JP6876049B2 - 細胞培養に使用されるペレットおよびその製造方法 - Google Patents

細胞培養に使用されるペレットおよびその製造方法 Download PDF

Info

Publication number
JP6876049B2
JP6876049B2 JP2018531335A JP2018531335A JP6876049B2 JP 6876049 B2 JP6876049 B2 JP 6876049B2 JP 2018531335 A JP2018531335 A JP 2018531335A JP 2018531335 A JP2018531335 A JP 2018531335A JP 6876049 B2 JP6876049 B2 JP 6876049B2
Authority
JP
Japan
Prior art keywords
medium
pellets
cell culture
pellet
feed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018531335A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018537113A5 (cg-RX-API-DMAC7.html
JP2018537113A (ja
Inventor
ムウィタ フェルプス
ムウィタ フェルプス
ポール グルデ
ポール グルデ
リチャード ファイク
リチャード ファイク
メアリー レイノルズ
メアリー レイノルズ
リチャード ハセット
リチャード ハセット
アンドリュー キャンベル
アンドリュー キャンベル
Original Assignee
ライフ テクノロジーズ コーポレーション
ライフ テクノロジーズ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライフ テクノロジーズ コーポレーション, ライフ テクノロジーズ コーポレーション filed Critical ライフ テクノロジーズ コーポレーション
Publication of JP2018537113A publication Critical patent/JP2018537113A/ja
Publication of JP2018537113A5 publication Critical patent/JP2018537113A5/ja
Priority to JP2021072968A priority Critical patent/JP7357657B2/ja
Application granted granted Critical
Publication of JP6876049B2 publication Critical patent/JP6876049B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/18Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles
    • B01J8/1845Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with particles moving upwards while fluidised
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16Vibrating; Shaking; Tilting
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18Flow directing inserts
    • C12M27/20Baffles; Ribs; Ribbons; Auger vanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M99/00Subject matter not otherwise provided for in other groups of this subclass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/22Processes using, or culture media containing, cellulose or hydrolysates thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/34Sugars
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/60Buffer, e.g. pH regulation, osmotic pressure

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Combustion & Propulsion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2018531335A 2015-12-17 2016-12-16 細胞培養に使用されるペレットおよびその製造方法 Active JP6876049B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021072968A JP7357657B2 (ja) 2015-12-17 2021-04-23 細胞培養に使用されるペレットおよびその製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562269031P 2015-12-17 2015-12-17
US62/269,031 2015-12-17
PCT/US2016/067374 WO2017106783A1 (en) 2015-12-17 2016-12-16 Pellets used in cell culture and methods of making thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021072968A Division JP7357657B2 (ja) 2015-12-17 2021-04-23 細胞培養に使用されるペレットおよびその製造方法

Publications (3)

Publication Number Publication Date
JP2018537113A JP2018537113A (ja) 2018-12-20
JP2018537113A5 JP2018537113A5 (cg-RX-API-DMAC7.html) 2019-12-19
JP6876049B2 true JP6876049B2 (ja) 2021-05-26

Family

ID=57738000

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018531335A Active JP6876049B2 (ja) 2015-12-17 2016-12-16 細胞培養に使用されるペレットおよびその製造方法
JP2021072968A Active JP7357657B2 (ja) 2015-12-17 2021-04-23 細胞培養に使用されるペレットおよびその製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021072968A Active JP7357657B2 (ja) 2015-12-17 2021-04-23 細胞培養に使用されるペレットおよびその製造方法

Country Status (8)

Country Link
US (2) US10822584B2 (cg-RX-API-DMAC7.html)
EP (2) EP3271452B1 (cg-RX-API-DMAC7.html)
JP (2) JP6876049B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180091923A (cg-RX-API-DMAC7.html)
CN (1) CN108495926A (cg-RX-API-DMAC7.html)
RU (2) RU2759945C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201805049TA (cg-RX-API-DMAC7.html)
WO (1) WO2017106783A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020218584A1 (ja) * 2019-04-26 2020-10-29 味の素株式会社 細胞培養用組成物
US20220372435A1 (en) * 2019-09-19 2022-11-24 Life Technologies Corporation Cell Culture Media Tablets and Methods of Manufacture
CN116438295A (zh) 2020-06-22 2023-07-14 生命技术公司 培养多能细胞悬浮液的方法和组合物
US20230287334A1 (en) * 2020-07-14 2023-09-14 Corning Incorporated Rapidly dissolving cell culture media powder and methods of making the same
JP2023544507A (ja) * 2020-09-22 2023-10-24 アルフィニティ ユーエスエイ,インコーポレイテッド バイオプロセスおよび医薬用途の流体を調製するためのシステムおよび方法
JP7651417B2 (ja) 2021-09-09 2025-03-26 株式会社クボタ 自動走行制御システムおよび圃場作業車
KR102633825B1 (ko) * 2021-10-18 2024-02-02 연세대학교 산학협력단 박테리아를 이용한 가스 중 질소산화물의 저감 방법 및 시스템

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2379001A (en) 1944-05-20 1945-06-26 Leonard W Moen Device for removing and applying chain links
SU1275042A1 (ru) * 1984-12-28 1986-12-07 Научно-Исследовательский Институт По Производству Питательных Сред, Г.Махачкала Способ производства сухих питательных сред
DE3609133A1 (de) 1986-03-19 1987-09-24 Glatt Gmbh Vorrichtung zum pelletieren od. dgl. behandeln von teilchen sowie damit durchfuehrbares verfahren
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JPH0257175A (ja) 1988-08-19 1990-02-26 Morinaga & Co Ltd 成形培地及びその製造法
US5132142A (en) * 1991-03-19 1992-07-21 Glatt Gmbh Apparatus and method for producing pellets by layering power onto particles
JP3347366B2 (ja) * 1992-06-23 2002-11-20 塩野義製薬株式会社 転動造粒装置及び方法
CA2261292C (en) * 1996-07-25 2008-09-30 Genzyme Corporation Chondrocyte media formulations and culture procedures
AU4330597A (en) * 1996-08-30 1998-03-19 Life Technologies, Inc. Serum-free mammalian cell culture medium, and uses thereof
US6383810B2 (en) * 1997-02-14 2002-05-07 Invitrogen Corporation Dry powder cells and cell culture reagents and methods of production thereof
US20060286668A1 (en) * 1999-04-30 2006-12-21 Invitrogen Corporation Animal-cell culture media comprising non-animal or plant-derived nutrients
JP2001170473A (ja) * 1999-12-17 2001-06-26 Hosokawa Micron Corp 造粒装置
AU2002232406C1 (en) * 2000-11-06 2009-03-05 Invitrogen Corporation Dry powder cells and cell culture reagents and methods of production thereof
CN1657604A (zh) * 2005-02-07 2005-08-24 黄宗堂 一种培养基的配制和使用方法
FR2910024B1 (fr) * 2006-12-19 2009-03-27 Agronomique Inst Nat Rech Milieu de culture synthetique chimiquement defini.
EP2563904B1 (en) * 2010-04-26 2015-01-21 Novartis AG Improved cell culture medium
CN103261404B (zh) * 2010-12-16 2017-06-09 默克专利有限公司 干的颗粒状细胞培养基
KR102007997B1 (ko) 2011-02-07 2019-08-07 라이프 테크놀로지스 코포레이션 감수성 화합물을 안정화시키는 조성물 및 방법
EP2794853B1 (en) * 2011-12-22 2020-04-22 Life Technologies Corporation Cell culture media and methods
EP2882842B1 (en) * 2012-08-07 2019-02-20 3M Innovative Properties Company Method of making agglomerated microbiological media and compositions thereof
CN104096510A (zh) * 2013-04-12 2014-10-15 上海源培生物科技有限公司 利用流化床干燥技术混匀培养基成分的工艺
US20150275167A1 (en) * 2014-03-28 2015-10-01 Corning Incorporated Composition and method for cell culture sustained release

Also Published As

Publication number Publication date
KR20180091923A (ko) 2018-08-16
EP3271452A1 (en) 2018-01-24
EP4036220A1 (en) 2022-08-03
SG11201805049TA (en) 2018-07-30
JP2021106613A (ja) 2021-07-29
JP2018537113A (ja) 2018-12-20
JP7357657B2 (ja) 2023-10-06
RU2759945C2 (ru) 2021-11-19
CN108495926A (zh) 2018-09-04
WO2017106783A1 (en) 2017-06-22
US10822584B2 (en) 2020-11-03
RU2018124447A (ru) 2020-01-22
RU2018124447A3 (cg-RX-API-DMAC7.html) 2020-11-06
RU2021132093A (ru) 2021-12-07
EP3271452B1 (en) 2021-12-08
US20210009942A1 (en) 2021-01-14
US20180142203A1 (en) 2018-05-24

Similar Documents

Publication Publication Date Title
JP6876049B2 (ja) 細胞培養に使用されるペレットおよびその製造方法
US12203095B2 (en) Cell culture media and methods
US11028361B2 (en) Compositions and methods for stabilizing susceptible compounds
US20220062186A1 (en) Composition and method for cell culture sustained release

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191107

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191107

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200722

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20201102

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210201

TRDD Decision of grant or rejection written
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20210324

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210329

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210423

R150 Certificate of patent or registration of utility model

Ref document number: 6876049

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE

Ref document number: 6876049

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250