CA2990686A1 - Methods of preventing toxicity of platinum drugs comprising administering an oct monitor - Google Patents

Methods of preventing toxicity of platinum drugs comprising administering an oct monitor Download PDF

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Publication number
CA2990686A1
CA2990686A1 CA2990686A CA2990686A CA2990686A1 CA 2990686 A1 CA2990686 A1 CA 2990686A1 CA 2990686 A CA2990686 A CA 2990686A CA 2990686 A CA2990686 A CA 2990686A CA 2990686 A1 CA2990686 A1 CA 2990686A1
Authority
CA
Canada
Prior art keywords
oct2
subject
platinum drug
cancer
selective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2990686A
Other languages
English (en)
French (fr)
Inventor
Yong Huang
Dominique P. Bridon
Xuexiang ZHANG
Chien-Ming Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xomics Biopharma Inc
Original Assignee
Amari Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amari Biopharma Inc filed Critical Amari Biopharma Inc
Publication of CA2990686A1 publication Critical patent/CA2990686A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2990686A 2015-07-16 2016-07-15 Methods of preventing toxicity of platinum drugs comprising administering an oct monitor Pending CA2990686A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562193529P 2015-07-16 2015-07-16
US62/193,529 2015-07-16
PCT/US2016/042673 WO2017011816A1 (en) 2015-07-16 2016-07-15 Methods of preventing toxicity of platinum drugs

Publications (1)

Publication Number Publication Date
CA2990686A1 true CA2990686A1 (en) 2017-01-19

Family

ID=57757682

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2990686A Pending CA2990686A1 (en) 2015-07-16 2016-07-15 Methods of preventing toxicity of platinum drugs comprising administering an oct monitor

Country Status (6)

Country Link
US (2) US11197862B2 (enExample)
EP (2) EP3777851B1 (enExample)
JP (2) JP6851639B2 (enExample)
CN (1) CN108024986A (enExample)
CA (1) CA2990686A1 (enExample)
WO (1) WO2017011816A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6851639B2 (ja) * 2015-07-16 2021-03-31 ゾミクス バイオファーマ， インコーポレイテッド プラチナ薬剤の毒性の予防方法
KR101859922B1 (ko) * 2017-02-07 2018-05-21 주식회사 온코크로스 클로페네신을 포함하는 대장암 증식 및 전이 억제용 조성물
CN109596818B (zh) * 2018-12-13 2024-03-19 丁蓉 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法
US20220125877A1 (en) * 2019-07-10 2022-04-28 Sun Yat-Sen University Method for treating colorectal cancer
CN114222573A (zh) * 2019-08-16 2022-03-22 普度研究基金会 蛋白酶体核心颗粒的小分子刺激物
CN111067894A (zh) * 2020-01-14 2020-04-28 广东药科大学 咪康唑在制备抗肺鳞癌药物和顺铂增敏剂中的应用
CN111110675A (zh) * 2020-02-25 2020-05-08 浙江大学 延胡索乙素在制备抗奥沙利铂外周神经毒性药物中的应用
CN113527333B (zh) * 2020-04-13 2022-08-05 南开大学 具有生物活性的度鲁特韦衍生物及其制备方法和应用
MX428431B (es) 2021-05-18 2025-11-13 Ltt Bio Pharma Co Ltd Composicion farmaceutica para tratar o prevenir un trastorno relacionado con la administracion de un agente anticancerigeno
CN117731671A (zh) * 2023-10-18 2024-03-22 山东第一医科大学(山东省医学科学院) 一种多替拉韦钠制备抗顺铂耳毒性药物的新型应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009032172A2 (en) * 2007-08-31 2009-03-12 Massachusetts Institute Of Technology Platinum compositions as treatment for oct-related cancers
RU2537226C2 (ru) 2008-02-18 2014-12-27 Лабораторьос Дель Др. Эстеве, С.А. Применение соединений, связывающихся с лигандами сигма-рецептора, для лечения развития невропатической боли вследствие химиотерапии
EP2090311A1 (en) * 2008-02-18 2009-08-19 Laboratorios Del. Dr. Esteve, S.A. Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy
EP3485908B1 (en) 2009-10-16 2021-08-18 Mereo BioPharma 5, Inc. Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents
HK1209040A1 (en) * 2012-05-30 2016-03-24 Sensorion Methods for treating vestibulotoxicity
KR102228358B1 (ko) 2012-12-21 2021-03-16 쉬케후세트 솔란데트 에이치에프 신경 장애 및 통증의 ｅｇｆｒ 표적 치료
JP6851639B2 (ja) 2015-07-16 2021-03-31 ゾミクス バイオファーマ， インコーポレイテッド プラチナ薬剤の毒性の予防方法

Also Published As

Publication number Publication date
EP3322414A4 (en) 2019-02-06
JP2021080296A (ja) 2021-05-27
JP7117797B2 (ja) 2022-08-15
US20180207169A1 (en) 2018-07-26
EP3777851A1 (en) 2021-02-17
EP3777851B1 (en) 2022-12-28
US20220202823A1 (en) 2022-06-30
JP2018521133A (ja) 2018-08-02
WO2017011816A1 (en) 2017-01-19
US11197862B2 (en) 2021-12-14
CN108024986A (zh) 2018-05-11
EP3322414B1 (en) 2020-09-30
JP6851639B2 (ja) 2021-03-31
EP3322414A1 (en) 2018-05-23

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Effective date: 20210713