CA2976258C - Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau - Google Patents
Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau Download PDFInfo
- Publication number
- CA2976258C CA2976258C CA2976258A CA2976258A CA2976258C CA 2976258 C CA2976258 C CA 2976258C CA 2976258 A CA2976258 A CA 2976258A CA 2976258 A CA2976258 A CA 2976258A CA 2976258 C CA2976258 C CA 2976258C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically acceptable
- stereoisomer
- tautomer
- solvate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562117888P | 2015-02-18 | 2015-02-18 | |
| US62/117,888 | 2015-02-18 | ||
| PCT/US2016/018305 WO2016134042A2 (en) | 2015-02-18 | 2016-02-17 | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2976258A1 CA2976258A1 (en) | 2016-08-25 |
| CA2976258C true CA2976258C (en) | 2024-02-20 |
Family
ID=56692299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2976258A Active CA2976258C (en) | 2015-02-18 | 2016-02-17 | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10618899B2 (https=) |
| EP (1) | EP3259274B1 (https=) |
| JP (1) | JP6830895B2 (https=) |
| KR (1) | KR102220260B1 (https=) |
| CN (1) | CN107709326B (https=) |
| AU (1) | AU2016220049C1 (https=) |
| CA (1) | CA2976258C (https=) |
| WO (1) | WO2016134042A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2976258C (en) | 2015-02-18 | 2024-02-20 | Buck Institute For Research On Aging | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau |
| WO2020231723A1 (en) | 2019-05-13 | 2020-11-19 | Ecolab Usa Inc. | 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor |
| ES2932481B2 (es) * | 2021-07-09 | 2023-09-11 | Consejo Superior Investigacion | Compuestos inhibidores de la quinasa de tau y tubulina (ttbk) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9407799A (pt) | 1993-10-12 | 1997-05-06 | Du Pont Merck Pharma | Composição de matéria método de tratamento e composição farmaceutica |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| US6245769B1 (en) * | 1997-09-02 | 2001-06-12 | Dupont Pharmaceuticals Company | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone(CRH) antagonists, useful for treating CNS and stress-related disorders |
| AU2001232271A1 (en) * | 2000-02-14 | 2001-08-20 | Japan Tobacco Inc. | Preventives/remedies for postoperative stress |
| WO2004037159A2 (en) | 2002-10-23 | 2004-05-06 | Obetherapy Biotechnology | Compounds, compositions and methods for modulating fat metabolism |
| WO2007076055A2 (en) | 2005-12-22 | 2007-07-05 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| ES2705027T3 (es) | 2010-08-19 | 2019-03-21 | Buck Institute For Age Res | Métodos de tratamiento del deterioro cognitivo leve (DCL) y trastornos relacionados |
| WO2013019901A2 (en) | 2011-08-02 | 2013-02-07 | Buck Institute For Research On Aging | Tropinol esters and related compounds to promote normal processing of app |
| WO2013026021A2 (en) | 2011-08-18 | 2013-02-21 | Buck Institute For Research On Aging | Trka as a target for inhibiting app cleavage and/or progression of alzheimer's disease |
| CN104270945B (zh) | 2012-03-19 | 2017-03-29 | 巴克老龄化研究所 | App特异性bace抑制剂(asbi)及其用途 |
| US9649317B2 (en) | 2012-09-19 | 2017-05-16 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
| CA2899938C (en) | 2013-02-12 | 2021-10-19 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| CA2976258C (en) | 2015-02-18 | 2024-02-20 | Buck Institute For Research On Aging | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau |
-
2016
- 2016-02-17 CA CA2976258A patent/CA2976258C/en active Active
- 2016-02-17 CN CN201680017456.6A patent/CN107709326B/zh active Active
- 2016-02-17 US US15/548,402 patent/US10618899B2/en active Active
- 2016-02-17 WO PCT/US2016/018305 patent/WO2016134042A2/en not_active Ceased
- 2016-02-17 AU AU2016220049A patent/AU2016220049C1/en active Active
- 2016-02-17 KR KR1020177025850A patent/KR102220260B1/ko active Active
- 2016-02-17 EP EP16752995.7A patent/EP3259274B1/en active Active
- 2016-02-17 JP JP2017543785A patent/JP6830895B2/ja active Active
-
2020
- 2020-02-21 US US16/797,846 patent/US10844071B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018505899A (ja) | 2018-03-01 |
| AU2016220049C1 (en) | 2021-02-25 |
| CN107709326B (zh) | 2021-12-17 |
| EP3259274A2 (en) | 2017-12-27 |
| US20180346466A1 (en) | 2018-12-06 |
| AU2016220049B2 (en) | 2020-09-24 |
| EP3259274A4 (en) | 2018-08-01 |
| KR20170117185A (ko) | 2017-10-20 |
| WO2016134042A2 (en) | 2016-08-25 |
| CA2976258A1 (en) | 2016-08-25 |
| US20200190094A1 (en) | 2020-06-18 |
| CN107709326A (zh) | 2018-02-16 |
| EP3259274B1 (en) | 2023-06-28 |
| AU2016220049A1 (en) | 2017-08-24 |
| JP6830895B2 (ja) | 2021-02-17 |
| US10618899B2 (en) | 2020-04-14 |
| KR102220260B1 (ko) | 2021-02-25 |
| US10844071B2 (en) | 2020-11-24 |
| WO2016134042A3 (en) | 2016-10-13 |
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| US10844071B2 (en) | Substituted [1,2,3]triazolo[4,5-d]pyrimidines that lower stress-induced p-tau | |
| EP3510029B1 (en) | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200226 |
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| U11 | Full renewal or maintenance fee paid |
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