JP6830874B2 - Reaction solution holding device and automatic analyzer - Google Patents

Description

The present disclosure relates to a reaction solution holding device and an automatic analyzer.

In an automatic analyzer that analyzes components contained in a biological sample such as blood or urine, for example, as described in Patent Document 1, the component to be measured and the labeling substance are subjected to an antigen-antibody reaction utilizing an immune reaction. Is bound, and the substance is identified by signals such as light emission and absorption obtained from the labeling substance. During the antigen-antibody reaction, a B / F (Bound / Free) separation operation is performed to remove excessively labeled substances and unbound standard substances, which hinder detection. In the automatic analyzer, a method of binding magnetic particles during an antigen-antibody reaction and performing B / F separation by a magnetic separation method is adopted.

Patent Document 1 discloses an automatic analyzer that efficiently supplies liquids such as a reaction solution, a washing solution, and a reaction auxiliary solution used for analysis, shortens the analysis cycle, and realizes highly accurate analysis. This automatic analyzer is, for example, a suction nozzle that sucks a solution used for detecting a sample, a container that holds the solution used for detecting a sample, a member that holds the container, and a nozzle that supplies the solution to the container. And a drive mechanism for moving the container holding member. Suppressing the influence of the temperature in the space containing these configurations on the temperature of the solution is related to the improvement of the reproducibility and sensitivity of the detection result, and is constant regardless of the influence of the temperature of the environment in which the device is installed. It is important to adjust to the temperature. Therefore, the automatic analyzer is equipped with a circulating air temperature control mechanism. Further, the solution controlled to a predetermined temperature flows into the nozzle that supplies the solution to the container by an external temperature control mechanism.

Japanese Unexamined Patent Publication No. 2012-26732

In a large-scale automatic analyzer, in order to increase the processing amount and meet the needs of space saving, cost saving, and energy saving, a plurality of detection units are installed and a parallel processing configuration is performed. The accommodating volume of the circulating air temperature control space increases in parallel. The air volume of the circulation fan increases in order to suppress temperature unevenness in the space, and the effect of the circulation air on the solution becomes remarkable. Further, the increase in the amount of heat generated by the circulation fan motor itself increases the load on the electronic cooler used for exhausting heat to the outside.

On the other hand, there is also a need for miniaturization of automatic analyzers. When downsizing the automatic analyzer, in order to meet the needs of space saving, cost saving, and energy saving, the magnetic separation unit (device) and the stirring unit (device) are in the circulating air temperature control space, that is, in the same housing. ), And a replacement unit (device) and the like are desired to be accommodated. However, if a plurality of units having various functions are housed in one housing, there is a problem that temperature unevenness occurs in the housing and the influence of circulating wind occurs.

The present disclosure has been made in view of such a situation, and when a plurality of units having various functions are housed in one housing, the influence of circulating air can be avoided and temperature unevenness can be suppressed. Provides an air temperature control space.

In order to solve the above problems, according to the present disclosure, a container holding portion for holding a container for accommodating a reaction solution is provided inside a sealed housing, and the container held by the container holding portion is provided. A reaction liquid holding device that adjusts the storage environment of the reaction liquid inside, and is provided through the housing and has a heat receiving block that transfers heat between the inside and outside of the housing, and the reaction liquid. At least one first heat pipe arranged so as to extend from the first surface inside the housing facing the outer surface of the housing to which the detection unit for detecting the sample inside is mounted to the heat receiving block. And at least one second heat pipe arranged so as to extend from the second surface inside the housing facing the outer surface of the housing to which the heat source is mounted to the heat receiving block. A liquid retention device is provided.

Further features relating to this disclosure will become apparent from the description herein and the accompanying drawings. Moreover, the aspect of the present invention is achieved and realized by the combination of elements and various elements and the following detailed description and the aspect of the appended claims.
It should be understood that the description herein is merely a exemplary example and is not intended to limit the claims or application of the present disclosure in any way.

According to the present disclosure, when a plurality of units having various functions are housed in one housing in an air temperature control space, the influence of circulating wind can be avoided and temperature unevenness can be suppressed. ..

The figure which shows the schematic configuration example of the automatic analyzer 10 including the reaction liquid holding device (sometimes referred to as a "temperature control device") 101. The figure which shows the schematic structure of the air temperature control space of an automatic analyzer 10, that is, the reaction liquid holding device (temperature control device) 101. The figure for demonstrating the operation of the reaction liquid holding device (temperature control device) 101 in a high temperature environment. The figure for demonstrating the operation of the reaction liquid holding device (temperature control device) 101 in a low temperature environment. The figure which shows the arrangement surface (inner wall of a housing 102) of a heat pipe. FIG. 5 is a diagram showing an arrangement example of a heat pipe (first heat pipe 105) in the direction of arrow A in FIG. The figure which shows the arrangement example of the heat pipe (second heat pipe 106) in the direction of arrow B of FIG. FIG. 5 is a diagram showing an arrangement example of heat pipes (first heat pipe 105 and second heat pipe 106) in the direction of arrow C in FIG.

Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. In the attached drawings, functionally the same elements may be displayed with the same number. The accompanying drawings show specific embodiments and implementation examples in accordance with the principles of the present disclosure, but these are for the purpose of understanding the present disclosure and in order to interpret the present disclosure in a limited manner. Not used.

In the present embodiment, the description is given in sufficient detail for those skilled in the art to carry out the present invention, but other implementations and embodiments are also possible, without departing from the scope and spirit of the technical idea of the present disclosure. It is necessary to understand that it is possible to change the structure and structure and replace various elements. Therefore, the following description should not be construed as limited to this.

In this embodiment, for example, a reaction liquid holding device (also referred to as a temperature control device) for holding a reaction liquid, which is mounted on an automatic analyzer that analyzes components contained in a biological sample such as blood or urine. ), In particular, the reaction solution holding device mounted on an automatic analyzer that requires highly accurate temperature control when analyzing a trace amount of sample.

In the reaction liquid holding device according to the present embodiment, two heat pipes, for example, a heat pipe attached to the ceiling surface inside the housing and a heat pipe attached to the bottom surface are automatically extended to the heat receiving block. It will be possible to autonomously and effectively control the heat transfer phenomenon peculiar to the analyzer.

<Configuration of automatic analyzer>
FIG. 1 is a diagram showing a schematic configuration example of an automatic analyzer 10 including a reaction liquid holding device (sometimes referred to as a “temperature control device”) 101 of the present embodiment.
The automatic analyzer 10 includes a sample transport unit 12 that transports a sample container 11 such as a blood collection tube containing a sample to be analyzed to a sample suction position 13, and a reagent container 20 that contains a reagent used for analysis. A reagent storage unit 19 that controls the temperature so that the temperature falls within a certain temperature range, a sample dispensing unit 14 that dispenses a sample in a sample container into a reaction vessel, and a reagent that dispenses a reagent in a reagent container into a reaction vessel. The dispensing unit 18, the reaction promoting unit 17 in which the reaction vessel containing the reaction liquid in which the sample and the reagent are mixed is installed, and the liquid temperature of the reaction liquid is controlled to be within a certain temperature range, and the reaction promoting unit A reagent holding unit (device) 101 for holding the reagent in which the reaction is promoted is provided. The reaction solution holding device 101 may include a detector (for example, the detection unit 200 shown in FIGS. 2 and later) that optically measures the amount of the substance in the reaction solution. In addition, an environmental temperature measurement sensor 40 for measuring the temperature of the ambient environment in which the automatic analyzer 10 is arranged is arranged. These units are controlled by the control device 30.

The sample transport unit 12 may be, for example, a sample rack on which one or a plurality of sample containers 11 are mounted, or a sample disk arranged on the circumference of the disk. In the case of a sample rack, the sample rack is transported to the suction position of the sample dispensing unit by a transport device such as a transport belt mechanism or a robot arm.

The reagent storage unit 19 may be, for example, a person who transports an arbitrary reagent container to a desired position by arranging a plurality of reagent containers on the circumference and rotating them, or arranges the reagent containers in a row or vertically and horizontally. The configuration may be such that a plurality of columns are arranged in each.

The reaction solution holding device 101 performs optical measurement on the reaction solution in the measurement flow path in the device, and the temperature of the reaction solution in the flow path is controlled within a certain temperature range. Measure. As an example of the measurement operation, the absorbance of the reaction solution is measured, the amount of light emitted when a reagent is added to the reaction solution or a voltage is applied, the number of particles in the reaction solution is measured, or the reaction solution is applied to the electrode film. For example, it is possible to measure fluctuations in the current value and voltage value at the time of contact. Therefore, the reaction liquid holding device 101 is provided with a photomultiplier tube, a photometer or the like, an imaging element such as a CCD, an ammeter for measuring fluctuations in the current value or the voltage value, a voltmeter, and the like. ..

The reaction promotion unit 17 promotes a stable reaction by keeping the temperature of the reaction vessel within a predetermined temperature range. For example, it may be an incubator whose temperature is controlled by heating the surroundings with a heater or the like in a state where a plurality of reaction vessels are arranged on the circumference, or in a tank in which a liquid controlled in a certain temperature range circulates. It may be a constant temperature bath in which the reaction vessel is immersed in.

Depending on the analysis performance required for the analyzer, when the sample dispensing unit dispenses the sample, the amount that can be replaced each time the sample changes to the part that comes into contact with the sample, considering the effect of carryover between the samples. In some cases, an unused reaction vessel may be used for the reaction vessel in which the injection tip is used or the sample and the reagent are reacted. At that time, the once used dispensing tip and reaction vessel are discarded. The consumables storage unit 16 stores new dispensing chips and reaction vessels necessary to perform the analysis for a certain period of time, and the consumables transport unit 15 supplies them to the place where they are used in a timely manner.

<Structure of reaction solution holding device>
FIG. 2 is a diagram showing a schematic configuration of an air temperature control space of the automatic analyzer 10, that is, a reaction liquid holding device (temperature control device) 101. The reaction liquid holding device 101 includes a housing 102, a container holding member 202 for holding the container 203, a magnetic separation device 302, and a stirring device 303 inside the housing 102. The housing 102 has a substantially rectangular parallelepiped shape, and is composed of two layers of a structural material (for example, a metal plate or a resin plate) and a heat insulating material (foam urethane or the like) for ensuring structural strength. The detection unit 200 is arranged directly above the ceiling surface 103 of the reaction liquid holding device 101. From the detection unit 200, the suction nozzle 201 is arranged so as to reach the container 203 in which the solution used for detecting the sample is held in the reaction liquid holding device 101. Further, a drive mechanism 204 for moving the container holding member 202 is arranged directly below the bottom surface 104 of the reaction liquid holding device 101. The magnetic separation device 302 and the stirring device 303 are arranged on the bottom surface 104 in the reaction liquid holding device 101, and the driving mechanism 304 of the stirring device 303 is arranged directly below the bottom surface 104 below the stirring device 303.

When the motor, which is the power of the drive mechanism 204, generates heat, the heat is transferred to the container holding member 202 through the drive system as indicated by an arrow. Further, when the motor that is the power of the drive mechanism 304 generates heat, the heat is transferred to the stirring device 303 through the drive system as shown by an arrow. Since the liquid level of the solution always faces the ceiling surface, the drive system is often arranged directly under the bottom surface 104 side, and heat intrusion from the bottom surface 104 side is remarkable regardless of the environmental temperature. ..

A first heat pipe (first heat pipe group: at least one) 105 is attached to the inside of the ceiling surface 103 (example) of the housing 102 of the reaction liquid holding device 101, and the bottom surface 104 (example). A second heat pipe (second heat pipe group: at least one is sufficient) is attached to the inside of the. Each of the first heat pipe 105 and the second heat pipe 106 is composed of, for example, an L-shaped pipe having both ends closed. One end of the first heat pipe 105 is attached to the inside of the ceiling surface 103, and the other end is attached (attached) to the heat receiving block 107. Here, the heat receiving block 107 is made of, for example, a metal block and is connected to the electronic cooler 108. The electronic cooler 108 is connected to the external heat dissipation fan 110 via an external heat sink 109. Further, the heat receiving block 107 is installed so as to penetrate the side surface of the housing 102. A plurality of first heat pipes 105 can be arranged on the ceiling surface side. Similarly, one end of the second heat pipe 106 is attached to the inside of the bottom surface 104, and the other end is attached to the heat receiving block 107. A plurality of second heat pipes 106 can also be arranged on the bottom surface side. The first heat pipe 105 and the second heat pipe 106 are each device or mechanism installed inside the housing 102 (for example, suction nozzle 201, container holding member 202, magnetic separation device 302, stirring device 303, etc.). It is desirable to arrange the housing 102 so as to be close to the housing 102 while avoiding interference with the housing 102. Details of the arrangement of the first heat pipe 105 and the second heat pipe 106 will be described later.

The first heat pipe 105 and the second heat pipe 106 are made of a copper container, and water, ethyl alcohol, or the like is used as the working liquid inside. Further, the surfaces of the heat pipes 105 and 106 can be plated to prevent corrosion. The amount of the hydraulic fluid enclosed is small because it is not a bubble-driven type. From the heat transport distance, the outer diameter of the pipe is 4 mm or more, and the reflux action in the container is controlled by the capillary action, and the difference in heat transport capacity due to the combined use of gravity can be about several tens of percent. Further, for example, a container having an outer diameter of about 8 mm to 16 mm can be flattened and adopted. Further, the heat pipes 105 and 106 are attached to the ceiling surface 103 and the bottom surface 104 with, for example, a sheet metal holding plate or the like in consideration of aging deterioration suppression and maintenance work. The heat pipes 105 and 106 can be fixed to the heat receiving block 107 (for example, metals such as aluminum and stainless steel and ceramics such as aluminum nitride) by using a holding plate or the like that has been grooved according to the outer diameter. it can. Some attachments to the ceiling surface 103 and the bottom surface 104 may be locally fixed.

<Action of the reaction solution holding device 101 in a high temperature environment>
FIG. 3 is a diagram for explaining the operation of the reaction liquid holding device (temperature control device) 101 according to the present embodiment in a high temperature environment. In FIG. 3, the arrows indicate the heat flow. Here, the high temperature environment means, for example, a state in which the internal temperature of the housing 102 is higher than the external temperature of the housing 102.

Since the solution (reaction liquid) held by the container holding member 202 does not generate heat in the space inside the housing 102 of the reaction liquid holding device 101, there is no particular heat source inside the housing 102, and the solution from the outside in a high temperature environment Invasion heat and intrusion heat from the drive system cause a temperature rise in the space. This invading heat is recovered by the first heat pipe 105 and the second heat pipe 106, and is exhausted to the outside by the electronic cooler 108 in the heat receiving block 107, so that the temperature rise in the internal space can be suppressed. Become. As shown by the arrow indicating the heat flow, since there is invading heat from the drive system, the invading heat from the bottom surface 104 side is large. For example, the inside (inside) of the first heat pipe 105 and the second heat pipe 106 is in a vacuum and constant pressure state, and the hydraulic fluid is vaporized at a place where there is invading heat of each of the pipes 105 and 106. It becomes a gas, and the gas moves in the pipe in a state close to the speed of sound. Further, a groove is formed in the inner wall of each of the pipes 105 and 106, and the gas that has moved from the heat-bearing portion of each of the pipes 105 and 106 to the heat receiving block 107 is cooled by the heat receiving block 107 and becomes a liquid (working liquid). , The liquid is transmitted through the groove by capillarity and returns to the place where there is heat.

In the heat receiving block 107, the heat of condensation of the hydraulic fluid inside the first heat pipe 105 and the second heat pipe 106 is transferred. Then, when the pipe returns to the ceiling surface 103 side and the bottom surface 104 side, it is the second heat pipe 106 on the bottom surface side that has a high transport capacity in combination with gravity. That is, when the inside of the housing 102 is in a high temperature environment, the second heat pipe 106 utilizes gravity to dissipate heat. Therefore, the distribution of the cooling capacity autonomously matches the amount of invading heat, and it acts as a lean cooling system. With respect to the heat entering from the side surface of the housing 102, an ascending flow due to buoyancy is generated near the wall and moves to the ceiling surface, so that the first heat on the ceiling surface side does not directly contribute to the temperature rise in the central portion. Heat is recovered in the pipe 105.

<Action of the reaction solution holding device 101 in a low temperature environment>
FIG. 4 is a diagram for explaining the operation of the reaction liquid holding device (temperature control device) 101 according to the present embodiment in a low temperature environment. In FIG. 4, the arrows indicate the heat flow. Here, the low temperature environment means, for example, a state in which the internal temperature of the housing 102 is lower than the external temperature of the housing 102.

In a low temperature environment, the reaction liquid holding device 101 is configured to reverse the polarity of the electronic cooler 108 and recover heat from the outside of the housing 102. The heat from the outside is composed of, for example, the heat generated from the external heat dissipation fan 110 and the heat generated by the thermoelectric semiconductor element in the electronic cooler 108. Such heat from the outside can be introduced into the housing 102 via, for example, the heat receiving block 107. More specifically, in the reaction liquid holding device 101, the temperature of the internal space of the housing 102 is raised by sending the heat leaking from the inside of the housing 102 to the outside through the first heat pipe 105 and the second heat pipe 106. It becomes possible to suppress the descent. For example, the invading heat from the drive system exists even in a low temperature environment, and the second heat pipe 106 on the bottom surface recovers the invading heat and compensates it as heat leaking to the outside in the nearby bottom surface. Play a role.

When there is a heat shortage in the internal space of the housing 102, the first heat pipe 105 and the second heat pipe 106 can receive heat from the heat receiving block 107 and compensate for the heat leakage in the bottom surface. .. At this time, the heat transport capacity of the first heat pipe 105 on the ceiling surface side is increased by the combined use of gravity. That is, when the inside of the housing 102 is in a low temperature environment, external heat is applied by utilizing gravity in the first heat pipe 105. In this way, the heat leakage on the ceiling surface 103 can be compensated for, and the heat leakage on the side surface can be compensated by forming a downward flow near the side surface of the housing 102, and the central temperature can be kept constant. Is possible.

<Heat pipe layout>
5 to 8 are views showing an example of the arrangement configuration of the heat pipe of the reaction liquid holding device 101 according to the present embodiment. FIG. 5 is a diagram showing an arrangement surface of the heat pipe (inner wall of the housing 102). FIG. 6 is a diagram showing an arrangement example of the heat pipe (first heat pipe 105) in the direction of arrow A in FIG. FIG. 7 is a diagram showing an arrangement example of the heat pipe (second heat pipe 106) in the direction of arrow B in FIG. FIG. 8 is a diagram showing an arrangement example of heat pipes (first heat pipe 105 and second heat pipe 106) in the direction of arrow C in FIG.

As shown in FIGS. 5 (2 to 4), in the reaction liquid holding device (temperature control device) 101 according to the present embodiment, the heat pipe is the ceiling surface, the bottom surface, and the heat receiving block of the inner wall of the housing 102. The 107 is arranged so as to be in contact with the side surface to which the 107 is connected. In the present embodiment, the outer bottom surface of the housing 102 is provided with the drive mechanism 204 of the container holding member serving as a heat source and the drive mechanism 304 of the stirring device, and the detection unit 200 is provided on the outer upper surface (top surface) of the housing 102 to receive heat. Since the block 107 is provided on the side surface of the housing 102, the heat pipe is attached to the ceiling surface, bottom surface, and side surface of the housing 102 shown in FIG. However, if the drive mechanisms 204 and 304, the heat receiving block 107, and the detection unit 200 are installed on a surface different from the surface shown in FIG. 5, it is desirable to attach the heat pipe so as to be in contact with the new installation surface.

As shown in FIG. 6, a plurality of first heat pipes 105 are arranged in parallel at predetermined intervals so as not to interfere with the suction nozzle 201 extending from the detection unit 200. The reason why the plurality of first heat pipes 105 are arranged in parallel at predetermined intervals (for example, evenly spaced) is to recover or release heat evenly. Some of the plurality of heat pipes 105 can be bent at vent positions 1051, 1052, and 1053 so that they can be brought into close contact with the heat receiving block 107 so as to be close to the side surface 1021 of the housing 102 provided with the heat receiving block 107. It is configured as follows. The vent positions 1051 to 1053 are merely examples and can be set arbitrarily. Further, the plurality of first heat pipes 105 are attached to the ceiling surface of the inner wall of the housing 102 by the plurality of pressing plates 130, and are in close contact with the ceiling surface.

Further, as shown in FIG. 7, a plurality of second heat pipes 106 are arranged in parallel at predetermined intervals. Further, the plurality of second heat pipes 106 are arranged so as not to interfere with the shaft 2041 connecting the container holding member 202 and the drive mechanism 204, the magnetic separation device 302, and the shaft 3041 connecting the stirring device 303 and the drive mechanism 304. Will be done. Further, the container holding member 202 and the stirring device 303 are arranged at predetermined clearance (height) positions by the shafts 2041 and 3041 so that their bottom surfaces and the second heat pipe 106 do not come into contact with each other. Similar to the first heat pipe 105, some of the plurality of heat pipes 106 are bent at vent positions 1061, 1062, and 1063 so that they are closer to the side surface 1021 of 102 of the housing provided with the heat receiving block 107. It is configured so that it can be brought into close contact with the heat receiving block 107. The vent positions 1061 to 1063 are merely examples and can be set arbitrarily. Further, the plurality of second heat pipes 106 are attached to the bottom surface of the inner wall of the housing 102 by the pressing plate 140, and are in close contact with the bottom surface.

As shown in FIG. 8, the plurality of first heat pipes 105 and the plurality of second heat pipes 106 are arranged alternately in the heat receiving block 107, for example. By arranging them alternately in this way, the plurality of first heat pipes 105 and the plurality of second heat pipes 106 can be arranged in a well-balanced manner on the ceiling surface and the bottom surface of the inner wall of the housing 102. .. Further, by arranging them alternately in this way, the heat from the heat receiving block 107 can be efficiently released and supplemented. Further, the plurality of first heat pipes 105 and the plurality of second heat pipes 106 are attached to the heat receiving block 107 by the pressing plate 170 and are in close contact with the heat receiving block.

<Summary>
The reaction liquid holding device (temperature control device) 101 according to the present embodiment includes two heat pipes. By utilizing these two heat pipes, a reaction liquid holding device (temperature control device) capable of autonomously and effectively controlling the heat transfer phenomenon peculiar to the automatic analyzer is realized. Specifically, a heat receiving block is provided that penetrates the housing 102 of the reaction liquid holding device 101 and transfers heat between the inside and the outside of the housing. Then, when the first surface inside the housing facing the outer surface of the housing 102 to which the detection unit 200 is attached (for example, a ceiling surface is conceivable, but the detection unit 200 is attached to the side surface of the housing 102). The first heat pipe group is arranged so as to extend from (which is the inner side surface of the housing 102 corresponding to the housing 102) to the heat receiving block 107. Further, the second surface inside the housing (for example, the bottom surface is considered, but the heat source is mounted on the side surface of the housing 102) facing the outer surface of the housing 102 to which the heat source (each drive mechanism 204 and 304) is mounted. If so, the second heat pipe group is arranged so as to extend from (which is the inner side surface of the corresponding housing 102) to the heat receiving block 107. When the temperature inside the housing 102 is higher than the temperature outside (in a high temperature environment), the heat transferred from the outside of the housing 102 to the inside (for example, each drive mechanism 204 or 304 (outside)) is applied to the housing. The invading heat transferred to the inside of the 102) is recovered by the first and second heat pipe groups and released to the outside through the heat receiving block 107. On the other hand, when the temperature inside the housing 102 is lower than the temperature outside (in a low temperature environment), the heat outside the housing 102 is transferred to the first and second heat pipe groups via the heat receiving block 107. It is filled inside the housing 102. In this way, the temperature inside the housing 102 can be controlled autonomously. Further, since the temperature inside the apparatus can be controlled autonomously, the volume of the reaction liquid holding apparatus (temperature adjusting apparatus) 101 can be easily expanded and energy saving can be realized. Therefore, it is possible to advance the parallel processing of large machines and the high-density mounting of small machines, and it is possible to save space and cost. In other words, in the air temperature control space that adjusts to a constant temperature regardless of the influence of the temperature of the environment where the automatic analyzer is installed, natural convection or heat diffusion control, the influence of circulating wind and the fan motor for circulation The influence of heat generation is eliminated, the accommodation volume can be expanded, the parallel processing amount can be expanded, and high-density mounting becomes possible.

10 Automatic analyzer 11 Specimen container 12 Specimen transport unit 13 Specimen suction position 14 Specimen dispensing unit 15 Consumables transport unit 16 Consumables storage unit 17 Reaction acceleration unit 18 Reagent dispensing unit 19 Reagent storage unit 20 Reagent container 30 Control device 40 Environmental temperature measurement sensor 101 Reagent holding device (temperature control device)
102 Housing 103 Ceiling surface 104 Bottom surface 105 First heat pipe (group)
106 Second heat pipe (group)
107 Heat receiving block 108 Electronic cooler 109 External heat sink 110 External heat sink fan 130, 140, 170 Presser plate 200 Detector 201 Suction nozzle 202 Container holding member 203 Container 204 Container holding member drive mechanism 302 Magnetic separation device 303 Stirrer 304 Stirrer Drive mechanism

Claims (9)

A reaction solution having a container holding portion for holding a container for accommodating the reaction solution inside the sealed housing and adjusting the storage environment of the reaction solution in the container held in the container holding portion. It is a holding device
A heat receiving block that is provided through the housing and transfers heat between the inside and the outside of the housing.
At least, it is arranged so as to extend from the first surface inside the housing facing the outer surface of the housing to which the detection unit for detecting the sample in the reaction solution is attached to the heat receiving block. One first heat pipe and
It comprises at least one second heat pipe arranged so as to extend from the second surface inside the housing facing the outer surface of the housing to which the heat source is attached to the heat receiving block. Reaction solution holding device. In claim 1,
The housing is a rectangular parallelepiped housing and has a rectangular parallelepiped shape.
The first surface is the inner ceiling surface of the rectangular parallelepiped housing.
The second surface is a reaction liquid holding device which is an inner bottom surface of the rectangular parallelepiped housing. In claim 1,
A reaction liquid holding device further comprising a stirring device attached to the second surface. In claim 3,
The heat source is a reaction liquid holding device including a first driving mechanism for moving the container holding portion inside the housing and a second driving mechanism for driving the stirring device. In claim 1,
The first and second heat pipes are containers in which both ends are closed.
The first heat pipe is curved from the first surface toward the surface of the housing provided with the heat receiving block.
The second heat pipe is curved from the second surface toward the surface of the housing provided with the heat receiving block.
One end of the first heat pipe is fixed to the first surface, and the other end of the first heat pipe is fixed to the heat receiving block.
A reaction liquid holding device in which one end of the second heat pipe is fixed to the second surface and the other end of the second heat pipe is fixed to the heat receiving block. In claim 1, further
An electronic cooler mounted on a surface of the heat receiving block on the outer side of the housing,
An external radiator mounted on a surface of the electronic cooler that is different from the surface attached to the heat receiving block.
A reaction liquid holding device. In claim 1,
When the temperature inside the housing is higher than the temperature outside the housing, the heat inside the housing is recovered by the first and second heat pipes and released to the outside through the heat receiving block. Liquid retention device. In claim 1,
When the temperature inside the housing is lower than the temperature outside the housing, the heat outside the housing is transferred to the first and second heat pipes via the heat receiving block and supplemented inside the housing. Reactor holding device. A sample transport unit that transports a sample container that houses the sample to be analyzed,
A sample dispensing section that dispenses the sample in the sample container into the reaction vessel,
A reagent dispensing section that dispenses reagents into the reaction vessel,
The reaction liquid holding device according to claim 1 and
A detection unit that detects a sample contained in the reaction solution in the reaction vessel held in the reaction solution holding device, and a detection unit.
An automatic analyzer equipped with.

Images