JP6934938B2 - 流体の成分の収集 - Google Patents
流体の成分の収集 Download PDFInfo
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- JP6934938B2 JP6934938B2 JP2019520011A JP2019520011A JP6934938B2 JP 6934938 B2 JP6934938 B2 JP 6934938B2 JP 2019520011 A JP2019520011 A JP 2019520011A JP 2019520011 A JP2019520011 A JP 2019520011A JP 6934938 B2 JP6934938 B2 JP 6934938B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/245—Discharge mechanisms for the sediments
- B01D21/2472—Means for fluidising the sediments, e.g. by jets or mechanical agitators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/34—Controlling the feed distribution; Controlling the liquid level ; Control of process parameters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36222—Details related to the interface between cassette and machine
- A61M1/362227—Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0021—Special media to be introduced, removed or treated removed from and reintroduced into the body, e.g. after treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0471—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with additional elutriation separation of different particles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Ecology (AREA)
- External Artificial Organs (AREA)
Description
Claims (8)
- 流体の成分を分離する方法であって、該方法は、
少なくとも1つのプロセッサによって、多成分流体の第1の成分の量に関する第1のデータを受け取るステップと、
前記少なくとも1つのプロセッサによって、前記第1のデータに基づいて、供給源から引き出して分離容器に導入する多成分流体の量に対する調整を決定するステップと、
前記多成分流体を前記分離容器に初期吸引流量で導入し、前記多成分流体から複合流体を分離する第1の分離ステップと、
前記多成分流体から分離された前記複合流体を分離チャンバに導入するステップと、
前記複合流体を、少なくとも、第1の成分と第2の成分とに分離する第2の分離ステップと、
前記第1の成分と前記第2の成分とに分離する前記第2の分離ステップ中に、前記分離チャンバにおいて、前記第1の成分と前記第2の成分のうちの少なくとも1つの成分の濃度を、所定量未満に維持するステップと、
前記第1のデータに基づいて、前記供給源から前記分離容器に引き出して導入する前記多成分流体の流量を、前記初期吸引流量から変更する流量変更ステップと、
前記第1の成分を含む製剤を貯蔵容器に収集するステップと、
を含む、
流体の成分を分離する方法。 - 請求項1記載の流体の成分を分離する方法において、前記多成分流体は、全血であり、前記複合流体は、前記全血から分離された、血小板と白血球である、
流体の成分を分離する方法。 - 請求項2記載の流体の成分を分離する方法において、前記第1の成分は、血小板である、
流体の成分を分離する方法。 - 請求項3記載の流体の成分を分離する方法において、前記第1のデータは、血小板数である、
流体の成分を分離する方法。 - 請求項1記載の流体の成分を分離する方法において、前記少なくとも1つの成分の濃度を、前記所定量未満に維持する前記ステップは、前記第1の成分の濃度を所定量未満に維持するステップを含む、
流体の成分を分離する方法。 - 請求項1記載の流体の成分を分離する方法において、前記第2の成分は、前記供給源に戻される、
流体の成分を分離する方法。 - 請求項6記載の流体の成分を分離する方法において、前記流量変更ステップは、
前記調整に基づいて、所定の時間の後、前記供給源から引き出して前記分離容器へ導入する前記多成分流体の流量を前記初期吸引流量から増やすステップ、
を含む、
流体の成分を分離する方法。 - 請求項3記載の流体の成分を分離する方法において、前記製剤は、3×1011個の血小板に対して、1×106個未満の白血球を含む、
流体の成分を分離する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662407607P | 2016-10-13 | 2016-10-13 | |
US62/407,607 | 2016-10-13 | ||
PCT/US2017/056658 WO2018071862A1 (en) | 2016-10-13 | 2017-10-13 | Collecting components of a fluid |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019534758A JP2019534758A (ja) | 2019-12-05 |
JP6934938B2 true JP6934938B2 (ja) | 2021-09-15 |
Family
ID=60191519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019520011A Active JP6934938B2 (ja) | 2016-10-13 | 2017-10-13 | 流体の成分の収集 |
Country Status (5)
Country | Link |
---|---|
US (4) | US10585085B2 (ja) |
EP (2) | EP4159254A1 (ja) |
JP (1) | JP6934938B2 (ja) |
CN (2) | CN114712586A (ja) |
WO (1) | WO2018071862A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10585085B2 (en) | 2016-10-13 | 2020-03-10 | Terumo Bct, Inc. | Collecting components of a fluid |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3632176A1 (de) * | 1986-09-22 | 1988-04-07 | Fresenius Ag | Steuerung eines systems zur trennung der bestandteile des einem spender "in vivo" entnommenen blutes |
US5951877A (en) * | 1995-04-18 | 1999-09-14 | Cobe Laboratories, Inc. | Particle filter method |
US6053856A (en) * | 1995-04-18 | 2000-04-25 | Cobe Laboratories | Tubing set apparatus and method for separation of fluid components |
US5939319A (en) * | 1995-04-18 | 1999-08-17 | Cobe Laboratories, Inc. | Particle separation method and apparatus |
US6022306A (en) * | 1995-04-18 | 2000-02-08 | Cobe Laboratories, Inc. | Method and apparatus for collecting hyperconcentrated platelets |
US5674173A (en) | 1995-04-18 | 1997-10-07 | Cobe Laboratories, Inc. | Apparatus for separating particles |
JP3300624B2 (ja) * | 1997-01-24 | 2002-07-08 | 東京エレクトロン株式会社 | 基板端面の洗浄方法 |
DE19728089A1 (de) * | 1997-07-02 | 1999-01-07 | Fresenius Ag | Verfahren zum Separieren einer Zellsuspension durch Zentrifugieren, insbesondere zum Trennen von Vollblut in seine Blutkomponenten |
US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
US6354986B1 (en) * | 2000-02-16 | 2002-03-12 | Gambro, Inc. | Reverse-flow chamber purging during centrifugal separation |
US7963901B2 (en) | 2008-09-12 | 2011-06-21 | Caridianbct, Inc. | Blood processing apparatus with cell capture chamber with protruding inlet |
WO2012091720A1 (en) * | 2010-12-30 | 2012-07-05 | Haemonetics Corporation | System and method for collecting platelets and anticipating plasma return |
US8852140B2 (en) * | 2011-01-12 | 2014-10-07 | Fenwal, Inc. | System and method for adjustment of blood separation procedure parameters |
US10166322B2 (en) * | 2014-03-28 | 2019-01-01 | Terumo Bct, Inc. | Gain in separation processes with control loop |
US10585085B2 (en) | 2016-10-13 | 2020-03-10 | Terumo Bct, Inc. | Collecting components of a fluid |
-
2017
- 2017-10-13 US US15/783,866 patent/US10585085B2/en active Active
- 2017-10-13 CN CN202210382336.3A patent/CN114712586A/zh active Pending
- 2017-10-13 EP EP22209152.2A patent/EP4159254A1/en active Pending
- 2017-10-13 JP JP2019520011A patent/JP6934938B2/ja active Active
- 2017-10-13 EP EP17791837.2A patent/EP3525837A1/en active Pending
- 2017-10-13 WO PCT/US2017/056658 patent/WO2018071862A1/en unknown
- 2017-10-13 CN CN201780071255.9A patent/CN110062639B/zh active Active
-
2020
- 2020-03-09 US US16/812,582 patent/US11366096B2/en active Active
- 2020-03-09 US US16/812,552 patent/US11360075B2/en active Active
-
2022
- 2022-05-16 US US17/745,352 patent/US11994509B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10585085B2 (en) | 2020-03-10 |
CN110062639B (zh) | 2022-05-13 |
US20200209216A1 (en) | 2020-07-02 |
US11366096B2 (en) | 2022-06-21 |
US11994509B2 (en) | 2024-05-28 |
EP4159254A1 (en) | 2023-04-05 |
US11360075B2 (en) | 2022-06-14 |
JP2019534758A (ja) | 2019-12-05 |
US20220276220A1 (en) | 2022-09-01 |
US20200209217A1 (en) | 2020-07-02 |
WO2018071862A1 (en) | 2018-04-19 |
US20180106778A1 (en) | 2018-04-19 |
EP3525837A1 (en) | 2019-08-21 |
CN110062639A (zh) | 2019-07-26 |
CN114712586A (zh) | 2022-07-08 |
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