JP6851639B2 - プラチナ薬剤の毒性の予防方法 - Google Patents

プラチナ薬剤の毒性の予防方法 Download PDF

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JP6851639B2
JP6851639B2 JP2018521498A JP2018521498A JP6851639B2 JP 6851639 B2 JP6851639 B2 JP 6851639B2 JP 2018521498 A JP2018521498 A JP 2018521498A JP 2018521498 A JP2018521498 A JP 2018521498A JP 6851639 B2 JP6851639 B2 JP 6851639B2
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oct2
cancer
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platinum drug
platinum
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JP2018521133A5 (enExample
JP2018521133A (ja
Inventor
ヨン ファン，
ヨン ファン，
ドミニク ピー． ブライドン，
ドミニク ピー． ブライドン，
シュエシャン チャン，
シュエシャン チャン，
チェン−ミン リ，
チェン−ミン リ，
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ゾミクス バイオファーマ， インコーポレイテッド
ゾミクス バイオファーマ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018521498A 2015-07-16 2016-07-15 プラチナ薬剤の毒性の予防方法 Expired - Fee Related JP6851639B2 (ja)

Applications Claiming Priority (3)

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US201562193529P 2015-07-16 2015-07-16
US62/193,529 2015-07-16
PCT/US2016/042673 WO2017011816A1 (en) 2015-07-16 2016-07-15 Methods of preventing toxicity of platinum drugs

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JP2018521133A JP2018521133A (ja) 2018-08-02
JP2018521133A5 JP2018521133A5 (enExample) 2019-08-29
JP6851639B2 true JP6851639B2 (ja) 2021-03-31

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JP2018521498A Expired - Fee Related JP6851639B2 (ja) 2015-07-16 2016-07-15 プラチナ薬剤の毒性の予防方法
JP2021033324A Active JP7117797B2 (ja) 2015-07-16 2021-03-03 プラチナ薬剤の毒性の予防方法

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US (2) US11197862B2 (enExample)
EP (2) EP3322414B1 (enExample)
JP (2) JP6851639B2 (enExample)
CN (1) CN108024986A (enExample)
CA (1) CA2990686A1 (enExample)
WO (1) WO2017011816A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021080296A (ja) * 2015-07-16 2021-05-27 ゾミクス バイオファーマ， インコーポレイテッド プラチナ薬剤の毒性の予防方法

Families Citing this family (8)

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KR101859922B1 (ko) * 2017-02-07 2018-05-21 주식회사 온코크로스 클로페네신을 포함하는 대장암 증식 및 전이 억제용 조성물
CN109596818B (zh) * 2018-12-13 2024-03-19 丁蓉 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法
US20220125877A1 (en) * 2019-07-10 2022-04-28 Sun Yat-Sen University Method for treating colorectal cancer
EP4013405A4 (en) * 2019-08-16 2023-08-09 Purdue Research Foundation SMALL MOLECULAR STIMULATORS OF THE NUCLEAR PARTICLE OF A PROTEASOME
CN111067894A (zh) * 2020-01-14 2020-04-28 广东药科大学 咪康唑在制备抗肺鳞癌药物和顺铂增敏剂中的应用
CN111110675A (zh) * 2020-02-25 2020-05-08 浙江大学 延胡索乙素在制备抗奥沙利铂外周神经毒性药物中的应用
CN113527333B (zh) * 2020-04-13 2022-08-05 南开大学 具有生物活性的度鲁特韦衍生物及其制备方法和应用
JP7504367B2 (ja) 2021-05-18 2024-06-24 株式会社Ｌｔｔバイオファーマ 抗癌剤の投与に伴う障害を治療又は予防するための医薬組成物

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
WO2009032172A2 (en) 2007-08-31 2009-03-12 Massachusetts Institute Of Technology Platinum compositions as treatment for oct-related cancers
EP2090311A1 (en) * 2008-02-18 2009-08-19 Laboratorios Del. Dr. Esteve, S.A. Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy
KR20110008166A (ko) 2008-02-18 2011-01-26 라보라토리오스 델 드라. 에스테브.에스.에이. 화학요법의 결과로 발생하는 신경병적 통증의 치료를 위한 시그마 수용체 리간드에 결합하는 화합물들의 용도
PL2488204T3 (pl) 2009-10-16 2016-10-31 Kombinacja terapeutyczna i zastosowanie przeciwciał antagonistycznych względem dll4 i środków antyhipertensyjnych
WO2013178763A1 (en) 2012-05-30 2013-12-05 Sensorion Methods for treating vestibulotoxicity
US20150320861A1 (en) 2012-12-21 2015-11-12 Sykehuset Sørlandet Hf Egfr targeted therapy of neurological disorders and pain
US11197862B2 (en) * 2015-07-16 2021-12-14 Xomics Biopharma, Inc. Methods of preventing toxicity of platinum drugs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021080296A (ja) * 2015-07-16 2021-05-27 ゾミクス バイオファーマ， インコーポレイテッド プラチナ薬剤の毒性の予防方法
JP7117797B2 (ja) 2015-07-16 2022-08-15 ゾミクス バイオファーマ， インコーポレイテッド プラチナ薬剤の毒性の予防方法

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CN108024986A (zh) 2018-05-11
US11197862B2 (en) 2021-12-14
EP3322414B1 (en) 2020-09-30
EP3777851A1 (en) 2021-02-17
EP3777851B1 (en) 2022-12-28
WO2017011816A1 (en) 2017-01-19
US20180207169A1 (en) 2018-07-26
JP2021080296A (ja) 2021-05-27
JP7117797B2 (ja) 2022-08-15
US20220202823A1 (en) 2022-06-30
EP3322414A1 (en) 2018-05-23
CA2990686A1 (en) 2017-01-19
EP3322414A4 (en) 2019-02-06
JP2018521133A (ja) 2018-08-02

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