JP6800474B2 - Nutrient absorption improver - Google Patents

Description

INDUSTRIAL APPLICABILITY The present invention mainly comprises a drug for improving nutrient absorption function, a food and drink composition for improving aging undernutrition containing the same, and for preventing aging undernutrition in elderly people with reduced nutrient absorption function. It relates to a food and drink composition and a food and drink composition for the treatment of aging undernutrition.

In Japan, the ratio of elderly people aged 65 and over to the total population (aging rate) reached a record high of 26.0% (25.1% in the previous year) as of October 2014 (non-patent documents). 1). Under this circumstance, the period of unlimited daily life (healthy life expectancy) tends to decrease, and an increase in the absolute number of bedridden elderly people has become a social problem. Disease prevention and health promotion, by preventive care, etc., possible to reduce the difference between the life expectancy and healthy life expectancy, as well as to improve the individual's quality of life, even the reduction of social security contributions can be expected, the realization of healthy longevity It is one of the important national strategies.

Undernutrition due to aging is one of the causes of bedridden elderly people. The mechanism of weakness induction in the elderly due to malnutrition is called the frailty cycle, and drugs and foods have been developed to overcome this cycle. This frailty cycle is triggered by malnutrition, which induces sarcopenia (muscle loss), reduces muscle strength, vitality, body speed, activity, followed by basal metabolism, energy consumption, and decreased appetite and food intake. As a result, it is a "negative cycle" that leads to further malnutrition (Non-Patent Document 2).

Efforts have been made to overcome this cycle by adding energy such as lipids and sugars and nutritional supplements such as vitamins and minerals, but it is a symptomatic measure for elderly people with impaired digestive and absorption functions and metabolic functions. It is not too much to overcome the frailty cycle.

In addition, excessive intake of lipids and sugars has a risk of exacerbating diseases such as hyperlipidemia and diabetes (Non-Patent Document 3). Excessive intake of minerals such as calcium was also unsuitable for elderly people with impaired renal function.

On the other hand, it was not known that pectin derived from persimmon and polysaccharide derived from pectin have a nutrient absorption improving effect.

Conventionally, pectin has been used as a food additive to add thickness to foods such as jam. In recent years, attention has been paid to its function as a water-soluble dietary fiber, and it is also used for the purpose of intestinal regulation that promotes physicochemical action in the large intestine and fermentation action by intestinal bacteria.

Studies related to aging can be performed using aging model mice (Non-Patent Document 4). In this aging model mouse SAMP8, 10 months of age is half the survival time, which corresponds to about 65 to 70 years of age in humans.

In the aging model mouse SAMP8, age-related weight loss is observed. From 10 to 12 months of age, body weight gain is observed in normal mice, but decreases in SAMP8 (Non-Patent Document 5). It has been reported that a decrease in nutrient absorption function is one of the causes of this weight loss (Non-Patent Document 6).

It has also been reported that a decrease in blood calcium concentration occurs due to a decrease in nutrient absorption (Non-Patent Document 7).

A known method can be adopted as a method for examining the absorption efficiency of nutrients. Specifically, the absorption efficiency of nutrients can be investigated by ingesting lycopene orally and measuring the blood lycopene concentration after a certain period of time (Non-Patent Document 8).
Lycopene belongs to carotenes and is one of the nutrients. Nutrients such as glucose and amino acids are absorbed from the small intestine and then metabolized in the body, and there is a large difference between the amount absorbed and the amount detected in the blood. However, lycopene is not decomposed in the digestive tract, is absorbed directly from the small intestine, and is not easily metabolized in the body. Therefore, after a certain amount of lycopene is orally ingested, the amount of lycopene in blood can be evaluated as the nutrient absorption efficiency.

Cabinet Office 2015 White Paper on Aging Society Japanese Dietary Intake Standards (2015 Edition) Kazushi Yamamoto, Takeshi Tsuzuki, High-fat diet intake from old age suppresses decrease in lipid absorption capacity, 2016 Annual Meeting of the Japanese Society of Nutrition and Food Science, Abstract Hiroshi Sato, Nagasaki University School of Medicine Atomic Bomb Data Center http: //www-sdc.med.nagasaki-u.ac.jp/abcenter/sdr/1994/RR94-011.PDF about aging acceleration model mouse (SAM) Hiroshi Sugiyama, Aging Acceleration Model Mouse (SAM). History of medicine. 146 (9): 619-621, 1988. Yamamoto K.Hatakeyama Y, Sakamoto Y, Tsuduki T. High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice.J Clin Biochem Nutr. 2015 Nov; 57 (3): 204-11. Isako Shioji, Takashi Ikeo, Effect of long-term fluoride administration on bone metabolism in Senescence Accelerated Mouse (SAMP), Dentistry, 2001, 64 (4): 351-357. .. Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, Crowell JA, Stacewicz-Sapuntzakis M, Bowen PE A physiological pharmacokinetic model describing the disposition of lycopene in healthy men J Lipid Res 2003 Oct;. 44 ( 10): 1927-39.

Therefore, the present invention contains a new and highly effective nutrient absorption improving agent, a weight loss suppressing agent, a blood calcium improving agent, or a lycopene absorption improving agent, which can be stably supplied. Food and drink composition (including health-oriented foods and drinks, for example, nutritional supplements, health supplements, nutritionally adjusted foods, health functional foods, foods for specified health use, nutritional functional foods, foods with functional claims, etc., pharmaceuticals, pharmaceuticals The issue was to provide it as an external product).

Based on the above findings, the present inventors have diligently examined the screening of useful components having excellent nutrient absorption improving action, body weight loss suppressing action, blood calcium improving action, and lycopene absorption improving action.

As a result, the present inventors have found that pectin derived from persimmon fruit is superior to various components in nutrient absorption improving action, body weight loss suppressing action, blood calcium improving action, and lycopene absorption improving action. Then, a nutrient absorption improving agent, a weight loss suppressing agent, a blood calcium improving agent, or a lycopene absorption improving agent, and a food or drink composition containing them (including health-oriented foods and drinks, for example, , Nutritional supplements, health supplements, nutritionally adjusted foods, health functional foods, foods for specified health uses, nutritional functional foods, foods with functional claims, pharmaceuticals, non-pharmaceutical products, etc.) to complete the present invention. I came to do it.

Further, according to the present invention, by providing a novel and useful nutrient absorption improving agent, a weight loss suppressing agent, a blood calcium improving agent, a lycopene absorption improving agent, or various food and drink compositions containing them, the elderly can be aged. It is effective in preventing or ameliorating various diseases of malnutrition against the aging of the person.

It is a figure which shows the result of suppressing the weight loss of the aged mouse by using the feed containing the persimmon fruit pectin of this invention. As a comparative control, a feed containing dextrin and a feed containing strawberry pectin were prepared under the same conditions in place of persimmon fruit pectin and used in the test. It is a figure which shows the result of suppressing the decrease in the blood calcium concentration of the aged mouse by using the feed containing the persimmon fruit pectin of this invention. As a comparative control, a feed containing dextrin and a feed containing strawberry pectin were prepared under the same conditions in place of persimmon fruit pectin and used in the test. It is a figure which shows the result of having improved the absorption of lycopene of an aged mouse by using the feed containing the persimmon fruit pectin of this invention. As a comparative control, a feed containing dextrin and a feed containing strawberry pectin were prepared under the same conditions in place of persimmon fruit pectin and used in the test.

As the pectin from the persimmon fruit of the present invention, the plant of the family Ebenaceae, the genus Diospyros: the fruit of the persimmon (Diospyros kaki Thunberg), the fruit containing the persimmon skin, the pectin obtained from the fruit containing the persimmon skin or the vine is used. ..
It is preferable that the molecular weight of the persimmon fruit pectin is in the range of 5,000 to 55,000.

A known method can be adopted for producing pectin from persimmon fruit. Specifically, the persimmon fruit used as a raw material may be a persimmon fruit or a fruit containing pericarp, a fruit containing pericarp and vines, and the persimmon fruit may be mature or immature. You may. Further, it may be a juice residue. Further, these may be frozen or freeze-dried.

The method for producing persimmon fruit pectin of the present invention includes a step of extracting persimmons (fruits) with water having a temperature of less than 100 ° C. As a pH adjuster, mineral acids such as hydrochloric acid, sulfuric acid and phosphoric acid, organic acids such as citric acid, oxalic acid, tartaric acid and acetic acid, or alkali metals such as sodium hydroxide and calcium hydroxide and hydroxylation of divalent cations. Substances, alkali metal and divalent cation carbonates and bicarbonates, various polysaccharide-degrading enzymes (amylase, takaamylase, cellulase, hemicellulase, pectinase, polygalacturonase, dextranase, planase, etc.), or It can be carried out using other enzymes or the like. Further, a substance having a chelating function such as hexametaphosphate, phytic acid and EDTA can be added. After extraction, the mixture is solid-liquid separated by a method such as centrifugation or filter press. The insoluble component is separated as a solid, while the persimmon fruit pectin is contained in the water-soluble fraction.

The water used for washing and suspending includes pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, which have been subjected to various treatments. Treatments applied to water include, for example, purification, heating, sterilization, filtration, ion exchange, osmotic pressure adjustment, buffering and the like. Therefore, the water that can be used as the extraction solvent in the present invention includes purified water, heat-treated water, ion-exchanged water, physiological saline, various buffer solutions, and the like.

The weight ratio of water to persimmon fruit can be arbitrarily set within the range of 1: 1 to 1:20, but in particular, the weight ratio of 1: 5 to 1:10 is the extraction efficiency of pectin and the subsequent drying treatment. It is preferable in terms of workability.

The extraction temperature with water can be arbitrarily set in the range of 10 to 55 ° C., and it is particularly preferable to obtain an extract containing persimmon fruit pectin at a high concentration around 25 to 55 ° C, and any extract containing persimmon fruit pectin. Just do it.

The persimmon fruit pectin or the extract containing the persimmon fruit pectin thus obtained can be subjected to component adsorption by activated carbon, diatomaceous soil, etc., and various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, size exclusion). , Barrage exchange, affinity, etc.) Fractionation using chromatography, filtration using filter paper, membrane filter, ultrafiltration membrane, etc., pressurization or depressurization, heating or cooling, drying, pH adjustment, deodorization , Decolorization, long-term storage, etc., and a purification method in which these are arbitrarily selected and combined is performed.

The nutrient absorption improving agent, the weight loss suppressing agent, the blood calcium improving agent, or the lycopene absorption improving agent of the present invention utilizes the processed persimmon fruit extract obtained in this process depending on the intended use. However, the shape may be any of liquid, solid, powder, paste, concentrated liquid and the like, if necessary, and the optimum shape for carrying out the present invention can be arbitrarily selected. Can be done.

In the case of drying, the persimmon fruit pectin or the extract containing the persimmon fruit pectin may be used as it is, or if necessary, an excipient or the like may be used to perform a usual drying treatment such as freeze-drying or spray-drying. .. In particular, spray drying has the advantages of higher productivity and lower cost than freeze drying. The dried product thus obtained can be subjected to a shifter or the like as necessary to obtain a dry powder having an appropriate particle size. Usability is good when the particle size is about 50 to 100 mesh passes, preferably about 60 mesh passes.

The nutrient absorption improving agent, the weight loss suppressing agent, the blood calcium improving agent, the lycopene absorption improving agent, or the food and drink composition of the present invention (including health-oriented foods and drinks, for example, nutritional supplements). , Health supplements, nutritionally adjusted foods, foods with health claims, foods for specified health use, foods with nutritional claims, foods with functional claims, pharmaceuticals, non-pharmaceutical products, etc.).

For example, as a food and drink composition, as it is or by adding various nutritional supplements, nutritional tonicity, fatigue recovery, constitution improvement, etc., it is contained in foods and drinks, and is contained in foods and drinks, dietary supplements, health supplements, nutritionally adjusted foods, health. It is eaten as a functional food, a food for specified health use, a nutritionally functional food, a food with a functional claim, a supplement, and a food material. For example, after adding the above-mentioned appropriate auxiliary agent, it may be formed into an edible form, for example, granules, granules, tablets, capsules, pastes, etc., by conventional means, and used for food. In addition, various foods such as processed marine products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat and other noodles, sauces, soy sauce, sauce, etc. Seasonings such as sugar, honey, powdered candy, water candy, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spreads, pickles, soybeans, sprinkles, or canned / bottled various vegetables / fruits, etc. Processed vegetables / fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, dairy drinks, soft drinks, beverages such as alcoholic beverages, general taste foods such as liquid foods It can also be used as a pet food, a feed for animals and plants, and the like.

As the pharmaceutical product, either oral administration or parenteral administration can be adopted. At the time of administration, the active ingredient can be mixed with a solid or liquid pharmaceutical non-toxic carrier suitable for administration methods such as oral administration, rectal administration, and injection, and administered in the form of a conventional pharmaceutical preparation. Examples of such preparations include solid preparations such as tablets, granules, powders and capsules, solutions, suspensions, liquid preparations such as emulsions, freeze-dried preparations and the like. It can be prepared by conventional means. Examples of the above-mentioned pharmaceutical non-toxic carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glucol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, gelatin, and the like. Albumin, water, physiological saline and the like can be mentioned. Further, if necessary, conventional additives such as stabilizers, wetting agents, emulsifiers, binders, and tensioning agents can be appropriately added and used.

The prescribed amount of the nutrient absorption improving agent, the body weight loss suppressing agent, the blood calcium improving agent, or the lycopene absorption improving agent of the present invention is not particularly limited as long as the effect can be confirmed, but for example. In the case of oral use, a formulation in the range of 5 mg to 3 g / day in terms of solid content is appropriate.

In addition, in food and drink compositions, it has effects such as nutritional supplementation, recovery from fatigue, tonicity, and cell activation (prevention of cell aging), as well as improvement of taste, addition of color tone, aroma, and luster, stabilization, and thickening. It can be used for such purposes. Furthermore, in addition to this, various medicinal effects of the nuclear raw materials known so far are expected, and by combining these, the effects aimed at by the present invention can be enhanced or multifunctional. It is also possible to make a product that is expected to have a positive effect.

The nutrient absorption improving agent of the present invention, the weight loss suppressing agent, the blood calcium improving agent, the lycopene absorption improving agent, or the food and drink composition (including health-oriented foods and drinks, for example, nutrition) For supplements, health supplements, nutritionally adjusted foods, foods with health claims, foods for specified health use, foods with nutritional claims, foods with functional claims, pharmaceuticals, non-pharmaceutical products, etc.), in addition to the above essential ingredients, if necessary Various preparations can be produced by arbitrarily selecting and using the ingredients and additives exemplified below within a range that does not impair the effects of the present invention, and the content in the preparation is not particularly limited, but is usually used. A concentration range of 0.0001 to 50% is preferred.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, chimil alcohol, seraquil alcohol, bacil alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Higher grades such as palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, sodium salts and potassium salts thereof, amine salts such as ethanolamine salts, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil) ), Heavy liquid isoparaffin, Light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, carbides such as solid paraffin; candelilla wax, carnauba wax , Rice wax, wood wax, honey wax, montan wax, ozokelite, ceresin, paraffin wax, microcrystallin wax, petrolatum, fishertroph wax, polyethylene wax, ethylene / propylene copolymer and other waxes; palm oil, palm oil, palm kernel oil , Saflower oil, olive oil, sunflower oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadow foam oil, persic oil, tea tree oil , Corn oil, rapeseed oil, sunflower oil, wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba Vegetable fats and oils such as oils; animal fats and oils such as beef fat, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; whale wax, lanolin, orange raffy oil and the like Physical Properties Rows; Liquid lanolin, reduced lanolin, adsorption purified lanolin, lanolin acetate, liquid acetate lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester Lanorins such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingolilipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybeans Phosphorlipid derivatives such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, Cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyldodecyl), N- Diacylsarcosine alkyl esters such as di-lauroyl-L-glutamate (phytosteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), N-lauroylsarcosin isopropyl, cholesteryl 12-hydroxystearate, macadamia nuts Sterol esters such as oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, isostearate phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; phospholipid-cholesterol complex, phosphorus Lipid complexes such as lipid-phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimitinate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanoate, isotolideyl isononanoate, isononanoic acid Isononyl, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopenta Isostearyl acid acid, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hardened castor oil isostearate, ethyl oleate, Monoalcohol carboxylic acid esters such as avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, triethyl citrate; cetyl lactate, diisostearyl malate, water monoisostearic acid Oxyacid esters such as capsicum oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (capric acid / capric acid) glyceryl, tri (capric acid / capric acid / myristic acid / stear) Acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behic acid eikosan diacid, (tetradecane diic acid / eikosan diacid) glyceryl, (tetradecane diic acid / eicosan diic acid) polyglyceryl -10, Trimethylol propane trioctanoate, Trimethylol propane triisostearate, Neopentyl glycol dioctanoate, Neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, 3-Methyl dineopenate -1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ( Isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythricyl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythricyl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (elca) Polyvalent alcohol such as acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate) Le fatty acid esters; diisopropyl dimergylinolate, diisostearyl dimerserinolate, dimerserylinolate di (isostearyl / phytosteryl), dimergylinolic acid (phytosteryl / behenyl), dimerserinol acid (phytosteryl / isostearyl) / Cetyl / stearyl / behenyl), dimerdilinoleyl dimersylinorate, dimerdilinoleylbis (phytosteryl / behenyl / isostearyl), dimerselynorail diisostearate, hydrogenated rosin condensation Dimeric acid or derivatives of dimeric acid or dimerdiol such as dimerdylinoic acid-hardened castor oil, hydroxyalkyl dimerdinorail ether; palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid. Monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), palm oil fatty acid methyl Fatty acid alkanolamides such as ethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyl Amino-modified silicones such as dimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymers, dimethiconol, dimethiconol crosspolymer, silicone resins, silicone rubber, aminopropyldimethicone and amodimethicone, cation-modified silicones, Polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, Peptide-modified silicone, fluorine-modified silicone, cationic-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and Silicones such as polyether-modified silicones and polysiloxane / oxyalkylene copolymers; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferable.

Moisturizers and feel improvers include water (normal water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water as water). Includes), glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylpropane, pentaerythritol , Hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymers and other polyols and their polymers; diethylene glycol monoethyl ether (ethoxydiglycol), Glycolalkyl ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose, treose, xylose, arabinose , Fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, β-glucan, chitin, chitosan, heparin and derivatives, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl methacrylate Sugars such as ethyl polymers or copolymers and their derivatives; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose Naturally-derived polysaccharides such as polysaccharides; organic acids such as citric acid, tartaric acid, and lactic acid and salts thereof; urea; salts such as 2-pyrrolidone-5-carboxylic acid and sodium thereof; betaine (trimethylglycine), proline, hydroxyproline Amino acids such as arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamate, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, etc. Kinds and salts thereof; collagen , Fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide, keratin-degrading peptide, hydrolyzed keratin, conchiolin-degrading peptide, hydrolyzed conchiolin, silk protein degradation Peptides, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein-degrading peptide, acylated peptide and other protein peptides and their derivatives; palmitoyl oligopeptide, palmitoyl pentapeptide , Palmitoyl tetrapeptide and other acylated peptides; Cyrilized peptides; Lactobacillus culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mutin, hypotaurine, sesame lignan glycoside, glutathione, albumin, lactose; choline chloride , Phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hechima water, chamomile extract, kanzo extract, comfrey extract, silk extract, isayoibara extract, sardine extract, eucalyptus extract, melilot extract, etc. Peptides such as plant extracts, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and sugar ceramide-containing extracts are preferred.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and high molecular weight surfactants. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulphates such as sodium lauryl sulphate, triethanolamine lauryl sulphate and ammonium lauryl sulphate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulphate and triethanolamine laures sulphate; sodium cocoyl methyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristyl methyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sarcosin, lauroyl sarcosin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine Acyl amino acid salts such as; polyoxyethylene alkyl ether acetate salts such as sodium laureth acetate; succinic acid ester salts such as lauroyl monoethanolamide sodium succinate; fatty acid alkanolamide ether carboxylate; acyl late; polyoxyethylene fatty amine Sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzene polyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate; sodium lauryl sulfosuccinate, sulfosuccinate Alkyl sulfosuccinates such as sodium dioctyl sulphonate; alkyl ether sulfosuccinates such as laureth disooxalate disodium, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, sodium lauryl polypropylene glycol sulfosuccinate; sodium tetradecylbenzene sulfonate, tetra Alkylbenzene sulfonates such as decylbenzene sulfonic acid triethanolamine; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; laurethrin Alkyl ether phosphates such as sodium acid, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monoolesphosphate; alkyl phosphates such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphate; fatty acid amide ether Phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicones, phosphate-modified silicones, and sulfate-modified silicones; for nonionic surfactants, Laures (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether) , Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as octyldodeces (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxy Ethylene-hardened castor oil monoisostearate, polyoxyethylene-hardened castor oil triisostearate, polyoxyethylene-hardened castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene-hardened castor oil maleic acid and other castor oils and cured castor oil Derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetra Polyoxyethylene / polyoxypropylene alkyl ethers such as decyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / poly Oxypropylene glycol; (poly) glycerin such as PPG-9 diglyceryl Polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate Glycerin fatty acid partial esters such as lyceryl, glyceryl oleate, coconut oil fatty acid glyceryl, monocotton seed oil fatty acid glycerin, monoercaate glycerin, sesquioleate glycerin, α, α'-pyroglutamate oleate glycerin, monostearate glycerin malic acid; Polyglyceryl-2 stearate, 3, 4, 4, 5, 6, 8, 10, distearate polyglyceryl-6, 10, triglyceryl-2, polyglyceryl decastarate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 6, 8, polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate-2, polyglyceryl tetraisostearate -2, Polyglyceryl decaisostearate-10, Polyglyceryl oleate-2, 3, 4, 5, 6, 8, 10, Dioleate polyglyceryl-6, Trioleate polyglyceryl-2, Decaoleate polyglyceryl Polyglycerin fatty acid ester such as -10; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; martitol partial fatty acid Estel; multitoll ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate , Solbitan fatty acid ester such as tetra-2-ethylhexyl diglycerol sorbitan; sugar derivative partial ester such as sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylate; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol Reduced lanolin; polyoxyethylene fatty acid monos and diesters such as polyoxyethylene distearate, polytilene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene / propylene glycol fatty acid esters Polyoxye Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monostearate, polyoxyethylene glycerin monostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monostearate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol honey; iso Alkyl glyceryl ethers such as stearyl glyceryl ether, chimil alcohol, ceracyl alcohol, batyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensate; saponin, Natural surfactants such as sophorolipid; polyoxyethylene fatty acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (Lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl MEA) and other fatty acid alkanolamides. Alcoholamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether-modified silicones such as dimethicone copolyol, polysiloxane oxy Siri such as alkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc. Cone-based nonionic surfactants, etc .; For cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyl such as stearyltrimonium bromide. Trimethylammonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; alkyletheramines such as stearoxypropyldimethylamine and salts thereof. The salt or quaternary salt; fatty acid amide type quaternary ammonium salt such as ethyl sulfate long chain branched fatty acid (12-31) aminopropyl ethyl dimethylammonium, ethyl sulfate lanolin fatty acid aminopropyl ethyl dimethyl ammonium; polyoxyethylene alkylamine and its Salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyletheraminemonium salt; alkyltrialkylene glycolammonium salt; benzalconium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt Alkylisoquinolinium salt; Dialkylmorihonium salt; Polyamine fatty acid derivative; Amino-modified silicone such as aminopropyldimethicone and amodimethicone, cationic-modified silicone, cationic-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, etc. Silicone-based cationic surfactants, etc .; Among amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); cocamidopropyl betaine, lauramide propyl betaine, etc. Amidazoline-type betaine such as sodium cocoamphoacetate and sodium lauroammonium acetate; alkylsulfobetaine such as alkyldimethyltaurin; sulfate-type betaine such as alkyldimethylaminoethanol sulfate ester; alkyldimethylamino Phosphate-type betaines such as ethanol phosphate ester; spingoli such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, etc.

Phospholipids, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as lecithin hydroxide; silicone-based amphoteric surfactants, etc .; As the surfactant, polyvinyl alcohol, sodium alginate, starch derivative, traganth gum, acrylic acid / alkyl methacrylic acid copolymer, 2-methacloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer; various silicone-based surfactants are preferable. Is listed as.

Examples of the polymer / thickener / gelling agent include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, alginic acid and sodium salt. Salts, mannans; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin, chitosan, agar, casso extract, chondroitin sulfate, Casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as sodium thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium sulfate cellulose, crystalline cellulose, cellulose powder, etc. Cellulose and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch and methyl starch, starch derivatives such as hydroxypropyltrimonium chloride starch and corn starch aluminum octenyl succinate; sodium alginate, propylene glycol alginate ester Equal alginate derivatives; polyvinylpidridone (PVP), polyvinyl alcohol (PVA), vinylpyridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; (methacryloyloxyethyl) Amphoteric methacrylic acid ester copolymers such as carboxybetaine / alkyl methacrylate) copolymers, (Acrylates / stearyl acrylate / ethylamine methacrylate) copolymers; (dimethicone / vinyldimethicone) crosspolymers, (alkyl acrylate / diacetoneacrylamide) Copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester ; Polyacrylamide; Polya such as ethyl polyacrylate; Crylic acid ester copolymer, carboxyvinyl polymer, salts such as polyacrylic acid and sodium salt thereof, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylic acid copolymer; cations such as polyquaternium-10. Diaryldimethylammonium chloride / acrylamide copolymers such as cellulose, polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-39. Combined, acrylate / cationized methacrylic acid ester copolymer, acrylate / cationized methacrylic acid amide copolymer, acrylate / methyl acrylate / methacrylate propyltrimethylammonium chloride copolymer such as polyquaternium-47, Chloride methacrylic acid ester polymer; cationized oligosaccharide, cationized dextran, cationized polysaccharide such as guarhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 And copolymers with butyl methacrylate copolymers, etc .; polymer emulsions such as acrylic resin emulsions, ethyl polyacrylic acid emulsions, polyacrylic alkyl ester emulsions, vinyl acetate resin emulsions, natural rubber latex, synthetic latex, etc .; nitrocellulose Polyurethanes and various copolymers; Various silicones; Various silicone-based copolymers such as acrylic-silicone graft copolymers; Various fluoropolymers; 12-Hydroxystearic acid and its salts; Dextrin palmitate, myristic acid Dextrin fatty acid esters such as dextrin; silicic anhydride, fumigant silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectrite, organically modified clay minerals , Sucrose fatty acid ester, fructo-oligosaccharide fatty acid ester are preferable.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as: ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, glycol ether esters such as propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl Propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flone; LPG, dimethyl ether, and carbon dioxide are preferred.

Antioxidants include α-lipoic acid, salts of α-lipoic acid, and derivatives of α-lipoic acid; tocopherol derivatives such as tocopherol (vitamin E), tocotrienol, tocopherol acetate; BHT, BHA; propyl gallate, etc. Vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; hydrogen sulfites such as sodium bisulfite; thiosulfites such as sodium thiosulfite; hydrogen metasulfite Salts; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable.

Examples of preservatives and antibacterial agents include hydroxybenzoic acids such as methylparaben, ethylparaben, propylparaben and butylparaben and salts thereof or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2-hexane. 1,2-diols such as diols; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and salts thereof; phenols; halogenated bisphenols such as triclosan, acid amides , Tertiary ammonium salts; trichlorocarbanide, zincpyrythion, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophenol, hinokithiol; phenol, isopropylphenol, cresol, timol, parachlorophenol, Other phenols such as phenylphenol and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, and silver ion are preferable.

Examples of the chelating agent include edetates (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytate; ethidroic acid and the like. Phosphonic acid and salts such as sodium salt thereof; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred.

As pH adjusters, acids and alkalis, citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amin, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxide Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, cay. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , Fine particles and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic or Inorganic powders such as hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethylmethacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate. -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface treatment powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates and magnesium phosphates are preferred.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoate ethyl. Anthralic acid-based UV absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl esters, N, N-dimethylparaaminobenzoic acid ethyl esters; Anthranilic acid-based UV absorbers such as homomentyl-N-acetylanthranilate; salicylic acid And salicylic acid-based ultraviolet absorbers such as sodium salts, amilsalicylate, menthyl salicylate, homomentyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl. -2,5-Diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cyraxic acid-based UV absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzophenones such as −phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone Ultraviolet absorbers; 3- (4'-methylbenzylene) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5-( 3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidine propionic acid Hydantin derivatives such as 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalylidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferred.

Examples of the whitening agent include ascorbic acid phosphate salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitic acid ester, and ascorbic acid ethyl ether. Ascorbic acid alkyl ethers such as ascorbic acid alkyl ethers, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid derivatives such as ascorbic acid sulfate esters, tocopheryl ascorbyl phosphate; kodiic acid, ellagic acid, tranexamic acid and its derivatives. Preferred are plant extracts such as derivatives, ferulic acid and derivatives thereof, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble kanzo extract, Nishikawayanagi extract, and Yukinoshita extract.

Examples of vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, and pyridoxin dipalmitate. Flavin adenine dinucleotide, cyanocobalamine, folic acids, nicotinic acids such as nicotinic acid amide and benzyl nicotinate, vitamin B group such as choline; vitamin Cs such as salts of ascorbic acid and its sodium; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as sodium ascorbic acid phosphate and magnesium ascorbic acid ester, tetra ascorbic acid Ascorbic acid fatty acid esters such as isoparmic acid ester, ascorbyl stearate, ascorvir palmitate, ascorvir dipalmitate, alkyl ascorbic acid ethers such as ethyl ascorbic acid, ascorbic acid glucosides such as ascorbic acid-2-glucoside, and their fatty acid esters. , Ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherols such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferrate, tocopherol phosphate, tocotrienol, and various other vitamin derivatives are preferable. Is listed as.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. , Plant extracts such as Honoha extract are preferred.

As hair growth agents, blood circulation promoters and stimulants, plant extracts and tinctures such as senburi extract, capsicum tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonylate valenylamide, zingerone, ictamol, tannic acid , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-oryzanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide benzyl nicotinate Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycoside, minoxidil are preferable. Is listed as.

As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable.

Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, stimulants, painkillers, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and its glycosides / esters, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosin; creatin; ceramides, spingosines; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene Antioxidants and active oxygen scavengers such as astaxanthin and lutein; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamine, protoanthocyanidin, chlorogenic acid and apple polyphenols; Derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; kanzo extract-related substances such as glabridin, glabrene, liquiritin, isoliquiritin; lactoferrin; gingerol, gingerol; menthol, camphor, sedrol, etc. Perfume substances and derivatives thereof; capsaicin, vanillin and the like and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred.

Plant / animal / microbial extracts include iris extract, acitaba extract, asunaro extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract. , Inchikou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otanenjinjin extract, Otogirisou extract, Odori kosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, calcade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, kuchinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshouko extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Dai Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Carrot extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Paris etalia extract, Hikiokoshi extract, Bisaborol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, crackle extract and the like are preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and a salt thereof, deoxyribonucleic acid and a salt thereof, and disodium adenosine triphosphate.

Fragrances include acetylsedrene, amylcinnamaldehyde, allylamylglycolate, β-ionone, isoesuper, isobutylquinolin, iris oil, iron, indol, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, olanthiol, galactosolid, carbachlor, L-carboxylic, camphor, cannon, carrot seed oil, clove oil, methyl silicate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzylcarbinate acetate, styralyl acetate, sedrill acetate, telepinel acetate, pt-butylcyclohexyl acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux Resinoid, cedarwood oil, sedren, sedrol, celery seed oil, thyme oil, damascon, damasenon, timol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinen, triplar, nerol, nonanaal, 2,6-nonazienol, nonalactone, pacholi Alcohol, vanilla absolute, vanillin, basil oil, patcholi oil, hydroxycitral, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, benzyl oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil , Lavender oil, D-rimonone, linalool, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances such as various essential oils and natural Fragrances and various blended fragrances are preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213 , Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 , Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505 , Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 , Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3 , 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
Nitro dyes such as phenylenediamine, HC Blue 2, Basic Blue 26; Dispersion dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and lower titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; chromium oxide and chromium hydroxide , Inorganic green pigments such as cobalt titanate; Inorganic blue pigments such as ultramarine and dark blue; Titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil Pearl pigments such as: Aluminum powder, Copper powder, Metal powder pigments such as gold; Surface-treated inorganic and metal powder pigments; Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, etc. Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401 Organic pigments such as zirconium, barium or aluminum lakes such as No., Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1; Surface-treated organic pigments Anthracinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantin, chalcone, calsamine, quercetin, crosin, chlorophyll, curcumin, cochineal, naphthoquinones such as ciconin, bixin, flavones, betacyanidine, henna , Ricopine, riboflavin, rutin and other natural pigments and dyes; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methyl Oxidation dye intermediates and couplers such as phenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof; auto-oxidation dyes such as indolin; dihydroxyacetones are preferred.

In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japanese Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, food additive official regulations, etc., and Japanese and foreign patent gazettes and patent publication gazettes (including publication gazettes and republishing) whose international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the described ingredients, in known combinations, blending ratios, and blending amounts.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Production Example 1) Preparation of pectin (1)
The crushed fruit (raw) of Fuyu persimmon from Gifu prefecture was used as a sample, and 6N hydrochloric acid was added to adjust the pH to 2.8. Next, the liquid temperature was raised to 90 ° C., and heat extraction was performed at that temperature for 90 minutes to obtain an extract. This extract was centrifuged to remove insoluble matters, and concentrated under reduced pressure to obtain a concentrated solution. 1.5 times the amount of ethanol was added to this concentrated solution, and the produced precipitate was recovered by centrifugation. Then, the precipitate was washed with 50% ethanol and freeze-dried to obtain powdered pectin. In order to reduce the molecular weight of high molecular weight pectin, the obtained powdered pectin is turbid in distilled water, heated to 40 ° C, an enzyme agent having enzymatic activity such as pectinase is added, and 120 at 40 ° C. The enzymatic reaction was carried out for 1 minute. After completion of the reaction, insoluble matter was removed by centrifugation, and pectin was prepared by lyophilization. Examples of commercially available pectinases include sucrase (manufactured by Sankyo Co., Ltd.), pectinase G, pectinase PL, neurase F, pectinase PL, pectinase G (manufactured by Amano Enzyme Co., Ltd.) and the like. It is not particularly limited.

(Production Example 2) Preparation of pectin (2)
Fuyu persimmon fruit (raw) from Gifu prefecture was crushed and 6N hydrochloric acid was added to adjust the pH to 2.8. Then, the liquid temperature was raised to 90 ° C. and heated at that temperature for 90 minutes to obtain an extract. This extract was centrifuged to remove insoluble matter. After adjusting the supernatant of the extract to a neutral pH, twice the amount of 95% ethanol was added, the precipitate was collected, and dried with hot air at 60 ° C. to obtain a freeze-dried powder of persimmon fruit pectin.

(Test 1) Measurement of molecular weight "Measurement method and measurement result"
The persimmon fruit pectin obtained in Production Example 1 of the present invention or the persimmon fruit pectin obtained in Production Example 2 of the present invention is dissolved in purified water, and the obtained persimmon fruit pectin aqueous solution is subjected to gel filtration chromatography ( It was subjected to HPLC) and its molecular weight was measured.
As a result of the measurement, the molecular weight range of the persimmon fruit pectin obtained in Production Example 1 of the present invention was in the range of 5,000 to 55,000. The molecular weight range of the persimmon fruit pectin obtained in Production Example 2 of the present invention was in the range of 10,000 to 300,000.

(Test 2) Anti-weight loss effect The anti-weight loss effect was evaluated using aging-promoting mouse SAMP8.
"Test method and evaluation method"
Feed for mice, rats and hamsters containing the persimmon fruit pectin of Production Example 1 of the present invention from 8 months of age, bred using male aging-accelerated mouse SAMP8 (manufactured by Nippon SLC Co., Ltd.) (Product name: MF) , Oriental Yeast Co., Ltd.) was allowed to ingest freely. As a comparative control, instead of persimmon fruit pectin, a feed containing dextrin and a feed containing strawberry pectin were freely ingested under the same conditions, and the body weights at 10 and 12 months of age were measured. The results are shown in FIG.
"sample"
As the sample of this test, the persimmon fruit pectin (solid content concentration 5 w / w%) obtained in Production Example 1 of the present invention was added to a feed for mice, rats and hamsters and subjected to the test. As comparative controls, dextrin (solid form concentration 5 w / w%) (paindex, manufactured by Matsutani Chemical Industry Co., Ltd.) and strawberry pectin (molecular weight adjusted to 5,000 to 55,000) ( The solid form concentration (5 w / w%) was used as a feed contained in the feed for mice, rats and hamsters, and used in the test under the same conditions.

(Test results)
As shown in FIG. 1, as a comparative control, the aging-accelerated mice that ingested the dextrin-containing diet weighed about 35 g at 10 months of age and about 30 g at 12 months of age. Comparing the 12-month-old and the 10-month-old, it was confirmed that the 12-month-old was about 5 g less than the 10-month-old, and the body weight was significantly reduced.
As a comparative control, the aging-accelerated mice that ingested the feed containing strawberry pectin also weighed about 34 g at 10 months of age and about 30 g at 12 months of age. Comparing the 12-month-old and the 10-month-old, the decrease was about 4 g at the 12-month-old, and it was confirmed that the body weight was significantly reduced even with the feed containing strawberry pectin.
On the other hand, in the aging-accelerated mice that ingested the feed containing the persimmon fruit pectin of the present invention, the body weight at 10 months of age was about 36 g, and that of 12 months of age was about 35 g. Comparing the 12-month-old and the 10-month-old, the decrease was only about 1 g at the 12-month-old, and it was confirmed that there was almost no change in body weight with the feed containing the persimmon fruit pectin.
Therefore, it can be confirmed that the persimmon fruit pectin of the present invention has a body weight loss inhibitory effect, and is useful as a body weight loss inhibitor.
Further, from the above-mentioned result of suppressing the decrease in body weight, it can be inferred that the persimmon fruit pectin of the present invention was able to sufficiently absorb nutrients in the body, and it is also useful as a nutrient absorption improving agent.
Furthermore, this test was the result of using the aging-promoting mouse SAMP8, and since the aging-promoting mouse SAMP8 corresponds to about 65 to 70 years old in humans, the weight loss of the elderly with age. It is also useful as an inhibitor and as a nutrient absorption improving agent for aging of the elderly.

(Test 3) Blood calcium improving effect Blood calcium improving effect was evaluated using aging-promoting mouse SAMP8.
"Test method and evaluation method"
Feed for mice, rats and hamsters containing the persimmon fruit pectin of Production Example 1 of the present invention from 8 months of age, bred using male aging-accelerated mouse SAMP8 (manufactured by Nippon SLC Co., Ltd.) (Product name: MF) , Oriental Yeast Co., Ltd.) was allowed to ingest freely. As a comparative control, instead of persimmon fruit pectin, a feed containing dextrin and a feed containing strawberry pectin were freely ingested under the same conditions, and blood was taken from the tail vein at 10 and 12 months of age. Was collected and the blood calcium concentration was measured. The results are shown in FIG.
"sample"
As the sample of this test, the persimmon fruit pectin (solid content concentration 5 w / w%) obtained in Production Example 1 of the present invention was added to a feed for mice, rats and hamsters and subjected to the test. As comparative controls, dextrin (solid form concentration 5 w / w%) (paindex, manufactured by Matsutani Chemical Industry Co., Ltd.) and strawberry pectin (molecular weight adjusted to 5,000 to 55,000) ( The solid form concentration (5 w / w%) was used as a feed contained in the feed for mice, rats and hamsters, and used in the test under the same conditions.

(Test results)
As shown in FIG. 2, as a comparative control, in the aging-accelerated mice fed the diet containing dextrin, the value of the blood calcium concentration at 10 months of age was about 7.6 mg / dL, and at 12 months of age it was about about. It was 7.0 mg / dL. Comparing the 12-month-old and the 10-month-old, it was confirmed that the calcium concentration decreased by about 0.6 mg / dL at the 12-month-old from the 10-month-old.
Also, as a comparative control, the value of blood calcium concentration at 10 months of age was about 7.6 mg / dL even in the aging-accelerated mice that ingested the feed containing strawberry pectin, and about 7.1 mg at 12 months of age. It was / dL. Comparing the 12-month-old and the 10-month-old, the decrease was about 0.5 mg / dL at the 12-month-old, confirming the decrease in blood calcium concentration.
On the other hand, in the aging-accelerated mice that ingested the feed containing the persimmon fruit pectin of the present invention, the value of the blood calcium concentration at 10 months of age was about 8.1 mg / dL, and at 12 months of age it was about 8. It was 2 mg / dL. Comparing 12-month-old and 10-month-old, it was confirmed that the blood calcium concentration increased by about 0.1 mg / dL at 12-month-old.
Therefore, it can be confirmed that the persimmon fruit pectin of the present invention has a blood calcium concentration improving effect, and is useful as a blood calcium concentration improving agent.
Furthermore, from the above-mentioned results of increasing blood calcium, it can be inferred that the persimmon fruit pectin of the present invention was able to sufficiently absorb nutrients in the body, and it is also useful as a nutrient absorption improving agent.
In addition, this test was the result of using the aging-promoting mouse SAMP8, and since the aging-promoting mouse SAMP8 is equivalent to about 65 to 70 years old in humans, blood calcium for the aging of the elderly. It is also useful as an improving agent and as a nutrient absorption improving agent for aging of the elderly.

(Test 4) Lycopene absorption improving action Lycopene absorption improving action was evaluated using aging-promoting mouse SAMP8.
"Test method and evaluation method"
Feed for mice, rats and hamsters containing the persimmon fruit pectin of Production Example 1 of the present invention from 8 months of age, bred using male aging-accelerated mouse SAMP8 (manufactured by Nippon SLC Co., Ltd.) (Product name: MF) , Oriental Yeast Co., Ltd.) was allowed to ingest freely. As a comparative control, instead of persimmon fruit pectin, a feed containing dextrin and a feed containing strawberry pectin were freely ingested under the same conditions, and blood was taken from the tail vein at 10 and 12 months of age. Was collected and the blood lycopene concentration was measured. The results are shown in FIG.
"sample"
As the sample of this test, the persimmon fruit pectin (solid content concentration 5 w / w%) obtained in Production Example 1 of the present invention was added to a feed for mice, rats and hamsters and subjected to the test. As comparative controls, dextrin (solid form concentration 5 w / w%) (paindex, manufactured by Matsutani Chemical Industry Co., Ltd.) and strawberry pectin (molecular weight adjusted to 5,000 to 55,000) ( The solid form concentration (5 w / w%) was used as a feed contained in the feed for mice, rats and hamsters, and used in the test under the same conditions.

(Test results)
As shown in FIG. 3, as a comparative control, in aging-accelerated mice fed a diet containing dextrin, the blood lycopene concentration at 10 months of age was about 6.8 mg / dL, and at 12 months of age it was about 6 It was .2 mg / dL. Comparing the 12-month-old and the 10-month-old, the 12-month-old decreased by about 0.6 mg / dL from the 10-month-old, confirming a decrease in the blood lycopene concentration.
Also, as a comparative control, the blood lycopene concentration at 10 months of age was about 6.7 mg / dL, and at 12 months of age, about 6.2 mg / dL even in the aging-accelerated mice that ingested the diet containing strawberry pectin. Met. Comparing 12-month-old and 10-month-old, it was confirmed that the blood lycopene concentration decreased by about 0.5 mg / dL at 12-month-old.
On the other hand, in the aging-accelerated mice fed the feed containing the persimmon fruit pectin of the present invention, the blood lycopene concentration at 10 months of age was about 7.2 mg / dL, and at 12 months of age it was about 7.5 mg. It was / dL. Comparing 12-month-old and 10-month-old, it was confirmed that the blood lycopene concentration increased by about 0.3 mg / dL at 12-month-old.
Therefore, it can be confirmed that the persimmon fruit pectin of the present invention has a lycopene absorption improving action, and is useful as a lycopene absorption improving agent.
Furthermore, from the above-mentioned results of improving the absorption of lycopene, it can be inferred that the persimmon fruit pectin of the present invention was able to sufficiently absorb nutrients in the body, and it is also useful as a nutrient absorption improving agent.
In addition, this test was conducted using the aging-promoting mouse SAMP8, and since the aging-promoting mouse SAMP8 is equivalent to about 65 to 70 years old in humans, improvement of lycopene absorption with aging of the elderly It is also useful as an agent and as a nutrient absorption improving agent for aging of the elderly.

(Test 5) Acute toxicity test In Production Examples 1 and 2, persimmon fruit pectin (adjusted with purified water so that the solid content concentration was about 5 w / w%) was fasted for 4 hours before the test. Male and female, 5 animals per group, 5 weeks old) were orally administered at an amount of 5,000 mg / kg, and the onset and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and the autopsy result was also normal. Therefore, the LD50 was 5,000 mg / kg or more, which was judged to be safe.

(Prescription example) Manufacture of nutrient absorption improving agent, weight loss inhibitor, blood calcium concentration improving agent, lycopene absorption improving agent, food and drink composition According to the above evaluation results, the prescription example is shown below. May be manufactured by a conventional method in the manufacture of each product, and only the blending amount is shown. Moreover, the present invention is not limited to these.

(Prescription example 1) Nutrient absorption improving agent (drinking) Mass%
Persimmon fruit pectin 3.0 of Production Example 1 of the present invention
Citric acid 1.0
Fructose-glucose liquid sugar 70.0
Perfume Residual with an appropriate amount of purified water 100

(Prescription example 2) Weight loss inhibitor (drinking) Mass%
Persimmon fruit pectin 3.0 of Production Example 2 of the present invention
Reduced maltose starch syrup 38.0
Microcrystalline Cellulose 59.0
Appropriate amount of fragrance

(Prescription example 3) Blood calcium concentration improving agent (oral) Mass%
Persimmon fruit pectin 2.0 of the present invention
Lactose 30.0
Cornstarch 58.0
Crystalline cellulose 7.0
Polyvinyl pyrrolidone 3.0

(Prescription example 4) Lycopene absorption improving agent (drinking) Mass%
Persimmon fruit pectin 2.0 of the present invention
Cellulose 98.0
Appropriate amount of fragrance

(Prescription example 5) Supplement mass%
Persimmon fruit pectin of the present invention 10.0
Hesperidin 80.0
Starch 10.0
Appropriate amount of fragrance

(Prescription example 6) Gummy mass%
Reduced starch syrup 40.0
Granulated sugar 20.0
Glucose 18.0
Persimmon fruit pectin 2.0 of the present invention
Water 10.0
Gelatin 9.0
Citric acid 0.9
Dye 0.1
Appropriate amount of fragrance

(Prescription example 7) Chewing gum mass%
Gum base 20.0
Sugar 15.0
Isomaltose 20.0
Palatinose 10.0
Xylitol 10.0
Corn syrup 13.0
Persimmon fruit pectin 2.0 of the present invention
Syrup 10.0
Appropriate amount of fragrance

(Prescription Example 8) Beverage mass%
Fructose-glucose liquid sugar 40.0
Grapefruit juice 40.0
Persimmon fruit pectin 2.0 of the present invention
Iyokan juice 2.0
Sodium ascorbate 1.0
Perfume Residual with an appropriate amount of purified water 100

(Prescription example 9) Vegetable juice beverage mass%
Commercial vegetable juice 99.0
Persimmon fruit pectin 1.0 of the present invention

(Prescription Example 10) Tablet mass%
Cornstarch 30.0
Carboxymethyl Cellulose Calcium 20.0
Microcrystalline Cellulose 38.0
Persimmon fruit pectin 2.0 of the present invention
Polyvinylpyrrolidone 6.0
Talc 3.0
Sodium ascorbate 1.0
Appropriate amount of fragrance

(Prescription example 11) Confectionery mass%
Powdered sugar 88.0
Lactose 2.0
Citric acid 2.0
Gelatin 1% aqueous solution 4.0
Persimmon fruit pectin (powder) 1.0 of the present invention
Sodium ascorbate 2.0
Sucrose fatty acid ester 1.0
Appropriate amount of fragrance

The present invention has found that pectin derived from persimmon fruit is excellent in nutrient absorption improving action, weight loss suppressing action, blood calcium improving action, lycopene absorption improving action, and a nutrient absorption improving agent or a weight loss suppressing agent. Alternatively, a blood calcium improver or a lycopene absorption improver, and a food or drink composition containing them (including, for example, a health-oriented food or drink, for example, a nutritional supplement, a health supplement, a nutritionally adjusted food, health We can provide functional foods, foods for specified health use, nutritionally functional foods, foods with functional claims, pharmaceuticals, non-pharmaceutical products, etc.), and various diseases with low nutritional status against aging of the elderly. It is effective for prevention or improvement of such things.

Claims (4)

A composition containing persimmon fruit pectin for prevention and / or improvement of aging undernutrition, and for suppressing weight loss . A composition containing persimmon fruit pectin for preventing and / or improving aging undernutrition , and further for improving blood calcium concentration . A composition containing persimmon fruit pectin for preventing and / or improving aging undernutrition , and further for improving blood lycopene concentration . The composition according to any one of claims 1 to 3 , wherein the persimmon fruit pectin has a molecular weight of 5,000 to 55,000.

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