JP6930916B2 - 疾患予防および治療における成長ホルモン受容体の遮断剤 - Google Patents

疾患予防および治療における成長ホルモン受容体の遮断剤 Download PDF

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JP6930916B2
JP6930916B2 JP2017541934A JP2017541934A JP6930916B2 JP 6930916 B2 JP6930916 B2 JP 6930916B2 JP 2017541934 A JP2017541934 A JP 2017541934A JP 2017541934 A JP2017541934 A JP 2017541934A JP 6930916 B2 JP6930916 B2 JP 6930916B2
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ghr
pharmaceutical composition
igf
disease
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JP2018506534A (ja
JP2018506534A5 (https=
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ディー． ロンゴ，ヴァルター
ディー． ロンゴ，ヴァルター
バラスブラマニアン，プリア
ネアマティ，ノウリ
ウェイ，ミン
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University of Southern California USC
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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JP2017541934A 2015-02-12 2016-02-12 疾患予防および治療における成長ホルモン受容体の遮断剤 Active JP6930916B2 (ja)

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US201562115356P 2015-02-12 2015-02-12
US62/115,356 2015-02-12
PCT/US2016/017717 WO2016130901A2 (en) 2015-02-12 2016-02-12 Blockers of the growth hormone receptor in disease prevention and treatment

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JP2021018032A Pending JP2021075553A (ja) 2015-02-12 2021-02-08 疾患予防および治療における成長ホルモン受容体の遮断剤

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US (2) US10246446B2 (https=)
EP (1) EP3256465B1 (https=)
JP (2) JP6930916B2 (https=)
KR (1) KR20180016333A (https=)
CN (1) CN107438605B (https=)
AU (1) AU2016219173B2 (https=)
BR (1) BR112017017182A2 (https=)
CA (1) CA2976219C (https=)
ES (1) ES2871551T3 (https=)
IL (1) IL253943A0 (https=)
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US11284640B2 (en) 2017-02-14 2022-03-29 University Of Southern California Fasting mimicking diet
MX2020009613A (es) 2018-03-15 2021-02-26 Univ Southern California Dieta que imita el ayuno (fmd) pero no ayuno solo con agua, promueve la reversion de la inflamacion y patologia de la enfermedad de intestino irritable (ibd).
TW202600604A (zh) * 2024-04-30 2026-01-01 大陸商長春金賽藥業有限責任公司 Ghr激動型抗體及其應用

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SE9701010D0 (sv) * 1997-03-19 1997-03-19 Pharmacia & Upjohn Ab Antibody
JPWO2002096892A1 (ja) * 2001-05-31 2004-09-09 小野薬品工業株式会社 オキサジアゾール誘導体化合物およびその化合物を有効成分とする薬剤
WO2006001770A1 (en) 2004-06-28 2006-01-05 Biovitrum Ab Method for identifying modulators of cytokine class i receptor
RU2415134C9 (ru) * 2005-08-15 2011-05-27 Этерна Центарис ГмбХ Способ лечения или профилактики физиологических и/или патофизиологических состояний, опосредуемых рецепторами, стимулирующими секрецию гормона роста, триазолы и фармацевтическая композиция на их основе
CN101883760A (zh) * 2007-10-11 2010-11-10 沃泰克斯药物股份有限公司 用作电压-门控钠通道抑制剂的杂芳基酰胺类
EA201001467A1 (ru) * 2008-03-14 2011-06-30 Биокон Лимитед Моноклональное антитело и способ его использования
EP2460394B1 (en) * 2009-07-28 2013-06-05 Koninklijke Philips Electronics N.V. Housing with locking structure
HK1204328A1 (en) * 2011-12-22 2015-11-13 瑞纳神经科学公司 Human growth hormone receptor antagonist antibodies and methods of use thereof
CN104334541A (zh) * 2012-02-16 2015-02-04 纽约大学 使用低聚氧代哌嗪非肽螺旋模拟物对低氧诱导基因表达的控制
WO2013192165A2 (en) * 2012-06-20 2013-12-27 University Of Kansas Compounds and methods for activating the apoptotic arm of the unfolded protein response
CN114236130A (zh) 2013-02-12 2022-03-25 南加利福尼亚大学 用于减轻年龄相关症状的膳食包装

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RU2726254C2 (ru) 2020-07-10
AU2016219173B2 (en) 2020-02-20
JP2018506534A (ja) 2018-03-08
EP3256465A4 (en) 2018-10-31
EP3256465B1 (en) 2021-04-07
MX383010B (es) 2025-03-13
EP3256465A2 (en) 2017-12-20
WO2016130901A2 (en) 2016-08-18
CN107438605B (zh) 2021-03-19
BR112017017182A2 (pt) 2018-04-03
US10246446B2 (en) 2019-04-02
RU2017129335A (ru) 2019-03-12
WO2016130901A3 (en) 2016-10-20
JP2021075553A (ja) 2021-05-20
CA2976219C (en) 2021-05-04
US20170342063A1 (en) 2017-11-30
NZ734252A (en) 2020-06-26
IL253943A0 (en) 2017-10-31
ES2871551T3 (es) 2021-10-29
CN107438605A (zh) 2017-12-05
AU2016219173A1 (en) 2017-08-17
KR20180016333A (ko) 2018-02-14
RU2017129335A3 (https=) 2019-08-07
CA2976219A1 (en) 2016-08-18
MX2017010306A (es) 2018-03-15
US20190276445A1 (en) 2019-09-12

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