JP6804436B2 - キャピラリー液体クロマトグラフィーのための低検出限界で低電力小型ｌｅｄベースの紫外線吸光検出器 - Google Patents

キャピラリー液体クロマトグラフィーのための低検出限界で低電力小型ｌｅｄベースの紫外線吸光検出器 Download PDF

Info

Publication number
JP6804436B2
JP6804436B2 JP2017512869A JP2017512869A JP6804436B2 JP 6804436 B2 JP6804436 B2 JP 6804436B2 JP 2017512869 A JP2017512869 A JP 2017512869A JP 2017512869 A JP2017512869 A JP 2017512869A JP 6804436 B2 JP6804436 B2 JP 6804436B2
Authority
JP
Japan
Prior art keywords
ultraviolet rays
capillary column
detector
led
lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017512869A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017516120A (ja
JP2017516120A5 (enExample
Inventor
ファーンズワース、ポール、ビー．
シャーマ、ソニカ
トリー、エイチ．、デニス
リー、ミルトン、エル．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham Young University filed Critical Brigham Young University
Publication of JP2017516120A publication Critical patent/JP2017516120A/ja
Publication of JP2017516120A5 publication Critical patent/JP2017516120A5/ja
Application granted granted Critical
Publication of JP6804436B2 publication Critical patent/JP6804436B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/022—Casings
    • G01N2201/0221—Portable; cableless; compact; hand-held
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0621—Supply
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
    • G01N2201/0693—Battery powered circuitry

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2017512869A 2014-05-15 2015-05-15 キャピラリー液体クロマトグラフィーのための低検出限界で低電力小型ｌｅｄベースの紫外線吸光検出器 Active JP6804436B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461996803P 2014-05-15 2014-05-15
US61/996,803 2014-05-15
PCT/US2015/031023 WO2015175906A1 (en) 2014-05-15 2015-05-15 Low-power miniature led-based uv absorption detector with low detection limits for capillary liquid chromatography

Publications (3)

Publication Number Publication Date
JP2017516120A JP2017516120A (ja) 2017-06-15
JP2017516120A5 JP2017516120A5 (enExample) 2018-06-28
JP6804436B2 true JP6804436B2 (ja) 2020-12-23

Family

ID=54480760

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017512869A Active JP6804436B2 (ja) 2014-05-15 2015-05-15 キャピラリー液体クロマトグラフィーのための低検出限界で低電力小型ｌｅｄベースの紫外線吸光検出器

Country Status (7)

Country Link
US (1) US10060889B2 (enExample)
EP (1) EP3142765B1 (enExample)
JP (1) JP6804436B2 (enExample)
CN (1) CN106536011B (enExample)
AU (1) AU2015259004B2 (enExample)
CA (1) CA2949213C (enExample)
WO (1) WO2015175906A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2539504B (en) * 2015-06-19 2019-04-17 Aqua21 Ltd Absorption Sensor for Measuring Substance Concentration
US20180231511A1 (en) * 2015-08-18 2018-08-16 Shimadzu Corporation Detector for liquid chromatography
AT518576B1 (de) * 2016-04-18 2018-07-15 Scan Messtechnik Gmbh Spektrometer
NL2019122A (en) * 2016-06-30 2018-01-09 Asml Holding Nv Adaptive filter for in-line correction
WO2018161090A1 (en) * 2017-03-03 2018-09-07 Brigham Young University Multi-modal, multi-detector liquid chromatographic system
CA3063957A1 (en) * 2017-05-18 2018-11-22 Brigham Young University Combined fluorescence and absorption detector for on-column detection after capillary separation techniques
CN108562540A (zh) * 2017-12-29 2018-09-21 深圳市华星光电技术有限公司 光学测试装置
JP7074305B2 (ja) * 2018-06-01 2022-05-24 アクアモニトリックス リミテッド 無機分析物を検出するための光学検出セルおよびシステム
US11982620B2 (en) * 2019-03-18 2024-05-14 Life Technologies Corporation Multi-capillary optical detection system
JP7235298B2 (ja) * 2019-03-20 2023-03-08 株式会社日立ハイテクサイエンス クロマトグラフのデータ処理装置、データ処理方法、およびクロマトグラフ
CN110047519B (zh) * 2019-04-16 2021-08-24 广州大学 一种语音端点检测方法、装置及设备
JP7739421B2 (ja) * 2020-09-22 2025-09-16 ベクトン・ディキンソン・アンド・カンパニー フローサイトメータにおけるベースラインノイズの連続測定方法およびそのためのシステム
CN115684446A (zh) * 2022-09-28 2023-02-03 上海交通大学 等电聚焦毛细管结构、毛细管盒、全柱成像装置
US20250321209A1 (en) * 2024-04-16 2025-10-16 Vuv Analytics, Inc. Spectroscopy Systems, Flow Cells And Methods For Analyzing Liquids At Vacuum Ultraviolet (VUV) Wavelengths

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927265A (en) * 1988-04-29 1990-05-22 501 Microphoretic Systems, Inc. Detector for fluorescence and absorption spectroscopy
US5124020A (en) * 1989-09-26 1992-06-23 Rutgers, The State University Adjustable height and width aperture for capillary photodetector cell
JPH04115084U (ja) * 1991-03-26 1992-10-12 九州電機製造株式会社 電気自動車用電池残存容量計
US5235409A (en) * 1991-08-13 1993-08-10 Varian Associates, Inc. Optical detection system for capillary separation columns
DE69230863T2 (de) * 1991-12-03 2000-07-27 Applied Biosystems, Inc. Kapillare durchflusszelle zum nachweis mehrerer wellenlängen
DE69323060T2 (de) * 1993-03-18 1999-06-10 Novartis Ag, Basel Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina
US5533063A (en) * 1994-01-31 1996-07-02 The Regents Of The University Of California Method and apparatus for multipath channel shaping
DE69735189T2 (de) * 1996-02-20 2006-10-26 Waters Investments Ltd., Milford Sensor für kapillarelektrophorese
US6788414B1 (en) 1999-09-09 2004-09-07 Iowa State University Research Foundation, Inc. Method of analyzing multiple sample simultaneously by detecting absorption and systems for use in such a method
EP1354192B1 (en) 2001-01-26 2011-08-31 Qiagen Sciences, LLC Multi-channel bio-separation cartridge
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US7122799B2 (en) * 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7497937B2 (en) * 2004-09-03 2009-03-03 Combisep, Inc. Microfabricated chip and method of use
CN1755351A (zh) * 2004-09-30 2006-04-05 中国科学院大连化学物理研究所 发光二极管诱导荧光微型检测器
GB0524225D0 (en) * 2005-11-29 2006-01-04 Amersham Biosciences Ab Methods and apparatus for detecting and measuring the concentration of a substance in a solution
US8137626B2 (en) * 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
US7846391B2 (en) * 2006-05-22 2010-12-07 Lumencor, Inc. Bioanalytical instrumentation using a light source subsystem
US8467059B2 (en) * 2006-10-27 2013-06-18 University Of South Florida Deep-UV LED and laser induced fluorescence detection and monitoring of trace organics in potable liquids
US7835000B2 (en) * 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US8098375B2 (en) * 2007-08-06 2012-01-17 Lumencor, Inc. Light emitting diode illumination system
JP2009080001A (ja) * 2007-09-26 2009-04-16 Fujitaro Imasaka ガスクロマトグラフ質量分析法におけるデータ処理方法
US20100324830A1 (en) * 2009-06-22 2010-12-23 Solie John B Handheld optical sensor for measuring the normalized difference vegetative index in plants
WO2013181362A1 (en) 2012-06-01 2013-12-05 Advanced Analytical Technologies, Inc. Multi-color detection system for multiplexed capillary electrophoresis
CN103529006B (zh) * 2013-10-18 2016-08-17 大连海事大学 一种基于微流控芯片的便携式荧光检测装置

Also Published As

Publication number Publication date
EP3142765B1 (en) 2019-08-14
JP2017516120A (ja) 2017-06-15
US20150330955A1 (en) 2015-11-19
CN106536011A (zh) 2017-03-22
WO2015175906A1 (en) 2015-11-19
AU2015259004A1 (en) 2016-12-01
CA2949213A1 (en) 2015-11-19
CA2949213C (en) 2022-07-12
US10060889B2 (en) 2018-08-28
AU2015259004B2 (en) 2018-11-08
EP3142765A1 (en) 2017-03-22
CN106536011B (zh) 2019-08-20
EP3142765A4 (en) 2018-01-17

Similar Documents

Publication Publication Date Title
JP6804436B2 (ja) キャピラリー液体クロマトグラフィーのための低検出限界で低電力小型ｌｅｄベースの紫外線吸光検出器
US7319522B2 (en) Systems and methods for in situ spectroscopic measurements
JP6595204B2 (ja) 光学分析装置
WO2008097700A2 (en) Chemical analyzer for industrial process control
JP4536754B2 (ja) 分光光度計及び液体クロマトグラフィ
US20220268628A1 (en) Devices, systems, and methods for spectroscopy having an adjustable pathlength
Li et al. High sensitivity deep-UV LED-based z-cell photometric detector for capillary liquid chromatography
CN108051413A (zh) 一种脉冲光激发的光致发光光谱测量系统
JPS5985945A (ja) 液体クロマトグラフ装置及びその分析方法
Schmid et al. UV-absorbance detector for HPLC based on a light-emitting diode
Šesták et al. Compact optical detector utilizing light emitting diodes, 50 nL L-shaped silica capillary cell and CCD spectrometer for simultaneous multi-wavelength monitoring of absorbance and fluorescence in microcolumn liquid chromatography
CN202794037U (zh) 一种用于原子荧光光度计扣除光源波动的装置
US20180335408A1 (en) Combined fluorescence and absorption detector for on-column detection after capillary separation techniques
CN102753949B (zh) 分光光度计及其性能测定方法
RU2279250C2 (ru) Устройство для неинвазивного измерения концентрации глюкозы в крови
EP1754045B1 (en) Apparatus for in situ spectroscopic measurements
KR20250006273A (ko) 유체 샘플 농도 측정을 위한 컴팩트한 고해상도 단색 광원
Renn et al. Single optical fiber, position-sensitive detector-based multiwavelength absorbance spectrophotometer
CN1904588B (zh) 微型芯片测定装置
JP2000074820A (ja) 液体クロマトグラフ
CN104833747B (zh) 一种采用深紫外led光源的制备色谱用紫外检测器
KR20250006274A (ko) 자동화된 연속 경사 측정 기능을 갖춘 가변 경로 길이 흡수 분광기
Kaltenbach A high-sensitivity diode array detector for on-column detection in capillary electrophoresis
CN120668618A (zh) 一种提高荧光检测器灵敏度的光路设计方法
CN107064095A (zh) 双波长量子点荧光探针呋喃酚酮检测装置及其检测方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180514

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180514

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190320

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190409

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190708

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190906

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191008

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200303

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200602

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200616

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200916

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201008

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201110

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201202

R150 Certificate of patent or registration of utility model

Ref document number: 6804436

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250