JP6807425B2 - Endo180産生促進剤 - Google Patents
Endo180産生促進剤 Download PDFInfo
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- JP6807425B2 JP6807425B2 JP2019073775A JP2019073775A JP6807425B2 JP 6807425 B2 JP6807425 B2 JP 6807425B2 JP 2019073775 A JP2019073775 A JP 2019073775A JP 2019073775 A JP2019073775 A JP 2019073775A JP 6807425 B2 JP6807425 B2 JP 6807425B2
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Description
本実施形態のEndo180産生促進剤は、ロスマリン酸、カフェ酸及びメリッサ抽出物から選ばれる少なくとも1種以上を有効成分として含有するものである。
なお、前記水と親水性有機溶媒との混合溶媒を使用する場合には、低級アルコールの場合は水10質量部に対して1質量部〜90質量部、低級脂肪族ケトンの場合は水10質量部に対して1質量部〜40質量部添加することが好ましい。多価アルコールの場合は水10質量部に対して1質量部〜90質量部添加することが好ましい。
試料No. 製品名 製造者名/販売者名
1 ロスマリン酸 和光純薬工業株式会社
2 カフェ酸 和光純薬工業株式会社
3 メリッサ抽出液BG−J凍結乾燥品 丸善製薬株式会社
−皮膚線維芽細胞におけるEndo180産生促進作用試験−
ヒト正常皮膚線維芽細胞 (NB1RGB)を10% FBS含有ダルベッコMEMを用いて培養した後、トリプシン処理により細胞を回収した。回収した細胞を1.0×105 cells/mLの濃度に0.25% FBS含有ダルベッコMEMで希釈した後、6wellマイクロプレートに1well当たり2mLずつ播種し、一晩培養した。培養終了後、培地を抜き、0.25% FBS含有ダルベッコMEMに溶解した被験試料を各wellに2mL添加し、24時間培養した。培養終了後、常法により総タンパクの調製を行った。
A :被験試料添加時の細胞あたりのEndo180産生量
B :被験試料無添加時の細胞あたりのEndo180産生量
試料濃度(μg/mL)
1 10
試料No.1 119.4% 114.3%
試料No.2 129.9% 174.6%
試料濃度(μg/mL)
5 50
試料No.3 105.4% 127.0%
Claims (1)
- カフェ酸を有効成分とすることを特徴とする、線維芽細胞におけるEndo180産生促進剤。
Priority Applications (1)
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JP2019073775A JP6807425B2 (ja) | 2019-04-08 | 2019-04-08 | Endo180産生促進剤 |
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JP2019073775A JP6807425B2 (ja) | 2019-04-08 | 2019-04-08 | Endo180産生促進剤 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2016009772A Division JP6781549B2 (ja) | 2016-01-21 | 2016-01-21 | Endo180産生促進剤 |
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JP2019108398A JP2019108398A (ja) | 2019-07-04 |
JP6807425B2 true JP6807425B2 (ja) | 2021-01-06 |
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JP4082823B2 (ja) * | 1999-05-06 | 2008-04-30 | 日本メナード化粧品株式会社 | 光毒性抑制剤 |
JP2008239545A (ja) * | 2007-03-27 | 2008-10-09 | Kose Corp | エラスターゼ活性抑制剤 |
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