JP6820319B2 - 増強された感度を有するイムノアッセイ - Google Patents

増強された感度を有するイムノアッセイ Download PDF

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JP6820319B2
JP6820319B2 JP2018510376A JP2018510376A JP6820319B2 JP 6820319 B2 JP6820319 B2 JP 6820319B2 JP 2018510376 A JP2018510376 A JP 2018510376A JP 2018510376 A JP2018510376 A JP 2018510376A JP 6820319 B2 JP6820319 B2 JP 6820319B2
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probe tip
analyte
antibody
immersed
probe
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JP2018528424A5 (enExample
JP2018528424A (ja
Inventor
エフ．ズーク ロバート
エフ．ズーク ロバート
タン ホン
タン ホン
シア チン
シア チン
リー プー
リー プー
チェン ハオトー
チェン ハオトー
ウー ホン
ウー ホン
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アクセス メディカル システムズ，リミティド
アクセス メディカル システムズ，リミティド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2018510376A 2015-08-26 2016-08-25 増強された感度を有するイムノアッセイ Active JP6820319B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210372P 2015-08-26 2015-08-26
US62/210,372 2015-08-26
PCT/US2016/048672 WO2017035343A1 (en) 2015-08-26 2016-08-25 Immunoassay with enhanced sensitivity

Publications (3)

Publication Number Publication Date
JP2018528424A JP2018528424A (ja) 2018-09-27
JP2018528424A5 JP2018528424A5 (enExample) 2019-08-29
JP6820319B2 true JP6820319B2 (ja) 2021-01-27

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JP2018510376A Active JP6820319B2 (ja) 2015-08-26 2016-08-25 増強された感度を有するイムノアッセイ

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US (2) US10809251B2 (enExample)
EP (1) EP3341726B1 (enExample)
JP (1) JP6820319B2 (enExample)
CN (1) CN107923908B (enExample)
WO (1) WO2017035343A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113710365B (zh) * 2019-04-03 2023-12-19 万迈医疗仪器有限公司 用于在免疫测定中重复使用半抗原涂覆的探针的方法
WO2021071903A1 (en) * 2019-10-09 2021-04-15 Access Medical Systems, Ltd. Method for re-using test probe and reagents in biochemical assay based on interferometry
CN115698055A (zh) * 2020-06-05 2023-02-03 万迈医疗仪器有限公司 用于确定抗体解离速率的方法
US20240302386A1 (en) * 2020-12-23 2024-09-12 Access Medical Systems, Ltd. Detection method using both fluorescence and chemiluminescence labels
CN114994302B (zh) * 2022-06-09 2024-11-22 星童医疗技术(苏州)有限公司 免疫类体外诊断试剂检测结果有效性确定方法及系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
US5650334A (en) 1995-08-31 1997-07-22 First Medical, Inc. Fluorescent labelling compositions and methods for their use
WO2002044726A1 (fr) * 2000-12-01 2002-06-06 International Reagents Corporation Procede de mesure ultrarapide et ultrasensible
DE602004028445D1 (de) * 2003-02-24 2010-09-16 Pritest Inc Lichtdurchlässige festmatrix-prüfvorrichtung zur mikroarray-analyse
CN100420947C (zh) * 2005-05-30 2008-09-24 孙东旭 用单一捕获剂定量检测特异性分析物的方法及其试剂盒
EP2404162B1 (en) 2009-03-03 2017-12-27 Access Medical System Co., Ltd. Detection system and method for high sensitivity fluorescent assays
WO2012145270A2 (en) * 2011-04-20 2012-10-26 Access Medical Systems, Ltd. Luminescent polymer cyclic amplification
US8293487B1 (en) * 2012-01-06 2012-10-23 Jiandi Zhang Zestern, a simple, fast, specific and quantifiable improvement of immunodetection process
US9568431B2 (en) 2012-04-16 2017-02-14 Access Medical Systems, Ltd. Luminescent immunoassays for quantitating analytes having a wide concentration range
CN103115934B (zh) * 2013-01-29 2015-08-12 南昌大学 一种基于Fe3O4@Au复合纳米粒子的NMR食源性致病菌快速检测方法

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Publication number Publication date
EP3341726B1 (en) 2021-08-25
CN107923908A (zh) 2018-04-17
CN107923908B (zh) 2021-01-05
WO2017035343A1 (en) 2017-03-02
JP2018528424A (ja) 2018-09-27
US20210041428A1 (en) 2021-02-11
EP3341726A4 (en) 2019-02-27
US20180180606A1 (en) 2018-06-28
US10809251B2 (en) 2020-10-20
EP3341726A1 (en) 2018-07-04
US12416627B2 (en) 2025-09-16
WO2017035343A9 (en) 2017-04-06

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