CN111423507B (zh) * 2019-01-10 2022-04-15 中国科学院分子细胞科学卓越创新中心 广谱性中和流感病毒的全人抗体
JP2022521819A (ja) 2019-03-25 2022-04-12 ビステラ， インコーポレイテッド インフルエンザを処置および予防するための組成物および方法
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Publication number Publication date
US11135282B2 (en) 2021-10-05
AU2016246065B2 (en) 2021-06-03
KR20170133507A (ko) 2017-12-05
CA2981969A1 (en) 2016-10-13
IL254951A0 (en) 2017-12-31
JP2021121204A (ja) 2021-08-26
JP2023130499A (ja) 2023-09-20
EP3280730A1 (en) 2018-02-14
CN107750253B (zh) 2022-10-04
AU2021225240A1 (en) 2021-09-30
KR102668588B1 (ko) 2024-05-22
EP3280730B1 (en) 2024-01-03
US12076390B2 (en) 2024-09-03
US20180099040A1 (en) 2018-04-12
WO2016164835A1 (en) 2016-10-13
IL286208A (en) 2021-10-31
CN107750253A (zh) 2018-03-02
AU2016246065A1 (en) 2017-10-26
US20220054624A1 (en) 2022-02-24
CA2981969C (en) 2023-12-05
JP2018518940A (ja) 2018-07-19
EP3280730C0 (en) 2024-01-03
IL254951B (en) 2021-09-30

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