JP6442378B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that automatically analyzes biological sample components such as blood, and more particularly to a discharge liquid temperature adjustment mechanism of a biological sample replacement unit that removes impurities in the biological sample.

  There is known an automatic analyzer that automatically analyzes a specific component in a specimen such as blood or urine using an immune reaction. In an immunoassay method using this immune reaction, a component to be measured and a labeling substance are bound by an antigen-antibody reaction, and the substance is quantified or qualitated by a signal obtained from the labeling substance, for example, light emission or absorption.

  At this time, in order to remove the excessively added labeling substance, an operation called B / F (Bound / Free) separation is performed to remove the labeling substance not bound to the target substance.

  In an automatic analyzer, a method using magnetic particles is used to automatically perform B / F separation.

  In B / F separation using magnetic particles, B / F separation is performed by further binding magnetic particles to an immune complex in which a measurement target substance and a labeling substance are bound, and adsorbing the magnetic particles with a magnet.

  In B / F separation, unnecessary labeled substances that are not bound to the target substance are removed by suction with a nozzle or the like, and the replacement liquid is dispensed to replace the reaction liquid in the sample. Since this method is suitable for automation, it is widely used in automatic analyzers.

  Here, the replacement liquid is stored in a replacement liquid tank and adjusted to an appropriate temperature using a Peltier element or the like. The temperature of the discharged replacement liquid is related to the subsequent reaction, that is, the reproducibility and sensitivity of the detection results, and it is important to adjust the temperature to a constant temperature regardless of the influence of the environmental temperature, which is the temperature of the environment in which the device is used. Because there is.

  In adjusting the metal member such as the replacement liquid tank to a constant temperature regardless of the environmental temperature, for example, Patent Document 1 discloses that the metal member is kept at a constant temperature by using a water distribution pipe in the thermostatic bath water in the apparatus. A regulating automatic analyzer is disclosed. In Patent Document 1, a water distribution pipe through which thermostatic bath water passes is brought into contact with a metal member to be adjusted, and the temperature of the metal member is adjusted to be constant regardless of the environmental temperature by circulating the thermostatic bath water.

Japanese Patent No. 5487324

  In the conventional discharge liquid temperature control mechanism, when the environmental temperature is higher than the target temperature to be controlled, the replacement liquid tank is cooled on the heat absorption surface of the Peltier element, and the heat dissipation surface of the Peltier element is radiated by heat transfer. Yes. When the environmental temperature is lower than the target temperature, the polarity of the current is reversed so that the heat absorbing surface becomes the heat radiating surface and the heat radiating surface becomes the heat absorbing surface.

  In order to be able to sufficiently meet the temperature control requirement corresponding to a wider range of environmental temperature, it is required to assist heat transfer from the Peltier element.

  For example, when the environmental temperature is high, the cooling capacity of the Peltier element can be made to function stably by preventing saturation of heat transmitted from the heat dissipation surface of the Peltier element to the base to which the replacement liquid tank and the Peltier element are fixed. is there. In patent document 1, the circulating water of a thermostat is drawn around, the distribution pipe through which thermostatic bath water passes is made to contact the metal member which is an adjustment object, and the temperature of object is adjusted. In Patent Document 1, the target temperature is constantly adjusted by circulating water. However, since circulating water is constantly flowing, cost and energy are required. Therefore, there is a demand for adjusting the temperature with further cost saving and energy saving.

  The purpose of the present invention is to realize a stable operation of the Peltier element without impairing the heat dissipation or heat absorption function of the Peltier element of the discharge liquid temperature adjustment mechanism by simplifying the mechanism and saving space and cost. It is an object of the present invention to provide an automatic analyzer that can adjust the temperature stably regardless of changes in the outside air temperature.

  In order to solve the above problems, the present invention controls the temperature of the heat transfer block based on, for example, opening / closing control of the replacement liquid solenoid valve, which intermittently controls the temperature of the heat transfer block.

  More specifically, a replacement liquid tank for storing the replacement liquid discharged to the reaction vessel, a Peltier element for adjusting the replacement liquid tank to a constant temperature, a heat transfer block for cooling or heating the Peltier element, and a replacement A replacement liquid electromagnetic valve that controls the inflow of liquid into the liquid tank, and a controller that intermittently controls the temperature of the heat transfer block.

  ADVANTAGE OF THE INVENTION According to this invention, the automatic analysis apparatus which can implement | achieve the stable operation | movement of a Peltier device without impairing the thermal radiation or heat absorption function of the Peltier device of a temperature control mechanism, and can adjust temperature stably irrespective of the change of external temperature. Can be realized by a simple mechanism and a space-saving and cost-saving configuration.

  Problems, configurations, and effects other than those described above will be clarified by the following description of embodiments.

It is a block diagram which shows the structure of the automatic analyzer which has a discharge liquid temperature control mechanism. It is a block diagram which shows the structure of a discharge liquid temperature control mechanism. It is a conceptual diagram which shows the opening / closing time chart of the substitution liquid solenoid valve and cooling water solenoid valve which were connected to the discharge liquid temperature control mechanism. It is a structural example which shows the structure which flows the circulating water of the thermostat in an apparatus in the auxiliary | assistant block water distribution pipe of the discharge liquid temperature control mechanism in Example 2. FIG. 10 is a configuration example showing a configuration in which a cooling mechanism using a heat sink and a fan is provided on the base of the discharge liquid temperature adjusting mechanism in Embodiment 3. FIG.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiment, and the repetitive description thereof will be omitted as much as possible.

  FIG. 1 is a schematic configuration diagram of an automatic analyzer including a discharge liquid temperature adjusting mechanism according to the present embodiment. As will be described in detail below, the automatic analyzer is an apparatus that measures the optical characteristics of a reaction liquid obtained by mixing and stirring a sample and a reagent in a reaction vessel and reacting them. Since the function of each part in FIG. 1 is known, detailed description is omitted.

  The automatic analyzer mainly includes a sample input unit, a container installation unit, a reagent installation unit, a reaction unit, a liquid replacement unit, and an analysis unit. The sample insertion unit includes a sample dispensing nozzle 106, a sample container 117, a sample transport rack 118 on which the sample container is placed, and a chip mounting location 119. The container installation unit includes a reaction container 107, a container holder 121 in which a plurality of reaction containers are installed, a sample dispensing tip 108, a sample dispensing tip holder 110 in which a plurality of sample dispensing chips are arranged, and a transport mechanism 111. The reagent erection unit 101 includes a reagent dispensing nozzle 103, a reagent stirring mechanism 112, a stirring rod cleaning mechanism 113, a reagent nozzle cleaning mechanism 114, and a reagent container 115. The reaction unit includes a reaction disk 102 and a sample dispensing place 120. The liquid replacement unit includes a discharge liquid temperature adjusting mechanism 11, a liquid replacement mechanism 21 having a discharge nozzle 22 and a suction nozzle 23, a nozzle cleaning tank 24, a magnetic separation unit 31, a redispersion stirring device 41, and a gripper 109. Yes. The analysis unit includes a reaction detection unit 104 and a sipper 105 that sucks and sucks the reaction liquid.

  The basic operation of the automatic analyzer will be described.

  In the sample insertion unit and the container installation unit, the container 107 first installed in the container holder 121 is installed on the reaction disk 102 by the transport mechanism 111. A sample is placed in a sample container 117 such as a test tube, and is placed on the sample transport rack 118 and carried to a sample aspiration site.

  The sample dispensing tip 108 installed in the sample dispensing tip holder 110 is carried to the tip mounting place 119 by the transport mechanism 111. Here, a sample dispensing tip 108 is attached to the tip of the sample dispensing nozzle 106.

  Next, the sample is aspirated by the sample dispensing nozzle 106 equipped with the sample dispensing chip 108 and discharged to the container 107 on the reaction disk 102 at the sample dispensing location 120. The sample dispensing tip 108 after the sample dispensing is discarded in a disposal box not shown.

  A plurality of reagent containers 115 are installed in the reagent erection unit 101. The reagent dispensing nozzle 103 can be rotated and moved up and down, and the tip of the reagent dispensing nozzle 103 is immersed in a reagent in a predetermined reagent container to suck a predetermined amount of reagent. The reagent dispensing nozzle 103 after the reagent dispensing is washed by the reagent dispensing nozzle washing mechanism 114. Further, the reagent is stirred by the reagent stirring mechanism 112 to prevent precipitation in the liquid. The stirring rod 112 after stirring the reagent is washed by the stirring rod washing mechanism 113.

  Next, after the reagent dispensing nozzle 103 is raised, the reagent dispensing nozzle 103 rotates and moves above a predetermined position of the reaction disk 102 to discharge the reagent into the container 107.

  The sample dispensed with the reagent is reacted for a predetermined time on the reaction disk 102 in the reaction section. Thereafter, the container 107 is moved to the magnetic separation device 31 by the gripper 109.

  In the liquid replacement unit, first, the reaction liquid is magnetically separated by the magnetic separation device 31, and the discharge nozzle 22 and the suction nozzle 23 are conveyed onto the container 107 by the liquid replacement mechanism 21. The unnecessary solution is sucked and removed by the suction nozzle 23, and the replacement liquid is discharged by the discharge nozzle 22 to replace the reaction liquid. The replacement liquid is stored in the replacement liquid tank 12 in the discharge liquid temperature adjusting mechanism 11, and the temperature is adjusted in the replacement liquid tank 12. The suction nozzle 23 is cleaned by the nozzle cleaning tank 24.

  Thereafter, the reaction solution is stirred by the gripper 109 and conveyed to the stirring device 41. After stirring, the container 107 is again conveyed to the reaction disk 102 by the gripper 109.

  Further, after reacting on the reaction disk 102 for a predetermined time, the reaction solution is caused to flow to the reaction detection unit 104 by the sipper 105 installed in the analysis unit, and a signal from the reaction solution is detected. Further, the sipper 105 sucks the buffer solution and the detection channel cleaning solution in addition to the reaction solution in accordance with a predetermined operation instruction.

  Next, the configuration and basic operation of the discharge liquid temperature adjusting mechanism of this embodiment will be described with reference to FIG. In the following embodiment, an example in which the environmental temperature is higher than the target temperature will be described. However, when the environmental temperature is lower than the target temperature, “cooling” is read as “heating” in the following description, and this embodiment is similarly applied. Can be applied. Hereinafter, a factor that indirectly changes the temperature of the Peltier element 13, such as a liquid passing through a water pipe or a wind by a fan, is defined as a heat exchange medium. Here, “indirectly” means that the member to which the Peltier element is fixed is cooled.

  The discharge liquid temperature adjusting mechanism 11 is disposed in the liquid replacement unit, and performs replacement of the reaction liquid to improve the analysis performance. In FIG. 2, the discharge liquid temperature adjusting mechanism 11 receives a heat from the replacement liquid tank 12 that stores the replacement liquid, a Peltier element 13 that cools the replacement liquid tank to a certain target temperature, and releases the heat to the outside. And the auxiliary block 16 in which the cooling water distribution pipe 15 is embedded. The base 14 and the auxiliary block 16 may be collectively referred to as a heat transfer block.

  A joint (IN) 17 for supplying the replacement liquid and a joint (OUT) 19 for discharging the replacement liquid are assembled in the replacement liquid tank. The joint (IN) 17 is connected by a tube (IN) 18 to the syringe 25 for discharging the replacement liquid via the replacement liquid electromagnetic valve 28. The joint (OUT) 19 is connected to the replacement liquid discharge nozzle 22 by a tube (OUT) 20. The flow of the replacement liquid into the replacement liquid tank is controlled by opening and closing the replacement liquid electromagnetic valve 28.

  Further, a thermistor (not shown) is disposed in the replacement liquid tank 12 to measure the temperature in the replacement liquid tank 12 and the replacement liquid tank 12.

  The auxiliary block 16 in which the cooling water distribution pipe 15 is embedded has a structure that can contact the base 14. The cooling water distribution pipe 15 of the auxiliary block 16 is connected via a cooling water electromagnetic valve 29 to a cleaning water supply unit 27 of the suction nozzle cleaning tank 24 and a cleaning water pump 26 for supplying the cleaning water. The washing water as the cooling water circulated through the cooling water distribution pipe 15 is controlled to flow into the cooling water distribution pipe 15 by the cooling water electromagnetic valve 29.

  The replacement liquid electromagnetic valve 28 and the cooling water electromagnetic valve 29 are controlled to be opened and closed by the control unit 30. As will be described later, the controller 30 can intermittently control the temperature of the auxiliary block 16 by controlling the opening and closing of the replacement liquid electromagnetic valve 28 and the cooling water electromagnetic valve 29. Further, as will be described later, the temperature of the auxiliary block is controlled by opening and closing the cooling water solenoid valve 29 based on the opening and closing control of the replacement liquid solenoid valve 28.

  The operation of the discharge liquid temperature adjusting mechanism shown in FIG. 2 will be described.

  After the container 107 into which the specimen has been dispensed is conveyed to the magnetic separation unit 31 by the gripper 109 and subjected to magnetic separation, an unnecessary solution in the container 107 is sucked by the reaction liquid suction nozzle 23.

  The reaction liquid suction nozzle 23 moves to the upper part of the suction nozzle cleaning tank 24, and is washed with water after discarding the suctioned unnecessary solution. At this time, the cleaning water pushed out by the cleaning water pump 26 passes through the cooling water solenoid valve 29, the cooling water distribution pipe 15, and the cleaning water supply unit 27 in the suction nozzle cleaning tank 24. Flows in the viewing direction 32. As the washing water passes through the cooling water distribution pipe 15, the heat of the auxiliary block 16 is taken and the temperature of the auxiliary block 16 itself is lowered. Then, the auxiliary block 16 whose temperature has been lowered takes heat away from the contacted base 14.

  After washing the reaction liquid suction nozzle 23, the replacement liquid discharge nozzle 22 moves to the upper part of the container 107.

  Next, the replacement liquid pushed out by the replacement liquid discharge syringe 25 is supplied to the replacement liquid tank 12 through the replacement liquid electromagnetic valve 28, the tube (IN) 18, and the joint (IN) 17. Then, the liquid in the replacement liquid tank 12 is pushed out by the amount of the supplied liquid, and discharged from the replacement liquid discharge nozzle 22 through the joint (OUT) 19 and the tube (OUT) 20.

  Here, since the temperature of the newly supplied liquid is not adjusted, the temperature is about the same as the environmental temperature. For example, when the environmental temperature is higher than the temperature in the replacement liquid tank, the temperature in the replacement liquid tank 12 is increased. The temperature rise is measured by the thermistor in the replacement liquid tank 12, the Peltier element 13 is cooled, and the replacement liquid tank 12 is cooled. At this time, heat is transferred from the heat dissipation surface of the Peltier element 13 to the base 14, but since the base 14 has already been deprived of heat by the auxiliary block 16, it is possible to avoid a situation where the heat is saturated.

  The above-described reaction liquid suction, reaction liquid suction nozzle cleaning, replacement liquid discharge nozzle movement, and replacement liquid discharge are defined as one cycle, which is repeated a plurality of times.

  FIG. 3 shows the timing at which the replacement liquid solenoid valve 28 and the cooling water solenoid valve 29 are opened in one cycle. First, after the reaction liquid is sucked, the cooling water electromagnetic valve 29 is opened to wash the suction nozzle. In this step, the auxiliary block 16 and the base 14 are cooled by the washing water flowing through the washing water distribution pipe 15. When the washing is finished, the cooling water solenoid valve 29 is closed.

  After cleaning the reaction liquid suction nozzle, the replacement liquid discharge nozzle 22 moves onto the reaction vessel, and when the replacement liquid electromagnetic valve 28 is opened, the replacement liquid is discharged from the replacement liquid discharge nozzle 22. At this time, the replacement liquid that has not been sufficiently cooled flows into the replacement liquid tank 12 and the temperature of the replacement liquid tank 12 rises. However, since the base 14 and the auxiliary block 16 are cooled in advance, the operation of the Peltier element immediately The replacement liquid tank 12 can be cooled.

  In this way, the operation of always aspirating the reaction liquid and the operation of discharging the replacement liquid are included in one cycle, and in order to perform the operation of aspirating the reaction liquid in advance before performing the operation of discharging the replacement liquid, The cooling water solenoid valve 29 is opened before the replacement liquid solenoid valve 28 is opened. That is, it can be said that the opening / closing timings of the replacement liquid solenoid valve 28 and the cooling water solenoid valve 29 are linked within one cycle. Here, interlocking does not mean opening and closing at the same time, but means that the other operation is performed within a predetermined time or within a predetermined processing step after one operation. In this embodiment, one feature is that the cooling water electromagnetic valve 29 is not always opened and the cooling water is not continuously flowed, but is cooled intermittently, that is, at a required timing. .

  After repeating the above cycle once more, the container 107 is conveyed to the reaction disk 102 by the gripper 109.

  According to the above configuration, heat does not saturate on the heat radiating surface of the Peltier element 13, so that the temperature of the cooling surface of the replacement liquid tank 12 does not rise. As a result, it becomes possible to stably satisfy the temperature control requirement. Further, according to the present embodiment, cooling is performed with the washing water passing through the cooling water distribution pipe 15 of the auxiliary block 16, so that it is not necessary to prepare cooling water separately, and the amount of water used can be reduced. Moreover, since it is the structure which draws the existing water distribution inside an apparatus, the said effect is realizable by space-saving and cost saving, without adding a new structure.

  In addition, as another effect, the cleaning water as the cooling water passes through the cooling water distribution pipe 15 only when the discharge operation is performed, and is therefore wasteful compared with the case where the cooling water is continuously circulated. Do not use water. Further, since the washing water is discarded after washing the reaction solution suction nozzle 23, it does not affect the subsequent analysis operation.

  Next, another configuration of the automatic analyzer having the discharge liquid temperature adjusting mechanism will be described with reference to FIG. FIG. 4 is an explanatory view of the discharge liquid temperature adjusting mechanism of the present embodiment, and shows a configuration in which the circulating water in the constant temperature bath in the apparatus flows through the cooling water distribution pipe 15 of the auxiliary block 16. Hereinafter, description of the same parts as those in the first embodiment will be omitted.

  In the reagent erection unit 101 in FIG. 1, circulating cooling water is allowed to flow from the constant temperature water tank 51 in the apparatus in order to cool a reagent storage for storing and keeping a reagent. The constant temperature water tank holds water as a heat exchange medium for cooling the reagent storage at a constant temperature.

  In the example shown in FIG. 2, the auxiliary block 16 in which the cooling water distribution pipe 15 through which the washing water passes is attached to the base 14 on the heat radiation side of the Peltier element 13 is attached. However, here, the circulating cooling water is cooled. Consider a structure that passes through a water pipe. That is, in this embodiment, the water in the constant temperature water tank 51 for keeping the reagent cold is used as the cooling water flowing through the cooling water distribution pipe 15 of the first embodiment. The cooling water distribution pipe 15 is connected to the thermostatic bath water 51.

  Circulating cooling water has a much lower temperature than the outside air temperature and has a great heat dissipation effect. Therefore, the voltage applied to the Peltier element 13 is reduced, and the power consumption can be reduced.

  At this time, in order to insulate the water distribution pipe through which the circulating cooling water passes (that is, the water distribution pipe at the portion connecting the cooling water distribution pipe 15 to the constant temperature water tank 51), the water distribution pipe is preferably covered with a heat insulating material. Thereby, deviation from outside temperature can be prevented, condensation can be prevented, and cooling capacity can be improved. In addition, since the circulating cooling water is intermittently flowed in this embodiment, the deviation from the outside air temperature is smaller than in the case where the circulating cooling water is continuously flowed, and as a result, a heat insulating material that covers the water distribution pipe is provided. Less is enough.

  Further, when the temperature of the base 14 becomes lower than the temperature of the Peltier element 13, the Peltier element cannot operate normally. Therefore, the cooling water electromagnetic valve 29 is arranged between the constant temperature water tank 51 in the apparatus and the cooling water distribution pipe 15, and the cooling water electromagnetic valve 29 is opened before the replacement liquid electromagnetic valve 28 is opened as in the time chart of FIG. 3. Is controlled by the control unit 30 so as to release the. As a result, excessive cooling can be prevented and the occurrence of condensation can be suppressed.

  Next, another configuration of the automatic analyzer having the discharge liquid temperature adjusting mechanism will be described with reference to FIG. FIG. 5 is an explanatory view of the discharge liquid temperature adjusting mechanism of this embodiment, and shows a configuration in which a cooling mechanism using a heat sink and a fan is provided on the base 14. Hereinafter, description of the same parts as those in the first embodiment will be omitted.

  As shown in FIG. 5, in this embodiment, a heat sink 61 is brought into contact with the base 14 that receives the heat radiation of the Peltier element 13 instead of the auxiliary block 16 in which the cooling water distribution pipe 15 is embedded, and the heat sink 61 is cooled by the fan 62. . The fan 62 is installed in a direction in which the wind direction axis of the fan 62 intersects the heat sink 61. Also in this method, heat dissipation by the base 14 can be assisted. In this embodiment, the control unit 30 controls the operation timing of the fan based on the opening / closing control of the replacement liquid solenoid valve 28. More specifically, the controller 30 controls the fan so that the fan also operates according to an electric signal given to open the replacement liquid electromagnetic valve 28. That is, the replacement liquid electromagnetic valve 28 is opened, and the replacement liquid whose temperature is not sufficiently adjusted flows into the replacement liquid tank 12, and at the same time, the control unit 30 drives the fan 62. The fan 62 may be controlled to stop after a predetermined time elapses or when a predetermined temperature is reached.

  Thereby, it is possible to operate only when the temperature of the replacement liquid tank 12 rises when the replacement liquid having the same temperature as the environmental temperature is supplied to the replacement liquid tank 12, thereby suppressing power consumption. When incorporating this structure, it is necessary to consider the addition of space, new parts, and securing of power.

  In addition, this invention is not limited to an above-described Example, Various modifications are included. For example, the above-described embodiments have been described in detail for easy understanding of the present invention, and are not necessarily limited to those having all the configurations described. Further, a part of the configuration of one embodiment can be replaced with the configuration of another embodiment, and the configuration of another embodiment can be added to the configuration of one embodiment. Further, it is possible to add, delete, and replace other configurations for a part of the configuration of each embodiment. Each of the above-described configurations, functions, processing units, processing means, and the like may be realized by hardware by designing a part or all of them with, for example, an integrated circuit. Each of the above-described configurations, functions, and the like may be realized by software by interpreting and executing a program that realizes each function by the processor.

  Information such as programs, tables, and files for realizing each function can be stored in a recording device such as a memory, a hard disk, or an SSD (Solid State Drive), or a recording medium such as an IC card, an SD card, or an optical disk.

  Further, the control lines and information lines indicate what is considered necessary for the explanation, and not all the control lines and information lines on the product are necessarily shown. Actually, it may be considered that almost all the components are connected to each other.

DESCRIPTION OF SYMBOLS 11 ... Discharge liquid temperature control mechanism, 12 ... Replacement liquid tank, 13 ... Peltier element, 14 ... Base, 15 ... Cooling water distribution pipe, 16 ... Auxiliary block, 17 ... Joint (IN), 18 ... Tube (IN), 19 ... Joint (OUT), 20 ... Tube (OUT), 21 ... Liquid replacement mechanism, 22 ... Discharge nozzle, 23 ... Suction nozzle, 24 ... Suction nozzle cleaning tank, 25 ... Syringe for discharging replacement liquid, 26 ... Pump for cleaning water , 27: Washing water supply unit, 28: Replacement liquid solenoid valve, 29 ... Cooling water solenoid valve, 30 ... Control unit, 31 ... Magnetic separation unit, 32 ... Direction of arrow, 41 ... Redispersion stirring device, 51 ... Device Internal water bath, 61 ... heat sink, 62 ... fan, 101 ... reagent erection unit, 102 ... reaction disk, 103 ... reagent dispensing nozzle, 104 ... reaction detector, 105 ... shipper, 106 ... specimen dispensing nozzle, 107 ... reaction Container, 108 ... inspection Dispensing tip, 109 ... gripper, 111 ... transport mechanism, 112 ... reagent stirring mechanism, 113 ... stirring bar cleaning mechanism, 114 ... reagent dispensing nozzle cleaning mechanism, 115 ... reagent container, 117 ... sample container, 118 ... sample transport Rack, 119 ... tip mounting location, 120 ... sample dispensing location, 121 ... container holder

Claims (6)

An automatic analyzer for measuring the optical characteristics of a reaction solution obtained by mixing and stirring a sample and a reagent in a reaction vessel and reacting them,
A replacement liquid tank for storing a replacement liquid to be discharged into the reaction vessel;
A Peltier element for adjusting the replacement liquid tank to a constant temperature;
A heat transfer block that receives heat radiation from the Peltier element and releases the heat to the outside;
A replacement liquid solenoid valve for controlling the inflow of the liquid into the replacement liquid tank;
And an automatic analyzer that intermittently controls the temperature of the heat transfer block. The automatic analyzer according to claim 1,
The automatic analyzer having a discharge liquid temperature adjusting mechanism, wherein the control unit controls the temperature of the heat transfer block based on opening / closing control of the replacement liquid electromagnetic valve. The automatic analyzer according to claim 1, further comprising:
A heat exchange medium pipe installed in the heat transfer block for circulating the heat exchange medium;
A heat exchange medium solenoid valve that controls the inflow of the heat exchange medium into the heat exchange medium pipe,
An automatic analyzer characterized in that opening / closing control of the replacement liquid solenoid valve and opening / closing control of the heat exchange medium solenoid valve are interlocked. The automatic analyzer according to claim 3, further comprising:
Equipped with a washing tank for the reaction solution suction nozzle,
The heat exchange medium pipe is connected to a cleaning water supply port to a cleaning tank of the reaction solution suction nozzle,
An automatic analyzer using the washing water as the heat exchange medium. The automatic analyzer according to claim 3, further comprising:
A reagent storage for cooling the reagent;
A constant temperature water tank that holds water for cooling the reagent storage at a constant temperature,
The heat exchange medium pipe is connected to the constant temperature water tank,
An automatic analyzer using water from the constant temperature bath as the heat exchange medium. The automatic analyzer according to claim 1, further comprising:
A fan in which the axis of the wind direction intersects the heat sink provided in the Peltier element,
The automatic analyzer according to claim 1, wherein the controller controls the operation timing of the fan based on opening / closing control of the replacement liquid solenoid valve.

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