JP6936453B2 - Metabolism measurement system - Google Patents

Description

The present invention relates to a metabolism measurement system and a metabolism measurement method, for example, various types of humans (humans) in sports gyms, hospitals, nursing homes for the elderly, general households and the like, dogs in animal hospitals and the like, and farmed fish in the culture system. It is suitable for measuring the metabolism of an organism, obtaining information such as metabolic activity and metabolic characteristics, and maintaining the health of the organism through these information.

Conventionally, as a method of measuring and detecting the exercise characteristics and metabolic capacity of athletes, patients, etc. at universities, hospitals, etc., or at home, and grasping the motor function status, cardiopulmonary function, health status, etc. The subject's appearance when an exercise load is applied, especially the movement of joint points, is digitally recorded, and a thermometer, pulse meter, pulse oximeter, gas analysis mask, etc. are attached, and body temperature, pulse, oxygen saturation, and exhalation. A method for measuring oxygen concentration and carbon dioxide concentration is known (see, for example, Non-Patent Document 1). In addition, a Newman calorimetry device has been developed that measures metabolism by measuring oxygen concentration and carbon dioxide concentration while controlling the supply and exhaust of gas to the room on a macro basis (see Non-Patent Document 2). ). Similarly, a system that exerts the same effect as high altitude training by artificially reducing the oxygen concentration in the room on a macro basis is also provided (see Non-Patent Document 3).

Japanese Patent No. 5329720

[Search on March 14, 2017], Internet <URL: http://www.soiken.info/clinical/area02/content03.html> [Search on October 9, 2017], Internet <URL: https://www.fujiika.com/> [Search on October 9, 2017], Internet <URL: http://www.snowdolphins.com/hypoxia/hypoxia_top.html> [Search on October 17, 2017], Internet <URL: https://www.nttdocomo.co.jp/info/news_release/2016/07/20_00.html>

However, in order to investigate the state of the subject during exercise, a method of measuring body temperature, pulse, oxygen saturation, oxygen concentration, carbon dioxide concentration, etc. by attaching a thermometer, pulse meter, pulse oximeter, breath analysis mask, etc. , It is a contact measurement, and there is an aspect that it cannot be said to be a non-invasive measurement in the sense that there is a risk of giving unnecessary stress to the subject's face, especially when wearing a breath analysis mask. In addition, considering the operation in a sports gym for an unspecified number of users, it is difficult to reuse masks, etc., it takes time to disinfect and wash, and it costs more to dispose of it at once. There is a problem. In addition, there is no metabolic measurement system in an environment where the oxygen concentration is controlled, especially in the non-contact type. Similarly, there is no system for measuring the metabolism of cultured terrestrial organisms in an environment in which the concentration of gas constituent molecules is controlled, or in an environment in which the concentration of dissolved gas in water is controlled.

Furthermore, when considering application in humans, since the subject's inspiration at the time of the measurement sucks the air in the measurement room, aerobic exercise is performed in a state where the number of floating dust is not small and the air is not clean. When doing this, especially when the amount of exercise is intense, the measurement must be a kind of invasive measurement in the sense that it forces the respiratory system to take in extra dust that does not normally need to be inhaled. ..

Furthermore, there is a drawback that the conventional metabolic analysis during activity by wearing a mask for performing breath analysis cannot be easily performed in a general sports gym or a general household.

In addition, the above-mentioned human calorimetry system has not necessarily been quantitatively evaluated and controlled in that it sufficiently reduces the number density of dust and bacteria (microbes) floating in the air. In addition, since the human caloriemetry system evaluates only from changes in gas concentration, it was not possible to distinguish whether the metabolism of a person is accompanied by body movement or not. It is possible to do this by measuring an electromyogram or the like, but there is a problem that it is a contact measurement and a slight bias can be applied. It was not possible to measure body movement information in a non-contact and non-invasive manner.

In addition, while controlling the oxygen concentration, the training system usually supplies nitrogen gas to a room isolated from the outside world to lower the oxygen concentration in the training room from the oxygen concentration in the normal atmosphere. Met. Therefore, if the volume of the room is V ₀ and the target oxygen concentration is η%, and the oxygen concentration in the normal atmosphere is η ₀ (= 20.9%), the oxygen volume V (O ₂ ) in the room = It becomes η _{0 V.} In this situation, in order to reduce the oxygen concentration in the room to η, V of nitrogen is introduced into the room from the outside, and for the sake of simplicity, if the pressure is allowed to rise once, the oxygen concentration is
η = η ₀ V ₀ / (V ₀ + V)
Will be. In this case, for example, in order to halve the oxygen concentration, it can be seen that the volume of nitrogen to be introduced needs to be the same as the volume of the room.

Therefore, the problem to be solved by the present invention is to stress the subjects such as athletes, inpatients during rehabilitation, people in general households who are practicing measures against metabolic syndrome, or more generally, organisms including animals. By providing a metabolic measurement system and a metabolic measurement method that can measure the metabolism of an organism under various conditions without giving it, and can grasp the metabolic capacity, health condition, etc. of the organism from the analysis results. be.

Another problem to be solved by the present invention is to improve the therapeutic effect of athletes and inpatients during rehabilitation under controlled low oxygen oxygen concentration with less nitrogen amount while measuring metabolism. Alternatively, by efficiently adding added gas species and molecular species to the normal air environment, the therapeutic effect, aroma effect, deodorizing effect, and bactericidal effect such as germs in the air are enhanced, thereby causing signs peculiar to the care period. By enabling detection and setting the molecular diffusion constant according to the corresponding molecular species in the gas exchange membrane, it is possible to monitor while amplifying the trace gas concentration (correspondence with the molecular species peculiar to the disease). By taking the above, for example, it is to provide a metabolism measurement system and a metabolism measurement method (which opens the way for non-contact and non-invasive discrimination of the presence or absence of cancer or other diseases).

Yet another problem to be solved by the present invention is the metabolism of the cultured terrestrial organism in an environment in which the concentration of gas constituent molecules is controlled, or the metabolism of the cultured aquatic organism in an environment in which the concentration of dissolved gas in water is controlled. By providing information on the metabolic activity and metabolic characteristics of the cultured organism, and by providing a metabolic measurement system and metabolic measurement method that maintain the health of the organism and contribute to high productivity through these information. be.

The above and other issues will be clarified by the following description with reference to the accompanying drawings.

In order to solve the above problems, the present invention
A room or closed space that constitutes an isolated closed system with no exchange of fluid as a mass flow between the outside world and the inside.
Oxygen concentration and dioxide inside at least the room or closed space of the organism, which is installed inside the room or closed space and is non-contact and non-invasive to the organism existing inside the room or closed space. It has a measuring device that measures the environment and / or biological information including carbon concentration.
It is a metabolism measurement system that measures the metabolism of the organism by measuring the environment and / or biological information with the measuring device in a state where the organism is inside the room or the closed space.

Here, the environmental information includes the oxygen concentration and the carbon dioxide concentration inside the room or the closed space, as well as the dust fine particle density, the temperature, the humidity, and the wind speed (the speed and direction of the air flow) inside the room or the closed space, for example. ), Pressure, odor (type and concentration of sweating components and chemical substances that cause odor), and in the case of terrestrial animals, for example, body movement, heartbeat, pulse, respiration, body temperature and its distribution. And so on. Environmental and / or biometric information is typically measured with, but is not limited to, time resolutions on the order of minutes.

The fluid is a gas or a liquid. Organisms include not only humans but also non-human animals such as terrestrial animals such as dogs, cows, horses, pigs and monkeys, as well as aquatic animals such as fish to be cultivated such as salmon.

The situation for measuring the metabolism of a subject is not only when performing various exercises (for example, exercise bike (registered trademark) rowing, running on a treadmill, strength training, etc.), but also when sleeping, eating and drinking, etc. You may.

This metabolic measurement system preferably further comprises a siege. This enclosure includes a first subspace that communicates with the room or closed space and a second subspace that communicates with the outside world, and the volume of the first and second subspaces is the volume of the internal space of the room or closed space. More than an order of magnitude smaller. Then, when there is a difference between the concentration of the constituent molecules of the fluid in the first subspace and the concentration of the constituent molecules of the fluid in the second subspace between the first subspace and the second subspace. Is due to a film capable of exchanging the above-mentioned constituent molecules in a direction in which the concentration of the constituent molecules of the fluid in the first subspace and the concentration of the constituent molecules of the fluid in the second subspace become the same depending on the concentration gradient. Separated. In this case, when controlling the internal environment of the room or the closed space, instead of directly controlling the internal environment of the room or the closed space, first change the internal environment of the second subspace, and then change the internal environment of the first subspace. By changing the internal environment, the internal environment of the room or closed space is controlled by the communication between the room or closed space and the first subspace. The outside world here does not necessarily mean the outdoors, but means the space outside the room or the closed space, and the form may be a room or a corridor adjacent to the room or the closed space. By doing so, the oxygen concentration inside the room or the closed space can be maintained at a sufficiently high concentration that does not interfere with the activity of the organism, and the carbon dioxide concentration inside the room or the closed space can be maintained at the activity of the organism. It can be maintained at a sufficiently low concentration that does not interfere with the production. This membrane is preferably a membrane that does not allow dust particles to pass through but allows molecules to pass through (a gas exchange membrane if the fluid is a gas). The membrane that does not allow the dust particles to pass through and allows the molecules to pass through is basically not limited as long as it allows the molecules to pass through between the spaces separated by the membrane, but for example, it allows the dust particles to pass through. Even if the pressure difference in the space separated by the membrane is 0, the molecules can be exchanged through this membrane when there is a difference in the partial pressure of the fluid components that make up the fluid on both sides of the membrane. Is preferable. From this, the membrane through which the molecules pass without passing through the dust fine particles can be, for example, a partition wall through which the molecules pass without passing through the dust fine particles. Here, "the dust fine particles do not pass through" includes not only the case where the dust fine particles do not pass completely (100%) but also the case where the dust fine particles do not pass exactly 100% (the same applies hereinafter). More specifically, the blocking rate (transmittance) of the dust fine particles is not 100% (0%), but at least 90% (10% or less), preferably 99%, for particles having a particle size of 10 μm or more. It is (1%) or less. As the film that does not allow dust particles to pass through but allows molecules to pass through, for example, when the fluid is a gas, it is preferably a film having a gas exchange function such as a dust filter material, a barrier paper, a non-woven fabric, or a barrier paper, and the fluid is a liquid. In the case of, it is preferable that the film has a liquid exchange function such as various liquid filter materials. When the fluid is a gas, as the material constituting this film, specifically, for example, synthetic fibers such as polyester or acrylic or cellulosic fibers such as pulp and rayon are used, and when the fluid is liquid. , Polyester, polyester, nylon 66, cellulose and the like are used. With the above action, this membrane converges the concentration of constituent molecules of the fluid in the room or closed space to almost the same value as that of the fluid in the outside world through the membrane, even if the fluid is not exchanged as a mass flow. Can be made to.

In this metabolism measurement system, preferably, the room or the closed space and the space in which the room or the closed space is installed do not pass through a membrane, especially a dust particle, capable of exchanging constituent molecules as described above. In addition to being separated by a passing membrane, the molecules are separated by an opening inside the room or closed space that sucks the fluid in the room or closed space, and after the suction fluid is cleaned, the whole amount is refilled in the room or closed space. A pair of outlets that return to the inside of the space are provided. By doing so, the density of dust particles inside the room or closed space can be maintained at a sufficiently low level, and the respiratory system of the organism is not overloaded. For this purpose, for example, a fan filter unit is installed inside or outside a room or closed space (eg, attic, etc.). Due to the installation of this fan filter unit, the total amount (100%) of the fluid after cleaning treatment via the fan filter unit, coupled with the fact that the room or closed space constitutes an isolated closed system, is inside the room or closed space. A 100% circulating feedback system that circulates is constructed.

In this metabolic measurement system, for example, the ultimate cleanliness of a room or closed space at rest is higher than the number density of dust particles released inside a room or closed space when the organism normally exercises. The cleanliness inside the room or closed space is set so that the corresponding number density of dust particles is reduced. Preferably, the interior of the room or closed space is maintained at a cleanliness of US209D class 100 or higher. If necessary, a dust counter (particle counter) that is non-contact and non-invasive to the organism is installed in a room or a closed space for this measurement of cleanliness. With this dust counter, it is possible to measure the time change of the number of dust particles inside a room or a closed space. In particular, when an organism moves inside a room or closed space, dust particles are generated. Therefore, by measuring the time change of the number of dust particles inside the room or closed space with a dust counter, the movement status of the organism can be determined. Can be detected. Further, preferably, with respect to the parameters of oxygen concentration, carbon dioxide concentration and the number of dust fine particles inside a room or a closed space, the state of activity of an organism or the like is detected by analyzing the time-varying characteristics of these parameters. Examples of the time change characteristic analysis include, but are not limited to, analysis based on a differential equation of concentration change. For example, by combining with machine learning and data mining software in the Big Data era, daily changes in the metabolic characteristics of living organisms, improvement of athletic ability, and detection / prevention of pathological changes can be mentioned. Be done.

により与えられる。流体が気体の場合、ηは上記部屋または閉空間の内部の目標酸素濃度であり、η＞０．１８程度である。 In this metabolism measurement system, typically, a membrane capable of exchanging constituent molecules, which separates the room or closed space from the space in which the room or closed space is installed, is a molecule that does not allow dust particles to pass through. In the case of a film to pass through, the volume of the chamber or closed space is V, the area of the membrane is A, the thickness of the membrane is L, the diffusion constant of oxygen in the membrane is D, inside the chamber or closed space. The oxygen consumption rate of the organism is B, the oxygen concentration inside the room or closed space when in equilibrium with the outside is η _o , the minimum allowable oxygen concentration in the fluid of the organism is η, and the time is t. When, η is

Given by. When the fluid is a gas, η is the target oxygen concentration inside the room or the closed space, and η> 0.18.

Further, in this metabolism measurement system, for example, in a state where an organism is inside a room or a closed space, the presence or absence of movement of the organism is quantitatively evaluated in a non-contact and non-invasive manner, and the environment is evaluated by the above-mentioned measuring device. And / or by measuring biological information, it is possible to discriminate and measure the dynamic metabolism and static metabolism of an organism. Alternatively, for example, by reducing the oxygen concentration in the second subspace of the enclosure, the oxygen concentration in the first subspace of the enclosure is reduced under quantitative control while maintaining isolation, through which the oxygen concentration is reduced. It is possible to reduce the oxygen concentration in the room or the closed space, improve the efficiency of the improvement of the cardiopulmonary function obtained by staying in the room or the closed space and performing training, and to investigate the biological condition of the above-mentioned organism. .. Further, for example, the fluid in the second subspace of the enclosure is supplied with molecules useful for the main organism in the room or closed space, and the first of the enclosure without compromising the closure of the room or closed space. It is present inside a room or closed space by increasing the concentration of the molecule in the subspace under quantitative control, thereby increasing its usefulness to the above-mentioned major organisms in the room or closed space. It is possible to restore, maintain or improve the vitality of an organism. In addition, the above membrane is composed of a material set to reduce the diffusion constant for the molecule of interest, and by increasing the concentration of specific gas molecules emitted from the organism, the detection accuracy is improved and the biological condition of the organism is investigated. You can also do it.

Moreover, this invention
The organism is non-contact and non-invasive to the organism in a state where the organism is inside a room or a closed space that constitutes an isolated closed system without exchange of fluid as a mass flow between the outside world and the inside. It is a metabolism measuring method for measuring the metabolism of the organism by measuring the environment and / or biological information including oxygen concentration and carbon dioxide concentration inside at least the room or the closed space of the body.

In the invention of this metabolism measurement method, as long as the property is not contrary to the above-mentioned invention of the metabolism measurement system, the above description holds.

According to the present invention, the organism includes at least an oxygen concentration meter and a carbon dioxide concentration of the organism in a non-contact and non-invasive manner with respect to the organism under various conditions such as a situation in which the organism is performing activities such as exercise. Since it measures the environment and / or biological information, it is possible to measure the metabolism without stressing the organism, thereby changing the metabolic capacity of the organism over time, anaerobic exercise compatible muscle mass, and aerobic exercise compatible. It is possible to grasp the muscle mass and the like, and further, by accumulating the measurement data, it is possible to grasp the change over time and the health state of the living body. In particular, dust inside a room or closed space is provided by a non-contact and non-invasive dust counter to the organism while the organism is moving, with the interior of the room or closed space maintained at a sufficiently high degree of cleanliness. When detecting the movement status of an organism by measuring the time change of the number of fine particles, it is possible to detect the metabolism status during exercise without giving stress to the organism, and the respiratory system of the organism. It is possible to grasp the above information and the health condition of the organism without giving a load such as inhalation of dust to the organism. In addition, by taking a liquid (water system) as an example of the above fluid, it is effective in improving the productivity of fish such as salmon and mackerel.

It is a schematic diagram which shows the metabolism measurement system by 1st Embodiment. It is a top view which shows an example of the gas exchange part of the gas exchange unit used in the metabolism measurement system by 1st Embodiment. It is a front view which shows an example of the gas exchange part of the gas exchange unit used in the metabolism measurement system by 1st Embodiment. It is a side view which shows an example of the gas exchange part of the gas exchange unit used in the metabolism measurement system by 1st Embodiment. It is sectional drawing along the 5-5 line of FIG. It is a front view, the left side view and the right side view which show an example of the gas exchange unit used in the metabolism measurement system by 1st Embodiment. It is a drawing substitute photograph which shows the metabolism measurement system by an Example. It is a drawing substitute photograph which shows the gas exchange unit used in the metabolism measurement system by an Example. It is a drawing substitute photograph which shows the state of performing the candle burning experiment in the room of the metabolism measurement system by an Example. It is a schematic diagram which shows the time change of oxygen concentration and carbon dioxide concentration at the time of performing a candle burning experiment in the room of the metabolism measurement system by Example. It is a schematic diagram which shows the logarithmic display result of the difference between the oxygen concentration and carbon dioxide concentration in a room, and the oxygen concentration and carbon dioxide concentration of the outside world based on the experimental result shown in FIG. It is a drawing-substituting photograph showing a state in which an exercise bike (registered trademark) is installed inside a room in the metabolism measurement system according to the embodiment. FIG. 5 is a schematic diagram showing changes and differences in oxygen concentration and carbon dioxide concentration with respect to the time after the start of exercise of exercise bike (registered trademark) of subject 1 in the metabolism measurement system according to the embodiment. FIG. 5 is a schematic diagram showing changes and differences in oxygen concentration and carbon dioxide concentration with respect to the time after the start of exercise of exercise bike (registered trademark) of subject 2 in the metabolism measurement system according to the embodiment. It is a schematic diagram which shows the change of the calorie consumption with respect to the walking speed converted from the exercise bike (registered trademark) rowing speed of subjects 1 and 2 in the metabolism measurement system by an Example. It is a schematic diagram which shows the time change of the carbon dioxide concentration and the count number of the dust fine particle of a particle size 0.5 μm or more when the subject 2 performed the behavior similar to the daily life in the metabolism measurement system by an Example. FIG. 5 is a schematic diagram showing a change in carbon dioxide concentration with respect to the count number of dust fine particles having a particle size of 0.5 μm or more, which is obtained from the data shown in FIG. FIG. 6 is a log-log diagram showing a change in the total carbon dioxide concentration for 65 seconds with respect to the count number of dust fine particles having a particle size of 0.5 μm or more, which is obtained from the data shown in FIG. It is a schematic diagram which shows the tent type CUSP. It is a schematic diagram which shows the body movement experiment result in the tent type CUSP shown in FIG. It is a drawing substitute photograph showing a measurement system showing that the oxygen concentration of the closed space itself can be changed by changing the oxygen concentration of the outside world and changing the oxygen concentration of the space communicating with the inside air of the gas exchange unit. It is a schematic diagram which shows the experimental result which shows that the oxygen concentration of a closed space itself can be changed by changing the oxygen concentration of the outside world and changing the oxygen concentration of the space which communicates with the inside air of a gas exchange unit. It is a schematic diagram for explaining the improved TPC. It is a schematic diagram for explaining the improved TPC. It is a schematic diagram which shows the result obtained in the experiment using the improved TPC shown in FIG. It is a schematic diagram which shows the result of the correspondence experiment with PSG and KSG. It is a schematic diagram which shows the result of another correspondence experiment with PSG and KSG. It is a schematic diagram which shows the metabolism measurement system by 2nd Embodiment. It is a schematic diagram which shows the metabolism measurement system by 3rd Embodiment.

Hereinafter, embodiments for carrying out the invention (hereinafter referred to as “embodiments”) will be described.

<First Embodiment>
[Metabolism measurement system]
FIG. 1 shows a metabolism measurement system according to the first embodiment. As shown in FIG. 1, this metabolic measurement system has a room or closed space 101 that constitutes an isolated closed system with no exchange as a mass flow of gas between the outside world and the inside. The side wall of the room or the closed space 101 is provided with an entrance (not shown) for the subject 102 to enter and exit the inside of the room or the closed space 101, for example, a sliding sliding door. Subject 102 is an organism, specifically a human or animal, but here humans are illustrated as an example. The size (width, depth, height) of the interior of the room or closed space 101 is chosen large enough to accommodate the subject 102 and measure metabolism under the required circumstances, and the interior of the room or closed space 101. It is selected as necessary in consideration of the size of incidental equipment to be installed in. The shape of the room or closed space 101 is also selected as needed. Inside the room or closed space 101, a measuring device 103 for measuring the environmental and / or biological information of the subject 102 including at least the oxygen concentration and the carbon dioxide concentration inside the room or the closed space 101 is provided. There is. A plurality of measuring devices 103 may be installed depending on the measurement environment and / or biological information. The position where the measuring device 103 is installed is selected as needed. Inside the room or closed space 101, there is an opening (not shown) that takes in the inside air of this room or closed space 101, and a blowout that returns the entire amount to the inside of the room or closed space 101 after cleaning the suction air. A pair of mouths (not shown) is provided. In this example, this is realized by the fan filter unit 104 installed on the floor of the room or the closed space 101, but the cleaning treatment portion itself can be provided outside the room or the closed space 101. A 100% circulation feedback system is configured by a fan filter unit 104 installed on the floor of a room or a closed space 101. The cleanliness of the background inside the room or closed space 101 is preferably maintained at US 209D Class 100 or higher. By maintaining a high degree of cleanliness inside the room or the closed space 101 in this way, the number of dust particles sucked by the subject 102 during the measurement can be significantly reduced, and the load applied to the subject 102 can be significantly reduced. It can be mitigated. Further, when the movement state of the subject 102 is detected by measuring the number of dust fine particles, the background noise due to the remaining dust fine particles can be significantly suppressed, and the density of the dust fine particles generated by the movement of the subject 102 can be significantly suppressed. Changes can be clearly extracted. Further, in order to provide a gas exchange ability between the inside of the room or the closed space 101 and the outside world, for example, at least one part of the wall of the room or the closed space 101 does not allow dust fine particles to pass through, and gas molecules are allowed to pass. A gas exchange unit composed of a passing membrane, that is, a gas exchange membrane, or using a gas exchange membrane is installed. The gas exchange unit is described in, for example, Patent Document 1 (in Patent Document 1, it is described as a gas exchange device). FIG. 1 shows an example in which the gas exchange unit 105 is installed on the floor of a room or a closed space 101. Here, equation (1) holds. A dust counter (not shown) is installed inside the room or the closed space 101 as needed. Inside the room or the closed space 101, necessary ancillary equipment is installed depending on the situation in which the metabolism of the subject 102 is measured. For example, when measuring the metabolism of the subject 102 during exercise, for example, an exercise bike (registered trademark) (fitness bike), a treadmill (running machine), or the like is installed on the floor of a room or a closed space 101. Alternatively, when measuring the metabolism of the subject 102 during eating and drinking, a table, a chair, or the like is installed according to the subject 102. Alternatively, when measuring the metabolism of the subject 102 during sleep, a bed, a futon, a mat, or the like is installed according to the subject 102. Environmental and / or biometric information as a function of time t, especially oxygen and carbon dioxide concentrations, measured by measuring device 103 is sent to a computer 106 installed outside the room or closed space 101 by wire or wirelessly. Can be done. For example, the measuring device 103 and the computer 106 are connected by a LAN. Then, the calorie consumption of the subject 102 and the like can be obtained from the measured environment and / or biological information, the oxygen concentration and the carbon dioxide concentration inside the special room or the closed space 101 by the computing device of the computer 106. It has become possible to perform time-varying characteristic analysis, for example, autocorrelation function analysis and analysis based on the fast Fourier transform. The results of oxygen concentration, carbon dioxide concentration, calorie consumption, etc. and time change characteristic analysis can be displayed on a display connected to the computer 106, and if necessary, a printer connected to the computer 106 (not shown). It can be printed with, and can be stored in the storage device of the computer 106 or an external storage device connected to the computer 106. In this case, for example, a mobile phone may be used to aggregate information by a computer installed at an analysis and corresponding service base by wireless communication for analysis and data management.

The room or closed space 101 may be provided independently, for example, a room of a general detached house, a room of an apartment such as an apartment, a room of a hospital, a room of an elderly care facility, etc. It may be.

Specifically, the gas exchange unit 105 is configured as follows, for example. 2 to 5 show an example of the configuration of the gas exchange unit 50 inside the gas exchange unit 105. Here, FIGS. 2, 3, 4, and 5 are a top view, a front view, a side view, and a cross-sectional view taken along line 5-5 of FIG. 2, respectively.

As shown in FIGS. 2 to 5, the gas exchange unit 50 is configured as follows. That is, for example, a gas exchange film 52 is stretched on _{two spacers S 1 having a height h 1} of a rectangular cross section provided along two sides facing each other on one surface of a rectangular flat plate 51, and a gas exchange film 52 is stretched on the two spacers S _1. A spacer S _{2 having a height h 2} of a rectangular cross section provided on a portion corresponding to two opposite sides orthogonal to the spacer S ₁ is laminated with a gas exchange film 52, and a gas exchange film 52 is laminated on _{the spacer S 2.} , A gas exchange film 52 stretched on the spacer S ₁ having a height h ₁ is laminated, and similarly, a gas exchange film 52 stretched on _{the spacer S 2} and gas exchange on the _{spacer S 1.} which membrane 52 is stretched and are repeatedly stacked alternately, on what the gas exchange membrane 52 is stretched over the end of the spacer S _1, opposite to each other on one surface of the flat plate 53 of the same shape as the flat plate 51 two spacers S ₂ of the two heights of the rectangular cross-section which is provided along the sides h ₂ is provided by the spacer S ₂ below. In this example, a total of 19 gas exchange films 52 are provided, but it goes without saying that the present invention is not limited to this. Because the gas exchange membrane 52 is typically extremely thin, ignoring the thickness of approximately h ₂ is the distance between the separated by a spacer S ₂ two gas exchange membrane 52, two of which are separated by a spacer S ₁ The distance between the gas exchange membranes 52 is approximately h ₁ . The space between the two gas exchange membranes 52 separated by the spacer S ₂ is a space through which the inside air passes, and the space between the two gas exchange membranes 52 separated by the _{spacer S 1 allows the outside air to pass through.} It is a space to be. The directions in which the outside air and the inside air flow are selected as necessary, and they do not have to be orthogonal to each other even if they are orthogonal to each other. h ₁ and h ₂ are selected as needed, but in order to efficiently exchange carbon dioxide in the inside air with oxygen in the outside air via the gas exchange membrane 52, the outside air is introduced with respect to the amount of the inside air introduced. Since it is desirable to increase the amount relatively, it is generally set to h ₁ ≧ h _2, and preferably h ₁ > h ₂ . In the gas exchange unit 50 shown in FIGS. 2 to 5, the case where _{h 1} > h _{2 is shown.} Specifically, for example, h ₁ ≈ (1 to 7) × h ₂ is selected. For example, h ₁ = 25 mm and h ₂ = 5 mm. If h ₁ and h ₂ are not equal, change the shape of the gas exchange part 50 in FIG. 4 from a square to the aspect ratio in the direction of aligning the ventilation conductance of the outside air and the inside air according to the ratio of _{h 1} and h _2. It is preferably a set rectangle.

The gas exchange unit 105 is configured, for example, as shown in FIGS. 6A, B and C. Here, FIGS. 6A, B, and C are a front view, a left side view, and a right side view of the gas exchange unit 105, respectively. As shown in FIGS. 6A, B and C, the gas exchange unit 105 has a rectangular parallelepiped enclosure 60. Inside the surrounding body 60, the gas exchange portion 50 shown in FIGS. 2 to 5 is housed in a state of being rotated by a predetermined angle, for example, 10 ° or more and 30 ° or less with respect to the surrounding body 60. Here, the gas exchange unit 50 is housed in the enclosure 60 with its four ridges inscribed on each inner surface of the enclosure 60. A cylindrical outside air introduction port 71 and a discharge port 72 are provided on one side surface of the enclosure 60 and an upper surface on the side surface side, respectively, and a cylindrical discharge port 73 is provided on the other side surface facing the side surface. A cylindrical inside air recovery port 74 is provided on the lower surface on the side surface side. In this case, the outside air introduced from the outside air introduction port 71 _{passes through the space between the two gas exchange membranes 52 separated by the spacer S 1} of the gas exchange section 50, and then is discharged from the discharge port 73 to the outside world. Communicate. Further, the inside air introduced from the inside air recovery port 74 _{passes through the space between the two gas exchange membranes 52 separated by the spacer S 2} of the gas exchange section 50, and then is returned from the discharge port 72 to the room (or). Closed space).

[How to use the metabolism measurement system]
How to use this metabolism measurement system will be described.

First, the inside of the room or the closed space 101 is maintained at a predetermined cleanliness by operating the fan filter unit 104. In this state, the subject 102 is put inside through the doorway of the room or the closed space 101. When the subject 102 enters the inside of the room or the closed space 101, the cleanliness of the inside of the room or the closed space 101 is temporarily lowered, so that the cleanliness of the inside of the room or the closed space 101 is waited to be restored to the predetermined cleanliness. When the cleanliness inside the room or the closed space 101 is restored to a predetermined cleanliness, the power of the measuring device 103 is turned on. If necessary, the power of the measuring device 103 may be turned on at all times. Inside the room or the closed space 101, necessary ancillary equipment is installed depending on the situation in which the metabolism of the subject 102 is measured. For example, if the subject 102 is a human and the metabolism of the human during exercise is to be measured, an exercise bike (registered trademark), a treadmill, or the like is installed. In this way, the environment and / or biological information of the subject 102, the oxygen concentration and the carbon dioxide concentration inside the special room or the closed space 101 are measured by the measuring device 103 in the target situation. Then, the environment and / or biological information thus acquired, the oxygen concentration and the carbon dioxide concentration inside the special room or the closed space 101 are sent to the computer 103, and the metabolism of the subject is measured by obtaining the calorie consumption, or the time. The metabolism of the subject is measured by performing change characteristic analysis or the like.

FIG. 7 shows the rooms constituting the isolated closed system used in the metabolism measurement experiment. This room has a rectangular parallelepiped shape of about 1.8 m in length, about 0.9 m in width, and about 1.6 m in height, which is composed of a transparent acrylic plate attached to a frame made of aluminum alloy. A rectangular parallelepiped gas exchange unit 105 is installed on the floor of this room, and an oxygen measuring device and a carbon dioxide measuring device are installed on the rectangular parallelepiped gas exchange unit 105 as a measuring device 103. A fan filter unit is installed on the floor of this room. As the fan filter unit, an air purifier (F-PDH35) manufactured by Panasonic Corporation was used. As the oxygen measuring instrument, GX-2009 and OX-01 of RIKEN Keiki Co., Ltd. were used, and as the carbon dioxide measuring instrument, GC-2028 of Mother Tool Co., Ltd. was used. The gas exchange unit 105 used is shown in FIG. However, FIG. 8 is a photograph of the side surface of the gas exchange unit 105. As the gas exchange unit 105, those shown in FIGS. 2 to 6 were used. However, the size of the enclosure of the gas exchange unit 105 is about 35 cm in length, about 90 cm in width, about 20 cm in depth, the size of the gas exchange part is about 20 cm in length, about 80 cm in width, about 20 cm in depth, and the total number of gas exchange membranes is 17. , The total area A of the gas exchange membrane is about 3 m ² . In FIG. 2, h ₁ is 15 mm and h ₂ is 5 mm. As the gas exchange film, a commercially available shoji paper having a thickness L of about 100 μm was used.

As shown in FIG. 9, a candle burning experiment placed on a digital cooking scale was carried out in the room shown in FIG. A digital cooking scale allows the weight of burned candles to be measured.

が成り立つ。ここでも（既に述べたように１００％循環フィードバック系が部屋内に構築されているので、ファンフィルターユニットにより発生する空気流により、部屋の内部空間の空気は十分早くかき回されるため、空気を構成するガス分子は部屋内部で十分早く均一化するので）部屋の内部空間では空間座標依存性を良い近似で無視することができることを用いた。式（２）の右辺第３項は、上記ガス交換膜の両側（すなわち部屋内部と外界との間）での酸素濃度差（濃度勾配）ために流入してくる酸素分子の数である（空気流としてではなく、分子の拡散として酸素が部屋内部に入ってくるのであり、上述の式（２）で記述される現象とは全く性質を異にする）。式（２）において、ｊは

で与えられる。ただし、φは部屋の内部の単位体積当たりの酸素分子数、Ｄはガス交換膜中の酸素の拡散定数で、ガス交換膜に垂直な方向をｘ軸としたとき、∇はこのｘ軸方向の微分演算子である。Ｌは、部屋の内部空間の厚みに比べ３桁以上程度小さく、極めて薄いと見なせるので、式（２）は、

と良い精度で近似することができる。η₀ は、式（１）、式（２）におけるのと同様に、外界の酸素濃度であり、通常２０．９％程度である。式（４）より、微分方程式

が導かれる。式（５）の厳密解は、

と求まる。ここでは十分時間がたった後の定常状態に対応する解に興味があるので、右辺のｅｘｐ（−［ＡＤ／Ｌ］ｔ／Ｖ）＝０とおくと、時刻ｔにおける酸素濃度は

と求まる（式（６）でｔ→∞とした場合に一致する）。 That is, assuming that oxygen is consumed at ^{B [m 3} / s] per unit time by burning a candle in a room constituting this isolated closed space _{, the number of avocadros is N 0} , and the pressure in which the system is placed (~ 1). Assuming that the gas volume per mole at (pressure) is C, the area of the gas exchange membrane is A, and the oxygen flux entering the inside of the room through the gas exchange membrane is j, the oxygen volume Vη (t + δt) at time t + δt. ) Uses the oxygen volume Vη (t) at time t

Is established. Again (as already mentioned, since the 100% circulation feedback system is built in the room, the air flow generated by the fan filter unit stirs the air in the internal space of the room sufficiently quickly, which constitutes the air. We used that the spatial coordinate dependence can be ignored with a good approximation in the internal space of the room (because the gas molecules homogenize quickly enough inside the room). The third term on the right side of the formula (2) is the number of oxygen molecules flowing in due to the oxygen concentration difference (concentration gradient) on both sides of the gas exchange membrane (that is, between the inside of the room and the outside world) (air). Oxygen enters the room not as a flow but as a diffusion of molecules, which is completely different from the phenomenon described by the above equation (2)). In equation (2), j is

Given in. However, φ is the number of oxygen molecules per unit volume inside the room, D is the diffusion constant of oxygen in the gas exchange membrane, and ∇ is the x-axis direction when the direction perpendicular to the gas exchange membrane is the x-axis. It is a differential operator. Since L is about 3 orders of magnitude smaller than the thickness of the internal space of the room and can be regarded as extremely thin, the formula (2) is

Can be approximated with good accuracy. η ₀ is the oxygen concentration in the outside world, as in the equations (1) and (2), and is usually about 20.9%. From equation (4), differential equation

Is guided. The exact solution of equation (5) is

Is sought. Here, we are interested in the solution corresponding to the steady state after a sufficient time, so if exp (-[AD / L] t / V) = 0 on the right side, the oxygen concentration at time t will be.

(It matches when t → ∞ in equation (6)).

となる。 When time t = 0 and the internal oxygen concentration is a certain value C ₀ larger than the equation (7), the solution of the equation (5) is.

Will be.

で、酸素消費と二酸化炭素発生とは１：１であるが、ろうそく（パラフィン）Ｃ_n Ｈ_2n+2（ｎ＞２０）が燃える場合は

となり、酸素消費と二酸化炭素発生とはほぼ１：２ｎ／（３ｎ＋１）〜１：０．６６であるということができる。この炭素系化合物の燃焼に伴う二酸化炭素の濃度ξ(t) の変化は、燃焼に伴い濃度が上昇する方向であり、内部の濃度が高まると外界に放出されるので、二酸化炭素発生レートをＢ’（ｍ³ ／ｓ）、外界の二酸化炭素濃度をξ_o 、ガス交換膜面積をＡ’、上記ガス交換膜中の二酸化炭素の拡散定数をＤ’として

が成立する。これより

が得られる。この方程式の解は、時刻ｔ＝０で、内部と外界とで二酸化炭素濃度が平衡状態にある場合は、ξ（０）＝ξo より

となる。十分時間がたった時は、二酸化炭素濃度は、

に収束する。 Next, consider oxygen consumption and carbon dioxide generation when combustion occurs inside the room. If carbon simply burns,

So, oxygen consumption and carbon dioxide generation are 1: 1 but if the candle (paraffin) C _n H _{2n + 2} (n> 20) burns

Therefore, it can be said that oxygen consumption and carbon dioxide generation are approximately 1: 2n / (3n + 1) to 1: 0.66. The change in the carbon dioxide concentration ξ (t) that accompanies the combustion of this carbon-based compound is in the direction that the concentration increases with combustion, and when the internal concentration increases, it is released to the outside world, so the carbon dioxide generation rate is set to B. '( ^{M 3} / s), the carbon dioxide concentration in the outside world is ξ _o , the gas exchange membrane area is A', and the diffusion constant of carbon dioxide in the gas exchange membrane is D'.

Is established. Than this

Is obtained. The solution of this equation is from ξ (0) = ξo when the carbon dioxide concentration is in equilibrium between the inside and the outside at time t = 0.

Will be. When enough time has passed, the carbon dioxide concentration will be

Converge on.

となる。 When time t = 0 and the internal carbon dioxide concentration is a certain value C ₀ larger than the equation (14), the solution of the equation (12) is

Will be.

Using the metabolism measurement system shown in FIG. 7, the oxygen concentration and carbon dioxide concentration when the candle was burned were measured. FIG. 10 shows the time change of the oxygen concentration (O ₂ concentration) and the carbon dioxide concentration (CO ₂ concentration) at this time. FIG. 10 shows the absolute values of oxygen concentration and carbon dioxide concentration. FIG. 11 is a logarithmic representation of the difference (deviation from the steady state) between the oxygen concentration and carbon dioxide concentration shown in FIG. 10 and the oxygen concentration and carbon dioxide concentration in the outside world. As shown in FIGS. 10 and 11, the candle burned out about 15 minutes after the candle was ignited. As a characteristic of the equipment, the carbon dioxide measuring instrument showed a response delay of about 5 minutes with respect to the oxygen measuring instrument. Comparison of this experimental result with the above-mentioned analytical formulas, that is, the formulas (6) and (13) and the decrease in oxygen concentration and the increase in carbon dioxide concentration after the start of combustion, and the formulas (8) and (15) and candles. From the comparison with the recovery of oxygen concentration and the decrease of carbon dioxide concentration after the end of combustion, while cross-checking, the diffusion constants D and D of oxygen molecules and carbon dioxide molecules in the gas exchange membrane of the gas exchange unit used this time. 'Can be asked. From FIG. 11, assuming that the slope of a line indicating the recovery of the oxygen concentration after the combustion of the candle is a (O ₂ ), a (O ₂ ) = (-2- (-5.4)) / (2280-5520). ) = 3.4 / 3240 = 1.049 × 10 ^-3 _{, where a (CO 2} ) is the slope of a line indicating the decrease in carbon dioxide concentration after the combustion of the candle, a (CO ₂ ) = (-3) -(-4.8)) / (3720-6000) = 1.8 / 2280 = 0.7895 × 10 ^-3 , and the ratio of the two is a (CO ₂ ) / a (O ₂ ) = 0.7895. × a 10 ^-3 /1.049×10 ^-3 = 0.753. From this, it can be seen that oxygen and carbon dioxide settle to an equilibrium value with the outside world with almost the same time constant, but the recovery of carbon dioxide is slightly slower than that of oxygen. This is because the molecular weight of oxygen is 32, while the molecular weight of carbon dioxide is 44, and the carbon dioxide molecule is heavier than the oxygen molecule. Therefore, the thermal energy kT at room temperature (k is the Boltzmann constant and T is the absolute temperature). ) It can be understood from the fact that the rate of movement of the molecule underneath is slower for the carbon dioxide molecule. That is, (molecular weight of oxygen / molecular weight of carbon dioxide) ^1/2 = (32/44) ^1/2 = 0.853. This value is almost the same as the value of a (CO ₂ ) / a (O _{2) of 0.753.}

Furthermore, under the equal distribution of thermal energy, it is possible to utilize the fact that the diffusion constant is inversely proportional to the root of the molecular weight to store heavy molecular species relatively in a closed space. For example, measurement of skin gas released from the sole of the foot has been reported (see Non-Patent Document 4), but in general, acetone is a metabolite released with the decomposition and burning of body fat, and thus loses weight. It can be more accurately determined whether is due to a decrease in body fat, but since the molecular weight of acetone is 58, which is _{even heavier than the CO 2} above, it tends to accumulate in a closed space. In this way, by setting the diffusion constant of the gas exchange membrane to be lower than that of the target molecular species, even an inexpensive organic compound (VOC) detector can increase the measurement rate of the target molecular species, which is more advanced. It can be linked to physical condition analysis and health examination. To control the diffusion constant, if the target molecule type is a polar molecule, include a polarized gas exchange membrane material to suppress the diffusion of the target molecule and increase the concentration in the closed space. By increasing the accuracy, it is possible to detect with higher accuracy (even with an inexpensive measuring instrument). This metabolism measurement system can be utilized as a non-contact non-invasive breath analyzer and can be put into practical use not only as a metabolic analysis that discriminates body movement information but also as a body information analyzer. Furthermore, by substituting the high sense of smell of so-called "cancer detection dogs" with relative concentration condensing ability, a way to finally realize the same function and detection ability will be opened. It is expected that physical information management, illness diagnosis, etc. can be performed non-contact and non-invasively from breath information during sleep. It can also contribute significantly to the development and realization of breath biomarkers.

As a result of obtaining the diffusion constants of oxygen molecules and carbon dioxide molecules based on the above experiments, the diffusion constants of oxygen molecules are 7.2 × 10 ^-7 [m ² / s], and the diffusion constants of carbon dioxide molecules are 5. It was 1 × 10 ^-7 [m ² / s]. Based on this, FIG. 12 shows an exercise device stored in the above room. Here, an exercise bike (registered trademark) is stored as an exercise device, but the present invention is not limited to this. Preferably, it is an exercise device capable of setting various exercise loads. The treadmill is one example.

脂質系の燃焼：

より、後述の図１５に示すように観測された二酸化炭素濃度に対応する消費カロリー量を、ウォーキング速度（運動速度）の関数として、非接触、非侵襲のしかも、有酸素運動時に置ける呼吸器の浮遊塵埃吸い込みの増加を抑えつつ、被験者毎に算出できることが実証された。 The time-dependent changes in oxygen concentration and carbon dioxide concentration when subjects 1 and 2 exercised in this room are plotted in FIGS. 13A and 14A, respectively. Subjects 1 and 2 are both adult males. From FIG. 13A, the ratio between the change amount of the change amount and the oxygen concentration of the carbon dioxide concentration during exercise (9200-1600) ppm / (20.9-19.8) % = 7800 × 1 × 10 -6 / 1 .1 x 10 ^-2 = 0.7. From FIG. 14A, the ratio of the amount of change in carbon dioxide concentration during exercise to the amount of change in oxygen concentration is (1080-1600) ppm / {(20.9-20.1) × 8/5%} = 9200 × 1. × 10 ^-6 /1.3 ^{× 10 -2} = 0.7. That is, the ratio of the amount of change in carbon dioxide concentration during exercise to the amount of change in oxygen concentration is the same for both subjects 1 and 2. 13B and 14B are the difference data of FIGS. 13A and 14A, respectively, and the inflection point (intersection of the plot curve and the vertical dotted line) in FIGS. 13A and 14A can be obtained. It is judged that the transition from sugar-based metabolism to lipid-based metabolism has been detected. Since the gas exchange capacity of the gas exchange unit is known from the experimental results shown in FIGS. 10 and 11, from the observed carbon dioxide concentration, the combustion of the reactive sugar system:

Lipid-based combustion:

Therefore, as shown in FIG. 15 described later, the calorie consumption corresponding to the observed carbon dioxide concentration is used as a function of the walking speed (exercise speed) of the respiratory organs that can be placed during aerobic exercise in a non-contact, non-invasive manner. It was demonstrated that it can be calculated for each subject while suppressing the increase in airborne dust inhalation.

As can be seen from FIG. 15, the calorie consumption changes super linearly with respect to the walking speed. In FIG. 15, the broken line corresponds to the basal metabolic rate of an adult male. Therefore, when the calorie consumption with respect to the walking speed is calculated after subtracting this amount, it can be seen that the amount increases according to the square of the exercise speed. In this way, it was found that the active metabolic rate of the subject can be measured from the carbon dioxide concentration observed in non-contact and non-invasive manner. It was also shown that since the amount of metabolism differs for each subject, it is possible to measure the amount of active metabolism according to the individual body weight and relative muscle mass. In addition, by measuring the same subject in chronological order, it is possible to measure the increase in metabolic rate and muscle mass due to regular exercise, and the decrease in metabolic rate due to aging and illness. As one of the data, it is expected that it can be effectively used not only for personal health management but also for statistical analysis as characteristics of family and race.

Next, the results of measuring the metabolism by measuring the carbon dioxide concentration when a human leads a general life (entering / exiting a room, eating / drinking, sleeping, etc.) using the metabolism measurement system shown in FIG. 7 will be described. do. The room was made to have a background cleanliness of US209D class 100 or higher by a fan filter unit. FIG. 16 shows the measurement results of the carbon dioxide concentration and the count number of dust fine particles having a particle size of 0.5 μm or more for 7 hours from the time of entering the room. The subject is subject 2. In FIG. 16, the timings of lunch, sneezing, moving, taking a nap, waking up, entering a sleeping bag, drinking alcohol, etc. are indicated by vertical arrows. As shown in FIG. 16, it can be seen that the carbon dioxide concentration changes in response to the event in which the subject 2 moves.

FIG. 17 shows the relationship between the count number (abbreviated as Σd> 0.5) of the number of dust fine particles having a particle size of 0.5 μm or more and the carbon dioxide concentration shown in FIG.

FIG. 18 is a log-log display of the count number of dust fine particles having a particle size of 0.5 μm or more and the total carbon dioxide concentration for 65 seconds shown in FIG. The horizontal axis of FIGS. 17 and 18 quantitatively indicates the amount of body movement. This is because the number of dust particles is generated when the trunk or hands / feet are intentionally moved in an isolated closed system in a clean environment equivalent to that in FIG. 12, as shown in FIG. Since it is obtained quantitatively as shown in FIG. 24, it is based on the fact that the body movement of the inside resident can be quantified as being proportional to the number of dust particles in the highly clean isolated closed system. The details of the isolated closed system shown in FIG. 19, that is, the one in which the fan filter unit is installed in the tent formed by the gas exchange membrane to form a 100% circulation feedback system (CUSP (Clean Unit System Platform) tent) will be described. As shown in FIG. 19, the fan filter unit 104 is installed on one side of the tent 300 (the side where the subject faces the head when sleeping), and the dust counter 310 is installed immediately next to the fan filter unit 104. , A dust counter 320 is installed on the other side of the tent 300 (the side on which the subject faces when he / she goes to bed). Subject 330 lays on his back with his head facing the fan filter unit 104 between the fan filter unit 104 and the dust counter 320. By operating the fan filter unit 104, air flows and circulates in the tent 300 as shown by an arrow, and a 100% circulation feedback system is configured. Dust fine particles are scattered or generated by the body movement of the sleeping subject 330. The measurement result of the time change of the dust fine particle density is shown in FIG. Subject 330 is an adult male. At first, the dust fine particle density is measured by the dust counters 310 and 320 with the operation of the fan filter unit 104 stopped, and 20 minutes after the start of the measurement (set as the origin (0 minutes) of the time on the horizontal axis in FIG. 20). The operation of the fan filter unit 104 was started (FFU on), and the dust fine particle density was measured by the dust counters 310 and 320. The dust counter 310 can measure the density of dust particles on the head side of the subject 330, and the dust counter 320 can measure the density of dust particles on the foot side of the subject 330. As shown in FIG. 20, the dust fine particle density was as high as 1000 to 20000 (1 / cf) before the operation of the fan filter unit 104, but after the operation of the fan filter unit 104 was started, the dust fine particle density decreased sharply. Five minutes after the start of operation, the amount decreased to 3000 to 6000 (1 / cf). The subject 330 rolled the body every 5 minutes from 5 minutes to 50 minutes after the start of operation of the fan filter unit 104. More specifically, from the state in which the subject 330 lies on his back (posture S), the subject 330 rotates to the right (posture R) when viewed from the head to the foot, and then rotates in the opposite direction to lie on his back. He returned to the sleeping state (posture S) and then rotated to the left (posture L). This rotation operation was repeated every 5 minutes. From 60 minutes after the start of driving, the subject 330 was asked to raise and lower both arms three times every 5 minutes, and then 75 minutes after the start of driving, both legs were raised and lowered three times every 5 minutes. From FIG. 20, it can be seen that the dust fine particle density changes significantly in response to the rotation of the body of the subject 330 and the raising and lowering of both arms and legs. From this, it is clear that the body movement information of the subject 330 can be obtained from the time-varying pattern of the dust fine particle density. As can be seen from FIG. 18, by plotting the correlation between the amount of body movement and the amount of metabolism, exercise metabolism and non-exercise metabolism (for example, digestive metabolism, alcohol metabolism, etc.) can be discriminated and analyzed.

Furthermore, the outside air side of the enclosure 60 of the gas exchange unit 105, for example, from N ₂ gas cylinder as shown in FIG. 21, on the side outside air communication with the gas exchange unit 105 through the N ₂ tubes, introducing extra nitrogen Therefore, the oxygen concentration on the side communicating with the outside air of the enclosure 60 can be relatively lowered.

_{The supply flow F 1} to the outside air introduction port 71 (indicated as the outside air side inlet in FIG. 21) of the gas exchange unit 105 in FIG. 21 is set to, for example, F ₁ = 4.3 liters (l) / s, and 7% thereof. When an amount F ₂ = 0.3 liter (l) / min corresponding to the above N ₂ cylinder is supplied from the above N 2 cylinder, the oxygen concentration is 0.21 / (1 + F ₂ / F ₁ ) = 0.21 as shown in FIG. / (1 + 0.07) = can be reduced to 19.5%. By controlling the concentration gradient via the gas exchange unit 105 in this way, as a result, the inflow of the fluid (gas in this case) as a net mass flow into the internal space is zero, and diffusion due to the concentration gradient of the molecule is achieved. It was shown that by allowing, the gas concentration of the system can be controlled without breaking the isolation and closure of the internal space as a system. In this way, it is possible to perform the above-mentioned metabolic analysis in a highly clean environment under a controlled oxygen concentration, that is, in an atmosphere with a low oxygen concentration, for example, under a non-contact / non-invasive situation. This is the first system that can perform the equivalent of high altitude training in a clean environment while performing metabolic analysis by body movement discrimination.

Further, since the reached oxygen concentration is _{controlled by F 2} / F ₁ as described above, the local space of the gas exchange unit 105 is controlled by sufficiently reducing the volume of the local space communicating with the outside air of the gas exchange unit 105. It is possible to reduce the oxygen concentration (by linking _{F 1} with F _{2 and setting F 2} itself to a low value while keeping the ratio F ₂ / F _{1 constant).} Compared to the case where nitrogen is directly sent into the room to control the oxygen concentration, it is possible to control the oxygen concentration in the internal environment with a smaller amount of nitrogen.

On the other hand, FIG. 23 shows a system that fully three-dimensionally recognizes the spatial address by using continuous projection of the elapsed time to the spatial coordinates in the minimum setup of the gas filled in the drum can-like container. There is a Time Projection Chamber (TPC), and its development and excellent performance have been reported by the present inventors (P.Nemethy, P.Oddone, N.Toge, and A.Ishibashi, Nuclear Instruments and Methods 212 (1983) 273-280). This TPC will be described in a little more detail. As shown in FIG. 23, the electron beam 222 and the positron beam 223 incident from both ends of the cylindrical TPC221 containing gas collide with each other to generate new elementary particles 224 in a jet shape. The electrons 225 generated along the track of the elementary particles 224 reach the two-dimensional detectors called sectors 226 at both ends of the TPC 221 at a constant drift velocity in the axial direction, so that the collision time is the starting point. The position in the axial direction, that is, the z direction can be known from the elapsed time until reaching the sector 226 at that time. FIG. 20 is an enlarged view of a portion of sector 226, where reference numeral 226a is a sense wire, 226b is a grid, 226c is a pad, and 226d is an electric line of force. As shown in FIG. 20, electrons cause an avalanche at the portion of the sense wire 226a of the sector 226, thereby giving an electric signal to the sense wire 226a and the pad 226c existing below the sense wire 226a so that the positions in the x and y directions are determined. I want it. In this way, the three-dimensional position can be obtained, but at the position in the z direction, time information is projected into space as described above because the drift velocity of electrons is constant. Because of this feature, the system is called a time projection chamber, and particles can be identified by simultaneously measuring the momentum and energy loss of the detected particles with a single measuring instrument called TPC.

FIG. 25 shows the momentum-energy loss characteristic (E _cm = 29 GeV) of the multihadron event obtained using this TPC. As shown in FIG. 25, electrons [e], kaons [K], protons [e], deuterons [d], etc.) can be detected separately.

Comparing FIG. 18 with FIG. 25, in this metabolism measurement system, it is possible to discriminate and detect and analyze whether it is exercise metabolism or non-exercise metabolism by measuring the amount of body movement and the amount of metabolism at the same time independently. In terms of points, TPC, which can identify particles from momentum and energy loss, has a similar excellent feature that it can discriminate and detect and analyze the measurement target by taking advantage of the advantage of simultaneously measuring two parameters with one device. It turns out that it shows that.

The above-mentioned active metabolism measurement is "human-related" and "conscious" information, and if this attribute is described as (↑↑), the kinetosomnogram (KSG) data is "human-related" and " It is "information" during unconsciousness (sleep) and can be written as (↑ ↓). In addition, the calorie calculation values of room runners and exercise bikes (registered trademarks) themselves are non-human information and are naturally categorized in an unconscious state (↓↓), but this system, KSG and IoT It is expected that health management will be possible through the enrichment of big data space by using data with new attributes (↑↑) (↑↓) (↓↓), which is a combination of (one of) data. Similarly, through analysis of the metabolic state of organisms in clean air, it can be linked to terrestrial animal farming, especially aseptic poultry farming and aseptic pig farming. Further, even if a liquid is taken as the fluid and a clean space similar to the above gas system is used, the metabolism analysis and motion analysis of the organism in the clean (liquid) space can be performed in the same manner. This, especially in aquaculture, will lead to the realization of efficient health management and quality control of living organisms, in combination with the high cleanliness of fluids, and as a result, it will be possible to maintain and improve productivity. Become.

26 and 27 show polysomnography (PSG) [two lines above, each measured by a separate PSG analyzer] and time-varying analysis of the number of dust particles during sleep in a clean space (KSG). The result of the correspondence experiment of [bottom line] is shown. In FIG. 26 and FIG. 27, the upper PSG analysis was analyzed at four levels of arousal, REM, light sleep, and deep sleep, and the middle PSG analysis was classified into three levels: Interrupted (awakening), Light, and Deep. There is. 26 and 27 are the experimental results of the same subject on different days. As can be seen from FIGS. 26 and 27, it can be seen that there are many cases in which the peak of KSG coincides with the light sleep transition or arousal transition in PSG. It can also be seen that the peak value for the transition between light sleep and REM sleep is as large as about 1000 in KSG, and the transition between light sleep and deep sleep is as small as about 100 in KSG. In addition, there is a good agreement that the number of generated particles is very small even in KSG in the time zone classified as deep sleep or deep in PSG. In the present invention, by further multiplying the above metabolic analysis while performing such analysis, it is possible to perform extremely advanced sleep analysis, sleep quality analysis, and metabolic analysis, through which appropriate health management and physical condition can be performed. It will be possible to maintain it.

As described above, according to the metabolism measurement system according to the first embodiment, the subject 102 for measuring metabolism is placed inside a room or a closed space 101, and the subject 102 is exercising or the like. Non-contact and non-invasive by measuring the environmental and / or biological information of the subject 102 including at least the oxygen concentration and the carbon dioxide concentration inside the room or the closed space 101 with the measuring device 103 under a desired situation such as. The metabolism of the subject 102 can be measured without stressing the subject 102. Then, it is possible to grasp the time-dependent change of the metabolic capacity of the subject 102, the anaerobic exercise-compatible muscle mass, the aerobic exercise-compatible muscle mass, and the like, and further, the time-dependent change by accumulating the measurement data, and eventually the subject. It is possible to grasp the health condition of 102. In particular, when the exercise state of the subject 102 is detected by measuring the time change of the number of dust particles inside the room or the closed space 101 with a dust counter while the subject 102 is exercising, the subject 102 is used. It is possible to detect the metabolic status during exercise without giving stress, and to grasp the above information and the health condition of the subject 102 without imposing a load such as dust inhalation on the respiratory system of the subject 102. be able to. This metabolism measurement system can be used as a health management system in the sense that the health condition of the subject 102 can be grasped. In addition, since this metabolism measurement system has high clean environment performance and metabolic analysis ability of the subject 102, if the subject 102 is a terrestrial animal to be bred / bred, the health condition of the terrestrial animal And quality control can be performed efficiently.

<Second Embodiment>
[Metabolism measurement system]
FIG. 28 shows a metabolism measurement system according to the second embodiment. As shown in FIG. 28, this metabolic measurement system has a room or closed space 401 that constitutes an isolated closed system with no exchange of fluid (gas or liquid) as a mass flow between the outside world and the inside. The interior of this room or closed space 401 is filled with a fluid (not shown). The wall of the room or the closed space 401 includes a first subspace 402a communicating with the room or the closed space 401 and a second subspace 402b communicating with the outside world, and the first subspace 402a and the second subspace 402b. An enclosure (molecular exchanger) 402 whose volume is one digit or more smaller than the volume of the internal space of the room or the closed space 401 is installed. The first subspace 402a and the second subspace 402b of the enclosure 402 are between the concentration of the constituent molecules of the fluid in the first subspace 402a and the concentration of the constituent molecules of the fluid in the second subspace 402b. When a difference occurs, the above-mentioned constituent molecules are in the direction in which the concentration of the constituent molecules of the fluid in the first subspace 402a and the concentration of the constituent molecules of the fluid in the second subspace 402b are the same due to the concentration gradient. Is separated by a molecular permeable membrane (molecular exchange membrane) 403 capable of exchanging. In FIG. 28, one molecular permeable membrane 403 is shown in the enclosure 402, which schematically shows that the enclosure 402 includes the molecular permeable membrane 403, and is typically Is provided in the enclosure 402 with a gas exchange section including a plurality of molecular permeable membranes 403 as in the gas exchange section 50 of the first embodiment. Although not shown, an internal fluid recovery port and a discharge port are provided in the portion of the enclosure 402 corresponding to the first subspace 402a, and an external fluid is introduced in the portion of the enclosure 402 corresponding to the second subspace 402b. A mouth and a discharge port are provided. In this case, when controlling the internal environment of the room or the closed space 401, instead of directly controlling the internal environment of the room or the closed space 401, the internal environment of the second subspace 402b is first changed, and then the first By changing the internal environment of the subspace 402a, the internal environment of the room or the closed space 401 is controlled. Further, inside the room or the closed space 401, a filter unit 404 with a sending power (a fan filter unit when the fluid is a gas) is installed, which incorporates a filter 404a for filtering particles, bacteria, and the like. The filter unit 404 with transmission power has an opening (not shown) for sucking the fluid in the room or the closed space 401, and after cleaning the suction fluid, the entire amount is returned to the inside of the room or the closed space 401 again. The outlet (not shown) is provided as a pair. The delivery powered filter unit 404, coupled with the fact that the room or closed space 401 constitutes an isolated closed system, allows the total amount (100%) of the fluid after cleaning through the delivery powered filter unit 404 to be in the room or A 100% circulation feedback system that circulates inside the closed space 401 is configured. A white arrow indicates how the fluid circulates inside the room or the closed space 401. A fluid (liquid or gas) is introduced into the second subspace 402b of the enclosure 402 from the external fluid inlet and discharged from the outlet. The state of the fluid flowing through the second subspace 402b is indicated by a white arrow. If necessary, an external fluid (indicated by a black arrow) for modulating the components of the fluid is introduced into the second subspace 402b. Although not shown, a measuring device similar to the measuring device 103 of the first embodiment is installed.

In this metabolism measurement system, as long as it does not contradict its properties, what has been described in relation to the metabolism measurement system according to the first embodiment holds true.

As discussed in the first embodiment, in this metabolic measurement system, by using the enclosure 402, a smaller amount of nitrogen is sent directly into the room or the closed space 401 to control the oxygen concentration. It is possible to control the oxygen concentration in the internal environment with nitrogen. This will be described in detail. That is, in the metabolism measurement system shown in FIG. 28, the volume of the second subspace 402b communicating with the outside world of the enclosure 402 is V, the volume of the room or closed space 401 is V ₀ , and the oxygen concentration of the room or closed space 401. Consider halving. Incorporating a piston-like mechanism into the second subspace 402b of volume V communicating with the outside world of the enclosure 402, first, nitrogen of the same volume v is pushed out and replaced (replaced) with air in the initial state. ) Let's consider the case of sending. At this time, since the oxygen partial pressure of the second subspace 402b communicating with the outside world of the surrounding body 402 becomes zero, the oxygen in the room is most efficiently diffused to the outside air side with a concentration gradient, and the oxygen concentration in the room becomes. , From the initial value η ₀ (= 2 0.9%) η ₁ = {V ₀ η ₀ + (V−v) η ₀ } / (V ₀ + v)
Will be. Now, for the sake of simplicity, if the volume v of nitrogen to be sent is equal to the volume of the second subspace 402b communicating with the outside world of the enclosure 402, then v = V.
η ₁ = ηo ・ V ₀ / (V ₀ + v)
Can be simplified.

In this state, when the nitrogen of the volume v is sent again so as to push out and replace the gas existing in the second subspace 402b of the volume V communicating with the outside world of the enclosure 402, the oxygen concentration in the room becomes high.
η ₂ = η ₁ · V ₀ / (V ₀ + v) = η ₀ · {V ₀ / (V ₀ + V)} ²
Will be. After repeating this process k times, the oxygen concentration in the room is
η _k = η _k-1 · V ₀ / (V ₀ + V) = η ₀ · {V ₀ / (V ₀ + V)} ^k
Will be. Assuming that the oxygen concentration is halved after the process k times, from η _k = 1/2 · η ₀ ,
1/2 = {V ₀ / (V ₀ + V} ^k
Will be. Since the volume of the enclosure 402 is set to be one digit or more smaller than the volume of the room or the closed space 401, if V = 1/10 V ₀ is set now,
k = log (1/2) / log (10/11) = log2 / log (11/10) = 7.2
Is sought. Nitrogen volume and fed to the second partial space 402b to the outside world communicates the enclosure 402, that the 7.2 × V ₀ /10=0.72V _0, the nitrogen in the room or closed space 401 from the outside world as a mass flow It can be seen that when the oxygen concentration is halved by feeding, the same decrease in oxygen concentration can be obtained with a smaller amount of nitrogen compared to the case where V _{0 was required as the amount of nitrogen (the oxygen concentration is halved).} However, if it is further reduced, this efficiency will be further increased. For example, if it is reduced to 1/10, direct feeding _{requires 9 times the volume of the room or closed space 401, that is, 9V 0} nitrogen. However, when nitrogen is delivered through the local enclosure 402, the amount of nitrogen is _{about 27%, at most 2.4V 0).} Moreover, there is no exchange of fluid (gas in this case) as a mass flow between the outside world and the inside of the room or the closed space 401. Therefore, the dust number density in the room or the closed space 401 is also kept good without deterioration.

In the above example, nitrogen was introduced into the second subspace 402b of the enclosure 402 to control the oxygen concentration in the room or closed space 401, but instead of or with nitrogen, for example hypochlorous acid. It is also possible to introduce a gas containing or other chemicals. As a result, there is no exchange of fluid (gas in this case) as a mass flow between the outside world and the inside of the room or the closed space 401, and the dust number density in the room remains good without deterioration. The air in the closed space 401 can be sterilized and deodorized. Similarly, by introducing a gas containing a necessary drug into the second subspace 402b of the enclosure 402, a treatment in which the respiratory system of a patient staying in a room or a closed space 401 is treated via the lungs is also possible. It will be possible.

According to this second embodiment, the same advantages as those of the first embodiment can be obtained, and in particular, the fluid filling the room or closed space 401 includes liquid, especially water (fresh water, salt water, seawater). ), And when the subject 102 is an aquatic animal such as a fish to be cultivated, it is possible to obtain the advantage that the health condition and quality can be efficiently controlled by the metabolic analysis of the aquatic animal. Can be done.

<Third embodiment>
[Metabolism measurement system]
FIG. 29 shows a metabolism measurement system according to the third embodiment. This metabolism measurement system also serves as an aquaculture system. As shown in FIG. 29, in this metabolism measurement system, a room or a closed space 401 is provided in the upper part of the building 1000, and a water tank 501 for aquatic animals such as aquaculture to be cultivated is provided in the lower part of the building 1000. There is. The water tank 501 is provided at a position lower than the floor 401a of the room or the closed space 401, and is filled with water (fresh water, salt water, seawater). The operator 405 engaged in aquaculture stays in a room or a closed space 401.

Since the room or the closed space 401 is configured in the same manner as in the second embodiment except that the fluid filled therein is air, the description thereof will be omitted. However, when the metabolism of the subject is not measured, it is not always necessary to install a measuring device for measuring the oxygen concentration and the carbon dioxide concentration.

The water tank 501 constitutes an isolated closed system without exchange as a mass flow of liquid between the outside world and the inside. The inside of the water tank 501 is filled with water. The wall of the water tank 501 includes a first subspace 502a communicating with the water tank 501 and a second subspace 502b communicating with the outside world, and the volumes of the first subspace 502a and the second subspace 502b are inside the water tank 501. An enclosure (molecular exchanger) 502 that is an order of magnitude smaller than the volume of space is installed. The first subspace 502a and the second subspace 502b of the enclosure 502 are between the concentration of the liquid constituent molecules in the first subspace 502a and the concentration of the liquid constituent molecules in the second subspace 502b. When a difference occurs, the above-mentioned constituent molecules are in the direction in which the concentration of the constituent molecules of the fluid in the first subspace 502a and the concentration of the constituent molecules of the fluid in the second subspace 502b become the same due to the concentration gradient. Is separated by a molecular permeable membrane (molecular exchange membrane) 503 that can be exchanged. In FIG. 29, one molecular permeable membrane 503 is shown in the enclosure 502, which schematically shows that the enclosure 502 includes the molecular permeable membrane 503, and is typically Is provided with a molecular exchange unit including a plurality of molecular permeable membranes 503 in the enclosure 502 as in the gas exchange unit 50 of the first embodiment. Although not shown, an internal fluid recovery port and a discharge port are provided in the portion of the enclosure 502 corresponding to the first subspace 502a, and an external fluid is introduced in the portion of the enclosure 502 corresponding to the second subspace 502b. A mouth and a discharge port are provided. In this case, when controlling the internal environment of the water tank 501, instead of directly controlling the internal environment of the water tank 501, the internal environment of the second subspace 502b is first changed, and then the internal environment of the first subspace 502a is changed. By changing the above, the internal environment of the water tank 501 is controlled. Further, inside the water tank 501, a filter unit 504 with a sending power is installed, which incorporates a filter 504a for filtering particles, bacteria, and the like. The filter unit 504 with delivery power has an opening (not shown) for sucking the liquid in the water tank 501 and an outlet (not shown) for returning the entire amount of the suction liquid to the inside of the water tank 501 again after the cleaning treatment. ) And are provided as a pair. The feed-powered filter unit 504, coupled with the fact that the water tank 501 constitutes an isolated closed system, causes the total amount (100%) of the fluid after the cleaning treatment to pass through the feed-powered filter unit 504 inside the water tank 501. A 100% circulating feedback system that circulates is constructed. Arrows indicate how the liquid circulates inside the water tank 501. The second subspace 502b of the enclosure 502 is in an adjacent chamber or an external water tank 505. Then, the liquid is introduced into the second subspace 502b from the external fluid introduction port in the water tank 505 and discharged from the discharge port. The state of the liquid flowing through the second subspace 502b is indicated by an arrow. In the water tank 501, a measuring device 506 for measuring the environment and / or biological information including at least the oxygen concentration and the carbon dioxide concentration inside the water tank 501 is installed above the outlet of the filter unit 504 with the transmission power. A mesh floor 507 is provided at the bottom of the water tank 501 at a position slightly higher than the bottom surface of the water tank 501. Particles and the like in the liquid of the water tank 501 pass through the mesh floor 507 and are deposited on the bottom surface of the water tank 501, and deposits are formed. This deposit is taken out into the sediment treatment tank 508 through an opening (not shown) provided at the bottom of the side wall of the water tank 501. The sediment taken out in the sediment treatment tank 508 is taken out to the outside. The sediment taken out in this way may be discarded, but if it can be used as fertilizer, it will be diverted to fertilizer.

According to this third embodiment, the room or closed space 401 can be maintained in a highly clean air environment by the 100% circulation feedback system, and the water tank 501 is also maintained in the highly clean air environment by the 100% circulation feedback system. can do. That is, in this metabolism measurement system, the highly clean air phase in the room or the closed space 401 and the highly clean liquid phase in the water tank 501 coexist in the building 1000. Therefore, the respiratory system of the operator 405 engaged in aquaculture in the room or the closed space 401 is not subjected to a load such as dust inhalation. In addition, the metabolism of aquatic animals can be measured in a non-contact and non-invasive manner without stressing aquatic animals such as fish to be cultivated. By doing so, it is possible to grasp the changes over time in the metabolic capacity of aquatic animals, the muscle mass corresponding to anaerobic exercise, the muscle mass corresponding to aerobic exercise, etc. You can grasp your health condition. In particular, when the movement status of aquatic animals is detected by measuring the time change of the number of dust particles inside the aquatic tank 501 with a dust counter while the aquatic animals are exercising, the aquatic animals are not stressed. It is possible to detect the metabolic status during exercise, and to grasp the above information and the health condition of aquatic animals without imposing a load such as dust inhalation on the respiratory system of aquatic animals. This system takes both gas and liquid as a fluid, and by including a space with a liquid as a fluid in a closed space with air as a fluid, a highly clean gas phase and a highly clean liquid phase coexist. It is a highly clean system. This system, combined with its high clean environment performance and metabolic analysis ability of the target organism, makes it a suitable system as an aquaculture environment for aquatic organisms.

Although the embodiments and examples of the present invention have been specifically described above, the present invention is not limited to the above-described embodiments and examples, and various modifications based on the technical idea of the present invention. Is possible. For example, the numerical values, structures, configurations, shapes, arrangements, etc. given in the above-described embodiments and examples are merely examples, and different numerical values, structures, configurations, shapes, arrangements, etc. may be used as necessary. May be good.

101 ... room or closed space, 102 ... subject, 103 ... measuring device, 104 ... fan filter unit, 105 ... gas exchange unit, 106 ... computer, 50 ... gas exchange unit, 52 ... gas exchange membrane

Claims (6)

A room or closed space that constitutes an isolated closed system with no exchange of fluid as a mass flow between the outside world and the inside.
Oxygen concentration and dioxide inside at least the room or closed space of the organism, which is installed inside the room or closed space and is non-contact and non-invasive to the organism existing inside the room or closed space. A measuring device that measures environmental and / or biological information including carbon concentration ,
It includes a first subspace that communicates with the room or closed space and a second subspace that communicates with the outside world, and the volume of the first subspace and the second subspace is greater than the volume of the internal space of the room or closed space. A siege that is an order of magnitude smaller and
Have,
There was a difference between the concentration of the constituent molecules of the fluid in the first subspace and the concentration of the constituent molecules of the fluid in the second subspace between the first subspace and the second subspace. In the case, the constituent molecules are exchanged in a direction in which the concentration of the constituent molecules of the fluid in the first subspace and the concentration of the constituent molecules of the fluid in the second subspace become the same depending on the concentration gradient. Separated by a resulting membrane,
When controlling the internal environment of the room or the closed space, instead of directly controlling the internal environment of the room or the closed space, first change the internal environment of the second subspace, and then change the internal environment of the first subspace. By changing the internal environment of the room or closed space, the internal environment of the room or closed space is controlled by the communication between the room or closed space and the first subspace.
A metabolism measurement system that measures the metabolism of the organism by measuring the environment and / or biological information with the measuring device in a state where the organism is inside the room or the closed space. Inside the room or closed space, there is an opening that sucks the fluid inside the room or closed space, and after cleaning the suction fluid, the entire amount is returned to the inside of the room or closed space again. The metabolic measurement system according to claim 1, wherein the mouth is provided as a pair. The membrane is a membrane that does not allow dust particles having a particle size of 0.5 μm or more to pass through, but allows molecules to pass through. The volume of the chamber or closed space is V, the area of the membrane is A, the thickness of the membrane is L, and the membrane is The diffusion constant of oxygen inside is D, the oxygen consumption rate of the organism inside the room or closed space is B, and the oxygen concentration inside the room or closed space when in equilibrium with the outside is η. _{o o} When the allowable minimum oxygen concentration in the fluid of the organism is η and the time is t, η is

The metabolism measurement system according to claim 1. With the organism inside the room or closed space, the environment and / or biological information is measured by the measuring device while quantitatively evaluating the presence or absence of body movement of the organism in a non-contact and non-invasive manner. The metabolism measurement system according to claim 1, wherein the metabolism of the organism in the presence of body movement and the metabolism in the absence of body movement are discriminated and measured. By reducing the oxygen concentration in the second subspace of the enclosure, the oxygen concentration in the first subspace of the enclosure is reduced under quantitative control while maintaining isolation, through which the oxygen concentration is reduced. Requests to reduce the oxygen concentration in the room or closed space, improve the efficiency of the improvement of cardiopulmonary function obtained by staying inside the room or closed space and performing training, and to investigate the biological condition of the organism. Item 1. The metabolic measurement system according to item 1. A request to improve the detection accuracy and investigate the biological condition of the organism by constructing the membrane with a material set so that the diffusion constant for the molecule of interest is reduced and increasing the concentration of a specific gas molecule emitted from the organism. Item 1. The metabolic measurement system according to item 1.

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