JP6933384B2 - 疾患の処置のための複素環化合物 - Google Patents

疾患の処置のための複素環化合物 Download PDF

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JP6933384B2
JP6933384B2 JP2018545102A JP2018545102A JP6933384B2 JP 6933384 B2 JP6933384 B2 JP 6933384B2 JP 2018545102 A JP2018545102 A JP 2018545102A JP 2018545102 A JP2018545102 A JP 2018545102A JP 6933384 B2 JP6933384 B2 JP 6933384B2
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JP2018535261A5 (enExample
JP2018535261A (ja
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モーハン，ラジュ
ヌス，ジョン
ハリス，ジェイソン
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オピラン ファーマ エルティーディー．
オピラン ファーマ エルティーディー．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Hospice & Palliative Care (AREA)
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  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018545102A 2015-11-13 2016-11-11 疾患の処置のための複素環化合物 Active JP6933384B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021131351A JP7174963B2 (ja) 2015-11-13 2021-08-11 疾患の処置のための複素環化合物
JP2022173717A JP7445325B2 (ja) 2015-11-13 2022-10-28 疾患の処置のための複素環化合物

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US201562255041P 2015-11-13 2015-11-13
US62/255,041 2015-11-13
PCT/US2016/061676 WO2017083756A1 (en) 2015-11-13 2016-11-11 Heterocyclic compounds for the treatment of disease

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JP2018535261A5 JP2018535261A5 (enExample) 2019-12-19
JP6933384B2 true JP6933384B2 (ja) 2021-09-08

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JP2022173717A Active JP7445325B2 (ja) 2015-11-13 2022-10-28 疾患の処置のための複素環化合物

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EP (2) EP4163281A1 (enExample)
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KR (1) KR102720397B1 (enExample)
CN (2) CN108463222B (enExample)
AU (2) AU2016353348A1 (enExample)
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EP4163281A1 (en) 2015-11-13 2023-04-12 Oppilan Pharma Ltd. Process for preparing heterocyclic compounds for the treatment of disease and intermediate compounds used therein
EP3625230A1 (en) * 2017-05-17 2020-03-25 Oppilan Pharma Ltd. Prodrugs for the treatment of disease
US20210163485A1 (en) * 2017-05-17 2021-06-03 Oppilan Pharma Ltd. Heterocyclic Compounds for the Treatment of Disease
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
JP2025524598A (ja) * 2022-07-06 2025-07-30 オピラン ファーマ リミテッド Ｓ１ｐ受容体モジュレーターの結晶形態
CN120835886A (zh) * 2023-01-13 2025-10-24 奥比兰制药有限公司 S1p受体调节剂的制备

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US4772597A (en) * 1983-10-14 1988-09-20 Pfizer Inc. 2-azacycloalkylthiopenem derivatives
US20070043014A1 (en) 2003-10-01 2007-02-22 Merck & Co., Inc. 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
BRPI0612028A2 (pt) * 2005-06-08 2010-10-13 Novartis Ag oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p
GB0511684D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
RU2425832C2 (ru) * 2006-04-03 2011-08-10 Астеллас Фарма Инк. Гетеросоединение
MX2009006304A (es) 2006-12-15 2009-06-23 Abbott Lab Nuevos compuestos de oxadiazol.
US20110207704A1 (en) 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
US20100160369A1 (en) * 2008-12-04 2010-06-24 Exelixis, Inc. S1P1 Agonists and Methods of Making And Using
US20100249071A1 (en) 2009-03-30 2010-09-30 Exelixis, Inc. Modulators of S1P and Methods of Making And Using
US9011494B2 (en) 2009-09-24 2015-04-21 Warsaw Orthopedic, Inc. Composite vertebral rod system and methods of use
PH12012500938A1 (en) 2009-11-13 2016-09-16 Receptos Llc Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
CN103124727B (zh) * 2010-07-20 2015-03-25 百时美施贵宝公司 取代的3-苯基-1,2,4-噁二唑化合物
CN103998451A (zh) 2011-10-20 2014-08-20 葛兰素史密斯克莱有限责任公司 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物
EP3074377B1 (en) 2013-11-27 2018-10-17 Genentech, Inc. Substituted benzamides and methods of use thereof
EP4163281A1 (en) 2015-11-13 2023-04-12 Oppilan Pharma Ltd. Process for preparing heterocyclic compounds for the treatment of disease and intermediate compounds used therein

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CN114149424A (zh) 2022-03-08
US20220227767A1 (en) 2022-07-21
WO2017083756A1 (en) 2017-05-18
AU2021202945B2 (en) 2022-06-23
HUE060594T2 (hu) 2023-03-28
US20190241556A1 (en) 2019-08-08
KR20180095811A (ko) 2018-08-28
PL3373931T3 (pl) 2023-02-06
JP2023017862A (ja) 2023-02-07
BR112018009745A2 (pt) 2018-11-06
IL259297A (en) 2018-07-31
CA3005236C (en) 2024-02-20
BR112018009745B1 (pt) 2023-09-26
BR112018009745A8 (pt) 2019-02-26
SI3373931T1 (sl) 2023-02-28
LT3373931T (lt) 2023-03-10
DK3373931T3 (da) 2022-11-28
EP3373931B1 (en) 2022-09-28
ES2932049T3 (es) 2023-01-09
AU2016353348A1 (en) 2018-07-05
RS63837B1 (sr) 2023-01-31
JP2021191753A (ja) 2021-12-16
HRP20221417T1 (hr) 2023-02-03
MX382092B (es) 2025-03-04
EP4163281A1 (en) 2023-04-12
EP3373931A4 (en) 2019-04-03
JP7445325B2 (ja) 2024-03-07
MX2018005987A (es) 2018-11-29
IL259297B (en) 2022-11-01
CA3005236A1 (en) 2017-05-18
US10683291B2 (en) 2020-06-16
EP3373931A1 (en) 2018-09-19
RU2018121416A3 (enExample) 2019-12-17
IL259297B2 (en) 2023-03-01
KR102720397B1 (ko) 2024-10-21
CN108463222A (zh) 2018-08-28
SMT202300062T1 (it) 2023-03-17
PT3373931T (pt) 2022-12-06
AU2021202945A1 (en) 2021-06-03
US20230339944A1 (en) 2023-10-26
JP7174963B2 (ja) 2022-11-18
CN114149424B (zh) 2025-05-13
CN108463222B (zh) 2021-10-22
RU2727194C2 (ru) 2020-07-21
RU2018121416A (ru) 2019-12-13
US20200325135A1 (en) 2020-10-15
JP2018535261A (ja) 2018-11-29

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