JP6860575B2 - 神経変性障害の処置に用いられるホメオタンパク質 - Google Patents

神経変性障害の処置に用いられるホメオタンパク質 Download PDF

Info

Publication number
JP6860575B2
JP6860575B2 JP2018534025A JP2018534025A JP6860575B2 JP 6860575 B2 JP6860575 B2 JP 6860575B2 JP 2018534025 A JP2018534025 A JP 2018534025A JP 2018534025 A JP2018534025 A JP 2018534025A JP 6860575 B2 JP6860575 B2 JP 6860575B2
Authority
JP
Japan
Prior art keywords
neurons
mice
ohda
disease
snpc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018534025A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018536697A5 (cg-RX-API-DMAC7.html
JP2018536697A (ja
Inventor
プロシアンツ、アラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of JP2018536697A publication Critical patent/JP2018536697A/ja
Publication of JP2018536697A5 publication Critical patent/JP2018536697A5/ja
Application granted granted Critical
Publication of JP6860575B2 publication Critical patent/JP6860575B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2018534025A 2015-09-23 2016-09-23 神経変性障害の処置に用いられるホメオタンパク質 Active JP6860575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306482 2015-09-23
EP15306482.9 2015-09-23
PCT/EP2016/072675 WO2017071889A1 (en) 2015-09-23 2016-09-23 Homeoproteins for use in the treatment of neurodegenerative disorders

Publications (3)

Publication Number Publication Date
JP2018536697A JP2018536697A (ja) 2018-12-13
JP2018536697A5 JP2018536697A5 (cg-RX-API-DMAC7.html) 2019-09-05
JP6860575B2 true JP6860575B2 (ja) 2021-04-14

Family

ID=54207439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018534025A Active JP6860575B2 (ja) 2015-09-23 2016-09-23 神経変性障害の処置に用いられるホメオタンパク質

Country Status (8)

Country Link
US (2) US20190247461A1 (cg-RX-API-DMAC7.html)
EP (2) EP3960195B1 (cg-RX-API-DMAC7.html)
JP (1) JP6860575B2 (cg-RX-API-DMAC7.html)
CN (1) CN108289929A (cg-RX-API-DMAC7.html)
CA (1) CA2999209A1 (cg-RX-API-DMAC7.html)
ES (2) ES2895154T3 (cg-RX-API-DMAC7.html)
PL (2) PL3960195T3 (cg-RX-API-DMAC7.html)
WO (1) WO2017071889A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024149784A1 (en) 2023-01-13 2024-07-18 Brainever Stabilized engrailed protein aqueous compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2662698A1 (fr) * 1990-06-05 1991-12-06 Centre Nat Rech Scient Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
FR2855178B1 (fr) * 2003-05-20 2005-08-05 Centre Nat Rech Scient Peptides modulateurs de l'activite du facteur de transcription engrailed
FR2897780B1 (fr) 2006-02-28 2008-05-23 Centre Nat Rech Scient Utilisation de la proteine a homeodomaine engrailed comme anxiolytique
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
FR2926023B1 (fr) 2008-01-09 2010-02-26 Centre Nat Rech Scient Utilisation d'une homoproteine de la famille bicoid pour le traitement du glaucome.
EP2454597A1 (en) * 2009-07-13 2012-05-23 The University of Surrey Therapeutic peptides, polypeptides ans nucleic acid sequences
WO2013128239A1 (en) 2012-02-29 2013-09-06 Centre National De La Recherche Scientifique Use of engrailed for increasing dopamine synthesis by dopaminergic neurons

Also Published As

Publication number Publication date
US20210379144A1 (en) 2021-12-09
ES3010130T3 (en) 2025-04-01
EP3352777B1 (en) 2021-09-15
JP2018536697A (ja) 2018-12-13
PL3352777T3 (pl) 2022-02-07
CA2999209A1 (en) 2017-05-04
EP3960195B1 (en) 2025-01-08
PL3960195T3 (pl) 2025-06-09
WO2017071889A1 (en) 2017-05-04
EP3352777A1 (en) 2018-08-01
US20190247461A1 (en) 2019-08-15
EP3960195A1 (en) 2022-03-02
CN108289929A (zh) 2018-07-17
ES2895154T3 (es) 2022-02-17

Similar Documents

Publication Publication Date Title
He et al. Targets of neuroprotection in glaucoma
Bertrand et al. Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats
Carty et al. SARM: From immune regulator to cell executioner
Shindler et al. SIRT1 activation confers neuroprotection in experimental optic neuritis
Shah et al. Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration
Conforti et al. Wallerian degeneration: an emerging axon death pathway linking injury and disease
Wu et al. Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4‐CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition
CN102449140A (zh) 抑制光感受器凋亡的方法
Sun et al. Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice
Gu et al. Piperlongumine attenuates experimental autoimmune encephalomyelitis through inhibition of NF-kappaB activity
Akaiwa et al. Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma
KR20170104457A (ko) 신경변성 장애
KR20190120197A (ko) 치료 및 신경보호 펩티드
US20130197069A1 (en) Methods for treating stress induced emotional disorders
Kojima et al. Axonal protection by modulation of p62 expression in TNF-induced optic nerve degeneration
JP6860575B2 (ja) 神経変性障害の処置に用いられるホメオタンパク質
Song et al. Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats
US7749496B2 (en) Neuronal regeneration
WO2019134574A1 (zh) 防治端粒功能异常相关疾病的多肽及医药用途
JP7630540B2 (ja) 神経保護ペプチド
CA3204205A1 (en) Lectin protein for treatment and prevention of neurodegenerative diseases
Fritzinger et al. Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration
CN115475247A (zh) β2-微球蛋白或其抑制剂的制药用途
US20240209038A1 (en) Targeting piezo1 to treat inherited and age-related macular degenerations
US20130130993A1 (en) Pimap39 modulates inflammatory response

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190729

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190729

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200807

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201029

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210107

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210303

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210326

R150 Certificate of patent or registration of utility model

Ref document number: 6860575

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250