JP6807500B1 - Cooperative measurement facility for thioredoxin reductase activity - Google Patents

Cooperative measurement facility for thioredoxin reductase activity Download PDF

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JP6807500B1
JP6807500B1 JP2019149189A JP2019149189A JP6807500B1 JP 6807500 B1 JP6807500 B1 JP 6807500B1 JP 2019149189 A JP2019149189 A JP 2019149189A JP 2019149189 A JP2019149189 A JP 2019149189A JP 6807500 B1 JP6807500 B1 JP 6807500B1
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胡徳栄
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Abstract

【課題】本発明はチオレドキシン還元酵素の活性に対する協同測定設備を開示した。【解決手段】主に測定機を含み、前記測定機の中には測定空間が設置され、前記測定空間の中には実験を支持できる測定機構が設置され、前記測定空間の下端壁の中には装置に動力を提供できる駆動機構が設置され、前記駆動機構は駆動空間を含み、前記駆動空間の下端壁にはモータが設置され、前記モータの上端には上端が前記測定空間の中に位置している駆動軸が伝動できるように連結され、該装置が測定する時、サンプル又は薬剤の添加を自動で完成でき、人が手動で添加する必要がなく、他の因子の測定に対する影響を減らし、測定の正確性を上げ、また測定の始めと終わりの時、シャーレを洗浄して乾かし、シャーレのきれいさを保証し、測定に対する影響を減らし、機械の伝動によって測定の効率を上げられる。【選択図】図1PROBLEM TO BE SOLVED: To disclose a collaborative measurement facility for the activity of thioredoxin reductase. SOLUTION: A measuring machine is mainly included, a measuring space is installed in the measuring machine, a measuring mechanism capable of supporting an experiment is installed in the measuring space, and a measuring mechanism is installed in a lower end wall of the measuring space. Is equipped with a drive mechanism capable of supplying power to the device, the drive mechanism includes a drive space, a motor is installed on the lower end wall of the drive space, and the upper end of the motor is located in the measurement space at the upper end. The drive shafts are connected so that they can be transmitted, and when the device measures, the addition of the sample or drug can be completed automatically, eliminating the need for manual addition by humans and reducing the effect on the measurement of other factors. , Increase the accuracy of the measurement, and at the beginning and end of the measurement, wash and dry the chalet to ensure the cleanliness of the chalet, reduce the influence on the measurement, and increase the efficiency of the measurement by the transmission of the machine. [Selection diagram] Fig. 1

Description

本発明は測定技術分野を取り上げて、具体的にはチオレドキシン還元酵素の活性に対する協同測定設備である。 The present invention takes up the field of measurement technology, and specifically is a collaborative measurement facility for the activity of thioredoxin reductase.

チオレドキシン還元酵素の活性を測定することは、腫瘍ができるかどうかを判断する直接の手段であり、そのため、医者にとってチオレドキシン還元酵素の活性の測定は重要である。
現段階で、チオレドキシン還元酵素の活性を測定する時、多種類の薬剤を添加する必要があり、また過程において主に測定者の手動添加に頼り、測定結果に影響を与える因子がそれなりに増加し、測定結果の正確性を妨害し、測定の効率もはるかに下がる。
Measuring the activity of thioredoxin reductase is a direct means of determining whether a tumor is formed, and therefore it is important for physicians to measure the activity of thioredoxin reductase.
At this stage, when measuring the activity of thioredoxin reductase, it is necessary to add many kinds of drugs, and in the process, mainly relying on the manual addition of the measurer, the factors that influence the measurement result increase accordingly. , Interferes with the accuracy of measurement results and greatly reduces the efficiency of measurement.

中国特許出願公開第103857690号明細書Chinese Patent Application Publication No. 1038776990

本発明はチオレドキシン還元酵素の活性に対する協同測定設備を提供し、測定に対する影響因子が多いことと測定の効率が低いことなどの問題を解消し、測定に対する影響因子を減らし、測定の効率を上げる。 The present invention provides a collaborative measurement facility for the activity of thioredoxin reductase, solves problems such as many influencing factors for measurement and low measurement efficiency, reduces influencing factors for measurement, and improves measurement efficiency.

本発明は以下の技術プランによって実現される。 The present invention is realized by the following technical plan.

チオレドキシン還元酵素の活性に対する協同測定設備は、主に測定機を含み、前記測定機の中には測定空間が設置され、前記測定空間の中には実験を支持できる測定機構が設置され、前記測定空間の下端壁の中には装置に動力を提供できる駆動機構が設置され、前記駆動機構は駆動空間を含み、前記駆動空間の下端壁にはモータが設置され、前記モータの上端には上端が前記測定空間の中に位置している駆動軸が伝動できるように連結され、前記駆動軸には第一スプロケットと、駆動板と、第一ベルトプーリとがスライドできるように連結され、前記駆動空間の左端壁にはそれぞれ前記第一スプロケットと前記第一ベルトプーリとを支持する二つの支持板が固定され、前記第一スプロケットの中には電磁空間が設置され、前記電磁空間の中には前記電磁空間の中に固定された第一電磁石及び前記電磁空間の中でスライドできる第二電磁石が設置され、前記第一電磁石と前記第二電磁石とが連結ばねにより連結され、前記第一ベルトプーリの中には上方に開口した伝動孔が設置され、前記駆動軸には駆動盤がスプラインにより連結され、前記駆動板の中には下方に開口した環状空間が設置され、前記環状空間の中にはスライドブロックが二つ設置され、前記スライドブロックの下端には下端が前記駆動盤と連結された駆動ロッドが固定され、前記駆動盤の中には下方に開口した押出孔が設置され、前記押出孔の中には下端が前記伝動孔の中に位置している伝動ロッド及び前記伝動ロッドを復帰させることができる押出ばねが設置され、前記駆動板の下端面には下端が前記第一電磁石と吸引する又は反発することができる磁石ロッドが固定され、前記駆動板の下端面にはまた下端が上側の前記支持板と連結された支持ばねが固定され、
前記測定機の中にはまたキャリアーを洗浄して乾かすことができる洗浄機構が設置され、前記測定空間の上端壁の中にはまたキャリアーに所要の薬剤又は測定サンプルを添加できる添加機構が設置され、前記洗浄機構の作業を通じて、他の因子の実験に対する妨害を減らせ、実験の正確性を保証する。
The cooperative measurement facility for the activity of thioredoxin reductase mainly includes a measuring machine, a measuring space is installed in the measuring machine, and a measuring mechanism capable of supporting an experiment is installed in the measuring space. A drive mechanism capable of supplying power to the device is installed in the lower end wall of the space, the drive mechanism includes the drive space, a motor is installed in the lower end wall of the drive space, and the upper end of the motor has an upper end. The drive shaft located in the measurement space is connected so as to be transmitted, and the first sprocket, the drive plate, and the first belt pulley are connected to the drive shaft so as to be slidable. Two support plates for supporting the first sprocket and the first belt pulley are fixed to the left end wall of the above, respectively, an electromagnetic space is installed in the first sprocket, and the electromagnetic space is contained in the electromagnetic space. A first electromagnet fixed in the electromagnetic space and a second electromagnet that can slide in the electromagnetic space are installed, and the first electromagnet and the second electromagnet are connected by a connecting spring to form the first belt pulley. A transmission hole opened upward is installed inside, a drive panel is connected to the drive shaft by a spline, an annular space opened downward is installed in the drive plate, and an annular space opened downward is installed in the annular space. Two slide blocks are installed, a drive rod whose lower end is connected to the drive panel is fixed to the lower end of the slide block, and an extrusion hole opened downward is installed in the drive panel. A transmission rod whose lower end is located in the transmission hole and an extrusion spring capable of returning the transmission rod are installed inside, and the lower end attracts the first electromagnet and attraction to the lower end surface of the drive plate. A magnet rod capable of repelling or repelling is fixed, and a support spring whose lower end is connected to the support plate on the upper side is fixed to the lower end surface of the drive plate.
A cleaning mechanism capable of cleaning and drying the carrier is also installed in the measuring machine, and an addition mechanism capable of adding the required drug or measurement sample to the carrier is also installed in the upper end wall of the measuring space. Through the work of the cleaning mechanism, the interference of other factors with the experiment can be reduced and the accuracy of the experiment is guaranteed.

好ましくは、前記測定機構は前記測定空間の下端壁に回転できるように連結された支持ブロックを含み、前記支持ブロックの中には下方に開口した回転空間が設置され、前記駆動軸の上端が前記回転空間の中に位置し、且つ前記駆動軸の上端には回転ブロックが固定され、前記回転ブロックの中には前記回転空間を連通するばね溝が二つ形成され、前記ばね溝の中にはばねブロック及び前記ばねブロックを復帰させることができる伸縮ばねが設置され、前記支持ブロックの中にはまた前記測定空間及び前記回転空間を連通するスライド孔が二つ設置され、前記スライド孔の中には一端が前記測定空間の中に位置している台形ロッドが設置され、前記測定空間の中にはまた前記台形ロッドを前記スライド孔の中に戻せる環状ブロックが設置され、前記環状ブロックの右端には下端が前記駆動板と連結された連結ロッドが固定され、前記支持ブロックの上端には伝動盤が固定され、前記伝動盤の中には回転溝が二つ形成され、前記回転溝の前後端壁の間には回転軸が回転できるように連結され、前記回転軸と前記回転溝の端壁とが捻りばねにより連結され、前記回転軸には回転板が固定され、前記回転板には吸盤が固定され、前記吸盤にはキャリアーとしてのシャーレが吸着され、前記伝動盤の中にはまた従動空間が設置され、前記従動空間の前後端壁の間には従動軸が回転できるように連結され、前記従動軸には従動輪が固定され、前記従動輪の上下両側にはいずれも前記従動輪と接触する従動ロッドが設置され、前記従動ロッドの一端が前記回転溝の中に位置し、前記回転軸にはまた前記従動ロッドと接触する摩擦輪が固定され、下側の前記従動ロッドの右端には下端が前記測定空間の中に位置している摩擦ブロックが固定され、前記測定空間の下端壁にはまた外部空間に連通する排水パイプが設置され、前記排水パイプの中には電磁スイッチが設置されている。 Preferably, the measuring mechanism includes a support block rotatably connected to the lower end wall of the measuring space, the support block is provided with a rotating space that opens downward, and the upper end of the drive shaft is said. A rotating block is fixed at the upper end of the drive shaft, which is located in the rotating space, two spring grooves communicating with the rotating space are formed in the rotating block, and two spring grooves communicating with the rotating space are formed in the rotating block. A spring block and a telescopic spring capable of returning the spring block are installed, and two slide holes communicating with the measurement space and the rotation space are also installed in the support block, and the slide holes are provided. A trapezoidal rod whose one end is located in the measurement space is installed, and an annular block capable of returning the trapezoidal rod into the slide hole is also installed in the measurement space at the right end of the annular block. A connecting rod whose lower end is connected to the drive plate is fixed, a transmission board is fixed to the upper end of the support block, two rotary grooves are formed in the transmission board, and front and rear ends of the rotary groove are formed. The rotating shaft is connected between the walls so that the rotating shaft can rotate, the rotating shaft and the end wall of the rotating groove are connected by a torsion spring, a rotating plate is fixed to the rotating shaft, and a suction plate is attached to the rotating plate. Is fixed, a chalet as a carrier is attracted to the suction plate, a driven space is also installed in the transmission plate, and a driven shaft is connected between the front and rear end walls of the driven space so that the driven shaft can rotate. A driven wheel is fixed to the driven shaft, and driven rods that come into contact with the driven wheel are installed on both upper and lower sides of the driven wheel, and one end of the driven rod is located in the rotating groove. A friction ring in contact with the driven rod is also fixed to the rotating shaft, and a friction block whose lower end is located in the measuring space is fixed to the right end of the driven rod on the lower side, and the lower end of the measuring space is fixed. A drain pipe communicating with the external space is also installed on the wall, and an electromagnetic switch is installed in the drain pipe.

好ましくは、前記洗浄機構は前記駆動空間の左右端壁の中に位置している伝動空間を含み、前記伝動空間の下端壁には伝動軸が回転できるように連結され、前記伝動軸には第二スプロケットが固定され、二つの前記第二スプロケットと前記第一スプロケットとがチェーンにより連結され、左側の前記伝動軸の上端には第一ベベルギヤが固定され、前記第一ベベルギヤの左端には第二ベベルギヤが噛み合われ、前記第二ベベルギヤの中心部には左端が左側の前記伝動空間の左端壁と連結されたベルト軸が固定され、前記ベルト軸には第二ベルトプーリが固定され、左側の前記伝動空間の上端壁の中には外部空間と前記測定空間とを連通する通風空間が設置され、前記通風空間の中には濾過網と加熱管とが固定され、前記通風空間の中にはまた支持ロッドが固定され、前記通風空間の中にはまた前記支持ロッドを貫通する旋転軸が設置され、前記旋転軸には第一ベルトにより前記第二ベルトプーリと連結された第三ベルトプーリが固定され、前記旋転軸にはまた旋転輪とファン羽根とが固定され、前記通風空間の後端壁の中には前方に開口した密封空間が設置され、前記測定機の中にはまた前記通風空間を貫通し、且つ前記密封空間と連通するスライド空間が設置され、前記スライド空間の中には前記旋転輪と接触するスライド板が設置され、前記スライド板の左端が前記密封空間の中に位置し、前記密封空間の中には前記通風空間を密封でき、且つ前記スライド板と連結された密封板が設置され、右側の前記伝動軸の上端にはカムが固定され、右側の前記伝動空間の上端壁の中には伸縮空間が設置され、前記伸縮空間の下端壁の右側が前記伝動空間と連通し、前記伸縮空間の中にはピストンと前記ピストンを復帰させることができる圧縮ばねとが設置され、前記ピストンの下端には下端が右側の前記伝動空間の中に位置している推動板が固定され、前記伸縮空間の左端壁が前記測定空間と連通し、且つ前記伸縮空間の上端壁には外部空間と連通した入水パイプが設置され、前記入水パイプの中には揚水ポンプが設置され、右側の前記伝動空間の中にはまた左端が前記摩擦ブロックと接触する摩擦板が設置され、前記摩擦板の右端には固定ブロックが固定され、前記固定ブロックの左端には左端が右側の前記伝動空間の左端壁と連結された復帰ばねが固定されている。 Preferably, the cleaning mechanism includes a transmission space located in the left and right end walls of the drive space, is connected to the lower end wall of the transmission space so that the transmission shaft can rotate, and is connected to the transmission shaft. The second sprocket is fixed, the two second sprocket and the first sprocket are connected by a chain, the first bevel gear is fixed to the upper end of the transmission shaft on the left side, and the second bevel gear is fixed to the left end of the first bevel gear. The bevel gears are engaged, and a belt shaft whose left end is connected to the left end wall of the transmission space on the left side is fixed to the center of the second bevel gear, and a second belt pulley is fixed to the belt shaft, and the left side is said. A ventilation space that communicates the external space and the measurement space is installed in the upper end wall of the transmission space, a filtration net and a heating pipe are fixed in the ventilation space, and the ventilation space also has a ventilation space. The support rod is fixed, a rotating shaft penetrating the support rod is installed in the ventilation space, and a third belt pulley connected to the second belt pulley by the first belt is fixed to the rotating shaft. A rotating wheel and a fan blade are fixed to the rotating shaft, a sealed space opened forward is installed in the rear end wall of the ventilation space, and the ventilation space is also in the measuring machine. A slide space is installed that penetrates the sealed space and communicates with the sealed space, a slide plate that contacts the rotating wheel is installed in the slide space, and the left end of the slide plate is located in the sealed space. A sealing plate that can seal the ventilation space and is connected to the slide plate is installed in the sealing space, a cam is fixed to the upper end of the transmission shaft on the right side, and the upper end of the transmission space on the right side. A telescopic space is installed in the wall, the right side of the lower end wall of the telescopic space communicates with the transmission space, and a piston and a compression spring capable of returning the piston are installed in the telescopic space. A thrust plate whose lower end is located in the transmission space on the right side is fixed to the lower end of the piston, the left end wall of the telescopic space communicates with the measurement space, and the upper end wall of the telescopic space A water inlet pipe communicating with the external space is installed, a pump is installed in the water inlet pipe, and a friction plate whose left end contacts the friction block is installed in the transmission space on the right side. A fixed block is fixed to the right end of the friction plate, and a return spring whose left end is connected to the left end wall of the transmission space on the right side is fixed to the left end of the fixed block.

好ましくは、前記添加機構は下圧空間を含み、前記下圧空間の下端壁の中にはまた左方に開口した移動空間が設置され、前記駆動空間の後端壁の中には上端壁が前記下圧空間と連通した連結空間が設置され、前記連結空間の下端壁には上端が前記下圧空間の中に位置している螺旋軸が回転できるように連結され、前記螺旋軸の下端には第二ベルトにより前記第一ベルトプーリと連結された第四ベルトプーリが固定され、前記螺旋軸の上端には移動板がネジ山で連結され、前記下圧空間の中には下圧板が二つ設置され、上側の前記下圧板の上端には上端が前記移動板を貫通している下圧ロッドが固定され、下側の前記下圧板の下端面には下端が前記移動空間の中に位置している下圧ブロックが四つ固定され、前記移動板と上側の前記下圧板とが二つの下圧ばねにより連結され、下側の前記下圧板と前記下圧空間の下端壁とが二つのリミットばねにより連結され、前記移動空間の右端壁には電磁ブロックが固定され、前記電磁ブロックの左端面には移動ロッドが固定され、前記移動ロッドには前記電磁ブロックと吸引し合う又は反発し合うことができる移動ブロックがスライドできるように連結され、前記移動空間の下端壁には薬剤又はサンプルを収容できる収容ケースが四つ固定され、前記移動ブロックの中には前方に開口し、且つ上下端壁が前記移動ブロックを貫通した持ち上げ空間が設置され、前記持ち上げ空間の中には持ち上げブロックが設置され、前記持ち上げ空間の左右端壁の中にはいずれも前記持ち上げ空間と連通した持ち上げ溝が形成され、前記持ち上げブロックの左右両端にはいずれも一端が前記持ち上げ溝の中に位置している持ち上げ板が設置され、前記持ち上げ溝の下端壁には上端が前記持ち上げ板と連結された持ち上げばねが固定され、前記持ち上げブロックの中にはまた押圧空間が設置され、前記押圧空間の中には電磁板が二つ設置され、二つの前記電磁板の間には下端が前記移動空間の中に位置しているドロッパーが設置され、前記移動空間の下端壁の右側が測定空間と連通し、前記測定機の左側には前記移動空間を密封できるL型板が設置され、前記移動板の下端面にはまた下圧柱が固定されている。 Preferably, the addition mechanism includes a lower pressure space, a moving space open to the left is also installed in the lower end wall of the lower pressure space, and an upper end wall is provided in the rear end wall of the drive space. A connected space communicating with the lower pressure space is installed, and a spiral shaft whose upper end is located in the lower pressure space is connected to the lower end wall of the connected space so as to be rotatable, and is connected to the lower end of the spiral shaft. The fourth belt pulley connected to the first belt pulley is fixed by the second belt, a moving plate is connected to the upper end of the spiral shaft with a screw thread, and two lower pressure plates are connected in the lower pressure space. A lower pressure rod whose upper end penetrates the moving plate is fixed to the upper end of the lower pressure plate on the upper side, and the lower end is located in the moving space on the lower end surface of the lower pressure plate on the lower side. Four lower pressure blocks are fixed, the moving plate and the upper lower pressure plate are connected by two lower pressure springs, and the lower lower pressure plate and the lower end wall of the lower pressure space are two. Connected by a limit spring, an electromagnetic block is fixed to the right end wall of the moving space, a moving rod is fixed to the left end surface of the electromagnetic block, and the moving rod attracts or repels the electromagnetic block. The movable blocks that can be moved are connected so as to be slidable, four storage cases that can store a drug or a sample are fixed to the lower end wall of the moving space, and the moving blocks are opened forward and upper and lower ends. A lifting space is installed in which the wall penetrates the moving block, a lifting block is installed in the lifting space, and a lifting groove communicating with the lifting space is formed in each of the left and right end walls of the lifting space. A lifting plate whose one end is located in the lifting groove is installed at both left and right ends of the lifting block, and a lifting spring whose upper end is connected to the lifting plate is installed on the lower end wall of the lifting groove. It is fixed, a pressing space is also installed in the lifting block, two electromagnetic plates are installed in the pressing space, and the lower end is located in the moving space between the two electromagnetic plates. A dropper is installed, the right side of the lower end wall of the moving space communicates with the measuring space, an L-shaped plate capable of sealing the moving space is installed on the left side of the measuring machine, and the lower end surface of the moving plate is also covered. The lower pressure column is fixed.

好ましくは、前記第一スプロケットの毎回の回転の始まりから終わりまで、前記第一電磁石が常に前記磁石ロッドの下側に位置し、前記第一電磁石と前記第二電磁石とが同じ時刻にひとつだけ磁性を生み出せる。 Preferably, from the beginning to the end of each rotation of the first sprocket , the first electromagnet is always located under the magnet rod, and the first electromagnet and the second electromagnet are magnetic at the same time. Can be produced.

好ましくは、前記摩擦板と前記測定機との間の摩擦力は前記復帰ばねの弾力より小さい。 Preferably, the frictional force between the friction plate and the measuring machine is smaller than the elasticity of the return spring.

好ましくは、前記下圧ロッドと前記移動板との間の摩擦力は二つの前記持ち上げばねの弾力と二つの前記リミットばねとの弾力の和より大きい。 Preferably, the frictional force between the lower pressure rod and the moving plate is larger than the sum of the elasticity of the two lifting springs and the elasticity of the two limit springs.

該装置は構成が簡単で、操作が便利であり、該装置が測定する時、サンプル又は薬剤の添加を自動で完成でき、人が手動で添加する必要がなく、他の因子の測定に対する影響を減らし、測定の正確性を上げ、また測定の始めと終わりの時、シャーレを洗浄して乾かし、シャーレのきれいさを保証し、測定に対する影響を減らし、機械の伝動によって測定の効率を上げられる。 The device is simple to configure and convenient to operate, when the device measures, the addition of sample or drug can be completed automatically, no manual addition is required by humans, and the effect on the measurement of other factors. It reduces, improves the accuracy of the measurement, and at the beginning and end of the measurement, the petri dish is washed and dried to ensure the cleanliness of the petri dish, reduce the influence on the measurement, and increase the efficiency of the measurement by the transmission of the machine.

下記に図1〜5をあわせて本発明について詳しく説明し、便利に説明するために、下記の方向を以下のように規定する:図1は本発明装置の正面図であり、以下に述べる上下左右前後の方向と図1の自身投影関係の上下左右前後の方向とが一致である。 In order to explain the present invention in detail with reference to FIGS. 1 to 5 below and to explain the present invention in a convenient manner, the following directions are defined as follows: FIG. 1 is a front view of the apparatus of the present invention, and is described above and below. The left-right front-back direction and the up-down, left-right front-back direction of the self-projection relationship in FIG. 1 are the same.

図1は本発明の実施例の構成模式図FIG. 1 is a schematic configuration diagram of an embodiment of the present invention. 図2は本発明の実施例の駆動機構の部分断面の正面拡大構成模式図FIG. 2 is a schematic front enlarged view of a partial cross section of the drive mechanism according to the embodiment of the present invention. 図3は本発明の実施例の連結空間の全断面の左面拡大構成模式図FIG. 3 is a schematic view of the left side enlarged configuration of the entire cross section of the connected space according to the embodiment of the present invention. 図4は本発明の実施例の移動ブロックの全断面の正面拡大構成模式図FIG. 4 is a schematic front enlarged configuration diagram of the entire cross section of the moving block according to the embodiment of the present invention. 図5は本発明の実施例の伝動盤の全断面の正面拡大構成模式図FIG. 5 is a schematic front enlarged view of the entire cross section of the transmission board according to the embodiment of the present invention.

図1〜5に記載のチオレドキシン還元酵素の活性に対する協同測定設備の機械構成図を参照し、チオレドキシン還元酵素の活性に対する協同測定設備は、主に測定機88を含み、前記測定機88の中には測定空間51が設置され、前記測定空間51の中には実験を支持できる測定機構106が設置され、前記測定空間51の下端壁の中には装置に動力を提供できる駆動機構104が設置され、前記駆動機構104は駆動空間70を含み、前記駆動空間70の下端壁にはモータ34が設置され、前記モータ34の上端には上端が前記測定空間51の中に位置している駆動軸35が伝動できるように連結され、前記駆動軸35には第一スプロケット36と、駆動板69と、第一ベルトプーリ80とがスライドできるように連結され、前記駆動空間70の左端壁にはそれぞれ前記第一スプロケット36と前記第一ベルトプーリ80とを支持する二つの支持板33が固定され、前記第一スプロケット36の中には電磁空間58が設置され、前記電磁空間58の中には前記電磁空間58の中に固定された第一電磁石62及び前記電磁空間58の中でスライドできる第二電磁石59が設置され、前記第一電磁石62と前記第二電磁石59とが連結ばね60により連結され、前記第一ベルトプーリ80の中には上方に開口した伝動孔63が設置され、前記駆動軸35には駆動盤84がスプラインにより連結され、前記駆動板69の中には下方に開口した環状空間82が設置され、前記環状空間82の中にはスライドブロック83が二つ設置され、前記スライドブロック83の下端には下端が前記駆動盤84と連結された駆動ロッド85が固定され、前記駆動盤84の中には下方に開口した押出孔66が設置され、前記押出孔66の中には下端が前記伝動孔63の中に位置している伝動ロッド64及び前記伝動ロッド64を復帰させることができる押出ばね65が設置され、前記駆動板69の下端面には下端が前記第一電磁石62と吸引する又は反発することができる磁石ロッド67が固定され、前記駆動板69の下端面にはまた下端が上側の前記支持板33と連結された支持ばね68が固定され、前記測定機88の中にはまたキャリアーを洗浄して乾かすことができる洗浄機構105が設置され、前記測定空間51の上端壁の中にはまたキャリアーに所要の薬剤又は測定サンプルを添加できる添加機構107が設置され、前記洗浄機構の作業を通じて、他の因子の実験に対する妨害を減らせ、実験の正確性を保証する。 With reference to the mechanical configuration diagram of the cooperative measurement facility for the activity of the thioredoxin reductase shown in FIGS. 1 to 5, the cooperative measurement facility for the activity of the thioredoxin reductase mainly includes a measuring device 88, and the measuring device 88 includes the measuring device 88. A measurement space 51 is installed, a measurement mechanism 106 capable of supporting an experiment is installed in the measurement space 51, and a drive mechanism 104 capable of providing power to the device is installed in the lower end wall of the measurement space 51. The drive mechanism 104 includes a drive space 70, a motor 34 is installed on the lower end wall of the drive space 70, and a drive shaft 35 whose upper end is located in the measurement space 51 at the upper end of the motor 34. The first sprocket 36, the drive plate 69, and the first belt pulley 80 are connected to the drive shaft 35 so as to be slidable, and the left end wall of the drive space 70 is connected to the drive space 70. Two support plates 33 that support the first sprocket 36 and the first belt pulley 80 are fixed, an electromagnetic space 58 is installed in the first sprocket 36, and the electromagnetic space 58 is inside the electromagnetic space 58. A first electric magnet 62 fixed in the space 58 and a second electric magnet 59 that can slide in the electromagnetic space 58 are installed, and the first electric magnet 62 and the second electric magnet 59 are connected by a connecting spring 60. A transmission hole 63 opened upward is installed in the first belt pulley 80, a drive board 84 is connected to the drive shaft 35 by a spline, and an annular space opened downward in the drive plate 69. 82 is installed, two slide blocks 83 are installed in the annular space 82, and a drive rod 85 whose lower end is connected to the drive panel 84 is fixed to the lower end of the slide block 83. An extrusion hole 66 opened downward is installed in the 84, and the transmission rod 64 and the transmission rod 64 whose lower end is located in the transmission hole 63 can be restored in the extrusion hole 66. An extruded spring 65 is installed, and a magnet rod 67 whose lower end can attract or repel the first electric magnet 62 is fixed to the lower end surface of the drive plate 69, and the lower end surface of the drive plate 69 is also fixed. A support spring 68 whose lower end is connected to the support plate 33 on the upper side is fixed, and a cleaning mechanism 105 capable of cleaning and drying the carrier is also installed in the measuring machine 88, and the upper end of the measuring space 51 is installed. Inside the wall, an addition mechanism 107 that can add the required drug or measurement sample to the carrier is also installed, and the cleaning mechanism is created. Through the work, we can reduce the interference of other factors with the experiment and guarantee the accuracy of the experiment.

有益的には、前記測定機構106は前記測定空間51の下端壁に回転できるように連結された支持ブロック71を含み、前記支持ブロック71の中には下方に開口した回転空間61が設置され、前記駆動軸35の上端が前記回転空間61の中に位置し、且つ前記駆動軸35の上端には回転ブロック78が固定され、前記回転ブロック78の中には前記回転空間61を連通するばね溝が二つ形成され、前記ばね溝75の中にはばねブロック74及び前記ばねブロック74を復帰させることができる伸縮ばね77が設置され、前記支持ブロック71の中にはまた前記測定空間51及び前記回転空間61を連通するスライド孔79が二つ設置され、前記スライド孔79の中には一端が前記測定空間51の中に位置している台形ロッド73が設置され、前記測定空間51の中にはまた前記台形ロッド73を前記スライド孔79の中に戻せる環状ブロック72が設置され、前記環状ブロック72の右端には下端が前記駆動板69と連結された連結ロッド81が固定され、前記支持ブロック71の上端には伝動盤76が固定され、前記伝動盤76の中には回転溝30が二つ形成され、前記回転溝30の前後端壁の間には回転軸37が回転できるように連結され、前記回転軸37と前記回転溝30の端壁とが捻りばね97により連結され、前記回転軸37には回転板32が固定され、前記回転板32には吸盤38が固定され、前記吸盤38にはキャリアーとしてのシャーレ31が吸着され、前記伝動盤76の中にはまた従動空間101が設置され、前記従動空間101の前後端壁の間には従動軸102が回転できるように連結され、前記従動軸102には従動輪103が固定され、前記従動輪103の上下両側にはいずれも前記従動輪103と接触する従動ロッド99が設置され、前記従動ロッド99の一端が前記回転溝30の中に位置し、前記回転軸37にはまた前記従動ロッド99と接触する摩擦輪98が固定され、下側の前記従動ロッド99の右端には下端が前記測定空間51の中に位置している摩擦ブロック100が固定され、前記測定空間51の下端壁にはまた外部空間に連通する排水パイプ39が設置され、前記排水パイプ39の中には電磁スイッチ108が設置されている。 Advantageously, the measuring mechanism 106 includes a support block 71 rotatably connected to the lower end wall of the measuring space 51, and a rotating space 61 that opens downward is installed in the support block 71. The upper end of the drive shaft 35 is located in the rotation space 61, the rotation block 78 is fixed to the upper end of the drive shaft 35, and the spring groove communicating the rotation space 61 in the rotation block 78. The spring block 74 and the telescopic spring 77 capable of returning the spring block 74 are installed in the spring groove 75, and the measurement space 51 and the measurement space 51 are also installed in the support block 71. Two slide holes 79 that communicate with the rotation space 61 are installed, and a trapezoidal rod 73 whose one end is located in the measurement space 51 is installed in the slide holes 79, and is installed in the measurement space 51. Also, an annular block 72 capable of returning the trapezoidal rod 73 into the slide hole 79 is installed, and a connecting rod 81 whose lower end is connected to the driving plate 69 is fixed to the right end of the annular block 72, and the supporting block A transmission board 76 is fixed to the upper end of the transmission board 76, two rotary grooves 30 are formed in the transmission board 76, and a rotary shaft 37 is connected between the front and rear end walls of the rotary groove 30 so as to be rotatable. The rotary shaft 37 and the end wall of the rotary groove 30 are connected by a torsion spring 97, a rotary plate 32 is fixed to the rotary shaft 37, a suction plate 38 is fixed to the rotary plate 32, and the suction plate is fixed. A chalet 31 as a carrier is attracted to 38, a driven space 101 is also installed in the transmission board 76, and a driven shaft 102 is connected between the front and rear end walls of the driven space 101 so as to be rotatable. A driven wheel 103 is fixed to the driven shaft 102, and a driven rod 99 that comes into contact with the driven wheel 103 is installed on both upper and lower sides of the driven wheel 103, and one end of the driven rod 99 is the rotary groove 30. A friction ring 98 is fixed to the rotating shaft 37 and is in contact with the driven rod 99, and a lower end is located in the measuring space 51 at the right end of the driven rod 99 on the lower side. The friction block 100 is fixed, a drain pipe 39 communicating with the external space is installed on the lower end wall of the measurement space 51, and an electromagnetic switch 108 is installed in the drain pipe 39.

有益的には、前記洗浄機構105は前記駆動空間70の左右端壁の中に位置している伝動空間25を含み、前記伝動空間25の下端壁には伝動軸27が回転できるように連結され、前記伝動軸27には第二スプロケット26が固定され、二つの前記第二スプロケット26と前記第一スプロケット36とがチェーン28により連結され、左側の前記伝動軸27の上端には第一ベベルギヤ24が固定され、前記第一ベベルギヤ24の左端には第二ベベルギヤ23が噛み合われ、前記第二ベベルギヤ23の中心部には左端が左側の前記伝動空間25の左端壁と連結されたベルト軸21が固定され、前記ベルト軸21には第二ベルトプーリ22が固定され、左側の前記伝動空間25の上端壁の中には外部空間と前記測定空間51とを連通する通風空間18が設置され、前記通風空間18の中には濾過網11と加熱管20とが固定され、前記通風空間18の中にはまた支持ロッド17が固定され、前記通風空間18の中にはまた前記支持ロッド17を貫通する旋転軸16が設置され、前記旋転軸16には第一ベルト29により前記第二ベルトプーリ22と連結された第三ベルトプーリ14が固定され、前記旋転軸16にはまた旋転輪19とファン羽根15とが固定され、前記通風空間18の後端壁の中には前方に開口した密封空間12が設置され、前記測定機88の中にはまた前記通風空間18を貫通し、且つ前記密封空間12と連通するスライド空間3が設置され、前記スライド空間3の中には前記旋転輪19と接触するスライド板10が設置され、前記スライド板10の左端が前記密封空間12の中に位置し、前記密封空間12の中には前記通風空間18を密封でき、且つ前記スライド板10と連結された密封板13が設置され、右側の前記伝動軸27の上端にはカム41が固定され、右側の前記伝動空間25の上端壁の中には伸縮空間47が設置され、前記伸縮空間47の下端壁の右側が前記伝動空間25と連通し、前記伸縮空間47の中にはピストン46と前記ピストン46を復帰させることができる圧縮ばね45とが設置され、前記ピストン46の下端には下端が右側の前記伝動空間25の中に位置している推動板40が固定され、前記伸縮空間47の左端壁が前記測定空間51と連通し、且つ前記伸縮空間47の上端壁には外部空間と連通した入水パイプ48が設置され、前記入水パイプ48の中には揚水ポンプ49が設置され、右側の前記伝動空間25の中にはまた左端が前記摩擦ブロック100と接触する摩擦板42が設置され、前記摩擦板42の右端には固定ブロック44が固定され、前記固定ブロック44の左端には左端が右側の前記伝動空間25の左端壁と連結された復帰ばね43が固定されている。 Advantageously, the cleaning mechanism 105 includes a transmission space 25 located in the left and right end walls of the drive space 70, and is connected to the lower end wall of the transmission space 25 so that the transmission shaft 27 can rotate. The second sprocket 26 is fixed to the transmission shaft 27, the two second sprocket 26 and the first sprocket 36 are connected by a chain 28, and the first bevel gear 24 is attached to the upper end of the transmission shaft 27 on the left side. Is fixed, the second bevel gear 23 is meshed with the left end of the first bevel gear 24, and the belt shaft 21 whose left end is connected to the left end wall of the transmission space 25 on the left side is located at the center of the second bevel gear 23. The second belt pulley 22 is fixed to the belt shaft 21, and a ventilation space 18 for communicating the external space and the measurement space 51 is installed in the upper end wall of the transmission space 25 on the left side. A filtration net 11 and a heating tube 20 are fixed in the ventilation space 18, a support rod 17 is fixed in the ventilation space 18, and the support rod 17 penetrates in the ventilation space 18. A rotating shaft 16 is installed, a third belt pulley 14 connected to the second belt pulley 22 by a first belt 29 is fixed to the rotating shaft 16, and a rotating wheel 19 and a fan are also fixed to the rotating shaft 16. The blades 15 are fixed, a sealed space 12 opened forward is installed in the rear end wall of the ventilation space 18, and the ventilation space 18 is also penetrated and sealed in the measuring machine 88. A slide space 3 communicating with the space 12 is installed, a slide plate 10 in contact with the rotating wheel 19 is installed in the slide space 3, and the left end of the slide plate 10 is located in the sealed space 12. A sealing plate 13 that can seal the ventilation space 18 and is connected to the slide plate 10 is installed in the sealing space 12, and a cam 41 is fixed to the upper end of the transmission shaft 27 on the right side, and the right side. A telescopic space 47 is installed in the upper end wall of the telescopic space 25, the right side of the lower end wall of the telescopic space 47 communicates with the transmission space 25, and the piston 46 and the piston are in the telescopic space 47. A compression spring 45 capable of returning the 46 is installed, and a thrust plate 40 whose lower end is located in the transmission space 25 on the right side is fixed to the lower end of the piston 46, and the left end of the expansion / contraction space 47. A water inlet pipe 48 whose wall communicates with the measurement space 51 and which communicates with the external space is installed on the upper end wall of the telescopic space 47, and a pump 49 is installed in the water inlet pipe 48. A friction plate 42 whose left end contacts the friction block 100 is installed in the transmission space 25 on the right side, and a fixed block 44 is fixed to the right end of the friction plate 42. A return spring 43 whose left end is connected to the left end wall of the transmission space 25 on the right side is fixed to the left end.

有益的には、前記添加機構107は下圧空間4を含み、前記下圧空間4の下端壁の中にはまた左方に開口した移動空間109が設置され、前記駆動空間70の後端壁の中には上端壁が前記下圧空間4と連通した連結空間89が設置され、前記連結空間89の下端壁には上端が前記下圧空間4の中に位置している螺旋軸53が回転できるように連結され、前記螺旋軸53の下端には第二ベルト86により前記第一ベルトプーリ80と連結された第四ベルトプーリ87が固定され、前記螺旋軸53の上端には移動板2がネジ山で連結され、前記下圧空間4の中には下圧板6が二つ設置され、上側の前記下圧板6の上端には上端が前記移動板2を貫通している下圧ロッド56が固定され、下側の前記下圧板6の下端面には下端が前記移動空間109の中に位置している下圧ブロック7が四つ固定され、前記移動板2と上側の前記下圧板6とが二つの下圧ばね5により連結され、下側の前記下圧板6と前記下圧空間2の下端壁とが二つのリミットばね57により連結され、前記移動空間109の右端壁には電磁ブロック50が固定され、前記電磁ブロック50の左端面には移動ロッド8が固定され、前記移動ロッド8には前記電磁ブロック50と吸引し合う又は反発し合うことができる移動ブロック55がスライドできるように連結され、前記移動空間109の下端壁には薬剤又はサンプルを収容できる収容ケース9が四つ固定され、前記移動ブロック55の中には前方に開口し、且つ上下端壁が前記移動ブロック55を貫通した持ち上げ空間90が設置され、前記持ち上げ空間90の中には持ち上げブロック54が設置され、前記持ち上げ空間90の左右端壁の中にはいずれも前記持ち上げ空間90と連通した持ち上げ溝92が形成され、前記持ち上げブロック54の左右両端にはいずれも一端が前記持ち上げ溝92の中に位置している持ち上げ板93が設置され、前記持ち上げ溝92の下端壁には上端が前記持ち上げ板93と連結された持ち上げばね91が固定され、前記持ち上げブロック54の中にはまた押圧空間95が設置され、前記押圧空間95の中には電磁板94が二つ設置され、二つの前記電磁板94の間には下端が前記移動空間109の中に位置しているドロッパー96が設置され、前記移動空間109の下端壁の右側が測定空間51と連通し、前記測定機88の左側には前記移動空間109を密封できるL型板1が設置され、前記移動板2の下端面にはまた下圧柱52が固定されている。 Advantageously, the addition mechanism 107 includes a lower pressure space 4, and a moving space 109 opened to the left is installed in the lower end wall of the lower pressure space 4, and the rear end wall of the drive space 70 is provided. A connected space 89 whose upper end wall communicates with the lower pressure space 4 is installed in the space 89, and a spiral shaft 53 whose upper end is located in the lower pressure space 4 rotates on the lower end wall of the connected space 89. A fourth belt pulley 87 is fixed to the lower end of the spiral shaft 53 so as to be able to be connected to the first belt pulley 80 by a second belt 86, and a moving plate 2 is fixed to the upper end of the spiral shaft 53. Two lower pressure plates 6 are installed in the lower pressure space 4 connected by threads, and a lower pressure rod 56 whose upper end penetrates the moving plate 2 is installed at the upper end of the upper lower pressure plate 6. Four lower pressure blocks 7 which are fixed and whose lower ends are located in the moving space 109 are fixed to the lower end surface of the lower pressure plate 6, and the moving plate 2 and the upper lower pressure plate 6 are fixed. Is connected by two lower pressure springs 5, the lower lower pressure plate 6 and the lower end wall of the lower pressure space 2 are connected by two limit springs 57, and an electromagnetic block 50 is connected to the right end wall of the moving space 109. Is fixed, a moving rod 8 is fixed to the left end surface of the electromagnetic block 50, and a moving block 55 capable of attracting or repelling the electromagnetic block 50 is connected to the moving rod 8 so as to slide. Four storage cases 9 capable of storing a drug or a sample are fixed to the lower end wall of the moving space 109, the moving block 55 is opened forward, and the upper and lower end walls penetrate the moving block 55. A lifting space 90 is installed, a lifting block 54 is installed in the lifting space 90, and a lifting groove 92 communicating with the lifting space 90 is formed in each of the left and right end walls of the lifting space 90. A lifting plate 93 having one end located in the lifting groove 92 is installed at both left and right ends of the lifting block 54, and an upper end thereof is connected to the lifting plate 93 on the lower end wall of the lifting groove 92. The lifting spring 91 is fixed, a pressing space 95 is also installed in the lifting block 54, two electromagnetic plates 94 are installed in the pressing space 95, and between the two electromagnetic plates 94. A dropper 96 whose lower end is located in the moving space 109 is installed, the right side of the lower end wall of the moving space 109 communicates with the measuring space 51, and the moving space 109 is placed on the left side of the measuring machine 88. L-shaped plate that can be sealed 1 Is installed, and a lower pressure column 52 is also fixed to the lower end surface of the moving plate 2.

有益的には、前記第一スプロケット36の毎回の回転の始まりから終わりまで、前記第一電磁石62が常に前記磁石ロッド67の下側に位置し、前記第一電磁石62と前記第二電磁石59とが同じ時刻にひとつだけ磁性を生み出せる。 Beneficially, from the beginning to the end of each rotation of the first sprocket 36 , the first electromagnet 62 is always located below the magnet rod 67, with the first electromagnet 62 and the second electromagnet 59. Can produce only one magnetism at the same time.

有益的には、前記摩擦板42と前記測定機88との間の摩擦力は前記復帰ばね43の弾力より小さい。 Advantageously, the frictional force between the friction plate 42 and the measuring machine 88 is smaller than the elasticity of the return spring 43.

有益的には、前記下圧ロッド56と前記移動板2との間の摩擦力は二つの前記持ち上げばね5の弾力と二つの前記リミットばね57との弾力の和より大きい。 Advantageously, the frictional force between the lower pressure rod 56 and the moving plate 2 is larger than the sum of the elasticity of the two lifting springs 5 and the elasticity of the two limit springs 57.

装置全体の作動手順は以下の通りである。 The operation procedure of the entire device is as follows.

1、L型板1を移動させ、四つの収容ケース9の中に生理食塩水と、二つ種類の薬剤と、測定待ちのサンプルとを入れ、第一電磁石62が作動せず、第二電磁石59が作動し、この時にモータ34が作動することで第一スプロケット36を回転させ、チェーン28の伝動で二つの第二スプロケット26を回転連動させ、これにより伝動軸27を回転連動させ、これにより第一ベベルギヤ24とカム41とを回転連動させ、第一ベベルギヤ24が回転することで第二ベベルギヤ23を回転連動させ、これによりベルト軸21を回転連動させ、更に第二ベルトプーリ22を回転連動させ、更に第三ベルトプーリ14を回転連動させ、更に旋転軸16を回転連動させ、更にファン羽根15と旋転輪19とを回転連動させ、旋転輪19が回転することでスライド板10を連動させて後方へ運動させ、これにより密封板13を連動させて後方へ運動させて通風空間18を開け、加熱管20が作動し、これにより測定空間51に向けて吹いた風が熱風となり、これにより左側のシャーレ31を乾かし、カム41が回転し、これにより圧縮ばね45の協動で、推動板40の左右運動を実現でき、推動板40が左方へ運動することで摩擦板42を連動させて左方へ運動させ、これにより摩擦ブロック100を左方へ運動させ、これにより右側の従動ロッド99を左方へ運動させ、これにより左側の摩擦輪98を回転させ、これにより二つの回転軸37を回転させ、これにより回転板32を回転させ、これにより二つのシャーレ31をそれぞれ通風空間18と伸縮空間47とに正対させ、揚水ポンプ47を作動させて伸縮空間47の中に水を注ぎ、ピストン46により測定空間51の中に水を噴き、これにより右側のシャーレ31を洗浄する。 1. Move the L-shaped plate 1 and put physiological saline, two kinds of drugs, and a sample waiting to be measured in the four storage cases 9. The first electromagnet 62 does not work and the second electromagnet 59 operates, and at this time, the motor 34 operates to rotate the first sprocket 36, and the transmission of the chain 28 causes the two second sprocket 26s to rotate and interlock, thereby causing the transmission shaft 27 to rotate and interlock. The first bevel gear 24 and the cam 41 are rotationally interlocked, and the rotation of the first bevel gear 24 causes the second bevel gear 23 to be rotationally interlocked, thereby rotating the belt shaft 21 and further rotating the second belt pulley 22. Further, the third belt pulley 14 is rotationally interlocked, the rotating shaft 16 is further rotationally interlocked, the fan blade 15 and the rotating wheel 19 are rotationally interlocked, and the rotating wheel 19 is rotated to interlock the slide plate 10. The sealing plate 13 is interlocked and moved rearward to open the ventilation space 18, and the heating tube 20 is activated, whereby the wind blown toward the measurement space 51 becomes hot air. The left side chalet 31 is dried, the cam 41 rotates, and the compression spring 45 cooperates to realize the left-right movement of the thrust plate 40, and the thrust plate 40 moves to the left to interlock the friction plate 42. To the left, which causes the friction block 100 to move to the left, which causes the driven rod 99 on the right side to move to the left, which causes the friction wheel 98 on the left side to rotate, thereby rotating the two rotating shafts. The 37 is rotated, thereby rotating the rotating plate 32, whereby the two chalets 31 are made to face the ventilation space 18 and the telescopic space 47, respectively, and the pumping pump 47 is operated to bring water into the telescopic space 47. Pour and spray water into the measurement space 51 by the piston 46, thereby cleaning the right side chalet 31.

2、第二電磁石59を制御して作動させず、第一電磁石62と磁石ロッド67とが作動させ、これにより第一電磁石62と磁石ロッド67とが反発し合い、これにより磁石ロッド67が上昇し、これにより駆動板69と連結ロッド81とが上昇し、これにより環状ブロック72が上昇し、これによりばねブロック74がスライド孔79の中に入り、この時、駆動軸35が回転ブロック78と支持ブロック71とを回転連動させ、これにより伝動盤76を回転連動させ、これにより左右の二つのシャーレ31が互いに位置を交換し、また第一電磁石62と磁石ロッド67との作動を止め、第二電磁石59を制御して作動させ、これにより右側のシャーレ31を乾かし、左側のシャーレ31を洗浄し、シャーレ31を乾かした又は洗浄した後、第二電磁石59の作動を止め、第一電磁石62と磁石ロッド67とを作動させ、再び左右両側のシャーレ31の位置を変え、そして第一電磁石62と磁石ロッド67との作動を止め、第二電磁石59を作動させ、この時に揚水ポンプ49が作動しなくなり、左側のシャーレ31を乾かし、乾かすことが終わった後、駆動軸35が作動し、伝動で旋転輪19を回転連動させ、これによりスライド板10と密封板13とを復帰させ、通風空間18を密封し、電磁スイッチ108を入れ、測定空間51の中の水を排出した後に電磁スイッチ108を切り、最後に第二電磁石59の作動を止め、第一電磁石62と磁石ロッド67とが作動して反発し合い、駆動軸35が回転して伝動盤76を回転連動させ、これにより二つのシャーレ31が測定空間51の中に前後に配置され、この時に摩擦ブロック100と摩擦ロッド42とが分離し、捻りばね97が復帰し、これにより摩擦輪98が復帰し、これにより回転板32が復帰する。 2. The second electromagnet 59 is not controlled and operated, but the first electromagnet 62 and the magnet rod 67 are operated, whereby the first electromagnet 62 and the magnet rod 67 repel each other, whereby the magnet rod 67 rises. As a result, the drive plate 69 and the connecting rod 81 rise, whereby the annular block 72 rises, whereby the spring block 74 enters the slide hole 79, and at this time, the drive shaft 35 and the rotation block 78 The support block 71 is rotationally interlocked, whereby the transmission board 76 is rotationally interlocked, whereby the two left and right chalet 31s exchange positions with each other, and the operation of the first electromagnet 62 and the magnet rod 67 is stopped. The second electromagnet 59 is controlled and operated, whereby the right side chalet 31 is dried, the left side chalet 31 is washed, and after the chalet 31 is dried or washed, the operation of the second electromagnet 59 is stopped and the first electromagnet 62 is operated. And the magnet rod 67, the positions of the chalet 31 on both the left and right sides are changed again, and the operation of the first electromagnet 62 and the magnet rod 67 is stopped, the second electromagnet 59 is operated, and the pump pump 49 is operated at this time. After the left side magnet 31 was dried and dried, the drive shaft 35 was activated and the rotating wheel 19 was rotated and interlocked by transmission, thereby returning the slide plate 10 and the sealing plate 13 to the ventilation space. 18 is sealed, the electromagnetic switch 108 is turned on, the water in the measurement space 51 is discharged, the electromagnetic switch 108 is turned off, and finally the operation of the second electromagnet 59 is stopped, and the first electromagnet 62 and the magnet rod 67 are operated. Then, they repel each other, the drive shaft 35 rotates, and the transmission board 76 is rotated and interlocked, whereby the two magnets 31 are arranged back and forth in the measurement space 51, and at this time, the friction block 100 and the friction rod 42 are engaged. After separation, the torsion spring 97 is restored, whereby the friction wheel 98 is restored, and the rotating plate 32 is restored.

3、第一電磁石62と磁石ロッド67とを作動させ、これにより第一電磁石62と磁石ロッド67とが吸引し合い、これにより磁石ロッド67が下降し、これにより駆動板69が下降し、これにより駆動盤84が下降し、これにより伝動ロッド64が下降して伝動孔63の中に入り、これにより伝動盤84が第一ベルトプーリ80を回転連動させ、これにより第二ベルト86の伝動で第四ベルトプーリ87を回転連動させ、これにより螺旋軸53を回転連動させ、これにより移動板2を制御して昇降させる。 3. The first electromagnet 62 and the magnet rod 67 are operated, whereby the first electromagnet 62 and the magnet rod 67 attract each other, whereby the magnet rod 67 is lowered, and the drive plate 69 is lowered, which is the same. As a result, the drive board 84 is lowered, whereby the transmission rod 64 is lowered and enters the transmission hole 63, whereby the transmission board 84 rotates and interlocks the first belt pulley 80, thereby transmitting the second belt 86. The fourth belt pulley 87 is rotationally interlocked, whereby the spiral shaft 53 is rotationally interlocked, whereby the moving plate 2 is controlled and moved up and down.

4、移動板2が下降し、まず二つの下圧板6を下降連動させ、これにより下圧ブロック7に持ち上げブロック54を下降連動させ、これによりドロッパー96の下端が収容ケース9の中に入り、二つの電磁板94の吸引し合い又は反発し合いを制御することで、ドロッパー96が収容ケース9の中の薬剤とサンプルとを吸い取ることを制御でき、電磁ブロック50と移動ブロック55との間の磁性の大きさで、移動ブロック55が移動ロッド8に位置するところを制御でき、ドロッパー96が収容ケース9の上側で昇降するたびに、ドロッパー96が右方へ移動して最後側まで至り、下圧柱52の昇降で、ドロッパー96が再び昇降し、これによりドロッパー96の下端が測定空間51の中に入り、これにより二つの電磁板94を制御し、これによりドロッパー96の中の薬剤又はサンプルがシャーレ31の中に滴る。 4. The moving plate 2 descends, and first the two lower pressure plates 6 are interlocked downward, whereby the lifting block 54 is interlocked downward with the lower pressure block 7, whereby the lower end of the dropper 96 enters the accommodation case 9. By controlling the suction or repulsion of the two electromagnetic plates 94, it is possible to control the dropper 96 to suck the drug and the sample in the storage case 9, and between the electromagnetic block 50 and the moving block 55. The size of the magnetism can control the position of the moving block 55 on the moving rod 8, and each time the dropper 96 moves up and down on the upper side of the storage case 9, the dropper 96 moves to the right to reach the rearmost side and lower. As the pressure column 52 moves up and down, the dropper 96 moves up and down again, causing the lower end of the dropper 96 to enter the measurement space 51, thereby controlling the two electromagnetic plates 94, thereby controlling the drug or sample in the dropper 96. Drip into the petri dish 31.

5、伝動盤76の回転を制御することで、ドロッパー96が二つのシャーレ31に同じ薬剤又はサンプルを入れ、加熱管20を開け、測定環境に所要の温度を提供し、シャーレ31の中に薬剤又はサンプルを入れた後に、しばらく待つと、実験対象を観察し、測定の結果を得て、そして洗浄機構105を制御して作動させ、再び二つのシャーレ31を洗浄して乾かす。 5. By controlling the rotation of the transmission board 76, the dropper 96 puts the same drug or sample in two dishes 31 and opens the heating tube 20 to provide the required temperature for the measurement environment and the drug in the dish 31. Alternatively, after inserting the sample, wait for a while, observe the experimental object, obtain the measurement result, and control and operate the cleaning mechanism 105 to wash and dry the two petri dishes 31 again.

以上の実施例はあくまで本発明の技術的原理と特徴を説明するためのものであり、本分野の技術者に本発明を理解できることと実施できることを目的とし、本発明を限定するためのものではなく、本発明の意義と原則のもとで行われたいかなる修正と、等価置換と改善などは本発明の保護範囲に含まれるべきである。 The above examples are merely for explaining the technical principle and features of the present invention, and are intended to allow engineers in the field to understand and implement the present invention, and are not intended to limit the present invention. However, any modifications, equivalent substitutions and improvements made under the significance and principles of the invention should be included in the scope of the invention.

Claims (7)

主に測定機を含み、前記測定機の中には測定空間が設置され、前記測定空間の中には実験を支持できる測定機構が設置され、前記測定空間の下端壁の中には装置に動力を提供できる駆動機構が設置され、前記駆動機構は駆動空間を含み、前記駆動空間の下端壁にはモータが設置され、前記モータの上端には上端が前記測定空間の中に位置している駆動軸が伝動できるように連結され、前記駆動軸には第一スプロケットと、駆動板と、第一ベルトプーリとがスライドできるように連結され、前記駆動空間の左端壁にはそれぞれ前記第一スプロケットと前記第一ベルトプーリとを支持する二つの支持板が固定され、前記第一スプロケットの中には電磁空間が設置され、前記電磁空間の中には前記電磁空間の中に固定された第一電磁石及び前記電磁空間の中でスライドできる第二電磁石が設置され、前記第一電磁石と前記第二電磁石とが連結ばねにより連結され、前記第一ベルトプーリの中には上方に開口した伝動孔が設置され、前記駆動軸には駆動盤がスプラインにより連結され、前記駆動板の中には下方に開口した環状空間が設置され、前記環状空間の中にはスライドブロックが二つ設置され、前記スライドブロックの下端には下端が前記駆動盤と連結された駆動ロッドが固定され、前記駆動盤の中には下方に開口した押出孔が設置され、前記押出孔の中には下端が前記伝動孔の中に位置している伝動ロッド及び前記伝動ロッドを復帰させることができる押出ばねが設置され、前記駆動板の下端面には下端が前記第一電磁石と吸引する又は反発することができる磁石ロッドが固定され、前記駆動板の下端面にはまた下端が上側の前記支持板と連結された支持ばねが固定され、
前記測定機の中にはまたキャリアーを洗浄して乾かすことができる洗浄機構が設置され、前記測定空間の上端壁の中にはまたキャリアーに所要の薬剤又は測定サンプルを添加できる添加機構が設置され、前記洗浄機構の作業を通じて、他の因子の実験に対する妨害を減らせ、実験の正確性を保証することを特徴とするチオレドキシン還元酵素の活性に対する協同測定設備。
Mainly including a measuring machine, a measuring space is installed in the measuring machine, a measuring mechanism capable of supporting an experiment is installed in the measuring space, and a device is powered in the lower end wall of the measuring space. The drive mechanism is installed, the drive mechanism includes a drive space, a motor is installed on the lower end wall of the drive space, and the upper end of the motor is located in the measurement space. The shafts are connected so as to be transmitted, the first sprocket, the drive plate, and the first belt pulley are connected to the drive shaft so as to be slidable, and the first sprocket is connected to the left end wall of the drive space. Two support plates that support the first belt pulley are fixed, an electromagnetic space is installed in the first sprocket, and a first electromagnet fixed in the electromagnetic space is provided in the electromagnetic space. A second electromagnet that can slide in the electromagnetic space is installed, the first electromagnet and the second electromagnet are connected by a connecting spring, and a transmission hole that opens upward is installed in the first belt pulley. A drive panel is connected to the drive shaft by a spline, an annular space opened downward is installed in the drive plate, and two slide blocks are installed in the annular space. A drive rod whose lower end is connected to the drive panel is fixed to the lower end of the drive plate, an extrusion hole opened downward is installed in the drive panel, and the lower end is inside the transmission hole in the extrusion hole. A transmission rod located in the above and an extrusion spring capable of returning the transmission rod are installed, and a magnet rod whose lower end can attract or repel the first electromagnet is fixed to the lower end surface of the drive plate. A support spring whose lower end is connected to the upper support plate is fixed to the lower end surface of the drive plate.
A cleaning mechanism capable of cleaning and drying the carrier is also installed in the measuring machine, and an addition mechanism capable of adding the required drug or measurement sample to the carrier is also installed in the upper end wall of the measuring space. A collaborative measurement facility for the activity of thioredoxin reductase, characterized in that through the work of the cleaning mechanism, interference with the experiment of other factors can be reduced and the accuracy of the experiment is guaranteed.
前記測定機構は前記測定空間の下端壁に回転できるように連結された支持ブロックを含み、前記支持ブロックの中には下方に開口した回転空間が設置され、前記駆動軸の上端が前記回転空間の中に位置し、且つ前記駆動軸の上端には回転ブロックが固定され、前記回転ブロックの中には前記回転空間を連通するばね溝が二つ形成され、前記ばね溝の中にはばねブロック及び前記ばねブロックを復帰させることができる伸縮ばねが設置され、前記支持ブロックの中にはまた前記測定空間及び前記回転空間を連通するスライド孔が二つ設置され、前記スライド孔の中には一端が前記測定空間の中に位置している台形ロッドが設置され、前記測定空間の中にはまた前記台形ロッドを前記スライド孔の中に戻せる環状ブロックが設置され、前記環状ブロックの右端には下端が前記駆動板と連結された連結ロッドが固定され、前記支持ブロックの上端には伝動盤が固定され、前記伝動盤の中には回転溝が二つ形成され、前記回転溝の前後端壁の間には回転軸が回転できるように連結され、前記回転軸と前記回転溝の端壁とが捻りばねにより連結され、前記回転軸には回転板が固定され、前記回転板には吸盤が固定され、前記吸盤にはキャリアーとしてのシャーレが吸着され、前記伝動盤の中にはまた従動空間が設置され、前記従動空間の前後端壁の間には従動軸が回転できるように連結され、前記従動軸には従動輪が固定され、前記従動輪の上下両側にはいずれも前記従動輪と接触する従動ロッドが設置され、前記従動ロッドの一端が前記回転溝の中に位置し、前記回転軸にはまた前記従動ロッドと接触する摩擦輪が固定され、下側の前記従動ロッドの右端には下端が前記測定空間の中に位置している摩擦ブロックが固定され、前記測定空間の下端壁にはまた外部空間に連通する排水パイプが設置され、前記排水パイプの中には電磁スイッチが設置されていることを特徴とする請求項1に記載のチオレドキシン還元酵素の活性に対する協同測定設備。 The measuring mechanism includes a support block connected to the lower end wall of the measuring space so as to be rotatable, a rotating space opened downward is installed in the supporting block, and the upper end of the drive shaft is the rotating space. A rotating block is fixed to the upper end of the drive shaft, and two spring grooves communicating with the rotating space are formed in the rotating block, and the spring block and the spring groove are formed in the spring groove. A telescopic spring capable of returning the spring block is installed, and two slide holes communicating with the measurement space and the rotation space are installed in the support block, and one end is provided in the slide hole. A trapezoidal rod located in the measurement space is installed, and an annular block capable of returning the trapezoidal rod into the slide hole is also installed in the measurement space, and a lower end is provided at the right end of the annular block. A connecting rod connected to the drive plate is fixed, a transmission board is fixed to the upper end of the support block, two rotation grooves are formed in the transmission board, and between the front and rear end walls of the rotation groove. The rotating shaft is connected so as to be rotatable, the rotating shaft and the end wall of the rotating groove are connected by a torsion spring, a rotating plate is fixed to the rotating shaft, and a suction plate is fixed to the rotating plate. A chalet as a carrier is adsorbed on the sucker, a driven space is also installed in the transmission board, and a driven shaft is connected between the front and rear end walls of the driven space so that the driven shaft can rotate. A driven wheel is fixed to the shaft, and driven rods that come into contact with the driven wheel are installed on both the upper and lower sides of the driven wheel, and one end of the driven rod is located in the rotating groove and is located on the rotating shaft. Also, a friction ring in contact with the driven rod is fixed, a friction block whose lower end is located in the measuring space is fixed to the right end of the driven rod on the lower side, and the lower end wall of the measuring space is fixed. The cooperative measurement facility for the activity of thioredoxin reductase according to claim 1, wherein a drainage pipe communicating with an external space is installed, and an electromagnetic switch is installed in the drainage pipe. 前記洗浄機構は前記駆動空間の左右端壁の中に位置している伝動空間を含み、前記伝動空間の下端壁には伝動軸が回転できるように連結され、前記伝動軸には第二スプロケットが固定され、二つの前記第二スプロケットと前記第一スプロケットとがチェーンにより連結され、左側の前記伝動軸の上端には第一ベベルギヤが固定され、前記第一ベベルギヤの左端には第二ベベルギヤが噛み合われ、前記第二ベベルギヤの中心部には左端が左側の前記伝動空間の左端壁と連結されたベルト軸が固定され、前記ベルト軸には第二ベルトプーリが固定され、左側の前記伝動空間の上端壁の中には外部空間と前記測定空間とを連通する通風空間が設置され、前記通風空間の中には濾過網と加熱管とが固定され、前記通風空間の中にはまた支持ロッドが固定され、前記通風空間の中にはまた前記支持ロッドを貫通する旋転軸が設置され、前記旋転軸には第一ベルトにより前記第二ベルトプーリと連結された第三ベルトプーリが固定され、前記旋転軸にはまた旋転輪とファン羽根とが固定され、前記通風空間の後端壁の中には前方に開口した密封空間が設置され、前記測定機の中にはまた前記通風空間を貫通し、且つ前記密封空間と連通するスライド空間が設置され、前記スライド空間の中には前記旋転輪と接触するスライド板が設置され、前記スライド板の左端が前記密封空間の中に位置し、前記密封空間の中には前記通風空間を密封でき、且つ前記スライド板と連結された密封板が設置され、右側の前記伝動軸の上端にはカムが固定され、右側の前記伝動空間の上端壁の中には伸縮空間が設置され、前記伸縮空間の下端壁の右側が前記伝動空間と連通し、前記伸縮空間の中にはピストンと前記ピストンを復帰させることができる圧縮ばねとが設置され、前記ピストンの下端には下端が右側の前記伝動空間の中に位置している推動板が固定され、前記伸縮空間の左端壁が前記測定空間と連通し、且つ前記伸縮空間の上端壁には外部空間と連通した入水パイプが設置され、前記入水パイプの中には揚水ポンプが設置され、右側の前記伝動空間の中にはまた左端が前記摩擦ブロックと接触する摩擦板が設置され、前記摩擦板の右端には固定ブロックが固定され、前記固定ブロックの左端には左端が右側の前記伝動空間の左端壁と連結された復帰ばねが固定されていることを特徴とする請求項2に記載のチオレドキシン還元酵素の活性に対する協同測定設備。 The cleaning mechanism includes a transmission space located in the left and right end walls of the drive space, is connected to the lower end wall of the transmission space so that the transmission shaft can rotate, and a second sprocket is attached to the transmission shaft. It is fixed, the two second sprocket and the first sprocket are connected by a chain, the first bevel gear is fixed to the upper end of the transmission shaft on the left side, and the second bevel gear meshes with the left end of the first bevel gear. A belt shaft whose left end is connected to the left end wall of the transmission space on the left side is fixed to the central portion of the second bevel gear, and a second belt pulley is fixed to the belt shaft so that the transmission space on the left side A ventilation space that communicates the external space and the measurement space is installed in the upper end wall, a filtration net and a heating pipe are fixed in the ventilation space, and a support rod is also provided in the ventilation space. A rotating shaft that is fixed and penetrates the support rod is installed in the ventilation space, and a third belt pulley connected to the second belt pulley by the first belt is fixed to the rotating shaft. A rotating wheel and a fan blade are also fixed to the rotating shaft, a sealed space opened forward is installed in the rear end wall of the ventilation space, and the measuring machine also penetrates the ventilation space. In addition, a slide space communicating with the sealed space is installed, a slide plate in contact with the rotating wheel is installed in the slide space, the left end of the slide plate is located in the sealed space, and the sealing A sealing plate that can seal the ventilation space and is connected to the slide plate is installed in the space, a cam is fixed to the upper end of the transmission shaft on the right side, and inside the upper end wall of the transmission space on the right side. A telescopic space is installed in the space, the right side of the lower end wall of the telescopic space communicates with the transmission space, and a piston and a compression spring capable of returning the piston are installed in the telescopic space. A thrust plate whose lower end is located in the transmission space on the right side is fixed to the lower end of the space, the left end wall of the telescopic space communicates with the measurement space, and the upper end wall of the telescopic space has an external space. A communicating water inlet pipe is installed, a pump is installed in the water inlet pipe, and a friction plate whose left end contacts the friction block is installed in the transmission space on the right side. The thioredoxin reduction according to claim 2 , wherein a fixed block is fixed to the right end, and a return spring whose left end is connected to the left end wall of the transmission space on the right side is fixed to the left end of the fixed block. Against the activity of the enzyme Cooperative measurement equipment. 前記添加機構は下圧空間を含み、前記下圧空間の下端壁の中にはまた左方に開口した移動空間が設置され、前記駆動空間の後端壁の中には上端壁が前記下圧空間と連通した連結空間が設置され、前記連結空間の下端壁には上端が前記下圧空間の中に位置している螺旋軸が回転できるように連結され、前記螺旋軸の下端には第二ベルトにより前記第一ベルトプーリと連結された第四ベルトプーリが固定され、前記螺旋軸の上端には移動板がネジ山で連結され、前記下圧空間の中には下圧板が二つ設置され、上側の前記下圧板の上端には上端が前記移動板を貫通している下圧ロッドが固定され、下側の前記下圧板の下端面には下端が前記移動空間の中に位置している下圧ブロックが四つ固定され、前記移動板と上側の前記下圧板とが二つの下圧ばねにより連結され、下側の前記下圧板と前記下圧空間の下端壁とが二つのリミットばねにより連結され、前記移動空間の右端壁には電磁ブロックが固定され、前記電磁ブロックの左端面には移動ロッドが固定され、前記移動ロッドには前記電磁ブロックと吸引し合う又は反発し合うことができる移動ブロックがスライドできるように連結され、前記移動空間の下端壁には薬剤又はサンプルを収容できる収容ケースが四つ固定され、前記移動ブロックの中には前方に開口し、且つ上下端壁が前記移動ブロックを貫通した持ち上げ空間が設置され、前記持ち上げ空間の中には持ち上げブロックが設置され、前記持ち上げ空間の左右端壁の中にはいずれも前記持ち上げ空間と連通した持ち上げ溝が形成され、前記持ち上げブロックの左右両端にはいずれも一端が前記持ち上げ溝の中に位置している持ち上げ板が設置され、前記持ち上げ溝の下端壁には上端が前記持ち上げ板と連結された持ち上げばねが固定され、前記持ち上げブロックの中にはまた押圧空間が設置され、前記押圧空間の中には電磁板が二つ設置され、二つの前記電磁板の間には下端が前記移動空間の中に位置しているドロッパーが設置され、前記移動空間の下端壁の右側が測定空間と連通し、前記測定機の左側には前記移動空間を密封できるL型板が設置され、前記移動板の下端面にはまた下圧柱が固定されていることを特徴とする請求項1に記載のチオレドキシン還元酵素の活性に対する協同測定設備。 The addition mechanism includes a lower pressure space, a moving space opened to the left is installed in the lower end wall of the lower pressure space, and the upper end wall is the lower pressure in the rear end wall of the drive space. A connecting space communicating with the space is installed, and a spiral shaft whose upper end is located in the lower pressure space is connected to the lower end wall of the connecting space so as to be rotatable, and a second is connected to the lower end of the spiral shaft. The fourth belt pulley connected to the first belt pulley is fixed by a belt, a moving plate is connected to the upper end of the spiral shaft with a screw thread, and two lower pressure plates are installed in the lower pressure space. A lower pressure rod having an upper end penetrating the moving plate is fixed to the upper end of the lower pressure plate on the upper side, and a lower end is located in the moving space on the lower end surface of the lower pressure plate on the lower side. Four lower pressure blocks are fixed, the moving plate and the upper lower pressure plate are connected by two lower pressure springs, and the lower lower pressure plate and the lower end wall of the lower pressure space are connected by two limit springs. Connected, an electromagnetic block is fixed to the right end wall of the moving space, a moving rod is fixed to the left end surface of the electromagnetic block, and the moving rod can attract or repel each other with the electromagnetic block. The moving blocks are connected so as to be slidable, four storage cases capable of storing a drug or a sample are fixed to the lower end wall of the moving space, and the upper and lower end walls are opened forward in the moving block. A lifting space penetrating the moving block is installed, a lifting block is installed in the lifting space, and a lifting groove communicating with the lifting space is formed in each of the left and right end walls of the lifting space. A lifting plate whose one end is located in the lifting groove is installed on each of the left and right ends of the lifting block, and a lifting spring whose upper end is connected to the lifting plate is fixed to the lower end wall of the lifting groove. A pressing space is also installed in the lifting block, two electromagnetic plates are installed in the pressing space, and a dropper whose lower end is located in the moving space is installed between the two electromagnetic plates. The right side of the lower end wall of the moving space communicates with the measuring space, an L-shaped plate capable of sealing the moving space is installed on the left side of the measuring machine, and a lower pressure column is also installed on the lower end surface of the moving plate. The collaborative measurement facility for the activity of the thioredoxin reductase according to claim 1, wherein the thioredoxin reductase is fixed. 前記第一スプロケットの毎回の回転の始まりから終わりまで、前記第一電磁石が常に前記磁石ロッドの下側に位置し、前記第一電磁石と前記第二電磁石とが同じ時刻にひとつだけ磁性を生み出せることを特徴とする請求項1に記載のチオレドキシン還元酵素の活性に対する協同測定設備。 From the beginning to the end of each rotation of the first sprocket, the first electromagnet is always located under the magnet rod, and the first electromagnet and the second electromagnet can generate only one magnetism at the same time. The collaborative measurement facility for the activity of the thioredoxin reductase according to claim 1. 前記摩擦板と前記測定機との間の摩擦力は前記復帰ばねの弾力より小さいことを特徴とする請求項3に記載のチオレドキシン還元酵素の活性に対する協同測定設備。 The cooperative measurement facility for the activity of thioredoxin reductase according to claim 3, wherein the frictional force between the friction plate and the measuring machine is smaller than the elasticity of the return spring. 前記下圧ロッドと前記移動板との間の摩擦力は二つの前記持ち上げばねの弾力と二つの前記リミットばねとの弾力の和より大きいことを特徴とする請求項4に記載のチオレドキシン還元酵素の活性に対する協同測定設備。 The thioredoxin reductase according to claim 4, wherein the frictional force between the lower pressure rod and the moving plate is larger than the sum of the elasticity of the two lifting springs and the elasticity of the two limit springs. Cooperative measurement equipment for activity.
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