JP6866397B2 - 液体薬剤の容器 - Google Patents
液体薬剤の容器 Download PDFInfo
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- JP6866397B2 JP6866397B2 JP2018555124A JP2018555124A JP6866397B2 JP 6866397 B2 JP6866397 B2 JP 6866397B2 JP 2018555124 A JP2018555124 A JP 2018555124A JP 2018555124 A JP2018555124 A JP 2018555124A JP 6866397 B2 JP6866397 B2 JP 6866397B2
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- container
- casing
- cavity
- filament
- outlet
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
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- 229920001184 polypeptide Polymers 0.000 description 1
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- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
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- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
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- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
Images
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/24—Check- or non-return valves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
- A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ある。
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
3 近位方向
4 遠位端部
5 近位端部
10 容器
11 ケーシング
12 壁部分
13 壁部分
14 フィラメント
14a 第1の端部
14b 第2の端部
15 出口
16 キャップ
17 封止材
18 圧力レギュレータ
19 キャビティ
20 薬剤
21 内部
22 最大容積
24 想像面
25 置換流体
28 絞り弁
30 プランジャ
31 圧力部片
32 当接部
33 入口パイプ
34 出口パイプ
35 入口チューブ
36 出口チューブ
38 逆止め弁
50 薬物送達デバイス
51 ハウジング
52 出口
53 ソケット
54 用量部材
60 駆動部材
110 容器
114 フィラメント
130 コイル部材
160 駆動機構
210 容器
214 フィラメント
310 容器
410 容器
501 サブキャビティ
502 分離壁
509 サブキャビティ
510 容器
511 ケーシング
515 出口
516 出口
519 キャビティ
601 サブアセンブリ
602 分離壁
609 サブキャビティ
610 容器
701 サブキャビティ
702 絞り部材
709 サブキャビティ
710 容器
711 ケーシング
715 出口
716 出口
719 キャビティ
Claims (15)
- 液体薬剤の容器(10;110;210;310;410;510;610;710)であって:
薬剤(20)を受けるための少なくとも1つのキャビティ(19)を形成する少なくとも1つの可撓性ケーシング(11)と、
キャビティ(19)と流体連結し、ケーシング(11)を通って延びる少なくとも第1の出口(15;515)とを含み、
ここで、ケーシング(11)は第1の壁部分(12)および第2の壁部分(13)を含み、該第2の壁部分(13)は第1の壁部分(12)の反対側にあり、容器はまた、
多数のフィラメント(14)を含み、そのそれぞれがキャビティ(19)の中に延びており、かつそのそれぞれが第1の端部(14a)および第2の端部(14b)を有し、第2の端部(14b)は第1の端部(14a)の反対側にあり、フィラメント(14)の第1の端部(14a)は第1の壁部分(12)に連結され、フィラメント(14)の第2の端部(14b)は第2の壁部分(13)に連結される、前記容器。 - フィラメント(14)は張力が安定している、請求項1に記載の容器(10;110;210;310;410;510;610;710)。
- キャビティ(19)は、少なくともフィラメント(14)が緊張し直線状になるまでは最大容積(22)および所定の内圧(P)まで膨張可能である、請求項1または2に記載の容器(10;110;210;310;410;510;610;710)。
- ケーシング(11)と、その第1および第2の壁部分(12、13)と、キャビティ(19)とは、最大容積(22)以上では非伸張性または非伸縮性である、請求項3に記載の容器(10;110;210;310;410;510;610;710)。
- 第1の出口(15)は、圧力レギュレータ(18)および絞り弁(28)の少なくとも一方を含む、請求項1〜4のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。
- ケーシング(11)は細長い形状であり、軸方向(z)に延び、またケーシング(11)は、軸方向(z)に沿って分離された遠位端部(4)および近位端部(5)を含む、請求項1〜5のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。
- 第1の出口(15)は遠位端部(4)にあり、近位端部(5)は遠位端部(4)に向けて変形可能、絞り可能または圧縮可能である、請求項6に記載の容器(10;110;210;310;410;510;610;710)。
- ケーシング(11)の近位端部(5)は遠位端部(4)に向けて巻くことが可能である、請求項6または7に記載の容器(10;110;210;310;410;510;610;710)。
- フィラメント(14)の少なくとも一部は、ケーシング(11)の軸方向(z)に対し実質的に垂直に延びる仮想面(24)にある、請求項6〜8のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。
- フィラメント(14)の少なくとも一部は互いに実質的に平行に延び、隣り合うフィラメント(114)の少なくとも一部はジグザグ構造を形成し、かつ/またはフィラメント(214)の少なくとも一部は軸方向(z)に対して径方向に延び、軸方向(z)は容器(10;110;210;310;410;510;610;710)の対称軸と一致する、請求項1〜9のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。
- キャビティ(519、719)を第1のサブキャビティ(509;609)および第2のサブキャビティ(501;601)に分割する分離壁(502;602)と、
第2の出口(516)とをさらに含み、ここで、第1の出口(515)は第1のサブキャビティ(509;609)と流体連結し、第2の出口(516)は第2のサブキャビティ(501;601)と流体連結している、請求項1〜10のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。 - 第1の出口(715)および第2の出口(716)はケーシング(711)の両端部にあり、ケーシング(711)は軸方向(2、3)に沿って細長く、ケーシング(711)は、絞り部材(702)によって軸方向(2、3)に対して直交する方向に圧縮されて、第1のサブキャビティ(701)および第2のサブキャビティ(709)を形成するように構成され、絞り部材(702)は、軸方向(2、3)に沿って変位されて、第2のサブキャビティ(701)のサイズが第1のサブキャビティ(709)のサイズを代償として増大するように、またはその逆になるように構成される、請求項1〜11のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。
- 出口(15;515,516;715,716)のうちの少なくとも1つは絞り弁(38)を含む、請求項1〜12のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)。
- 液体薬剤(20)を投与するための薬物送達デバイスであって:
請求項1〜13のいずれか1項に記載の容器(10;110;210;310;410;510;610;710)を収容するためのハウジング(51)と、
a)容器(10;110;210;310;410;510;610;710)のケーシング(11)に投薬圧力をかけるための、かつ
b)容器(10;110;210;310;410;510;610;710)のキャビティ(19)の中に置換流体(25)を導入するための
駆動機構(60)とを含む前記薬物送達デバイス。 - 容器(10;110;210;310;410;510;610;710)はハウジング(51)の内側に配置され、また、容器は液体薬剤(20)で充填される、請求項14に記載の薬物送達デバイス。
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EP16166383.6 | 2016-04-21 | ||
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PCT/EP2017/059321 WO2017182540A1 (en) | 2016-04-21 | 2017-04-20 | Container for a liquid medicament |
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US2764979A (en) * | 1953-04-09 | 1956-10-02 | Henderson Edward | Medicament dispensing unit |
AU414085B2 (en) | 1967-01-31 | 1971-06-14 | M. S. F. R. C. S. F. RA. C. S. and IAN HOWARD MUDIE ROEGER NOEL JAMES BONNIN | An improved dispensing container |
US4318400A (en) * | 1980-01-18 | 1982-03-09 | Alza Corporation | Medical infusor |
US4360736A (en) * | 1980-04-15 | 1982-11-23 | Weissenfluh John A | Radiation shield |
US4795432A (en) | 1987-02-19 | 1989-01-03 | Karczmer Claude M | Shield assembly for hypodermic injection devices |
JPH07206007A (ja) | 1994-01-14 | 1995-08-08 | Ube Package Kk | 梱包用具 |
WO1997009079A1 (en) | 1995-09-08 | 1997-03-13 | Yoshino, Shigeo | Syringe serving also as an ampule and syringe for collecting blood |
US20070297701A1 (en) * | 2006-01-19 | 2007-12-27 | Tiger Medical Products (Us), Inc. | Pill crusher pouch for use with a pill crusher |
CN102151346A (zh) | 2011-04-26 | 2011-08-17 | 上海白塔医药科技有限公司 | 一种皮下植入式给药装置 |
EP2869870B1 (en) | 2012-07-06 | 2018-11-14 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
BR112016010210A2 (pt) | 2013-11-06 | 2017-08-08 | Procter & Gamble | recipientes flexíveis e métodos para a produção dos mesmos |
CN204723399U (zh) | 2014-05-01 | 2015-10-28 | 楚天科技股份有限公司 | 一种医疗用多腔容器 |
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