JP6933384B2 - 疾患の処置のための複素環化合物 - Google Patents
疾患の処置のための複素環化合物 Download PDFInfo
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- JP6933384B2 JP6933384B2 JP2018545102A JP2018545102A JP6933384B2 JP 6933384 B2 JP6933384 B2 JP 6933384B2 JP 2018545102 A JP2018545102 A JP 2018545102A JP 2018545102 A JP2018545102 A JP 2018545102A JP 6933384 B2 JP6933384 B2 JP 6933384B2
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- MSHWTKGAZGNGGH-UHFFFAOYSA-N CC(C)C(N1)=NOC1=O Chemical compound CC(C)C(N1)=NOC1=O MSHWTKGAZGNGGH-UHFFFAOYSA-N 0.000 description 1
- JIGWGQHXYRNBOY-UHFFFAOYSA-O CC(C)C(N[NH3+])=NN Chemical compound CC(C)C(N[NH3+])=NN JIGWGQHXYRNBOY-UHFFFAOYSA-O 0.000 description 1
- IWKXXMBGUWZVMK-UHFFFAOYSA-N CC(C1=O)=COC=C1O Chemical compound CC(C1=O)=COC=C1O IWKXXMBGUWZVMK-UHFFFAOYSA-N 0.000 description 1
- KGVPNLBXJKTABS-UHFFFAOYSA-N Cc1cc(O)n[o]1 Chemical compound Cc1cc(O)n[o]1 KGVPNLBXJKTABS-UHFFFAOYSA-N 0.000 description 1
- QXWKDPPQOJKKFQ-UHFFFAOYSA-N Cc1cc(O)n[s]1 Chemical compound Cc1cc(O)n[s]1 QXWKDPPQOJKKFQ-UHFFFAOYSA-N 0.000 description 1
- LAHGPTMNWMCUNX-UHFFFAOYSA-N Cc1n[s]nc1O Chemical compound Cc1n[s]nc1O LAHGPTMNWMCUNX-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021131351A JP7174963B2 (ja) | 2015-11-13 | 2021-08-11 | 疾患の処置のための複素環化合物 |
| JP2022173717A JP7445325B2 (ja) | 2015-11-13 | 2022-10-28 | 疾患の処置のための複素環化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255041P | 2015-11-13 | 2015-11-13 | |
| US62/255,041 | 2015-11-13 | ||
| PCT/US2016/061676 WO2017083756A1 (en) | 2015-11-13 | 2016-11-11 | Heterocyclic compounds for the treatment of disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131351A Division JP7174963B2 (ja) | 2015-11-13 | 2021-08-11 | 疾患の処置のための複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535261A JP2018535261A (ja) | 2018-11-29 |
| JP2018535261A5 JP2018535261A5 (enExample) | 2019-12-19 |
| JP6933384B2 true JP6933384B2 (ja) | 2021-09-08 |
Family
ID=58696139
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545102A Active JP6933384B2 (ja) | 2015-11-13 | 2016-11-11 | 疾患の処置のための複素環化合物 |
| JP2021131351A Active JP7174963B2 (ja) | 2015-11-13 | 2021-08-11 | 疾患の処置のための複素環化合物 |
| JP2022173717A Active JP7445325B2 (ja) | 2015-11-13 | 2022-10-28 | 疾患の処置のための複素環化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131351A Active JP7174963B2 (ja) | 2015-11-13 | 2021-08-11 | 疾患の処置のための複素環化合物 |
| JP2022173717A Active JP7445325B2 (ja) | 2015-11-13 | 2022-10-28 | 疾患の処置のための複素環化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US10683291B2 (enExample) |
| EP (2) | EP4163281B1 (enExample) |
| JP (3) | JP6933384B2 (enExample) |
| KR (1) | KR102720397B1 (enExample) |
| CN (2) | CN114149424B (enExample) |
| AU (2) | AU2016353348A1 (enExample) |
| BR (1) | BR112018009745B1 (enExample) |
| CA (1) | CA3005236C (enExample) |
| DK (1) | DK3373931T3 (enExample) |
| ES (1) | ES2932049T3 (enExample) |
| HR (1) | HRP20221417T1 (enExample) |
| HU (1) | HUE060594T2 (enExample) |
| IL (1) | IL259297B2 (enExample) |
| LT (1) | LT3373931T (enExample) |
| MX (1) | MX382092B (enExample) |
| PL (1) | PL3373931T3 (enExample) |
| PT (1) | PT3373931T (enExample) |
| RS (1) | RS63837B1 (enExample) |
| RU (1) | RU2727194C2 (enExample) |
| SI (1) | SI3373931T1 (enExample) |
| SM (1) | SMT202300062T1 (enExample) |
| WO (1) | WO2017083756A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20221417T1 (hr) | 2015-11-13 | 2023-02-03 | Oppilan Pharma Ltd. | Heterociklički spojevi za liječenje bolesti |
| WO2018211323A1 (en) * | 2017-05-17 | 2018-11-22 | Oppilan Pharma Ltd. | Hetercyclic compounds for the treatment of disease |
| EP3625230A1 (en) * | 2017-05-17 | 2020-03-25 | Oppilan Pharma Ltd. | Prodrugs for the treatment of disease |
| GB201815018D0 (en) * | 2018-09-14 | 2018-10-31 | Univ Oxford Innovation Ltd | Enantiomeric compounds |
| US12612401B2 (en) | 2022-07-06 | 2026-04-28 | Oppilan Pharma Limited | Crystalline forms of an S1P receptor modulator |
| CN120835886A (zh) * | 2023-01-13 | 2025-10-24 | 奥比兰制药有限公司 | S1p受体调节剂的制备 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772597A (en) * | 1983-10-14 | 1988-09-20 | Pfizer Inc. | 2-azacycloalkylthiopenem derivatives |
| WO2005032465A2 (en) | 2003-10-01 | 2005-04-14 | Merck & Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
| GB0511684D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| US20080306124A1 (en) * | 2005-06-08 | 2008-12-11 | Rainer Albert | Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands |
| RU2425832C2 (ru) * | 2006-04-03 | 2011-08-10 | Астеллас Фарма Инк. | Гетеросоединение |
| US20110207704A1 (en) | 2006-12-15 | 2011-08-25 | Abbott Laboratories | Novel Oxadiazole Compounds |
| RU2009127095A (ru) | 2006-12-15 | 2011-01-20 | Эбботт Лэборетриз (Us) | Новые оксадиазольные соединения |
| US20100160369A1 (en) * | 2008-12-04 | 2010-06-24 | Exelixis, Inc. | S1P1 Agonists and Methods of Making And Using |
| WO2010117662A1 (en) | 2009-03-30 | 2010-10-14 | Exelixis, Inc. | Modulators of s1p and methods of making and using |
| US9011494B2 (en) | 2009-09-24 | 2015-04-21 | Warsaw Orthopedic, Inc. | Composite vertebral rod system and methods of use |
| HUE036391T2 (hu) | 2009-11-13 | 2018-07-30 | Celgene Int Ii Sarl | Szfingozin 1 foszfát receptor modulátorok és királis szintézis eljárások |
| JP5788507B2 (ja) * | 2010-07-20 | 2015-09-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 置換３−フェニル−１，２，４−オキサジアゾール化合物 |
| US20140288052A1 (en) | 2011-10-20 | 2014-09-25 | GlaxoSmithKline, LLC | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| JP6383418B2 (ja) | 2013-11-27 | 2018-08-29 | ジェネンテック， インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
| HRP20221417T1 (hr) | 2015-11-13 | 2023-02-03 | Oppilan Pharma Ltd. | Heterociklički spojevi za liječenje bolesti |
-
2016
- 2016-11-11 HR HRP20221417TT patent/HRP20221417T1/hr unknown
- 2016-11-11 RU RU2018121416A patent/RU2727194C2/ru active
- 2016-11-11 PL PL16865156.0T patent/PL3373931T3/pl unknown
- 2016-11-11 EP EP22195151.0A patent/EP4163281B1/en active Active
- 2016-11-11 WO PCT/US2016/061676 patent/WO2017083756A1/en not_active Ceased
- 2016-11-11 CA CA3005236A patent/CA3005236C/en active Active
- 2016-11-11 US US15/775,723 patent/US10683291B2/en active Active
- 2016-11-11 IL IL259297A patent/IL259297B2/en unknown
- 2016-11-11 PT PT168651560T patent/PT3373931T/pt unknown
- 2016-11-11 CN CN202111183182.7A patent/CN114149424B/zh active Active
- 2016-11-11 DK DK16865156.0T patent/DK3373931T3/da active
- 2016-11-11 LT LTEPPCT/US2016/061676T patent/LT3373931T/lt unknown
- 2016-11-11 KR KR1020187016508A patent/KR102720397B1/ko active Active
- 2016-11-11 EP EP16865156.0A patent/EP3373931B1/en active Active
- 2016-11-11 AU AU2016353348A patent/AU2016353348A1/en not_active Abandoned
- 2016-11-11 RS RS20221070A patent/RS63837B1/sr unknown
- 2016-11-11 HU HUE16865156A patent/HUE060594T2/hu unknown
- 2016-11-11 MX MX2018005987A patent/MX382092B/es unknown
- 2016-11-11 SM SM20230062T patent/SMT202300062T1/it unknown
- 2016-11-11 JP JP2018545102A patent/JP6933384B2/ja active Active
- 2016-11-11 CN CN201680078856.8A patent/CN108463222B/zh active Active
- 2016-11-11 SI SI201631650T patent/SI3373931T1/sl unknown
- 2016-11-11 BR BR112018009745-4A patent/BR112018009745B1/pt active IP Right Grant
- 2016-11-11 ES ES16865156T patent/ES2932049T3/es active Active
-
2020
- 2020-05-01 US US16/865,212 patent/US20200325135A1/en not_active Abandoned
-
2021
- 2021-05-10 AU AU2021202945A patent/AU2021202945B2/en active Active
- 2021-08-11 JP JP2021131351A patent/JP7174963B2/ja active Active
-
2022
- 2022-03-18 US US17/698,991 patent/US20220227767A1/en not_active Abandoned
- 2022-10-28 JP JP2022173717A patent/JP7445325B2/ja active Active
-
2023
- 2023-06-29 US US18/344,594 patent/US20230339944A1/en not_active Abandoned
-
2025
- 2025-05-14 US US19/207,818 patent/US20260092064A1/en active Pending
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