JP6834086B2 - 10−ヒドロキシステアリン酸組成物 - Google Patents
10−ヒドロキシステアリン酸組成物 Download PDFInfo
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- JP6834086B2 JP6834086B2 JP2018553073A JP2018553073A JP6834086B2 JP 6834086 B2 JP6834086 B2 JP 6834086B2 JP 2018553073 A JP2018553073 A JP 2018553073A JP 2018553073 A JP2018553073 A JP 2018553073A JP 6834086 B2 JP6834086 B2 JP 6834086B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
両方のエナンチオマーが本発明に従って使用され得、好ましいエナンチオマー形態は、(R)−10−ヒドロキシステアリン酸である。
脂肪酸を使用しないか(基準1)又は異なる脂肪酸(ステアリン酸(基準2)、オレイン酸(基準3)及び12−ヒドロキシステアリン酸(本発明))を添加剤として使用した種々の製剤を表1に列記の通り調製した。最初に、製剤のいずれにおいても、顕微鏡分析により結晶は全く観察されなかった。次いで、製剤を室温で保存し、10−ヒドロキシステアリン酸の再結晶化に関して、3か月まで繰り返し顕微鏡で分析した。その結果を表2に列記する。
Claims (14)
- 10−ヒドロキシステアリン酸又はその塩及び12−ヒドロキシステアリン酸又はその塩を含む局所組成物。
- 前記10−ヒドロキシステアリン酸又はその塩の量は、前記組成物の総重量に基づいて0.001〜5重量%の範囲、好ましくは0.01〜3重量%の範囲、最も好ましくは0.1〜2重量%の範囲、例えば特に0.1〜1.5重量%の範囲で選択されることを特徴とする、請求項1に記載の局所組成物。
- 本発明による前記局所組成物中の12−ヒドロキシステアリン酸又はその塩の量は、有利には、前記組成物の前記総重量に基づいて0.001〜5重量%の範囲、好ましくは0.01〜3重量%の範囲、最も好ましくは0.1〜2重量%の範囲、例えば特に0.1〜1.5重量%の範囲で選択されることを特徴とする、請求項1又は2に記載の局所組成物。
- 10−ヒドロキシステアリン酸又はその塩と12−ヒドロキシステアリン酸又はその塩とのモル比は、20:1〜1:10の範囲、好ましくは15:1〜1:10の範囲、最も好ましくは10:1〜1:1の範囲で選択されることを特徴とする、請求項1〜3のいずれか一項に記載の局所組成物。
- 10−ヒドロキシステアリン酸、特に(R)−10−ヒドロキシステアリン酸が使用されることを特徴とする、請求項1〜4のいずれか一項に記載の局所組成物。
- 12−ヒドロキシステアリン酸が使用されることを特徴とする、請求項1〜5のいずれか一項に記載の局所組成物。
- 水相及び油相並びに少なくとも1種のO/W又はSi/W乳化剤を含むO/Wエマルションであることを特徴とする、請求項1〜6のいずれか一項に記載の局所組成物。
- 前記組成物の前記総重量に基づいて、前記水相は、少なくとも50重量%を構成し、及び前記油相は、少なくとも10重量%を構成することを特徴とする、請求項7に記載の局所組成物。
- 前記少なくとも1種のO/W乳化剤は、セチルリン酸カリウムであることを特徴とする、請求項7又は8に記載の局所組成物。
- 前記少なくとも1種のO/W又はSi/W乳化剤は、前記組成物の前記総重量に基づいて0.5〜10重量%、特に0.5〜6重量%の範囲、例えばより特に0.5〜5重量%の範囲、例えば最も特に1〜4重量%の範囲の総量で使用されることを特徴とする、請求項7〜9のいずれか一項に記載の局所組成物。
- 12〜22個の炭素原子を有する非イオン性固体脂肪族アルコール及びそれらの混合物の群から、好ましくはセチルアルコール、ベヘニルアルコール、ステアリン酸グリセリル及びセテアリルアルコール並びにそれらの混合物から選択される共乳化剤を含むことを特徴とする、請求項1〜10のいずれか一項に記載の局所組成物。
- 共乳化剤の量は、前記組成物の前記総重量に基づいて0.1〜20重量%の範囲、より好ましくは0.5〜10重量%の範囲、最も好ましくは1〜5重量%の範囲で選択されることを特徴とする、請求項11に記載の局所組成物。
- フェノキシエタノール、エチルヘキシルグリセリン、ソルビン酸カリウム及び安息香酸ナトリウム並びにそれらの混合物からなる群から選択される少なくとも1種の保存剤を含むことを特徴とする、請求項1〜12のいずれか一項に記載の局所組成物。
- 局所組成物中の10−ヒドロキシステアリン酸又はその塩の再結晶化を抑制又は阻止する方法であって、10−ヒドロキシステアリン酸又はその塩を12−ヒドロキシステアリン酸又はその塩の存在下で製剤することを含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16164997 | 2016-04-13 | ||
EP16164997.5 | 2016-04-13 | ||
PCT/EP2017/057425 WO2017178236A1 (en) | 2016-04-13 | 2017-03-29 | 10-hydroxystearic acid compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019511517A JP2019511517A (ja) | 2019-04-25 |
JP6834086B2 true JP6834086B2 (ja) | 2021-02-24 |
Family
ID=55752209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018553073A Active JP6834086B2 (ja) | 2016-04-13 | 2017-03-29 | 10−ヒドロキシステアリン酸組成物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10463587B2 (ja) |
EP (1) | EP3442495B1 (ja) |
JP (1) | JP6834086B2 (ja) |
KR (1) | KR102321759B1 (ja) |
CN (1) | CN109069384B (ja) |
BR (1) | BR112018071158B8 (ja) |
WO (1) | WO2017178236A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102019110921A1 (de) * | 2019-04-26 | 2020-10-29 | Fuchs Petrolub Se | Schmierfette umfassend Metallseifen und Metallkomplexseifen auf Basis von R-10-Hydroxyoctadecansäure |
WO2022135882A1 (en) * | 2020-12-25 | 2022-06-30 | Unilever Ip Holdings B.V. | Personal care composition |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3694069B2 (ja) * | 1995-08-04 | 2005-09-14 | ポーラ化成工業株式会社 | 液体の固化抑制剤 |
GB0202853D0 (en) | 2002-02-07 | 2002-03-27 | Dow Corning | Encapsulation process and encapsulated compositions |
JP2009051732A (ja) * | 2005-12-13 | 2009-03-12 | Meiji Seika Kaisha Ltd | Pparリガンド活性を有する組成物 |
JP5312847B2 (ja) * | 2008-05-30 | 2013-10-09 | 株式会社マンダム | 非水系温感皮膚洗浄用組成物 |
US20090317341A1 (en) | 2008-06-18 | 2009-12-24 | Conopco, Inc., D/B/A Unilever | Compositions for Lightening Skin Color |
JP2010138110A (ja) * | 2008-12-11 | 2010-06-24 | Shiseido Co Ltd | 皮膚隠蔽力に優れる外用組成物 |
US8613939B2 (en) * | 2010-12-15 | 2013-12-24 | Conopco, Inc. | Leave-on nonsolid skin conditioning compositions containing 12-hydroxystearic acid and ethoxylated hydrogenated castor oil |
US20120214871A1 (en) | 2011-02-17 | 2012-08-23 | Conopco, Inc., D/B/A Unilever | Leave-on nonsolid oil-continuous skin conditioning compositions containing 12-hydroxystearic acid |
FR2993885A1 (fr) * | 2012-07-27 | 2014-01-31 | Arkema France | Diamides d'acides gras comprenant des hydroxyacides steariques comme organogelateurs |
WO2014095257A1 (en) * | 2012-12-20 | 2014-06-26 | Unilever N.V. | Eutectic mixtures in personal care compositions |
JP6285953B2 (ja) * | 2012-12-20 | 2018-02-28 | ユニリーバー・ナームローゼ・ベンノートシヤープ | パーソナルケア組成物中の共融混合物 |
US20170304169A1 (en) * | 2014-10-17 | 2017-10-26 | Dsm Ip Assets B.V. | Use of a cosmetic composition comprising 10-hydroxystearic acid |
-
2017
- 2017-03-29 US US16/092,555 patent/US10463587B2/en not_active Expired - Fee Related
- 2017-03-29 WO PCT/EP2017/057425 patent/WO2017178236A1/en active Application Filing
- 2017-03-29 CN CN201780023090.8A patent/CN109069384B/zh not_active Expired - Fee Related
- 2017-03-29 KR KR1020187031228A patent/KR102321759B1/ko active IP Right Grant
- 2017-03-29 EP EP17713684.3A patent/EP3442495B1/en active Active
- 2017-03-29 BR BR112018071158A patent/BR112018071158B8/pt not_active IP Right Cessation
- 2017-03-29 JP JP2018553073A patent/JP6834086B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
BR112018071158B8 (pt) | 2021-12-21 |
EP3442495B1 (en) | 2020-07-15 |
US20190117539A1 (en) | 2019-04-25 |
BR112018071158B1 (pt) | 2021-10-26 |
CN109069384B (zh) | 2022-10-18 |
BR112018071158A2 (pt) | 2019-02-05 |
CN109069384A (zh) | 2018-12-21 |
KR20180130543A (ko) | 2018-12-07 |
US10463587B2 (en) | 2019-11-05 |
EP3442495A1 (en) | 2019-02-20 |
WO2017178236A1 (en) | 2017-10-19 |
JP2019511517A (ja) | 2019-04-25 |
KR102321759B1 (ko) | 2021-11-05 |
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