JP6830895B2 - ストレス誘発性ｐ−ｔａｕを低下させるトリアゾロピリジン及びトリアゾロピリミジン - Google Patents
ストレス誘発性ｐ−ｔａｕを低下させるトリアゾロピリジン及びトリアゾロピリミジン Download PDFInfo
- Publication number
- JP6830895B2 JP6830895B2 JP2017543785A JP2017543785A JP6830895B2 JP 6830895 B2 JP6830895 B2 JP 6830895B2 JP 2017543785 A JP2017543785 A JP 2017543785A JP 2017543785 A JP2017543785 A JP 2017543785A JP 6830895 B2 JP6830895 B2 JP 6830895B2
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- JP
- Japan
- Prior art keywords
- alzheimer
- disease
- tau
- compound
- mammals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CCC(COC)*/C1=C(\*=C(CC)C*2*)/C2=C/CC(C)/C(/*)=*1 Chemical compound CCC(COC)*/C1=C(\*=C(CC)C*2*)/C2=C/CC(C)/C(/*)=*1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562117888P | 2015-02-18 | 2015-02-18 | |
| US62/117,888 | 2015-02-18 | ||
| PCT/US2016/018305 WO2016134042A2 (en) | 2015-02-18 | 2016-02-17 | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505899A JP2018505899A (ja) | 2018-03-01 |
| JP2018505899A5 JP2018505899A5 (https=) | 2019-03-14 |
| JP6830895B2 true JP6830895B2 (ja) | 2021-02-17 |
Family
ID=56692299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543785A Active JP6830895B2 (ja) | 2015-02-18 | 2016-02-17 | ストレス誘発性ｐ−ｔａｕを低下させるトリアゾロピリジン及びトリアゾロピリミジン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10618899B2 (https=) |
| EP (1) | EP3259274B1 (https=) |
| JP (1) | JP6830895B2 (https=) |
| KR (1) | KR102220260B1 (https=) |
| CN (1) | CN107709326B (https=) |
| AU (1) | AU2016220049C1 (https=) |
| CA (1) | CA2976258C (https=) |
| WO (1) | WO2016134042A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102220260B1 (ko) | 2015-02-18 | 2021-02-25 | 버크 인스티튜트 포 리서치 온 에이징 | 스트레스-유도성 p-tau 를 낮추는 트리아졸로피리딘 및 트리아졸로피리미딘 |
| EP3969639B1 (en) | 2019-05-13 | 2025-03-12 | Ecolab Usa Inc. | 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor |
| ES2932481B2 (es) * | 2021-07-09 | 2023-09-11 | Consejo Superior Investigacion | Compuestos inhibidores de la quinasa de tau y tubulina (ttbk) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL313973A1 (en) | 1993-10-12 | 1996-08-05 | Du Pont Merck Pharma | 1 n-alkyl-n-arylopyrimidin amines and their derivatives |
| US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| EP1012151B1 (en) * | 1997-09-02 | 2002-08-07 | Bristol-Myers Squibb Pharma Company | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders |
| CA2398956A1 (en) | 2000-02-14 | 2001-08-16 | Japan Tobacco Inc. | A pharmaceutical composition for prophylaxis or therapy of a postoperative stress |
| WO2004037159A2 (en) | 2002-10-23 | 2004-05-06 | Obetherapy Biotechnology | Compounds, compositions and methods for modulating fat metabolism |
| WO2007076055A2 (en) | 2005-12-22 | 2007-07-05 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| JP6250394B2 (ja) | 2010-08-19 | 2017-12-20 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | 軽度の認知障害（ｍｃｉ）および関連障害の処置方法 |
| US11325904B2 (en) | 2011-08-02 | 2022-05-10 | Buck Institute For Research On Aging | Tropinol esters and related compounds to promote normal processing of APP |
| WO2013026021A2 (en) | 2011-08-18 | 2013-02-21 | Buck Institute For Research On Aging | Trka as a target for inhibiting app cleavage and/or progression of alzheimer's disease |
| AU2013235422B2 (en) | 2012-03-19 | 2016-12-15 | Buck Institute For Research On Aging | APP specific BACE inhibitors (ASBIs) and uses thereof |
| EP2903436B1 (en) * | 2012-09-19 | 2019-07-17 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
| US20140371283A1 (en) | 2013-02-12 | 2014-12-18 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| KR102220260B1 (ko) | 2015-02-18 | 2021-02-25 | 버크 인스티튜트 포 리서치 온 에이징 | 스트레스-유도성 p-tau 를 낮추는 트리아졸로피리딘 및 트리아졸로피리미딘 |
-
2016
- 2016-02-17 KR KR1020177025850A patent/KR102220260B1/ko active Active
- 2016-02-17 AU AU2016220049A patent/AU2016220049C1/en active Active
- 2016-02-17 WO PCT/US2016/018305 patent/WO2016134042A2/en not_active Ceased
- 2016-02-17 US US15/548,402 patent/US10618899B2/en active Active
- 2016-02-17 EP EP16752995.7A patent/EP3259274B1/en active Active
- 2016-02-17 CN CN201680017456.6A patent/CN107709326B/zh active Active
- 2016-02-17 CA CA2976258A patent/CA2976258C/en active Active
- 2016-02-17 JP JP2017543785A patent/JP6830895B2/ja active Active
-
2020
- 2020-02-21 US US16/797,846 patent/US10844071B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180346466A1 (en) | 2018-12-06 |
| AU2016220049A1 (en) | 2017-08-24 |
| EP3259274A4 (en) | 2018-08-01 |
| US10618899B2 (en) | 2020-04-14 |
| WO2016134042A2 (en) | 2016-08-25 |
| CA2976258A1 (en) | 2016-08-25 |
| CN107709326B (zh) | 2021-12-17 |
| EP3259274A2 (en) | 2017-12-27 |
| AU2016220049C1 (en) | 2021-02-25 |
| AU2016220049B2 (en) | 2020-09-24 |
| US10844071B2 (en) | 2020-11-24 |
| WO2016134042A3 (en) | 2016-10-13 |
| KR102220260B1 (ko) | 2021-02-25 |
| KR20170117185A (ko) | 2017-10-20 |
| EP3259274B1 (en) | 2023-06-28 |
| CN107709326A (zh) | 2018-02-16 |
| US20200190094A1 (en) | 2020-06-18 |
| CA2976258C (en) | 2024-02-20 |
| JP2018505899A (ja) | 2018-03-01 |
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| JP2020513005A (ja) | Ｃｃｒ３阻害剤を用いて、加齢性機能障害を治療するための方法及び組成物 | |
| US10844071B2 (en) | Substituted [1,2,3]triazolo[4,5-d]pyrimidines that lower stress-induced p-tau | |
| JP2019515004A (ja) | Ａｐｐの正常なプロセシングを促進する化合物 |
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