JP6847824B2 - 神経保護および神経修復用のepha4環状ペプチドアンタゴニスト - Google Patents

神経保護および神経修復用のepha4環状ペプチドアンタゴニスト Download PDF

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JP6847824B2
JP6847824B2 JP2017501706A JP2017501706A JP6847824B2 JP 6847824 B2 JP6847824 B2 JP 6847824B2 JP 2017501706 A JP2017501706 A JP 2017501706A JP 2017501706 A JP2017501706 A JP 2017501706A JP 6847824 B2 JP6847824 B2 JP 6847824B2
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epha4
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disease
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JP2017526644A (ja
JP2017526644A5 (enExample
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パスクワレ,エレナ,ビー.
ドーソン,フィリップ
リードル,ステファン,ジェー.
オルソン,エリカ
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サンフォード バーナム プレビーズ メディカル ディスカバリー インスティテュート
サンフォード バーナム プレビーズ メディカル ディスカバリー インスティテュート
ザ スクリプス リサーチ インスティテュート
ザ スクリプス リサーチ インスティテュート
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12Cyclic peptides with only normal peptide bonds in the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2017501706A 2014-07-15 2015-07-15 神経保護および神経修復用のepha4環状ペプチドアンタゴニスト Active JP6847824B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462025002P 2014-07-15 2014-07-15
US62/025,002 2014-07-15
PCT/US2015/040649 WO2016011201A2 (en) 2014-07-15 2015-07-15 Epha4 cyclic peptide antagonists for neuroprotection and neural repair

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JP2017526644A JP2017526644A (ja) 2017-09-14
JP2017526644A5 JP2017526644A5 (enExample) 2018-09-20
JP6847824B2 true JP6847824B2 (ja) 2021-03-31

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JP2017501706A Active JP6847824B2 (ja) 2014-07-15 2015-07-15 神経保護および神経修復用のepha4環状ペプチドアンタゴニスト

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US (1) US10322161B2 (enExample)
EP (1) EP3169344B1 (enExample)
JP (1) JP6847824B2 (enExample)
WO (1) WO2016011201A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017011812A1 (en) * 2015-07-15 2017-01-19 Sanford Burnham Prebys Medical Discovery Institute Modified epha4 cyclic peptide antagonists for neuroprotection and neural repair
WO2019213620A1 (en) * 2018-05-04 2019-11-07 Iron Horse Therapeutics, Inc. Epha4 cyclic peptide antagonists and methods of use thereof
CN114302735B (zh) * 2019-06-07 2025-03-18 密苏里大学管理者 抑制hiv衣壳的肽抑制剂
WO2024233346A1 (en) * 2023-05-05 2024-11-14 Sanford Burnham Prebys Medical Discovery Institute Epha4 antagonists and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003268345A1 (en) * 2002-09-24 2004-04-19 The Burnham Institute Novel agents that modulate eph receptor activity
WO2006026820A1 (en) * 2004-09-08 2006-03-16 The University Of Queensland Treating gliosis, glial scarring, inflammation or inhibition of axonal growth in the nervous system by modulating eph receptor

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Publication number Publication date
US10322161B2 (en) 2019-06-18
EP3169344A2 (en) 2017-05-24
JP2017526644A (ja) 2017-09-14
WO2016011201A2 (en) 2016-01-21
EP3169344A4 (en) 2018-04-04
US20190038704A1 (en) 2019-02-07
EP3169344B1 (en) 2021-09-29
WO2016011201A3 (en) 2016-03-10

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