JP6923509B2 - 切断型のｔｒｋｂおよびｔｒｋｃのアンタゴニストを使用する処置 - Google Patents

切断型のｔｒｋｂおよびｔｒｋｃのアンタゴニストを使用する処置 Download PDF

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JP6923509B2
JP6923509B2 JP2018502404A JP2018502404A JP6923509B2 JP 6923509 B2 JP6923509 B2 JP 6923509B2 JP 2018502404 A JP2018502404 A JP 2018502404A JP 2018502404 A JP2018502404 A JP 2018502404A JP 6923509 B2 JP6923509 B2 JP 6923509B2
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nucleic acid
seq
pharmaceutical composition
truncated
trkc
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JP2018522013A5 (enExample
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ウリ サラゴヴィ，オラシオ
ウリ サラゴヴィ，オラシオ
ピュー，ファブリス
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
JP2018502404A 2015-07-28 2016-07-28 切断型のｔｒｋｂおよびｔｒｋｃのアンタゴニストを使用する処置 Active JP6923509B2 (ja)

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US201562198062P 2015-07-28 2015-07-28
US62/198,062 2015-07-28
PCT/US2016/044570 WO2017019905A1 (en) 2015-07-28 2016-07-28 Treatment using truncated trk b and trk c antagonists

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JP2018522013A JP2018522013A (ja) 2018-08-09
JP2018522013A5 JP2018522013A5 (enExample) 2019-09-05
JP6923509B2 true JP6923509B2 (ja) 2021-08-18

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US (2) US10066229B2 (enExample)
EP (1) EP3328440A4 (enExample)
JP (1) JP6923509B2 (enExample)
WO (1) WO2017019905A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017019905A1 (en) 2015-07-28 2017-02-02 Otonomy, Inc. Treatment using truncated trk b and trk c antagonists
EP3406259A1 (en) * 2017-05-24 2018-11-28 Dompé farmaceutici S.p.A. Neurotrophins for use in the treatment of hearing loss
EP3820483A4 (en) * 2018-07-13 2023-03-01 Yale University COMPOSITIONS AND METHODS FOR THE TREATMENT OF ENDOMETRIOSIS
US11911416B2 (en) 2018-08-01 2024-02-27 University Of Iowa Research Foundation Compositions and methods to restore hearing loss and balance through embryonic ear transplant
WO2020115114A1 (en) * 2018-12-04 2020-06-11 Sirion Biotech Gmbh Viral transduction using poloxamines
US10561736B1 (en) 2019-01-09 2020-02-18 Spiral Therapeutics, Inc. Apoptosis inhibitor formulations for prevention of hearing loss

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US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
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US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
NZ333650A (en) 1996-07-19 2000-02-28 Amgen Inc Analogs of cationic proteins like NT-3 (neurotrophin-3) and BDNF (brain derived neurotrophic factor) that are circulated more readily due to a lower isoelectric point and a lower protein charge relative to the native protein
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
JP2001521753A (ja) 1997-10-31 2001-11-13 アフィメトリックス インコーポレイテッド 成人臓器及び胎児臓器中の発現プロフィール
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EP3328440A4 (en) 2019-01-16
WO2017019905A1 (en) 2017-02-02
JP2018522013A (ja) 2018-08-09
US20190017053A1 (en) 2019-01-17
EP3328440A1 (en) 2018-06-06
US10066229B2 (en) 2018-09-04
US20170029822A1 (en) 2017-02-02
US11034961B2 (en) 2021-06-15

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